Natural Product Research最新文献

Antimicrobial p-terphenyl derivatives from the deep-sea cold seep-derived fungus Aspergillus candidus. 深海冷液源真菌假丝曲霉的抗菌对terphenyl衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-09 DOI: 10.1080/14786419.2025.2487153

Yi-Yi Liu, Jing-Ya Shi, Qi-Ran Liang, Guang-Ying Chen, Hai-Xin Chen, Zhuang Han, Xu-Hua Nong

引用次数: 0

Microbial transformation of oleanonic acid by Aspergillus minisclerotigenes and the -anti-neuroinflammatory properties of products. 微绿曲霉对齐墩果酸的微生物转化及其产物的抗神经炎症特性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-09 DOI: 10.1080/14786419.2025.2487684

Da-Wei Xu, Jin Zhou, Si-Yi Zhou, Sheng-Nan Gong, Wei Zhao

引用次数: 0

Bioassay-guided isolation of dehydrocostus lactone from Echinops kebericho as potential biopesticide against Aedes aegypti. 用生物测定法分离kebericho脱氢木香内酯作为潜在的抗埃及伊蚊杀虫剂。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-07 DOI: 10.1080/14786419.2025.2486341

Bekri Melka Abdo, Bizuayehu Tesfaye Asfaw, M Iqbal Choudhary

{"title":"Bioassay-guided isolation of dehydrocostus lactone from Echinops kebericho as potential biopesticide against Aedes aegypti.","authors":"Bekri Melka Abdo, Bizuayehu Tesfaye Asfaw, M Iqbal Choudhary","doi":"10.1080/14786419.2025.2486341","DOIUrl":"https://doi.org/10.1080/14786419.2025.2486341","url":null,"abstract":"Dengue fever is the most prevalent viral infection, which transmits by the vector mosquito Aedes aegypti and Aedes albopictus. The development of an effective dengue vaccine is still challenging. Thus, the prevention and control of dengue depend on controlling the transmitting vectors. Traditionally, Echinops kebericho roots are known to have mosquito-repellant properties. Dehydrocostus lactone, one of the major constituents of the roots extract, showed similar larvicidal activity as the standard pesticide permethrin (100% mortality) against the larvae of A. aegypti at 10 µg/mL concentration at 24 h exposure. The derivative compound (13-methoxy dehydrocostus lactone) was inactive against the larvae of A. aegypti. The structure-activity relationship (SAR) suggested that the presence of α- methylene and γ- lactone moieties are responsible for the larvicidal activity of dehydrocostus lactone against the larvae of A. aegypti. Overall, dehydrocostus lactone can be a potential biopesticide against the dengue vector mosquito, A. aegypti.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical constituents and biological activities of the whole plant of Cuscuta chinensis Lam. 菟穗子全株化学成分及生物活性研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-06 DOI: 10.1080/14786419.2025.2487155

Erkin Tursun, Yujie Qiao, Le Dai, Jiaxing Yu, Abdulla Yusuf, Adila Abudurexiti

{"title":"Chemical constituents and biological activities of the whole plant of Cuscuta chinensis Lam.","authors":"Erkin Tursun, Yujie Qiao, Le Dai, Jiaxing Yu, Abdulla Yusuf, Adila Abudurexiti","doi":"10.1080/14786419.2025.2487155","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487155","url":null,"abstract":"A total of twenty-one compounds were obtained from the whole plant of Cuscuta chinensis Lam. The compounds' structures were identified as 3-hydroxy-N-phenethylpropanamide (1), (+)-pinoresinol-O-β-D- glucopyranoside (2), simplexoside (3), (+)-pinoresinol (4), scopoletin (5), (-)-loliolide (6), N-trans-feruloyltyramine (7), (+)-syringaresinol (8), medioresinol (9), 3,4-dehydrotheaspirone (10), 2-ethoxy-1H-pyrimidine-4,6-dione (11), ethyl 4-hydroxybenzoate(12), hydroquinone (13), vanillic acid (14), β-daucosterol (15), methyl 2,4,6-trihydroxybenzoate (16), roseoside (17), vomifoliol (18), pyrocatechol (19), E-p-coumaric acid (20), Z-p-hydroxy-cinnamic acid (21). Among them, ten compounds (1,3,5,6,10,11,16,17,18,19) were isolated from this plant for the first time, while compound 1 was isolated as an undescribed natural compound. Moreover, the dichloromethane and ethyl acetate extracts indicated potential bioactivity, and compound 2 showed certain anti-inflammatory activity. This study provides a scientific basis for elucidating the composites and activity of C. chinensis.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larvicidal activity of Magonia pubescens A. St.-Hil. (Sapindaceae) seed and leaf extract on Aedes aegypti. Magonia pubescens A. St.-Hil.(无患子科）种子和叶提取物对埃及伊蚊的杀幼虫活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-06 DOI: 10.1080/14786419.2025.2484258

