Natural Product Research最新文献

Hylotelephium telephium (L) H. Ohba leaves juice improves herpetic lesions: new findings from in vitro investigations. Hylotelephium telephium (L) H. Ohba 叶汁可改善疱疹病变：体外研究的新发现。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-04 DOI: 10.1080/14786419.2024.2423378

Rosaria Arvia, Marco Biagi, Giulia Baini, Giorgio Cappellucci, Paolo Governa, Sergio Balatri, Krystyna Zakrzewska

{"title":"Hylotelephium telephium (L) H. Ohba leaves juice improves herpetic lesions: new findings from in vitro investigations.","authors":"Rosaria Arvia, Marco Biagi, Giulia Baini, Giorgio Cappellucci, Paolo Governa, Sergio Balatri, Krystyna Zakrzewska","doi":"10.1080/14786419.2024.2423378","DOIUrl":"https://doi.org/10.1080/14786419.2024.2423378","url":null,"abstract":"The efficacy of Hylotelephium telephium (L.) H. Ohba (better known with its botanical synonym Sedum telephium L.) fresh leaf juice in the treatment of Herpes labialis wounds has been reported in traditional medicine in particular in Central regions of Italy; however, scientific insights are missing and the mechanism of action is not well understood. Aim of this study was to investigate the biological properties of S. telephium that underlie its ability to heal herpetic lesions. S. telephium fresh leaf juice (STJ) was analysed to obtain phytochemical information and tested in vitro to evaluate its antiviral activity against HSV-1 in Vero cells, then, according to computational predictions, immunomodulatory properties of STJ in human lympho-monocytes (PBMC), as well as its effect on cell viability in human keratinocytes (HaCaT cells), were also evaluated. Our results, at least in part, may explain the improvement of herpetic lesions empirically observed in patients treated with STJ: such improvement was not related to direct anti-viral effect of the juice but to its experimentally confirmed activity as cell viability booster and immunomodulatory agent.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review on Cynara cardunculus L.: bioactive compounds, nutritional properties and food-industry applications of a sustainable food. Cynara cardunculus L.系统综述：一种可持续食品的生物活性化合物、营养特性和食品工业应用。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-03 DOI: 10.1080/14786419.2024.2423046

Carla Buzzanca, Vita Di Stefano, Angela D'Amico, Alessandro Gallina, Maria Grazia Melilli

{"title":"A systematic review on Cynara cardunculus L.: bioactive compounds, nutritional properties and food-industry applications of a sustainable food.","authors":"Carla Buzzanca, Vita Di Stefano, Angela D'Amico, Alessandro Gallina, Maria Grazia Melilli","doi":"10.1080/14786419.2024.2423046","DOIUrl":"https://doi.org/10.1080/14786419.2024.2423046","url":null,"abstract":"The cardoon (Cynara cardunculus L.), is a perennial plant belonging to the Asteraceae family, and its cultivated species are widely used in the Mediterranean diet. This review provides an overview of cardoons' chemical composition, bioactive properties and multiple industrial and food applications. Thanks to its nutritional composition, the use of cardoon has increased in food, cosmetic and industrial sectors, such as the energy industry or in the production of paper pulp or bio-packaging. An application in the food industry has involved using of cardoon as a vegetable coagulant for gourmet cheeses-making, as the flowers are rich in aspartic proteases. Cardoon by-products are also rich in bioactive compounds with important health benefits. Most of these nutritional activities are due to the presence of phenolic compounds, minerals, inulin, fibre and sesquiterpene lactones with interesting antioxidant and antimicrobial, anti-inflammatory, anti-tumour, lipid-lowering, cytotoxic and anti-diabetic activities.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Algerian Ilex aquifolium L.'s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer's, diabetes and skin diseases. 评估阿尔及利亚 Ilex aquifolium L. 的酚类化合物、抗氧化和酶抑制特性，以找到治疗老年痴呆症、糖尿病和皮肤病的新天然疗法。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-02 DOI: 10.1080/14786419.2024.2419498

