Natural Product Research最新文献_第4页

Isolation and identification of diverse steroids as Escherichia coli β-glucuronidase inhibitors from the Submerge-cultured mycelia of Hirsutella sinensis. 从中华毛杆菌菌丝体中分离鉴定多种甾体类大肠杆菌β-葡萄糖醛酸酶抑制剂。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-10 DOI: 10.1080/14786419.2025.2571857

Youmin Ying, Xiaoxiao Chen, Ling Li, Jianwei Wang, Yun Zhang, Wei Mao, Weiguang Shan, Sha Xu

引用次数: 0

Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation. 阿兰妥内酯：结构增强和治疗癌症和炎症的见解。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-10 DOI: 10.1080/14786419.2025.2571848

Muzaffar Kayumov, Fotima A Sobirova, Okhunjon Khasanov, Nurkhodja Mukhamedov, Akmal M Asrorov, Sharafitdin Mirzaakhmedov

{"title":"Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation.","authors":"Muzaffar Kayumov, Fotima A Sobirova, Okhunjon Khasanov, Nurkhodja Mukhamedov, Akmal M Asrorov, Sharafitdin Mirzaakhmedov","doi":"10.1080/14786419.2025.2571848","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571848","url":null,"abstract":"Alantolactone (ATL) is a bioactive sesquiterpene lactone derived from medicinal plants that exhibits numerous biological activities, especially its anti-cancer and anti-inflammatory properties. The review examines the current evidence on ATL's bioactivity and details how ATL functions across various cancer cell lines (breast, lung, gastric, pancreatic, bone and liver cancers) and inflammation processes. The clinical application of ATL faces limitations due to its inadequate solubility in water and non-selectively binding to non-target proteins. Therefore, we summarised existing structural transformation methods, including acid-catalyzed, oxidative, reductive reactions, cycloaddition, rearrangement of lactone ring, Aza-Michael, cross-coupling and click reactions that might further promote to overcome these limitations. This work presents ATL as an effective anticancer natural product and reviews the last decade of anti-tumour and inflammatory activities, with the mechanism of actions and gives the main points of existing structural optimisation techniques which may assist the researchers to improve effectiveness while minimising negative side effects.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The new ten-numbered macrolide, diaporthsin L, from endophytic fungus Diaporthe sp. G-4 isolated from Strobilanthes cusia (Nees) Kuntze. 从孔子花内生真菌Diaporthe sp. G-4中分离得到新的十编号大环内酯类化合物diaporsin L。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-10 DOI: 10.1080/14786419.2025.2568950

Jun-Yi Li, Zhen-Xian Cun, Hui-Hui Sun, Jie-Zheng Shi, Wen-Xiang Yan, Jun-Meng Xia, Dong Gan, Mao-Ru Li, Ju-Cheng Zhang, Zhong-Tao Ding

引用次数: 0

Inulevs-A, a new sesquiterpene lactone from the leaves of Inula racemosa Hook. f." 从总状菊叶中提取的一种新的倍半萜内酯。f。”

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-10 DOI: 10.1080/14786419.2025.2569805

Komal, Chandan Thappa, Kritika Sharma, Safeya Begum, Farina Sultan, Manu Khajuria, Yedukondalu Nalli

引用次数: 0

An efficient stereochemical elucidation of the aromatic polyketide NFAT-133 using the novel NOE quantification combined with ⁿJ _H-H and ⁿJ _C-H coupling constants. 结合nJ H-H和nJ C-H偶联常数的新型NOE定量方法对芳香族聚酮NFAT-133进行了立体化学分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-09 DOI: 10.1080/14786419.2025.2570506

Kazuo Furihata, Yusuke Ogura, Hirosato Takikawa, Hiroyuki Watanabe, Yoko Suzuki, Takashi Fujimoto, Mitsuru Tashiro

{"title":"An efficient stereochemical elucidation of the aromatic polyketide NFAT-133 using the novel NOE quantification combined with nJ H-H and nJ C-H coupling constants.","authors":"Kazuo Furihata, Yusuke Ogura, Hirosato Takikawa, Hiroyuki Watanabe, Yoko Suzuki, Takashi Fujimoto, Mitsuru Tashiro","doi":"10.1080/14786419.2025.2570506","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570506","url":null,"abstract":"NFAT-133, which was isolated from Streptomyces sp., is an immunosuppressive and antidiabetic aromatic polyketide containing three contiguous stereocenters. Although its absolute configuration was first proposed mainly based on NMR data, the later study employing the total synthesis of the proposed structure and its epimer resulted in the stereochemical revision of NFAT-133. The difficulty of determining relative configuration in polyketides arises from spin systems consisting of a methine group directly bonded to a methyl group (e.g. -CH(OH)-CH(CH3)-CH(OH)-). In this case, the stereochemical analysis of the aforementioned chain structure is generally hard due to the limited information of nJC-H and nJH-H. In an aim of developing a reliable analytical method based on NMR spectroscopy, we applied a novel NOE quantification in a 1D double pulsed field gradient spin echo (DPFGSE)-NOESY spectra. The combinational analysis of the proposed NOE quantification with nJC-H and nJH-H provided an accurate determination of the relative configurations.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing conventional and sustainable solvents for plant-based cosmetic bioactives: from extraction to application. 比较传统和可持续溶剂的植物性化妆品生物活性：从提取到应用。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-09 DOI: 10.1080/14786419.2025.2568954

Santa Maria Del Rosário Orrillo Lindo, Daniela Osorio, Karina Bispo-Dos-Santos, Paulo Chanel Deodato Freitas, Juliano Lemos Bicas, Gislaine Ricci Leonardi

