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Changes of peripheral serotonin in the psychosocially stressed rats treated with linden honey.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2443487
Ljubica Gavrilović, Vesna Stojiljković, Vojislav Stanić, Nebojša Jasnić, Snežana Pejić, Marija Pantelić, Snežana B Pajović, Slađana Tanasković
{"title":"Changes of peripheral serotonin in the psychosocially stressed rats treated with linden honey.","authors":"Ljubica Gavrilović, Vesna Stojiljković, Vojislav Stanić, Nebojša Jasnić, Snežana Pejić, Marija Pantelić, Snežana B Pajović, Slađana Tanasković","doi":"10.1080/14786419.2024.2443487","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443487","url":null,"abstract":"<p><p>This study aimed to investigate the effects of linden honey in maintaining the stability of peripheral serotonergic system in the psychosocially stressed rats. In this experiment we examined concentration of serotonin (5-HT) in Serbian linden honey, as well as concentrations of 5-HT and MAO A activity in the blood of chronically stressed rats treated with linden honey. The investigated parameters were quantified using HPLC method with electrochemical detector, HPLC method with a fluorescent detector, and assay of enzyme activities. An important result of this study is that using analytical chemistry methods we have detected 5-HT in linden honey from Serbia for the first time. Also, we found that treatment with linden honey in the socially isolated animals increased concentration of 5-HT and decreased MAO A activity. Our results may by important in the research of the role of linden honey in maintaining stability of peripheral serotonergic system in stress condition.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salvia abrotanoides methanolic extract Fe3O4@Carbon nanocomposite as biological approach for protection against the Potato Tuber Moth.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2443488
Zahra Alizadeh, Zahra Sadeghi, Fereshteh Khorrami, Khadijeh Ojaghi Aghbash, Mahdi Moridi Farimani
{"title":"<i>Salvia abrotanoides</i> methanolic extract Fe<sub>3</sub>O<sub>4</sub>@Carbon nanocomposite as biological approach for protection against the <i>Potato Tuber</i> Moth.","authors":"Zahra Alizadeh, Zahra Sadeghi, Fereshteh Khorrami, Khadijeh Ojaghi Aghbash, Mahdi Moridi Farimani","doi":"10.1080/14786419.2024.2443488","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443488","url":null,"abstract":"<p><p>Plant-based nano-insecticides like <i>Salvia abrotanoides</i> provide eco-friendly pest control with low resistance risk. This study aimed to evaluate the insecticidal activity of the Fe<sub>3</sub>O<sub>4</sub> @Carbon nanoformulation of <i>S. abrotanoides</i> extract with a carbon shell and pure extract against <i>Phthorimaea operculella</i> (eggs and larvae), a significant potato pest in Iran. A modified solvothermal method produced highly water-dispersible magnetite (Fe<sub>3</sub>O<sub>4</sub>) particles, with citrate as a stabilising agent. A carbon layer was added through hydrothermal treatment, using polyethylene glycol as a linking agent between glucose and the Fe<sub>3</sub>O<sub>4</sub> spheres. SEM analysis confirmed the structure of the Fe<sub>3</sub>O<sub>4</sub>@Carbon nanocomposite, while FTIR and EDS verified the methanolic extract's presence. The Fe<sub>3</sub>O<sub>4</sub>@Carbon nano extract demonstrated greater toxicity to the pest's eggs and larvae than the pure extract, with lower LC<sub>50</sub> values (752.23-355 ppm), indicating higher potency. These findings confirm that Fe<sub>3</sub>O<sub>4</sub>@Carbon <i>S. abrotanoides</i> nanoparticles are effective, pollution-free, and green nano-insecticides against <i>Ph. operculella</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyketide production in a mangrove-associated fungus Diaporthe goulteri, induced by chemical epigenetic modification.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2441496
