Natural Product Research最新文献

{"title":"In-vitro cell migration enhancing constituents from Decalepis hamiltonii, a plant used in the preparation of ‘Pinda oil’, a medicinal oil used in Ayurveda for wound management","authors":"D. R. Kulatunge ,&nbsp;K. Hector Jayawardana ,&nbsp;Ajita M. Abeysekera ,&nbsp;S. Chandrani Wijeyaratne ,&nbsp;G. M. Kamal B. Gunaherath","doi":"10.1080/14786419.2024.2305220","DOIUrl":"10.1080/14786419.2024.2305220","url":null,"abstract":"<div><div><em>Decalepis hamiltonii</em>, Wight &amp; Arn. (Apocyanaceae) is a one of the raw materials used in the preparation of ‘Pinda oil’, a medicinal oil which is used for treatment of wounds in Ayurveda. Of the hexanes, dichloromethane, and ethyl acetate extracts derived from the plant raw materials used to prepare ‘Pinda oil’, the hexanes extract of <em>D. hamiltonii</em> exhibited the highest mean percentage wound closure (75.1 ± 2.9) compared to the negative controls (1% DMSO in DMEM, 4.2 ± 1.2 and 100% DMEM, 4.1 ± 0.9) in the scratch wound assay (SWA). Fractionation of the hexanes extract of stem of <em>D. hamiltonii</em> led to the isolation of 2-hydroxy-4-methoxybenzaldehyde (<strong>1</strong>) and a mixture of long chain esters of lupeol (<strong>2</strong>), which showed enhanced cell migration in SWA. It was observed that the esters of lupeol bind to the cell membrane and/or enter the cells during the SWA. It was found that these constituents are also present in ‘Pinda oil’ which may contribute to the enhancement of wound healing activity of ‘Pinda oil’.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2990-2996"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from Vitex negundo","authors":"Nancy Tripathi ,&nbsp;Aliva Naik ,&nbsp;Dulla Naveen Kumar ,&nbsp;Nivedita Bhardwaj ,&nbsp;Bharat Goel ,&nbsp;Sanjay Kumar ,&nbsp;Sanheeta Chakrabarty ,&nbsp;Amit Ranjan ,&nbsp;Santosh Kumar Guru ,&nbsp;Sanjeev Kumar ,&nbsp;Ashish Agrawal ,&nbsp;Shreyans K. Jain","doi":"10.1080/14786419.2024.2312542","DOIUrl":"10.1080/14786419.2024.2312542","url":null,"abstract":"<div><div>The compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans – silybin, silychristin and silydianin − 2,3-dehydrosilychristin is reported in this study from <em>Vitex negundo</em> Linn. leaves. 2,3-Dehydrosilychristin (<strong>7</strong>) and 14 other compounds were isolated through focused extraction. Its subsequent pharmacological evaluation demonstrated potent antioxidant and <em>in-vitro</em> anti-inflammatory effects, notably inhibiting cytokines TNF-α, IL-6, IL-8 and VEGF. In <em>in-vivo</em> assessments, 2,3-dehydrosilychristin (<strong>7</strong>) revealed remarkable hepatoprotective potential by reducing liver enzyme levels AST and ALT. These findings expand the potential of 2,3-dehydrosilychristin and suggest bioprospecting <em>Vitex</em> species as alternate sources of bioactive flavonolignans.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2771-2779"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and phylogenetic perspective of medicinal plants used for cancer treatment in Egypt","authors":"Dalia Youssef El-Berawey","doi":"10.1080/14786419.2024.2405012","DOIUrl":"10.1080/14786419.2024.2405012","url":null,"abstract":"<div><div>With a global increase in mortality, particularly in low-income countries, cancer remains one of the most devastating diseases. Medicinal plants rich in phytochemicals have shown promise as chemoprotective and anticancer agents. As a result, in this study, we compiled a list of medicinal plant species that have been used to treat cancer in the last decade. The results of our review show that 170 plant species from 53 plant families have been used to treat various types of cancer. Plant species are categorised based on their taxonomic position and level of cytotoxicity (very strong, strong, cytotoxic, moderate, and weak). The phylogenetic relationships between these plant species were also reconstructed. The most frequently mentioned plant families were