Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-06-22DOI: 10.1080/14786419.2024.2368750
Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno
{"title":"<i>Stachys durandiana</i> Coss., an endemic plant of Morocco: chemical composition of its aerial parts essential oil.","authors":"Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno","doi":"10.1080/14786419.2024.2368750","DOIUrl":"10.1080/14786419.2024.2368750","url":null,"abstract":"<p><p>The genus <i>Stachys</i> L. (Lamiaceae) comprises more than 300 species as annual or perennial herbs or small shrubs, spread in temperate regions of Mediterranean, Asia, America, and Southern Africa and several species have been used in the traditional medicine of many countries. Section <i>Stachys</i>, one of nineteen sections of genus <i>Stachys</i>, is divided in two subsections: <i>Sylvaticae</i> and <i>Circinatae</i>. In the present study the chemical composition of the essential oil from aerial parts of <i>Stachys durandiana</i> Coss., endemic of Morocco, and belonging to subsection <i>Circinatae</i>, was analysed by GC-MS. No report has been previously published on this species. The result showed the presence of large quantity of monoterpene hydrocarbons (73.3%), being <i>α</i>-pinene (38.0%) <i>β</i>-pinene (14.8%), and limonene (11.1%) the principal constituents. Furthermore, a complete review on the chemical composition and biological properties of all the other <i>Stachys</i> taxa, belonging to section <i>Stachys</i>, studied so far, was carried out.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4502-4506"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-06-22DOI: 10.1080/14786419.2024.2370040
Jéssica Lima de Souza, Adrianne Bastos Ferreira, Elinalva Maciel Paulo, Clayton Queiroz Alves, Carlos Alfredo Lopes de Carvalho, Fábio de Souza Dias, Anibal de Freitas Santos Junior, Hugo Neves Brandão, Humberto Fonseca de Freitas
{"title":"Analysing chemical composition and antimicrobial activity of geopropolis from <i>Melipona scutellaris</i>: HPLC-DAD and <i>in vitro/in silico</i> investigations.","authors":"Jéssica Lima de Souza, Adrianne Bastos Ferreira, Elinalva Maciel Paulo, Clayton Queiroz Alves, Carlos Alfredo Lopes de Carvalho, Fábio de Souza Dias, Anibal de Freitas Santos Junior, Hugo Neves Brandão, Humberto Fonseca de Freitas","doi":"10.1080/14786419.2024.2370040","DOIUrl":"10.1080/14786419.2024.2370040","url":null,"abstract":"<p><p>This study evaluated the chemical profile, antimicrobial activity, and the presence of potentially toxic elements in geopropolis extracts produced by <i>Melipona scutellaris</i> in the Recôncavo region of Bahia, Brazil. It was found that the major chemical compounds belong to the class of phenolic compounds, with emphasis on the presence of gallic acid. In this study, no potentially toxic elements were found in the analysed geopropolis. Regarding the antimicrobial potential, gram-positive bacteria were susceptible to the action of geopropolis extract at concentrations of 0.25 to 2.5 mg.mL<sup>-1</sup>, highlighting its microbiological activity against <i>Streptococcus mitis</i> (ATCC 00456) and <i>Candida albicans</i> (CCMB 251). Thus, this geopropolis extract can be used as a bacteriostatic rather than a bactericide. Our results suggest the potential for the economic and therapeutic use of <i>M. scutellaris</i> geopropolis, adding value to one of the meliponiculture products.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4520-4526"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First total synthesis of Macrotricolorin A and its enantiomer.","authors":"Prakash Gupta Tanguturi, Balraju Gangapuram, Chinna Ashalu Kashamalla, Jhillu Singh Yadav","doi":"10.1080/14786419.2024.2341289","DOIUrl":"10.1080/14786419.2024.2341289","url":null,"abstract":"<p><p>Herein, we demonstrate the first total synthesis of Macrotricolorin A <b>(1)</b> and its enantiomer <b>1'</b> from the key intermediate which is accessible from two precursors phenol and resorcinol, by two different sequences. Macrotricolorin A <b>(1)</b> possesses anti-inflammatory properties and is a novel diarylpropanoid. The first total synthesis of Macrotricolorin A <b>(1)</b> was accomplished using simple reactions such as Williamson's etherification, Claisen-Schmidt condensation, reduction, and chiral resolution.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4428-4436"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-06-17DOI: 10.1080/14786419.2024.2367239
Hong Li, Cankai Lin, Kaixin Chen, Zhihui Zhou, Zanhong Chen, Bo Ding, Hongbo Huang, Yiwen Tao