Xiaolin Ma, Xia Wei, Shangping Xing, Xue Cheng, Junfei Lu, Chunxia Yang, Genshi Zhao, Ziteng Dai, Shiyu Hou, Yanying Liu, Dan Zhu
{"title":"Polyketide production in a mangrove-associated fungus <i>Diaporthe goulteri</i>, induced by chemical epigenetic modification.","authors":"Xiaolin Ma, Xia Wei, Shangping Xing, Xue Cheng, Junfei Lu, Chunxia Yang, Genshi Zhao, Ziteng Dai, Shiyu Hou, Yanying Liu, Dan Zhu","doi":"10.1080/14786419.2024.2441496","DOIUrl":"https://doi.org/10.1080/14786419.2024.2441496","url":null,"abstract":"<p><p>Studies on the chemical composition of endophytic fungus <i>Diaporthe goulteri</i>, isolated from the <i>Acanthus ilicifolius</i> L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (<b>1</b>), cytosporin D1 (<b>2</b>), cytosporin G1 (<b>3</b>), cytosporin J1 (<b>4</b>), cytosporin K1 (<b>5</b>), cytosporin F1 (<b>6</b>), and four known compounds, cytosporin E (<b>7</b>), cytosporin Y3 (<b>8</b>), cytosporin D (<b>9</b>), and cytosporin L (<b>10</b>). The structures of the compounds were established by comprehensive spectroscopic analysis, quantum-chemical calculations, and the modified Mosher's method. The cytotoxic, antioxidant and anti-inflammatory activities of the isolated compounds were evaluated.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics to target insecticidal compounds of Cenostigma pluviosum var. peltophoroides against Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae).
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2441494
João Luiz Baldim Zanin, Andréia Pereira Matos, Antônio Rogério Bernardo, Ana Carolina Volante, Daniele de Oliveira Silva, Danielle Ferreira Dias, João Henrique Ghilardi Lago, Daniela Aparecida Chagas-Paula, Marisi Gomes Soares
{"title":"Metabolomics to target insecticidal compounds of <i>Cenostigma pluviosum</i> var. <i>peltophoroides</i> against <i>Spodoptera frugiperda</i> (J. E. Smith) (Lepidoptera: Noctuidae).","authors":"João Luiz Baldim Zanin, Andréia Pereira Matos, Antônio Rogério Bernardo, Ana Carolina Volante, Daniele de Oliveira Silva, Danielle Ferreira Dias, João Henrique Ghilardi Lago, Daniela Aparecida Chagas-Paula, Marisi Gomes Soares","doi":"10.1080/14786419.2024.2441494","DOIUrl":"https://doi.org/10.1080/14786419.2024.2441494","url":null,"abstract":"<p><p>The fall armyworm <i>Spodoptera frugiperda</i> is the most prevalent plague in crops associated with a reduction in corn production by up to 34%. Pesticides have been used to reduce this plague, but they cause several environmental problems including resistance, ecological imbalance, and toxicity to the final consumer. The use of plant extracts has been an effective manner of eradicating this plague from crop plantations. In this sense, the hexane, EtOAc, and EtOH/H<sub>2</sub>O fractions from EtOH extract from different parts of <i>Cenostigma pluviosum</i> were investigated against this fall armyworm leading to a percentage of mortality around 96% in the larval phase for the fraction EtOAc of fruits (FrEA). The fractions were analysed in HPLC-ESI-HRMS for dereplication. Additionally, using multivariate statistical analysis permitted the development of an O2PLS-DA method based on the chemical constitution of fractions shedding light on promising constituents to the insecticidal activity of <i>C. pluviosum</i> against the <i>Spodoptera frugiperda</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of the GC/MS profiles of the hydrodistilled essential oils and volatile components from the aerial parts of Datura stramonium L.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2443951
Majid Mohammadhosseini, Mohammad Reza Kianasab, Mehdi Nekoei
