Natural Product Research最新文献

A preliminary in-vitro and in-silico investigation into the cytotoxic and anti-metastatic activity of Smilax ovalifolia Roxb. ex D.Don against non-small cell lung cancer cells. 卵形菝葜细胞毒性和抗转移活性的体外和计算机初步研究。don抗非小细胞肺癌细胞。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-08 DOI: 10.1080/14786419.2026.2669980

Pitambar Baishya, Taranga Jyoti Baruah

引用次数: 0

Structure elucidation and partial characterisation of compounds isolated from root bark extracts of Moringa stenopetala plant using acetone as extraction solvent and its antibacterial activity evaluation. 以丙酮为萃取溶剂对辣木根皮提取物中化合物的结构分析、部分特性及抑菌活性评价。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-08 DOI: 10.1080/14786419.2026.2669210

Mulugeta Tesemma Kassa, Dessalew Berihun Adam, Yinebeb Tariku, Legesse Adane Bahiru

{"title":"Structure elucidation and partial characterisation of compounds isolated from root bark extracts of Moringa stenopetala plant using acetone as extraction solvent and its antibacterial activity evaluation.","authors":"Mulugeta Tesemma Kassa, Dessalew Berihun Adam, Yinebeb Tariku, Legesse Adane Bahiru","doi":"10.1080/14786419.2026.2669210","DOIUrl":"https://doi.org/10.1080/14786419.2026.2669210","url":null,"abstract":"Moringa Stenopetala plant is well-known in Ethiopia for its traditional use in treating various ailments. In this study, five compounds were isolated from root bark of a plant using petroleum ether-ethyl acetate in varying ratios as isolation mixture and evaluated its antibacterial properties. The compounds MSP-1, MSP-2, and MSP-3 structure were fully elucidated, while MSP-4 and MSP-5 were partially characterised using 1H NMR,1³C NMR, and FTIR. MSP-1 was identified as Cholesterol (S1) from steroid family, MSP-2 as Palmitic acid (S2), a long-chain saturated fatty acid, and MSP-3 as Oleic acid (S3), a mono-unsaturated omega-9 fatty acid. The partially characterised compounds likely contain large molecules with carbonyl and nitrogen-based functional groups and show notable antibacterial activity, supporting the traditional use of Moringa stenopetala as medicinal plant. These findings underscore the efficacy of plant components against strains and evaluate their potential as candidates for the formulation of modern antibacterial agents.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The polyketide-macrolactone phomolide I produced by the endophytic fungus Arthrinium marii M-211. 内生真菌海蓟马M-211产生的聚酮-内酯磷内酯I。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-08 DOI: 10.1080/14786419.2026.2669214

Ferry Ferdiansyah Sofian, Takuma Suzuki, Unang Supratman, Desi Harneti, Rani Maharani, Supriatno Salam, Fajar Fauzi Abdullah, Mayuka Hakozaki, Shota Uesugi, Takuya Koseki, Yoshihito Shiono

引用次数: 0

Thelesperma filifolium (Hook.) A.Gray Essential Oil: GC/MS Analysis and Chemical Significance. 叶柄（钩状）a .灰色精油的GC/MS分析及其化学意义

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-08 DOI: 10.1080/14786419.2026.2666671

Abdullah Haikal

引用次数: 0

A novel monoterpene indole alkaloid from Uncaria sessilifructus Roxb. and its antitumor activity and action mechanism. 一种新的钩藤单萜吲哚类生物碱。及其抗肿瘤活性和作用机制。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-08 DOI: 10.1080/14786419.2026.2666668

Li Huang, Wenyan Liu, Xinyue Li, Zheng Li, Xiang Nan, Wei Wang, Ziming Wang, Song Jin, Yanchao Wu