{"title":"New polyketides and cytotoxic alkaloids from the mangrove endophytic fungus <i>Talaromyces</i> sp. SAF14.","authors":"Hong Li, Cankai Lin, Kaixin Chen, Zhihui Zhou, Zanhong Chen, Bo Ding, Hongbo Huang, Yiwen Tao","doi":"10.1080/14786419.2024.2367239","DOIUrl":"10.1080/14786419.2024.2367239","url":null,"abstract":"<p><p>Investigation of secondary metabolites from the mangrove endophytic fungus <i>Talaromyces</i> sp. SAF14 led to the isolation of two new polyketides, methyl (<i>R</i>)-3-(6,8-dihydroxy-7-methoxy-1-oxoisochroman-3-yl)propanoate (<b>1</b>), (<i>R</i>)-3-(5,8- dihydroxy-1-oxoisochroman-3-yl)propanoic acid (<b>2</b>), together with four known alkaloids (<b>3</b>-<b>6</b>). The planar structures of new compounds were elucidated by comprehensive analysis of HR-ESI-MS and NMR data. The absolute configurations were determined by comparison of the calculated ECD spectrum with the measured one. All the isolated compounds were tested for cytotoxic activities against three human cancer cell lines. The known beauvericin (<b>3</b>) exhibited strong cytotoxic activity against A549, MCF-7, and KB cell lines with IC<sub>50</sub> values of 5.36 ± 2.49, 1.96 ± 1.09 and 4.46 ± 0.68 μM, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4497-4501"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two alkenyl phenol derivatives from the fungus <i>Pestalotiopsis clavata</i> JSQ 12 isolated from the mushroom <i>Lanmaoa asiatica</i>.","authors":"Jing Tang, Rui Xu, Hao Ma, Shuai-Ming Zhu, Fu-Yao Luo, Xue Zhao, Ya-Shuai Kang, Yuan-Wei Gao, Yu Yang, Chang-Wei Li","doi":"10.1080/14786419.2024.2367012","DOIUrl":"10.1080/14786419.2024.2367012","url":null,"abstract":"<p><p>Two new alkenyl phenol derivatives, namely pestalol F (<b>1</b>) and pestalol G (<b>2</b>), along with two known compounds, pestalachloride A (<b>3</b>) and pestalotiopsin J (<b>4</b>), were isolated from the culture of the fungus <i>Pestalotiopsis clavata</i> JSQ 12. The structures of these compounds were primarily elucidated by MS, NMR and specific rotation data analysises. These secondary metabolites of <i>Pestalotiopsis clavata</i> were reported for the first time. Compound <b>2</b> displayed interesting cytotoxic activity against MCF-7 cell line with the IC<sub>50</sub> value of 29.16 μM, whereas compound <b>3</b> exhibited moderate activity towards A549 cell line with the IC<sub>50</sub> value of 35.71 μM. The positive control 5-FU showed cytotoxic effects on MCF-7 and A549 cell lines with the respective IC<sub>50</sub> values of 26.70 and 26.07 μM. Compounds <b>1</b> and <b>2</b> displayed mild antibacterial activities against <i>Staphylococcus aureus</i> with MIC values of 128 and 64 μg/mL (MIC of positive control, penicillin, was 0.016 μg/mL), respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4488-4492"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-03-29DOI: 10.1080/14786419.2024.2334325
Siyuan Ma, Li Ge, Hongyu Lu, Jianhua Yan, Kedi Yang
{"title":"Two undescribed compounds from <i>Aspergillus Niger</i>, an endophytic fungus isolated from <i>Camellia flavida</i>.","authors":"Siyuan Ma, Li Ge, Hongyu Lu, Jianhua Yan, Kedi Yang","doi":"10.1080/14786419.2024.2334325","DOIUrl":"10.1080/14786419.2024.2334325","url":null,"abstract":"<p><p>A new naphtho-<i>γ</i>-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus <i>Aspergillus niger</i> from the stem of <i>Camellia flavida</i>. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC<sub>50</sub> values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i> and methicillin-resistant <i>S. aureus</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4239-4246"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-06-28DOI: 10.1080/14786419.2024.2371566
Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno
{"title":"The essential oil chemical composition of a sicilian (Italy) accession of <i>Doronicum caucasicum</i> M. Bieb.","authors":"Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno","doi":"10.1080/14786419.2024.2371566","DOIUrl":"10.1080/14786419.2024.2371566","url":null,"abstract":"<p><p><i>Doronicum</i> is a relatively small genus belonging to the tribe Senecioneae (Fam. Asteraceae), distributed in Asia, Europe, and North Africa. Some of its species are considered toxic due to the presence of pyrrolizidine alkaloids whereas some other ones are largely utilised in the ethnopharmacology of several countries. In the present study, the essential oil composition of a Sicilian accession of <i>Doronicum caucasicum</i> M. Bieb (syn. <i>D. orientale</i> Hoffm.), not previously investigated, is particularly rich in sesquiterpene hydrocarbons (80.3%) with germacrene D (58.9%), <i>α</i>-humulene (8.8%), and <i>β</i>-caryophyllene (6.5%) as main metabolites. A comparison with all the essential oils from <i>Doronicum</i> taxa studied so far has been carried out.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4527-4532"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-03-27DOI: 10.1080/14786419.2024.2335362
Nathalia Peres, Matheus L Silva, Anderson K Ueno, Guilherme M Antar, Erica V C Levatti, Andre G Tempone, João Henrique G Lago
