Natural Product Research最新文献

Phytochemical profiling of Pelargonium graveolens l'Hér and evaluation of its activity against D-galactose induced skin ageing.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-05 DOI: 10.1080/14786419.2025.2487148

Sanagik Sabry Abu El Wafa, Hanaa A H Kassem, Nehal M Ramadan, Mai M Eltaweel, Nermin A Younis, Inas Y Younis

{"title":"Phytochemical profiling of Pelargonium graveolens l'Hér and evaluation of its activity against D-galactose induced skin ageing.","authors":"Sanagik Sabry Abu El Wafa, Hanaa A H Kassem, Nehal M Ramadan, Mai M Eltaweel, Nermin A Younis, Inas Y Younis","doi":"10.1080/14786419.2025.2487148","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487148","url":null,"abstract":"Pelargonium graveolens L'Hér is an evergreen small shrub with pink flowers. Metabolite profiling of its extract by UHPLC/MS analysis revealed the identification of 51 secondary metabolites. Interestingly, 29 compounds identified for the first time. The colorimetric assays revealed high content of phenolic, flavonoids and tannins (100.19 ± 3.94 µg Gallic acid Eq/mg, 47.38 ± 2.04 µg Rutin Eq/mg and 332.75 ± 8.85 µg Catechin Eq/mg of extract) respectively along with good antioxidant activity. Moreover, the in vitro analysis showed a significant anti-hyaluronidase activity (IC50 ± SD = 15.75 ± 0.8), as compared to standard luteolin. Topical application of the characterised P. graveolens hydrogel (1% and 2% w/w) was tested using the D-galactose-induced ageing model in mice. Histopathological examination demonstrated an increase in the dermal collagen expression, alleviation of ageing-related oxidative stress, and stabilisation of MMP-1/TIMP-1 balance. Ultimately, P. graveolens could be a valuable source of natural antioxidants with a promising antiaging activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical characterisation of biochar derived from sargassum spp. and its antibacterial activity.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-05 DOI: 10.1080/14786419.2025.2484269

Carlos Hernández-Calderón, B Escobar, Ruby Valdez-Ojeda, Ana Arroyo-Herrera, Tanit Toledano-Thompson, José Baas-López

{"title":"Physicochemical characterisation of biochar derived from sargassum spp. and its antibacterial activity.","authors":"Carlos Hernández-Calderón, B Escobar, Ruby Valdez-Ojeda, Ana Arroyo-Herrera, Tanit Toledano-Thompson, José Baas-López","doi":"10.1080/14786419.2025.2484269","DOIUrl":"https://doi.org/10.1080/14786419.2025.2484269","url":null,"abstract":"This experiment aims to study the potential use of biochar derived from Sargassum spp. as an innovative ingredient in homemade soap, focusing on its antibacterial activity. The pyrolysis process was conducted at 700 °C with a heating rate of 10 °C min-1 for 2 h under a nitrogen atmosphere with KOH chemical activation. The physicochemical properties of the biochar were investigated using XRD, FTIR, Raman, BET surface analysis, and SEM. Highly porous biochar was successfully synthesised, achieving a large specific surface area of 1600 m2 g-1 and a well-developed microporous structure distributed across the surface of the biochar. Klebsiella pneumoniae, Staphylococcus aureus, and Salmonella choleraesuis were used as model pathogens to evaluate the antibacterial activity of biochar-enriched homemade soap using Müeller-Hinton Agar and the Kirby-Bauer test. The antibacterial evaluations demonstrated that the incorporation of biochar into homemade soap partially inhibited the growth of these model pathogens bacteria.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial, antibiofilm activities of Jatropha gossypiifolia L. floral extracts and molecular docking study of the major compound.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2487693