Elisangela Oliveria Desiderio, Valdo Soares Martins Júnior, Alisson Samuel Portes Caldeira, Tânia Maria de Almeida Alves, Juliana Pimenta Cruz, Thallyta Maria Vieira, Viviane Oliveira Vasconcelos, Eduardo Robson Duarte

{"title":"Larvicidal activity of Magonia pubescens A. St.-Hil. (Sapindaceae) seed and leaf extract on Aedes aegypti.","authors":"Elisangela Oliveria Desiderio, Valdo Soares Martins Júnior, Alisson Samuel Portes Caldeira, Tânia Maria de Almeida Alves, Juliana Pimenta Cruz, Thallyta Maria Vieira, Viviane Oliveira Vasconcelos, Eduardo Robson Duarte","doi":"10.1080/14786419.2025.2484258","DOIUrl":"https://doi.org/10.1080/14786419.2025.2484258","url":null,"abstract":"Plant-derived compound emerges as alternatives to integrated control of Aedes aegypti, the main transmitter of Chikungunya, Dengue, Zika virus. The effects of Magonia pubescens A. St.-Hill extracts on Ae. aegypti larval development were assessed. Four in vitro assays analysed the insecticidal potential (% larval mortality) of aqueous and ethanolic (EE) extracts of leaves and seeds. The extracts were analysed using UHPLC-MS/MS. By comparing to data from three databases, 12 compounds from different classes were identified in the EE, including coumarins, phenolic acids, polyphenols, and flavonoids. The EE from the leaves was the most effective, with an LC90 of 0.262 mg/mL. Morphological alterations were observed in larvae exposed to the extracts, showing epithelial walls with extravasation of intestinal contents. These findings highlight the effectiveness of M. pubescens extract as a bioinsecticidal agent against Ae. aegypti larvae.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical profiling of Pelargonium graveolens l'Hér and evaluation of its activity against D-galactose induced skin ageing. 枸杞的植物化学特征及其抗d -半乳糖致皮肤老化活性的评价。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-05 DOI: 10.1080/14786419.2025.2487148

Sanagik Sabry Abu El Wafa, Hanaa A H Kassem, Nehal M Ramadan, Mai M Eltaweel, Nermin A Younis, Inas Y Younis

{"title":"Phytochemical profiling of Pelargonium graveolens l'Hér and evaluation of its activity against D-galactose induced skin ageing.","authors":"Sanagik Sabry Abu El Wafa, Hanaa A H Kassem, Nehal M Ramadan, Mai M Eltaweel, Nermin A Younis, Inas Y Younis","doi":"10.1080/14786419.2025.2487148","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487148","url":null,"abstract":"Pelargonium graveolens L'Hér is an evergreen small shrub with pink flowers. Metabolite profiling of its extract by UHPLC/MS analysis revealed the identification of 51 secondary metabolites. Interestingly, 29 compounds identified for the first time. The colorimetric assays revealed high content of phenolic, flavonoids and tannins (100.19 ± 3.94 µg Gallic acid Eq/mg, 47.38 ± 2.04 µg Rutin Eq/mg and 332.75 ± 8.85 µg Catechin Eq/mg of extract) respectively along with good antioxidant activity. Moreover, the in vitro analysis showed a significant anti-hyaluronidase activity (IC50 ± SD = 15.75 ± 0.8), as compared to standard luteolin. Topical application of the characterised P. graveolens hydrogel (1% and 2% w/w) was tested using the D-galactose-induced ageing model in mice. Histopathological examination demonstrated an increase in the dermal collagen expression, alleviation of ageing-related oxidative stress, and stabilisation of MMP-1/TIMP-1 balance. Ultimately, P. graveolens could be a valuable source of natural antioxidants with a promising antiaging activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical characterisation of biochar derived from sargassum spp. and its antibacterial activity. 从马尾藻提取的生物炭的物理化学特性及其抗菌活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-05 DOI: 10.1080/14786419.2025.2484269

