Inulevs-A, a new sesquiterpene lactone from the leaves of Inula racemosa Hook. f."

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-10 DOI:10.1080/14786419.2025.2569805

Komal, Chandan Thappa, Kritika Sharma, Safeya Begum, Farina Sultan, Manu Khajuria, Yedukondalu Nalli

引用次数: 0

Abstract

The Himalayan herb Inula racemosa has long been valued for its therapeutic benefits, which are largely attributed to the bioactive compounds present in its roots. However, the chemical and medicinal potential of its leaves has remained largely unexplored. This study addresses this gap by isolating one new (2) and ten known (1, 3-11) sesquiterpene lactones from leaves of Inula racemosa. Inulevs-A (2) was identified as the 11,13-dihydro analogue of the leaf major metabolite 4,5-epoxy-11(13)-guaien-12,8-olide (1) through 1D/2D NMR and mass data. The biological activity of 1 and 2 are analysed for regulating GLUT4 expression, a key protein involved in insulin-dependent glucose uptake.

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从总状菊叶中提取的一种新的倍半萜内酯。f。”

喜马拉雅草本植物总状菊因其治疗益处而长期受到重视，这在很大程度上归功于其根中存在的生物活性化合物。然而，其叶子的化学和药用潜力在很大程度上仍未被开发。本研究从总状菊叶中分离出1个新的(2)和10个已知的（1,3 -11）倍半萜内酯，填补了这一空白。通过1D/2D 核磁共振和质量数据，Inulevs-A(2)被鉴定为叶片主要代谢物4,5-环氧-11(13)-愈伤木-12,8-olide(1)的11,13-二氢类似物。分析了1和2的生物活性，以调节GLUT4的表达，GLUT4是参与胰岛素依赖性葡萄糖摄取的关键蛋白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.