{"title":"Comparing conventional and sustainable solvents for plant-based cosmetic bioactives: from extraction to application.","authors":"Santa Maria Del Rosário Orrillo Lindo, Daniela Osorio, Karina Bispo-Dos-Santos, Paulo Chanel Deodato Freitas, Juliano Lemos Bicas, Gislaine Ricci Leonardi","doi":"10.1080/14786419.2025.2568954","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568954","url":null,"abstract":"Natural cosmetics are gaining prominence in the market, making the efficient and safe extraction of bioactive compounds essential. This review, based on more than 130 articles retrieved from reliable databases, analysed the importance of selecting the safest and most efficient extracting liquid for cosmetic applications. Traditional solvents such as methanol and hexane have been used less frequently in human applications due to toxicity, which affects both use and disposal when separated from the target molecule. As an alternative, interest in green solvents, such as deep eutectic solvents (DES) and ionic liquids (ILs), is increasing. These solvents offer sustainability advantages but may also present challenges due to complexity, requiring further study. In cosmetic formulations, the multifunctionality of glycols allows their use as extraction liquids or as vehicles for resuspending dried extracts. Understanding plant composition is crucial for selecting the most suitable extraction liquid, ensuring effective isolation of bioactive compounds for cosmetic applications.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-28"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance liquid chromatography analysis of phenolics in Casuarina cunninghamiana: extraction, quantification and antioxidant evaluation. 木麻黄酚类物质的高效液相色谱分析：提取、定量及抗氧化评价。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-09 DOI: 10.1080/14786419.2025.2569804

Nourhene Aroua, Maher Boukhris, Wissal Ayouni, Sirine Choura, Mohamed Chamkha, Ridha Ben Salem, Rigane Ghayth

{"title":"High-performance liquid chromatography analysis of phenolics in Casuarina cunninghamiana: extraction, quantification and antioxidant evaluation.","authors":"Nourhene Aroua, Maher Boukhris, Wissal Ayouni, Sirine Choura, Mohamed Chamkha, Ridha Ben Salem, Rigane Ghayth","doi":"10.1080/14786419.2025.2569804","DOIUrl":"https://doi.org/10.1080/14786419.2025.2569804","url":null,"abstract":"The study was carried out to evaluate the phenolic compounds and antioxidant activity in the aqueous extract from leaves, stems and flowers of Casuarina cunninghamiana Miq. subsp. Cunninghamiana through ultrasound-assisted and maceration extractions from Sfax, Tunisia. The leaves exhibited the highest total phenolic and flavonoid contents. HPLC analysis identified 14 phenolic compounds across all extracts, including caffeic acid, epicatechin and verbascoside. Remarkably, catechin was present at the highest concentration in C. cunninghamiana flowers extracts. The antioxidant activity was assessed using the DPPH radical scavenging assay and FRAP assay. The leaves extract exhibited the strongest antioxidant activity, with an IC50 value of 204.17 µg/mL in the DPPH assay and 197.5 µM BHT/g DW in the FRAP assay. These findings highlight the potential of C. cunninghamiana being studied for the first time in Tunisia as a natural source of bioactive compounds, with potential applications in biotechnology, pharmacology and natural product research.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biflavonoids and glucopyranoside derivatives from Ouratea polygyna (Ochnaceae) and their inhibition of the SARS-CoV-2 3CL^Pro main protease. 龙葵类生物黄酮和葡萄糖苷衍生物及其对SARS-CoV-2 3CLPro主蛋白酶的抑制作用

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-09 DOI: 10.1080/14786419.2025.2570499

L S Julião, A L Haick, M R Silva, D C N Grillo, C J Riger, T Saldanha, A C H F Sawaya, G S Siqueira, M G De Carvalho

{"title":"Biflavonoids and glucopyranoside derivatives from Ouratea polygyna (Ochnaceae) and their inhibition of the SARS-CoV-2 3CLPro main protease.","authors":"L S Julião, A L Haick, M R Silva, D C N Grillo, C J Riger, T Saldanha, A C H F Sawaya, G S Siqueira, M G De Carvalho","doi":"10.1080/14786419.2025.2570499","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570499","url":null,"abstract":"Ouratea polygyna is a plant endemic to Brazil whose phytochemical and/or biological properties have not yet been studied. Studies point to flavonoids and phenols as inhibitors of the proliferation of coronaviruses. Therefore, we proceeded to the identification of compounds present in the extracts of this plant and evaluated their potential for viral inhibition on SARS-CoV-2 3CLPro. The results showed that the bioflavonoids fractions with amentoflavone and robustaflavone inhibited the viral protease at the levels of a synthetic inhibitor at all concentrations evaluated (10, 25 and 50 µM). Fractions with glucopyranoside derivatives (1-O-(4-hydroxyphenyl)-6-O-(4-hydroxybenzoyl)-β-D-glucopyranoside and 4-hydroxyphenyl-(6'-O-benzoyl)-O-β-glucopyranoside) also showed inhibition of this enzyme at all concentrations, with an increase in inhibition above the positive control when used at 50 µM concentration. These results demonstrate an important role of amentoflavone, robustaflavone, and glycopyranoside derivatives in the inhibition of viral replication and transcription.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and modeling of natural product-inspired cyclic peptides. 天然产物启发环肽的合成与建模。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-09 DOI: 10.1080/14786419.2025.2569803

Andrew M Kim, Runjie Xia, Matthew J Bertin

引用次数: 0

Three new phenylpropanoids from Atractylodes japonica Koidz. ex kitam. 白术中三个新苯丙类化合物。kitam交货。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-08 DOI: 10.1080/14786419.2025.2569806

Zhao Sun, Jing Wang, Yan Liu, Jie Sun, Zhen-Xing Fang, Hai-Long Yu, Bing-You Yang, Yuan-Yuan Zhou

引用次数: 0