Fabaceae, Asteraceae, Solanaceae, Brassicaceae and Polygonaceae. Phytochemicals such as flavonoids, alkaloids, betalains, saponins and polyphenols are found in highly therapeutic plants. The species <em>Solanum</em>, <em>Khaya</em>, <em>Eichhornia</em>, <em>Coccoloba</em>, <em>Annona</em>, <em>Withania</em>, <em>Salicornia</em>, <em>Beta</em>, <em>Persicaria</em>, <em>Persea</em>, <em>Hyphaene</em> and <em>Kalanchoe</em> showed high potency against a range of cancer cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2944-2962"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of autophagy activity by dipsacoside B alleviates exhaustive exercise-induced kidney injury via the AMPK/mTOR pathway","authors":"Zhenyu Li ,&nbsp;Zhuang Tian","doi":"10.1080/14786419.2024.2308002","DOIUrl":"10.1080/14786419.2024.2308002","url":null,"abstract":"<div><div>Exhaustive exercise (EE) induces kidney injury, but its concrete mechanism has not been fully elucidated. Hepatoprotective effects of dipsacoside B (DB) have been found previously, involving in autophagy induction. However, whether DB exerts renal protective effect and its potential mechanism are still unknown. The present study aimed to investigate the benefit of DB in EE-induced kidney injury and decipher its underlying mechanism. Here, we found that DB ameliorated EE-induced renal dysfunction and renal histopathological injury in rats. DB possessed anti-inflammatory, anti-oxidative, and anti-apoptotic functions in kidneys of exercise-induced exhausted rats. Besides, DB improved autophagy function in kidneys of EE rats. Mechanically, activation of the adenylate-activating protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway was implicated in the kidney injury-relieving effects and autophagy restoration induced by DB. Collectively, these findings provide reference for the clinical application of DB in preventing and managing EE-induced kidney injury.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2703-2709"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Punicalagin improves inflammation and oxidative stress in rat model of pelvic inflammatory disease","authors":"Ushna Zoofeen ,&nbsp;Mohsin Shah ,&nbsp;Sidra Sultan ,&nbsp;Ehtesham Ehtesham ,&nbsp;Inayat Shah ,&nbsp;Navid Sharif ,&nbsp;Momin Khan ,&nbsp;Fawad Ali Shah","doi":"10.1080/14786419.2024.2313183","DOIUrl":"10.1080/14786419.2024.2313183","url":null,"abstract":"<div><div>Pelvic inflammatory disease (PID) is one of the major public health concerns accounting for 30% of infertility and 50% of ectopic pregnancy cases due to severe inflammation and fibrosis. Punicalagin® are known to exhibit potent anti-inflammatory activity. The aim of this study was to demonstrate the anti-inflammatory and antioxidant effects of Punicalagin®, against pelvic inflammatory disease in rats. Female Sprague Dawley rats (<em>n</em> = 24) were divided into 6 groups (<em>n</em> = 4) as control, PID, prophylactic (low dose and high dose) and therapeutic group (low dose and high dose). PID model was constructed by implanting the rat cervix with mixed microbe (<em>Escherichia Coli</em> and <em>Staphylococcus Aureus</em>) solution. Prophylactic group was gavaged with 3 mg/kg (low dose) and 6 mg/kg (high dose) Punicalagin® daily starting one day before PID induction and therapeutic group was gavaged with 3 mg/kg (low dose) and 6 mg/kg (high dose) Punicalagin® daily starting 1 day after confirmation of PID model. Rats were sacrificed at the end of experiment and samples from upper genital tract were collected for ELISA, antioxidant assay and histopathological examination. According to results, obvious signs of inflammation and oxidative stress including infiltration of neutrophils and significantly raised levels of cytokines, and oxidative stress markers were observed in PID group when compared to control group. Punicalagin® significantly decreased the levels of IL-1β, catalase and lipid peroxidation in both prophylactic and therapeutic groups when compared to PID group. Punicalagin® also decreased the infiltration of leucocytes in uterus of prophylactic and therapeutic group when compared to PID group, as determined by histological examination. On basis of these results, we concluded that Punicalagin® showed anti-inflammatory and antioxidant potential in rat model of pelvic inflammatory disease and could be used as possible therapeutic agent in treatment of PID.