{"title":"Highly selective alkylcoumarates and diterpenoids isolated from leaves of <i>Baccharis quitensis</i>: a search for new hit compounds against <i>Trypanosoma cruzi</i>.","authors":"Nathalia Peres, Matheus L Silva, Anderson K Ueno, Guilherme M Antar, Erica V C Levatti, Andre G Tempone, João Henrique G Lago","doi":"10.1080/14786419.2024.2335362","DOIUrl":"10.1080/14786419.2024.2335362","url":null,"abstract":"<p><p>In the present work, the hexane extract of aerial parts of <i>Baccharis quitensis</i> Kunth. was subjected to chromatographic fractionation to afford two alkyl phenylpropanoids: <i>n</i>-docosyl (<i>E)-p</i>-coumarate (<b>1</b>) and <i>n</i>-tetracosyl <i>(E)-p</i>-coumarate (<b>2</b>) as well as five diterpenes: <i>ent-</i>kaurenoic acid (<b>3</b>), grandifloric acid (<b>4</b>), 15β-senecioyl-oxy-<i>ent</i>-kaur-16-en-19-oic acid (<b>5</b>), and 15-oxo-<i>ent</i>-kaurenoic acid (<b>6</b>). Using an <i>ex-vivo</i> assay with macrophages infected with <i>Trypanosoma cruzi</i>, compounds <b>1</b> and <b>2</b> demonstrated high potency against intracellular amastigotes, with EC<sub>50</sub> values of 7.5 and 6.9 µM, respectively. Compound <b>6</b> revealed a moderate potency against <i>T. cruzi</i>, with an EC<sub>50</sub> of 25.6 µM, and compounds <b>3-5</b> showed no effectiveness. Additionally, compounds <b>1-6</b> compounds presented no toxicity for mammalian cells to the highest tested concentration of 200 µM. Based on potency and the selectivity indexes of <b>1</b>, <b>2</b> and <b>6</b>, these compounds could be future candidates for optimisation studies for the design of prototypes against Chagas disease.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4254-4260"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural Product ResearchPub Date : 2025-08-01Epub Date: 2024-05-16DOI: 10.1080/14786419.2024.2340754
Liang Zhang, Hui-Lin Zhao, Shang-De Peng, Sempere Deguol Mawunya, Yao Zhang, Hai-Chen Li, Yu Luo, Yan Wen
{"title":"Whitening and antioxidant activities of <i>Inonotus sanghuang</i> Extract and development of primary whitening gel products.","authors":"Liang Zhang, Hui-Lin Zhao, Shang-De Peng, Sempere Deguol Mawunya, Yao Zhang, Hai-Chen Li, Yu Luo, Yan Wen","doi":"10.1080/14786419.2024.2340754","DOIUrl":"10.1080/14786419.2024.2340754","url":null,"abstract":"<p><p>Polysaccharides and flavonoids have excellent antioxidant properties and tyrosinase inhibitory effects. In this paper, the antioxidant capacity of <i>Inonotus sanghuang</i> extract and its inhibition kinetics on mushroom tyrosinase were investigated to determine the preparation process of <i>Inonotus sanghuang</i> primary whitening gel. By conducting experimental studies on the effects of water extract and alcohol extract of <i>Inonotus sanghuang</i> on antioxidant capacity and tyrosinase activity, their inhibitory ability and types of inhibitory effects were determined. The single factor experiment was used to determine the preparation process of Sanghuang primary whitening gel. This study has proven that the extract of <i>Inonotus sanghuang</i> possesses antioxidant and tyrosinase inhibitory capabilities. It also identified the preparation process for the primary whitening gel of <i>Inonotus sanghuang</i>, thereby providing a theoretical and experimental basis for the development of whitening products utilising <i>Inonotus sanghuang</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4364-4370"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of geographical origin on the chemical characteristics of <i>Q. canariensis</i> acorns: profiling fatty acids, tocopherols, and phenolic composition.","authors":"Sondes Fkiri, Bagues Mohamed, Mariem Khouja, Boutheina Stiti, Ridha Ben Salem, Zouhair Nasr, Lasâad Ben Slimane, Kamel Nagaz, Rigane Ghayth, Abdelhamid Khaldi","doi":"10.1080/14786419.2024.2335355","DOIUrl":"10.1080/14786419.2024.2335355","url":null,"abstract":"<p><p>The impact of geographical origin on the chemical composition of acorns from Quercus species has significant attention. This study aimed to explore the phenolic composition of methanolic extracts, tocopherol content, and fatty acid composition of acorn oils from six different populations of <i>Q. canariensis</i> acorns. The obtained results revealed that acorn oil from BniMtir exhibited high levels of α-tocopherol (58 mg/kg). The fatty acids identified across all samples were Z-vaccenic + oleic acids (38.44-58.58%). In addition, the data highlighted the presence of quinic (32.514-60.216 µg/g DW) and gallic acids (1.674-10.849 µg/g DW), as well as catechin (+) (0.096-12.647 µg/g DW) in all populations. These variations in chemical composition from different regions are likely linked to their geographical origin. In conclusion, this study's finding should significance for the industry, offering valuable insights into the potential production of bioactive compounds from <i>Q. canariensis</i> acorns, which could have various applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4247-4253"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}