Shimaa M Khalifa, Marwa F Harras, Mona Shaban E M Badawy

{"title":"Antibacterial, antibiofilm activities of Jatropha gossypiifolia L. floral extracts and molecular docking study of the major compound.","authors":"Shimaa M Khalifa, Marwa F Harras, Mona Shaban E M Badawy","doi":"10.1080/14786419.2025.2487693","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487693","url":null,"abstract":"This study looked at the phytochemical composition, antimicrobial, and antibiofilm properties of Jatropha gossypiifolia L. floral extracts. Broth dilution determined the minimum inhibitory (MIC) and bactericidal concentrations (MBC). MOE software was utilised to perform molecular docking against some biofilm-forming proteins. The extracts and the major compound (vitexin) showed different degrees of activity against strains of S. aureus, E. coli, K. pneumoniae, A. baumannii, and S. mutants but had moderate activity against P. aeruginosa. The diameters of the clear zones surrounding the wells ranged from 12.0 ± 1.0 to 25.0 ± 1.0 mm. Methanolic extracts were higher in antibacterial activity than the methylene chloride extract. The MIC values of the extracts ranged from 12.5 to 200 mg/mL. The extract's MBC values ranged from 50 to >400 mg/mL. The Vitexin exerted significant biofilm attenuation against the S. aureus, A. baumannii, and P. aeruginosa biofilm, with maximum activity measured at 78, 156, and 525 mg/mL doses, respectively. Docking results revealed that vitexin fitted well in the active sites of these proteins forming stable complexes with significant binding scores. Interestingly, both the glycoside and flavone moieties of vitexin were highly involved in the binding with the three examined proteins via making a network of hydrogen bond interactions and non-polar interactions.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new insecticidal sesquiterpene from a mangrove endophytic fungus Aspergillus strain sp. GXNU R1.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2487687

Xiongtao Yu, Meijing Tan, Xianglong Bo, Zhifan Lin, Jinwei Chen, Xishan Huang, Jiguo Huang

引用次数: 0

Glucosinolate profiles in wild-growing Lepidium draba L. from Tunisia and Croatia.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2486339

Wissal Saadellaoui, Azra Đulović, Ileana Žeravica, Fethia Harzallah-Skhiri, Patrick Rollin, Ivica Blažević, Sondes Stambouli-Essassi

引用次数: 0

Novel eudesmanolides from the flowers of Pentanema britannicum (L.) D.Gut.Larr with antidepressant activities.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-04 DOI: 10.1080/14786419.2025.2487683

Yu-Qing Xie, Xin-Yue Zhang, Jun-Hui Zhang, Ping He, Sheng-He Yang, Yan Fu, Zhi-Yu Ni, Jian Su, Yu-Cheng Gu, Yi-Bing Wu

引用次数: 0

Vasodilator activity of methanol extract obtained from Crataegus rosei leaves and the chemical characterization of its main constituents.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-03 DOI: 10.1080/14786419.2025.2486334

Diana López-Fitz, Eloy Rodríguez-de-León, Rebeca Rodríguez-Martínez, César Ibarra-Alvarado, Moustapha Bah, Mahinda Martínez, Leticia García-Aguilar

{"title":"Vasodilator activity of methanol extract obtained from Crataegus rosei leaves and the chemical characterization of its main constituents.","authors":"Diana López-Fitz, Eloy Rodríguez-de-León, Rebeca Rodríguez-Martínez, César Ibarra-Alvarado, Moustapha Bah, Mahinda Martínez, Leticia García-Aguilar","doi":"10.1080/14786419.2025.2486334","DOIUrl":"https://doi.org/10.1080/14786419.2025.2486334","url":null,"abstract":"Persistent arterial hypertension (AHT) plays a very important role in the development of cardiovascular diseases (CVD). The present study assessed the vasodilator activities of the methanol extract (ME) and its fractions obtained from leaves of a Mexican Crataegus rosei plant. The fat- and tannin-free ME fraction (FTFME) produced the most potent vasodilator effect [EC50 8.253 (4.672 to 14.58 μg/mL)], that was 6.7-fold higher than that of the ME [EC50 = 55.49 (29.78 to 68.69) μg/mL], which was similar to that of ACh used as a positive control. This effect was dependent on the nitric oxide/cGMP pathway. Six triterpene acids (ursolic, oleanolic, euscaphic, maslinic, corosolic, and alphitolic) were identified as the main constituents of this fraction. In contrast to the commercially available Crataegus extracts, these compounds must be the most suitable chemical and pharmacological markers for this methanol extract in research into obtaining a standardised antihypertensive extract.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant compounds inhibit UV radiation-induced erythema in mice skin.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-02 DOI: 10.1080/14786419.2025.2486331