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2780-2786"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic constituents from the fruit of Solanum aculeastrum","authors":"Nadine-Phalone Tinguep Tchapnda ,&nbsp;Ruth Bibiane Njinkou Njambouo ,&nbsp;Marguerite Hortence Tchuendem Kenmogne ,&nbsp;Pascal Djimeli Douanla ,&nbsp;Yoshihito Shiono ,&nbsp;Turibio Kuiate Tabopda","doi":"10.1080/14786419.2024.2320738","DOIUrl":"10.1080/14786419.2024.2320738","url":null,"abstract":"<div><div>A new triterpene, aculeastrumone A (<strong>1</strong>), a new triterpene saponin aculeastrumoside A (<strong>2</strong>), and eleven known compounds (<strong>3–13</strong>) were isolated from MeOH/Water (80/20) extract of the fruits of <em>Solanum aculeastrum</em> (Solanaceae). Their structures were established by detailed 1D and 2D NMR spectroscopic studies and mass spectrometry. The isolated compounds were evaluated against three human cancer cells ((MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer)) and normal human fibroblast (BJ) cell lines. Among them, saponins <strong>2–5, 7–8</strong>, and Carpesterol <strong>10</strong> possess significant cytotoxic activity with IC₅₀ ≤ 10 µM against the three cancer cell lines.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2863-2871"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue healing: marine biopolymers’ dual role in diabetic wounds and palliative care","authors":"Gokul Sudhakaran","doi":"10.1080/14786419.2024.2358523","DOIUrl":"10.1080/14786419.2024.2358523","url":null,"abstract":"<div><div>Chronic Diabetic wounds pose significant challenges in healthcare due to prolonged healing times and increased susceptibility to infections. Traditional wound dressings often fall short in providing an optimal environment for healing. Owing to their biocompatibility and biodegradability, natural polysaccharides present promising wound management alternatives. This review highlights the potential of polysaccharides derived from diverse sources, including marine organisms, in promoting wound healing. While considerable progress has been made in understanding their haemostatic, antimicrobial, and immunomodulatory properties, further research is needed to elucidate their precise mechanisms of action and optimise their therapeutic efficacy. Harnessing the unique characteristics of marine-based polysaccharides holds excellent promise for future advancements in wound care, particularly in the detection and treatment of diabetic wound infections.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2999-3001"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hallmarks of diabetes mellitus and insights into the therapeutic potential of synergy-based combinations of phytochemicals in reducing oxidative stress-induced diabetic complications","authors":"Mohammad Irfan Dar ,&nbsp;Anu Gulya ,&nbsp;Sageer Abass ,&nbsp;Kapil Dev ,&nbsp;Rabea Parveen ,&nbsp;Sayeed Ahmad ,&nbsp;Mohammad Irfan Qureshi","doi":"10.1080/14786419.2024.2402461","DOIUrl":"10.1080/14786419.2024.2402461","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a serious health issue and is still one of the major causes of mortality around the globe. Natural products have progressively integrated into modern, advanced medical practices. Phytoconstituents from some medicinal plants have demonstrated therapeutic activity in treating different metabolic disorders and have been used to treat DM and its severe complications. The present review provides details of the major anti-diabetic targets identified in the literature and also provides comprehensive information regarding the therapeutic role of a synergy-based combination of phytoconstituents that functions by controlling specific molecular pathways synchronously by inhibiting certain key regulators involved in the development and progression of DM. The review also implicated the role of oxidative stress in diabetic complications and presented scientific validations of phytochemicals and their synergy-based combination using <em>in vitro</em> and or <em>in vivo</em> approaches.