{"title":"A novel monoterpene indole alkaloid from Uncaria sessilifructus Roxb. and its antitumor activity and action mechanism.","authors":"Li Huang, Wenyan Liu, Xinyue Li, Zheng Li, Xiang Nan, Wei Wang, Ziming Wang, Song Jin, Yanchao Wu","doi":"10.1080/14786419.2026.2666668","DOIUrl":"https://doi.org/10.1080/14786419.2026.2666668","url":null,"abstract":"Uncaria sessilifructus Roxb. (U. sessilifructus) remains largely unexplored in chemical constituents and antitumor bioactivities. Ten compounds were isolated and structurally elucidated from the hooked stems and branches of U. sessilifructus. Herein, a novel compound 1 was identified through various spectroscopic analyses. In vitro antitumor assays revealed that compound 1 exhibited broad-spectrum antiproliferative activity against six tumour cell lines, with potent efficacy against HL-60 (IC50 = 8.21 μM) and HeLa (IC50 = 9.04 μM) cells, while showing low cytotoxicity towards L02 human normal liver cells (IC50 > 40 μM). Network pharmacology analysis revealed that the enriched signalling pathways of compound 1 are mainly the MAPK and PI3K-AKT pathways, closely associated with the progression of leukaemia and cervical cancer. Molecular docking confirmed the stable binding of compound 1 to B-cell lymphoma 2 (BCL-2) and mitogen-activated protein kinase kinase 1 (MAP2K1) with binding free energies of -8.9 kcal mol-1 and -9.6 kcal mol-1, respectively. Overall, these results elucidate the dual antitumor mechanisms of compound 1, demonstrating its potential as a lead candidate for treating leukaemia and cervical cancer.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capilliposides from Lysimachia capillipes: triterpene saponins with potential anticancer activities. 毛缕草毛脂苷：具有潜在抗癌活性的三萜皂苷。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-07 DOI: 10.1080/14786419.2026.2664710

Sabrin R M Ibrahim, Gamal A Mohamed, Ali Sharif, Marwa A A Fayed, Wafaa M Fouda, Hagar M Mohamed

{"title":"Capilliposides from Lysimachia capillipes: triterpene saponins with potential anticancer activities.","authors":"Sabrin R M Ibrahim, Gamal A Mohamed, Ali Sharif, Marwa A A Fayed, Wafaa M Fouda, Hagar M Mohamed","doi":"10.1080/14786419.2026.2664710","DOIUrl":"https://doi.org/10.1080/14786419.2026.2664710","url":null,"abstract":"Capilliposides (CPSs) are oleanane-type triterpene saponins derived from Lysimachia capillipes, a traditional Chinese herb widely utilised for treating inflammatory illnesses, cancer, and arthritis disorders. CPSs have been reported to exhibit anticancer activity against different cancers, including lung, prostate, ovarian, colorectal, nasopharyngeal, and breast cancers. Mechanistically, CPSs have been suggested to induce apoptosis via regulating oxidative stress and mitochondrial pathways, as well as inhibiting angiogenesis and metastasis, promoting cell cycle arrest, and interfering with PI3K/Akt/mTOR, MAPK, and JAK/STAT3 signalling cascades. Additionally, CPSs have demonstrated anti-inflammatory and cytoprotective properties; they lowered oxidative stress, relieved experimental colitis, preserved intestinal barrier integrity, and regulated gut microbiota. This review discussed the reported data on the separation, chemistry, pharmacokinetics, and biological activities of CPSs. Although CPSs represent prominent multi-target natural triterpenes, current findings are largely preclinical and require further interpretation. Future research and clinical trials are recommended to confirm their safety and therapeutic potential.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical constituents and ferroptosis inhibitory activity of the deep-sea-derived fungus Penicillium citrinum W24. 深海来源真菌青霉W24的化学成分及抑制铁下垂活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-07 DOI: 10.1080/14786419.2026.2669680

Cheng-You Lin, Yuan Wang, Tai-Zong Wu, Rong Chao, Zheng-Biao Zou, Li-Sheng Li, Tian-Hua Zhong, Xian-Wen Yang