{"title":"Screening of the GC/MS profiles of the hydrodistilled essential oils and volatile components from the aerial parts of <i>Datura stramonium</i> L.","authors":"Majid Mohammadhosseini, Mohammad Reza Kianasab, Mehdi Nekoei","doi":"10.1080/14786419.2024.2443951","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443951","url":null,"abstract":"<p><p>The present study is centred on the analysis of the chemical compositions of essential oils (EOs) and volatile fractions extracted from the aerial parts of <i>Datura stramonium</i> L. (APDSL) utilising traditional hydrodistillation (HD), solid phase microextraction (SPME), and a novel method known as innovative cigarette ignition (Incigig), all in combination with GC/MS. The results of this investigation reveal notable differences in both the types and relative percentages of the primary constituents; however, all identified profiles exhibit a significant presence of non-terpene hydrocarbons.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chrydintins A and B, two new sesquiterpenoids from Chrysanthemum indicum with cardioprotective activities.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2444570
Guanghui Zhang, Chunxiang Zhou, Donglin Wang, Junxia Liu, Xinyong Zhao
{"title":"Chrydintins A and B, two new sesquiterpenoids from <i>Chrysanthemum indicum</i> with cardioprotective activities.","authors":"Guanghui Zhang, Chunxiang Zhou, Donglin Wang, Junxia Liu, Xinyong Zhao","doi":"10.1080/14786419.2024.2444570","DOIUrl":"https://doi.org/10.1080/14786419.2024.2444570","url":null,"abstract":"<p><p>Chrydintins A (<b>1</b>) and B (<b>2</b>), two new sesquiterpenoids were isolated from <i>Chrysanthemum indicum</i>., together with four known ones identified as 9-hydroxyeudesma-4,7(11)-dien-6-one (<b>3</b>), (7<i>S</i>,9<i>S</i>,10<i>S</i>)-9-hydroxy-11-methoxyeudesm-4-en-6-one (<b>4</b>), curcumenone (<b>5</b>), and polydactin B (<b>6</b>), respectively. The structures of isolated compounds were determined by HR-ESI-MS, NMR analysis, and quantum chemical calculation. The <i>in vitro</i> cardioprotective activities of all compounds were studied on H<sub>2</sub>O<sub>2</sub>-injured H9C2 cells using MTT assay method. Compound <b>5</b> exhibited considerable protective effect with cell viability at 81.45 ± 1.07%.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2440537
Beibei Geng, Man Zhao, Jun Wang, Tian Zhong, Chaoyan Kang, Zizhen Wang, Xin Ma, Ting Xia
{"title":"Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.","authors":"Beibei Geng, Man Zhao, Jun Wang, Tian Zhong, Chaoyan Kang, Zizhen Wang, Xin Ma, Ting Xia","doi":"10.1080/14786419.2024.2440537","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440537","url":null,"abstract":"<p><p>T-cell acute lymphoblastic leukaemia (T-ALL) is a common childhood malignant tumour, which has poor prognosis and high recurrence rate. Ginsenoside Rh2 (GRh2), a bioactive ingredient of <i>Panax ginseng</i> has significant anti-tumour effect. In this study, we found that gene expressions of Jurkat cells were significantly changed in the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signalling pathways after 35 µm GRh2 treatment, involving in JUN, PIEN, AKT3 and MAPK8IP2. Target proteins including PI3K, AKT, ASK, caspase 8 and caspase 9 were bind tightly with GRh2 by molecular docking. Moreover, the protein expression ratios of p-PI3K/PI3K and p-AKT/AKT were significantly reduced, and the expression ratios of p-ASK1/ASK1, p-JNK/JNK and p-c-JUN/c-JUN, Bax/Bcl-2, and the levels of cleaved caspase 8, 9, 3 were increased significantly in GRh2-treated Jurkat cells. The results imply that GRh2 induced T-ALL apoptosis by activating the MAPK pathway and inhibiting the PI3K-AKT pathway.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2438269
Lakmal Gonawala, Maheehsa Madhumaali, Hanouf Ismail, Nishara Jayasooriya, Nalaka Wijekoon, Shanuk Rajapakshe, Harshanie Erangika, Dhammika Amaratunga, Rajitha Gunaratna, Harry W M Steinbusch, Chandra Mohan, Yu-Chung Chiang, Priyani Paranagama, K Ranil D de Silva
{"title":"Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.","authors":"Lakmal Gonawala, Maheehsa Madhumaali, