Natural Product Research最新文献_第4页

Cost-efficient analysis of cannabinoids in therapeutic oils using HPLC with UV and mass spectrometry detection. 利用高效液相色谱法和紫外及质谱检测技术，对食疗油中的大麻素进行经济高效的分析。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-13 DOI: 10.1080/14786419.2024.2439024

Alexander Fries, Carlos Alberto Moldes, Laura S Mazzaferro

引用次数: 0

Quantitative analysis of vasicine and vasicinone in Adhatoda vasica (Nees.) using RP-HPLC: distribution and solvent extraction efficiency. 利用 RP-HPLC 法定量分析 Adhatoda vasica (Nees.) 中的 vasicine 和 vasicinone：分布和溶剂萃取效率。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-13 DOI: 10.1080/14786419.2024.2440521

C Rohini, T A Kavya, A Niranjana Kumar, J Kotesh Kumar, K V N Satya Srinivas, B Venkatesh, P Ravi Kumar

{"title":"Quantitative analysis of vasicine and vasicinone in Adhatoda vasica (Nees.) using RP-HPLC: distribution and solvent extraction efficiency.","authors":"C Rohini, T A Kavya, A Niranjana Kumar, J Kotesh Kumar, K V N Satya Srinivas, B Venkatesh, P Ravi Kumar","doi":"10.1080/14786419.2024.2440521","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440521","url":null,"abstract":"Adhatoda vasica Nees (Acanthaceae), an ayurvedic shrub, is used widely in respiratory disorders. The pharmacologically most studied phytoconstituent in A. vasica is vasicine, a bitter quinazoline alkaloid present in leaves. A robust method was developed for the simultaneous quantification and analysis of two major alkaloids i.e. vasicine and vasicinone by RP-HPLC. This paper describes the distribution of these markers in different parts of the plant along with the best extraction method for their recovery. The highest abundance of vasicine was observed in the leaves (0.7332%), than in the stems and roots, whereas vasicinone was present only in the leaves (0.0436%). Methanol was identified as the most effective solvent for the extraction of vasicine in successive extraction (the herb was extracted sequentially with increasing solvent polarity) whereas 30% aq. Methanol is recommended for extraction of vasicinone in individual solvent extraction (the fresh herb was extracted separately with different solvents) method.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iridoid glycosides from the flowering plant Lamourouxia dasyantha (Cham. & Schltdl.) W.R. Ernst. 来自开花植物 Lamourouxia dasyantha (Cham. & Schltdl.) W.R. Ernst 的铱苷。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-13 DOI: 10.1080/14786419.2024.2438280

Manuel Jiménez-Estrada, Arturo Navarro-Ocaña, Alfonso Lira-Rocha, Rosario Tavera-Hernández, Jesús Javier Alvarado-Sansininea, Maira Huerta-Reyes

引用次数: 0

Unveilling the antidiabetic potential of ashwagandha (Withania somnifera L.) and its withanolides-a review.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-13 DOI: 10.1080/14786419.2024.2439009

Eman A Makhlouf, Youmna K AlamElDeen, Riham A El-Shiekh, Mona M Okba

{"title":"Unveilling the antidiabetic potential of ashwagandha (Withania somnifera L.) and its withanolides-a review.","authors":"Eman A Makhlouf, Youmna K AlamElDeen, Riham A El-Shiekh, Mona M Okba","doi":"10.1080/14786419.2024.2439009","DOIUrl":"https://doi.org/10.1080/14786419.2024.2439009","url":null,"abstract":"Withania somnifera, commonly known as Ashwagandha, is a prominent herb in Ayurvedic medicine, recognised for its diverse pharmacological properties, particularly its potential anti-diabetic effects. With the global incidence of diabetes mellitus (DM) surpassing 366 million, interest in herbal remedies like Ashwagandha has surged. Active compounds known as withanolides have demonstrated efficacy in modulating glucose homeostasis and enhancing insulin sensitivity. Systematic reviews indicate that Ashwagandha effectively restores altered blood glucose and glycosylated haemoglobin (HbA1c) levels without significant safety concerns. Animal studies reveal hypoglycaemic effects from both root and leaf extracts, improving metabolic parameters. Although clinical evidence remains limited, existing trials suggest that Ashwagandha may enhance insulin sensitivity and overall metabolic profiles in diabetic patients. This review underscores the potential of Ashwagandha as a complementary approach in DM management, warranting further research to confirm its therapeutic benefits and elucidate underlying mechanisms.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of validated HPTLC methods for determination of triterpenoids and flavan-3-ols in leaf and stembark of Manilkara hexandra Dubard. 开发测定 Manilkara hexandra Dubard 叶片和茎皮中三萜类化合物和黄烷-3-醇的有效 HPTLC 方法。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-13 DOI: 10.1080/14786419.2024.2435533

Sapna Sharma, Karuna Modi, Milankumar Thakar, Gaurang Sindhav, Mamta B Shah

{"title":"Development of validated HPTLC methods for determination of triterpenoids and flavan-3-ols in leaf and stembark of Manilkara hexandra Dubard.","authors":"Sapna Sharma, Karuna Modi, Milankumar Thakar, Gaurang Sindhav, Mamta B Shah","doi":"10.1080/14786419.2024.2435533","DOIUrl":"https://doi.org/10.1080/14786419.2024.2435533","url":null,"abstract":"Manilkara hexandra Dubard is a highly reputed medicinal plant of Ayurveda. In the current study, High-performance Thin-layer chromatographic (HPTLC) techniques were established for the analysis of triterpenoids like lupeol (LU), betulinic acid (BA), epimeric flavan-3-ols (+)-catechin (CA), and (-)-epicatechin (ECA), in its leaf and stembark. HPTLC separation was performed using petroleum ether: ethyl acetate: toluene: formic acid (7:2:1:0.3, v/v/v/v) as a mobile phase to resolve LU and BA at Rf 0.51 and 0.34, respectively. Further, derivatization was done using a 1% anisaldehyde-sulphuric acid reagent. For CA and ECA, the mobile phase was di-isopropyl ether: ethyl acetate: formic acid (9:0.5:1, v/v/v), resulting in sharp bands at Rf 0.43 and 0.38. The result showed that the leaf contains high levels of BA and CA, while the stem bark is rich in LU and ECA. Both methods were simple, accurate, and reproducible and would potentially be useful for the standardisation of M. hexandra Dubard.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catechin inhibits glycosidases, ameliorates glucose uptake and Glut-4 expression in 3T3-L1 adipocytes.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-11 DOI: 10.1080/14786419.2024.2439007

Kavishankar Gawli

{"title":"Catechin inhibits glycosidases, ameliorates glucose uptake and Glut-4 expression in 3T3-L1 adipocytes.","authors":"Kavishankar Gawli","doi":"10.1080/14786419.2024.2439007","DOIUrl":"https://doi.org/10.1080/14786419.2024.2439007","url":null,"abstract":"The research aimed to determine the inhibitory effects of different fractions of Camellia sinensis on α-glucosidase, α-amylase, glucose uptake, and Glut-4 expression in 3T3-L1 adipocytes and identification of the active principle. The crude aqueous extract was sequentially sub-fractionated using preparative HPLC and subjected to in vitro assays. Fraction 1 (F1) exhibited effective inhibition of both α-glucosidase and α-amylase with an IC50 value of 90.31 µg/mL and 112.82 µg/mL, respectively. Sub-fraction 5 (F5) effectively inhibited α-glucosidase (IC50 = 37.86 µg/mL) compared to acarbose (IC50 = 76.19 µg/mL). The glucose uptake was significantly increased to 1.5 (p < 0.05) and 2.5-fold (p < 0.05) by F5 at 50 and 100 µM concentration, respectively. The synergistic effect of F1 to enhance glucose uptake (1.15 and 1.5-fold stimulation) was significantly higher than the control but less effective than F5. Furthermore, structure elucidation of the principle present in F5 revealed the presence of (2 R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new sesquiterpenes from Ainsliaea glabra.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-11 DOI: 10.1080/14786419.2024.2437014

Xiao-Li Ma, Guo-Dong Jiang, Ji-Yuan Wei, Ze-Dong Nan, Chang-Ting Zhang, Zhi-Jun Song

引用次数: 0

Amentoflavone, a biflavonoid with potential anticancer properties against viral oncoprotein E6 in Human papilloma virus-16 (HPV-16) positive cervical cancer cells.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-09 DOI: 10.1080/14786419.2024.2438273