Diego Armando Villamizar-Mantilla, Elena E Stashenko, Jorge Luis Fuentes Lorenzo

引用次数: 0

Integration of metabolomics and bioinformatics: exploring medicinal potential value of Duchesnea indica and its endophytic fungus Aspergillus sp. through UPLC-Orbitrap HRMS based metabolomics.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-02 DOI: 10.1080/14786419.2025.2487692

Guiwen Li, Hui Zhang, Shuifeng Zhang, Xiangjie Pan, Gongnian Xiao, Shengli Yang

{"title":"Integration of metabolomics and bioinformatics: exploring medicinal potential value of Duchesnea indica and its endophytic fungus Aspergillus sp. through UPLC-Orbitrap HRMS based metabolomics.","authors":"Guiwen Li, Hui Zhang, Shuifeng Zhang, Xiangjie Pan, Gongnian Xiao, Shengli Yang","doi":"10.1080/14786419.2025.2487692","DOIUrl":"https://doi.org/10.1080/14786419.2025.2487692","url":null,"abstract":"Duchesnea indica is a traditional medicinal plant known for its antioxidant, anticancer and antibacterial properties. This study is the first to investigate endophytic fungi in D. indica, isolating PS4 (Aspergillus sp.) and employing the innovative OSMAC strategy to enhance its metabolomic profile, analysing the metabolites of both D. indica and its endophytic fungus for the first time using UPLC-Orbitrap HRMS. Specifically, in potato dextrose broth (PDB), PS4's metabolites showed remarkable potential for antioxidant, antibacterial and anticancer effects. The potential targets for the anticancer effects of D. indica and its endophytic fungus were innovatively predicted using network pharmacology and molecular docking, identifying 17 key compounds and six core target genes for the first time in this context. Strong binding between these components and target genes underscores the value of integrating metabolomics and network pharmacology in natural product research, laying a foundation for future drug development.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic acids and flavonoids from three Jacaranda Juss. (Bignoniaceae) and their acetylcholinesterase inhibitory activity.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-04-01 DOI: 10.1080/14786419.2025.2484251

Eliane Cristina Costa, Vinicius Viana Pereira, Alexandre Milanez Brandão, Carlos Victor Mendonça Filho, Jacqueline Aparecida Takahashi, Roqueline Rodrigues Silva

{"title":"Phenolic acids and flavonoids from three Jacaranda Juss. (Bignoniaceae) and their acetylcholinesterase inhibitory activity.","authors":"Eliane Cristina Costa, Vinicius Viana Pereira, Alexandre Milanez Brandão, Carlos Victor Mendonça Filho, Jacqueline Aparecida Takahashi, Roqueline Rodrigues Silva","doi":"10.1080/14786419.2025.2484251","DOIUrl":"https://doi.org/10.1080/14786419.2025.2484251","url":null,"abstract":"The genus Jacaranda Juss. (Bignoniaceae) is native to Central and South America and are known to have antioxidant, antimicrobial and anticancer activities. This study aimed to identify phenolic and flavonoid compounds from leaves and twigs of three species of the genus Jacaranda Juss. using HPLC-DAD-MS, ESI-MS and Tandem MS (ESI-MS/MS), as well as to evaluate the inhibitory activity of the extracts on the enzyme acetylcholinesterase. Leaves and twigs of Jacaranda caroba, Jacaranda mimosifolia and Jacaranda oxyphylla were dried and subjected to extraction with hexane, chloroform and methanol to obtain crude extracts. In the methanol extracts, a total of seventeen metabolites (mainly phenolic acids and flavonoids) were found. Methanol extracts from J. caroba and J. oxyphylla twigs showed a pronounced acetylcholinesterase inhibition (IC50= 4.2 and 10.2 µg.mL-1, respectively). This inhibition activity can be related to phenolic derivatives and flavonoids identified in methanol extracts of Jacaranda species.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0