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2929-2943"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LC-ESI-MS/MS analysis of phenolic compounds and in vitro cytotoxicity and apoptosis-inducing effects of Nonea pulmonarioides extracts","authors":"Fuad O. Abdullah ,&nbsp;Haval H. Muhammed ,&nbsp;Mustafa Abdullah Yilmaz ,&nbsp;Oguz Cakir ,&nbsp;Abbas Tarhan","doi":"10.1080/14786419.2024.2306914","DOIUrl":"10.1080/14786419.2024.2306914","url":null,"abstract":"<div><div>The chemical composition of <em>Nonea pulmonarioides</em> extracts were investigated for the first time. The phytoconstituents of the methanol extracts were screened by using LC/MS-MS technique. The anticancer activity of the acetone and methanol extracts were measured against four cancer cell lines; MCF-7, PC3, HT-29, and U-87 MG. Thirty phenolic compounds were identified, rosmarinic (90.06 mg analyte/g extract) and fumaric acids (39.737 mg analyte/g extract) were major compounds of the studied species. Moreover, both methanol and acetone extracts were found to have strong anticancer activities. The acetone extract HT-29 (with IC₅₀ of 10.17 ± 0.25 µg/mL) compared with standard cis-platin (with IC₅₀ of 22.20 ± 0.72 µg/mL) with apoptotic mediated programmed cell death. These findings identified <em>N. pulmonarioides</em> as a potential species exhibiting anticancer properties. In conclusion, the compelling results show that the methanol extract contains possible bioactive compounds with anticancer properties that require isolation and further characterisation.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2687-2694"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conamonin A and dihydrochalcones from the whole plants of Conamomum rubidum (Lamxay & N.S.Lý) Škorničk. & A.D. Poulsen showing anti-inflammatory and cytotoxic activities","authors":"Hanh Nhu Thi Hoang ,&nbsp;Hung Quoc Vo ,&nbsp;Linh Thuy Khanh Nguyen ,&nbsp;Linh Thuy Thi Tran ,&nbsp;Hoai Thi Nguyen ,&nbsp;Ty Viet Pham ,&nbsp;Hieu Trung Le ,&nbsp;Cuong Viet Canh Le ,&nbsp;Bao Chi Nguyen ,&nbsp;Duc Viet Ho","doi":"10.1080/14786419.2024.2315595","DOIUrl":"10.1080/14786419.2024.2315595","url":null,"abstract":"<div><div>A new compound, conamonin A (<strong>1</strong>), was isolated from the whole plants of <em>Conamomum rubidum</em> with eight known dihydrochalcones (<strong>2</strong>-<strong>9</strong>). Their structures were elucidated by a combination of spectroscopic methods as well as by comparison with previously reported data. The absolute configuration of <strong>1</strong> was assigned by TDDFT-ECD method. Compounds <strong>1</strong> and <strong>8</strong> showed inhibitory activity against LPS-induced NO production in the RAW 264.7 cells, with IC₅₀ values of 58.29 ± 2.88 and 81.77 ± 5.99 μM, respectively. Compounds <strong>3/4</strong> and <strong>5/6</strong> exhibited inhibitory effects, with IC₅₀ values of 28.76 ± 1.16 and 29.89 ± 1.79 μg/mL, respectively. Compounds <strong>2</strong>, <strong>7</strong>-<strong>9</strong> exhibited significant cytotoxic activity against human lung carcinoma (the SK-LU-1 cell line) with IC₅₀ values ranging from 9.87 to 17.99 µM. This study offers valuable insights into the chemical constituents and biological activities of <em>Conamomum rubidum</em>, highlighting its potential as a source for discovering new anti-inflammatory and cytotoxic agents.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 10","pages":"Pages 2804-2809"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}