Aldjia Hadroug, Gokhan Zengin, Rachid Belhattab, Yavuz S Cakmak, Khellaf Rebbas

{"title":"Assessing Algerian Ilex aquifolium L.'s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer's, diabetes and skin diseases.","authors":"Aldjia Hadroug, Gokhan Zengin, Rachid Belhattab, Yavuz S Cakmak, Khellaf Rebbas","doi":"10.1080/14786419.2024.2419498","DOIUrl":"https://doi.org/10.1080/14786419.2024.2419498","url":null,"abstract":"This research explored the impact of methanolic extracts from the fruits and leaves of Ilex aquifolium L., a rare Algerian species, on several enzymes, focusing on tyrosinase, α-amylase, α-glucosidase, and cholinesterases, as well as their antioxidant potential in vitro assays, including phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and MCA. HPLC-DAD analysis identified chlorogenic acid, rosmarinic acid, hesperidin, and quercetin as predominant phenolic components. Both extracts exhibited notable antioxidant properties, up to 250.08 mg TE/g for fruits and 237.08 mg TE/g for leaf extracts. Enzyme inhibitory assays demonstrated significant inhibition against AChE and BChE with maximum activities of 2.34 mg GALAE/g in leaves and 4.32 mg GALAE/g in fruits. Additionally, considerable tyrosinase inhibition was observed in leaves at 39.69 mg KAE/g. These findings highlight I. aquifolium L. as a valuable source for investigating natural antioxidants and enzyme inhibitors, particularly for possible cosmetics and food additives applications.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of catechin as main protease inhibitor of SARS-CoV-2 Omicron variant using molecular docking, molecular dynamics, PCA, DCCM, MM/GBSA and ADMET profiling. 利用分子对接、分子动力学、PCA、DCCM、MM/GBSA 和 ADMET 分析鉴定儿茶素是 SARS-CoV-2 Omicron 变体的主要蛋白酶抑制剂。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-02 DOI: 10.1080/14786419.2024.2421907

Kalpana Gyawali, Rajesh Maharjan, Arjun Acharya, Madan Khanal, Madhav Prasad Ghimire, Tika Ram Lamichhane

{"title":"Identification of catechin as main protease inhibitor of SARS-CoV-2 Omicron variant using molecular docking, molecular dynamics, PCA, DCCM, MM/GBSA and ADMET profiling.","authors":"Kalpana Gyawali, Rajesh Maharjan, Arjun Acharya, Madan Khanal, Madhav Prasad Ghimire, Tika Ram Lamichhane","doi":"10.1080/14786419.2024.2421907","DOIUrl":"https://doi.org/10.1080/14786419.2024.2421907","url":null,"abstract":"The Omicron variant of SARS-CoV-2 spreads more rapidly than other variants and can affect even vaccinated individuals. The Omicron variant main protease (Mpro), crucial for viral replication and transcription, is an attractive target for antiviral drug discovery. This research aims to investigate non-toxic flavonoids that follow Lipinski's rule of five (RO5) and inhibit the Omicron variant Mpro. Molecular docking was performed on 35 flavonoids screened by analysing their medicinal values and adherence to RO5. Catechin (2-(3,4-dihydroxyphenol) chroman-3,5,7-triol), a non-toxic natural compound having predicted toxicity class 6 and LD50 value 10,000 mg/kg, exhibited a docking score of -7.1 kcal/mol with Mpro. The Mpro-catechin complex remained stable during 250 ns MD simulations. The post-MD free energy (MM/GBSA) calculations showed a binding energy of -20.5 kcal/mol, indicating strong interactions with the active amino acid residues. These findings suggest that catechin is a promising drug candidate against the Omicron variant.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A butyrolactone derivative from marine-derived fungal strain Aspergillus terreus BTBU20211037. 一种来自海洋源真菌菌株赤曲霉 BTBU20211037 的丁内酯衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-02 DOI: 10.1080/14786419.2024.2422515

Xinwan Zhang, Renming Jia, Jinpeng Yang, Zhijun Song, Xiuli Xu, Fuhang Song

引用次数: 0

Ethnopharmacological insights: hyperoside from Marsdenia latifolia (Benth.) K.Schum. Mitigates reproductive toxicity in male Wistar rats induced by manganese exposure. 民族药理学启示：Marsdenia latifolia（Benth.）K.Schum.中的金丝桃苷能减轻锰暴露对雄性 Wistar 大鼠的生殖毒性。减轻锰暴露对雄性 Wistar 大鼠的生殖毒性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-01 DOI: 10.1080/14786419.2024.2423041

Olalekan Bukunmi Ogunro, Anthonia Oluyemi Agboola, Folake Olubukola Asejeje, Gideon Ampoma Gyebi

{"title":"Ethnopharmacological insights: hyperoside from Marsdenia latifolia (Benth.) K.Schum. Mitigates reproductive toxicity in male Wistar rats induced by manganese exposure.","authors":"Olalekan Bukunmi Ogunro, Anthonia Oluyemi Agboola, Folake Olubukola Asejeje, Gideon Ampoma Gyebi","doi":"10.1080/14786419.2024.2423041","DOIUrl":"https://doi.org/10.1080/14786419.2024.2423041","url":null,"abstract":"This study provides novel findings on the ameliorative effect of hyperoside isolated from Marsdenia latifolia leaves (HIGLL) in reproductive health challenged by manganese toxicity. The study investigated the efficacy of HIGLL on male fertility in rats exposed to manganese chloride (MnCl2). The rats received either MnCl2 (30 mg/L) or in combination with HIGLL (100 mg/kg or 200 mg/kg). MnCl2 reduced fluid intake, organ-body weight, body weight; sperm count, sperm viability, sperm density, sperm motility, semen viscosity, daily sperm production, testicular sperm number; testosterone, follicle-stimulating and luteinising hormones, oestradiol, testosterone/oestradiol ratio; G6PDH, ALP, glucose, NO, acid phosphatase, sialic acid, 17-β-HSD, superoxide dismutase, CAT, GST, GSH, and T-SH without modifying the semen pH and volume, while it correspondingly raised the abnormalities associated with morphology of sperm cells in head, neck, and tail; H2O2 and lipid peroxidation levels. HIGLL abrogated the damaged histoarchitecture of the testes and epididymis caused by MnCl2. HIGLL can serve as a therapeutic agent in the management of male reproductive disorders related to oxidative stress and endocrine disruption.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical profiling and spectroscopic studies of leaf volatile oil of Eucalyptus globulus from Botswana isolated by conventional hydrodistillation and ultrasound assisted hydrodistillation. 通过传统水蒸馏法和超声波辅助水蒸馏法分离的博茨瓦纳蓝桉叶片挥发油的化学成分分析和光谱研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-10-31 DOI: 10.1080/14786419.2024.2411721