Ashish Kumar

{"title":"Amentoflavone, a biflavonoid with potential anticancer properties against viral oncoprotein E6 in Human papilloma virus-16 (HPV-16) positive cervical cancer cells.","authors":"Ashish Kumar","doi":"10.1080/14786419.2024.2438273","DOIUrl":"https://doi.org/10.1080/14786419.2024.2438273","url":null,"abstract":"Cervical cancer is predominantly associated with Human Papillomavirus (HPV) infection via HPV16-E6This interdisciplinary investigation investigates the effects of amentoflavone, a bioflavonoid on HPV16-E6, unravelling its impact on the protein's structural dynamics to explore its potential as a therapeutic agent for cervical cancer. MD simulations demonstrated stable binding dynamics between amentoflavone and HPV16-E6. RMSD analysis revealed alterations in the E6 protein structure, and Gibbs binding free energy calculations indicated an energetically favourable interaction. Control simulations enhanced the interpretability of the results. Amentoflavone inhibited the proliferation of SiHa and CaSki cells with GI50 values of 47.2 ± 9.64 μM and 29.1 ± 4.38 μM respectively. Treatment with amentoflavone promoted early and late-phase apoptosis in these cells. The compound reduced HPV-16 E6 while increasing p53-positive populations in SiHa and CaSki cells. In conclusion, the findings of this study suggest that amentoflavone may act as a potential inhibitor of HPV16-E6, disrupting its structural integrity and dynamics.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new terpestacin-type sesterterpenoid with tricyclic 3/15/5 scaffold from an endophytic fungus Neofusicoccum sp. J019.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-09 DOI: 10.1080/14786419.2024.2438268

Peishan Gu, Shujie Jia, Zhaolin Chen, Xiao-Nian Li, Yongbo Xue

{"title":"A new terpestacin-type sesterterpenoid with tricyclic 3/15/5 scaffold from an endophytic fungus Neofusicoccum sp. J019.","authors":"Peishan Gu, Shujie Jia, Zhaolin Chen, Xiao-Nian Li, Yongbo Xue","doi":"10.1080/14786419.2024.2438268","DOIUrl":"https://doi.org/10.1080/14786419.2024.2438268","url":null,"abstract":"ABSTACTChemical investigation of an endophytic fungus, Neofusicoccum sp. J019, isolated from the plant species Cynanchum chinense R. Br., has led to the identification of an undescribed terpestacin-type sesterterpenoid, neofusistacin (1), together with two analogues (2 and 3). The structure of 1 was elucidated by extensive spectroscopic analyses including UV, IR, 1D, and 2D NMR, HRESIMS, and its absolute configuration was unambiguously confirmed by a single crystal X-ray diffraction analysis. Compound 1 is featured by a rare 3/15/5-fused tricyclic scaffold in terpestacin-type sesterterpenoid. The anti-inflammatory activities of compounds 1-3 were evaluated in vitro, but none of them showed obvious anti-inflammatory activities at the concentration of 100 μM. No antibacterial activity against Escherichia coli ATCC 25922, Salmonella enterica subsp. enterica ATCC 14028, and Staphylococcus aureus subsp. aureus ATCC 29213 was found for compounds 1-3 at the concentration of 100 μM.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terrein: isolation, chemical synthesis, bioactivity and future prospects of a potential therapeutic fungal metabolite.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-06 DOI: 10.1080/14786419.2024.2436112

Rashi Srivastava, Faraz Ahmad, Bhartendu Nath Mishra, Darin Mansor Mathkor, Vineeta Singh, Shafiul Haque

{"title":"Terrein: isolation, chemical synthesis, bioactivity and future prospects of a potential therapeutic fungal metabolite.","authors":"Rashi Srivastava, Faraz Ahmad, Bhartendu Nath Mishra, Darin Mansor Mathkor, Vineeta Singh, Shafiul Haque","doi":"10.1080/14786419.2024.2436112","DOIUrl":"https://doi.org/10.1080/14786419.2024.2436112","url":null,"abstract":"The increasing risk of drug-resistant infections and unexpected pandemics like Covid-19 has prompted researchers to explore the area of drug repurposing. Natural products, being a result of the evolutionary optimisation processes can be potential starting points for such drug discovery programs. One such unexplored chemical is terrein, a secondary fungal metabolite. Although discovered in 1935 from Aspergillus terreus, the therapeutic potential of terrein has largely remained undeciphered. Research has primarily been focused on its biosynthetic pathways and its mycotoxic effects. However, in the last two decades, its biological properties including anticancer, anti-inflammatory anti-melanogenic, and bacteriocidal activities have been reported. These reports are preliminary in nature and do not adequately establish its overall therapeutic application. From its structural and therapeutic properties, it can be conjectured that terrein may act as a novel multimodal therapeutic. This comprehensive study reviews the synthesis, production and application aspects of terrein to understand its importance.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0