引用次数: 0

Bioactive phenolic allelochemicals from mulberry leaf litter through bioassay-guided fractionation and their bioherbicidal activity. 桑叶凋落物中生物活性酚类化感物质的生物测定及其生物除草活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-05 DOI: 10.1080/14786419.2026.2666672

Shagufta Perveen, Muhammad Naeem Mushtaq, Muhammad Yousaf, Raihan Ismil

{"title":"Bioactive phenolic allelochemicals from mulberry leaf litter through bioassay-guided fractionation and their bioherbicidal activity.","authors":"Shagufta Perveen, Muhammad Naeem Mushtaq, Muhammad Yousaf, Raihan Ismil","doi":"10.1080/14786419.2026.2666672","DOIUrl":"https://doi.org/10.1080/14786419.2026.2666672","url":null,"abstract":"Leaf litter may prevent related plants from growing through the release of natural bioactive allelochemicals into agroecosystems, which may also be employed as sustainable bioherbicides. The current study was carried out to assess mulberry leaf litter bioherbicidal capabilities and identify allelochemicals responsible for phytotoxic action through bioassay-guided fractionation. The findings showed that mulberry leaf aqueous and fractions of methanolic extract considerably reduced garden cress germination and early seedling growth by as much as 90%. Eleven allelochemicals [p-coumaric acid (the predominant), salicylic acid, vanillin, protocatechuic acid, vanillic acid, sinapic acid, 4-hydroxybenzoic acid, syringic acid, 2,4-dihydroxy benzoic acid, gallic acid, and m-hydroxy benzaldehyde (the lowest)] were identified in mulberry leaf extract. The findings suggest the presence of 11 phytotoxic phenolic allelochemicals in mulberry leaf litter, which may affect the co-cultivation of mulberry with associated crops in agroecosystems, and may also be exploited as future eco-friendly bioherbicides like BeloukhaTM and WeedLockTM.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC-MS-based phytochemical profiling and antimicrobial activity against Vibrio cholerae of Ziziphus mucronata stem bark: implications for therapeutic use. 基于gc - ms的紫茎皮植物化学分析及其对霍乱弧菌的抗菌活性：对治疗应用的意义。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-05 DOI: 10.1080/14786419.2026.2657031

Jerikias Marumure, Monde A Nyila

{"title":"GC-MS-based phytochemical profiling and antimicrobial activity against Vibrio cholerae of Ziziphus mucronata stem bark: implications for therapeutic use.","authors":"Jerikias Marumure, Monde A Nyila","doi":"10.1080/14786419.2026.2657031","DOIUrl":"https://doi.org/10.1080/14786419.2026.2657031","url":null,"abstract":"The objective of this study was to investigate the phytochemical composition and antimicrobial properties of Ziziphus mucronata stem bark extracts. GC-MS analysis of the ethyl acetate extract identified fourteen detected compounds. The major validated constituents included 5-hydroxymethylfurfural (26.47%), 9-octadecenamide (Z) (23.71%), cis-vaccenic acid (13.07%), and n-hexadecanoic acid (9.23%). Antimicrobial activity was evaluated against Vibrio cholerae clinical isolates using the agar well diffusion method. The stembark extracts demonstrated notable antibacterial activity, exhibiting a minimum inhibitory concentration (MIC) of ≤ 1 mg/mL. In addition to the experimental assays, a comprehensive literature review was conducted to evaluate the biological activities of the validated compounds identified through GC-MS. Notably, these phytochemicals have been previously reported to possess significant antimicrobial properties. These preliminary findings support the traditional use of Ziziphus mucronata and suggest potential as an antimicrobial agent, warranting further investigation with broader spectrum testing and safety evaluation.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iris planifolia (Mill.) T. Durand & Schinz: geographical variation in phenolic profile and antidiabetic activity. 鸢尾（植物）T. Durand & Schinz：酚谱和抗糖尿病活性的地理变异。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-05 DOI: 10.1080/14786419.2026.2669208

Faten Mezni, Hamdi Aouinti, Nouhe Ben Belaid, Faten Ayari, Ammar El Hadj

引用次数: 0