Tshepo Pheko-Ofitlhile, Nicholas Phiri, Eniah Serame, Lucia M Lepodise

引用次数: 0

Simultaneous quantification of chlorogenic acid, quercetin, and kaempferol in Urceola rosea leaves by CE and HPLC techniques: method validation and comparative study. 利用 CE 和 HPLC 技术同时定量分析蔷薇叶中的绿原酸、槲皮素和山柰醇：方法验证与比较研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-10-31 DOI: 10.1080/14786419.2024.2422520

Maneewan Suwatronnakorn, Somchai Issaravanich, Yamon Pitakpawasutthi, Sukanjana Kamlungmak, Anchalee Prasansuklab

{"title":"Simultaneous quantification of chlorogenic acid, quercetin, and kaempferol in Urceola rosea leaves by CE and HPLC techniques: method validation and comparative study.","authors":"Maneewan Suwatronnakorn, Somchai Issaravanich, Yamon Pitakpawasutthi, Sukanjana Kamlungmak, Anchalee Prasansuklab","doi":"10.1080/14786419.2024.2422520","DOIUrl":"https://doi.org/10.1080/14786419.2024.2422520","url":null,"abstract":"Two analytical methods, CE and HPLC, were developed, validated, and compared for simultaneously determining chlorogenic acid, quercetin, and kaempferol in Urceola rosea leaves collected from twelve different sources of Thailand. The determination was accomplished by CE on the uncoated fused silica capillary tube and by HPLC on the ZORBAX Eclipse Plus C18 column. Chlorogenic acid was found to have the highest average amount in U. rosea leaves, followed by kaempferol and quercetin, respectively. Compared to CE, HPLC is considered to provide higher sensitivity and robustness as indicated by lower LOD and LOQ values as well as % RSD of robustness for all analytes. Overall, the present study first demonstrated that both methods were selective, sensitive, and robust, allowing reliable simultaneous quantification of three major bioactive compounds in U. rosea leaves, which could be beneficially applied for quality control assessment of this plant material, particularly those cultivated in Thailand.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, molecular docking, ADMET studies and antimicrobial activities of coumarin-chalcone hybrid derivatives. 香豆素-查耳酮混合衍生物的合成、分子对接、ADMET 研究和抗菌活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-10-30 DOI: 10.1080/14786419.2024.2422524

Zainab Ngaini, Mohamad Asri Jefferi, Saba Farooq

{"title":"Synthesis, molecular docking, ADMET studies and antimicrobial activities of coumarin-chalcone hybrid derivatives.","authors":"Zainab Ngaini, Mohamad Asri Jefferi, Saba Farooq","doi":"10.1080/14786419.2024.2422524","DOIUrl":"https://doi.org/10.1080/14786419.2024.2422524","url":null,"abstract":"The exploitation of naturally derived drugs can become a replacement for ineffective drugs due to the relentless antimicrobial resistance. A series of natural-product-based coumarin-chalcones (4a-4i) were synthesised via facile Steglich esterification. The coumarin-chalcones (4a-4i) showed effective inhibition against P. aeruginosa (7-13 mm) and E. coli (8-12 mm) in comparison to the standard drug ampicillin and coumarin alone. Compounds 4b and 4g exhibited the highest inhibition zone against P. aeruginosa (13 mm) and E. coli (12 mm) respectively. The hybridisation of chalcone in the coumarin network introduced active C = CH, C = O and C-O moieties, contributing to significant microbial inhibition. The molecular docking of 4b exhibited the highest binding affinity -10.1 kcal/mol as compared to 4a, 4c and 4g -9.2 kcal/mol, -9.2 kcal/mol and -9.1 kcal/mol respectively. The ADMET studies also supported natural-product-based coumarin-chalcones as suitable drug candidates. This study is noteworthy for coumarin-based drug development in the medicinal field.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Tephrosin and obovatachalcone with antibacterial activity from Tephrosia vogelii Hook.f". 关于 "Tephrosin and obovatachalcone with antibacterial activity from Tephrosia vogelii Hook.f "的评论

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-10-30 DOI: 10.1080/14786419.2024.2423044

Dhivya Viswanathan, Rajakumar Govindasamy

引用次数: 0