Carlos Hernández-Calderón, B Escobar, Ruby Valdez-Ojeda, Ana Arroyo-Herrera, Tanit Toledano-Thompson, José Baas-López

{"title":"Physicochemical characterisation of biochar derived from sargassum spp. and its antibacterial activity.","authors":"Carlos Hernández-Calderón, B Escobar, Ruby Valdez-Ojeda, Ana Arroyo-Herrera, Tanit Toledano-Thompson, José Baas-López","doi":"10.1080/14786419.2025.2484269","DOIUrl":"https://doi.org/10.1080/14786419.2025.2484269","url":null,"abstract":"This experiment aims to study the potential use of biochar derived from Sargassum spp. as an innovative ingredient in homemade soap, focusing on its antibacterial activity. The pyrolysis process was conducted at 700 °C with a heating rate of 10 °C min-1 for 2 h under a nitrogen atmosphere with KOH chemical activation. The physicochemical properties of the biochar were investigated using XRD, FTIR, Raman, BET surface analysis, and SEM. Highly porous biochar was successfully synthesised, achieving a large specific surface area of 1600 m2 g-1 and a well-developed microporous structure distributed across the surface of the biochar. Klebsiella pneumoniae, Staphylococcus aureus, and Salmonella choleraesuis were used as model pathogens to evaluate the antibacterial activity of biochar-enriched homemade soap using Müeller-Hinton Agar and the Kirby-Bauer test. The antibacterial evaluations demonstrated that the incorporation of biochar into homemade soap partially inhibited the growth of these model pathogens bacteria.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial, antibiofilm activities of Jatropha gossypiifolia L. floral extracts and molecular docking study of the major compound. 麻疯树花提取物的抑菌、抗膜活性及主要化合物的分子对接研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2487693

Shimaa M Khalifa, Marwa F Harras, Mona Shaban E M Badawy

{"title":"Antibacterial, antibiofilm activities of Jatropha gossypiifolia L. floral extracts and molecular docking study of the major compound.","authors":"Shimaa M Khalifa, Marwa F Harras, Mona Shaban E M Badawy","doi":"10.1080/14786419.2025.2487693","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487693","url":null,"abstract":"This study looked at the phytochemical composition, antimicrobial, and antibiofilm properties of Jatropha gossypiifolia L. floral extracts. Broth dilution determined the minimum inhibitory (MIC) and bactericidal concentrations (MBC). MOE software was utilised to perform molecular docking against some biofilm-forming proteins. The extracts and the major compound (vitexin) showed different degrees of activity against strains of S. aureus, E. coli, K. pneumoniae, A. baumannii, and S. mutants but had moderate activity against P. aeruginosa. The diameters of the clear zones surrounding the wells ranged from 12.0 ± 1.0 to 25.0 ± 1.0 mm. Methanolic extracts were higher in antibacterial activity than the methylene chloride extract. The MIC values of the extracts ranged from 12.5 to 200 mg/mL. The extract's MBC values ranged from 50 to >400 mg/mL. The Vitexin exerted significant biofilm attenuation against the S. aureus, A. baumannii, and P. aeruginosa biofilm, with maximum activity measured at 78, 156, and 525 mg/mL doses, respectively. Docking results revealed that vitexin fitted well in the active sites of these proteins forming stable complexes with significant binding scores. Interestingly, both the glycoside and flavone moieties of vitexin were highly involved in the binding with the three examined proteins via making a network of hydrogen bond interactions and non-polar interactions.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new insecticidal sesquiterpene from a mangrove endophytic fungus Aspergillus strain sp. GXNU R1. 从红树林内生真菌曲霉菌株sp. GXNU R1中分离出一种新的杀虫倍半萜。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2487687

Xiongtao Yu, Meijing Tan, Xianglong Bo, Zhifan Lin, Jinwei Chen, Xishan Huang, Jiguo Huang

引用次数: 0

Glucosinolate profiles in wild-growing Lepidium draba L. from Tunisia and Croatia. 突尼斯和克罗地亚野生枸杞硫代葡萄糖苷谱。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2486339

Wissal Saadellaoui, Azra Đulović, Ileana Žeravica, Fethia Harzallah-Skhiri, Patrick Rollin, Ivica Blažević, Sondes Stambouli-Essassi

引用次数: 0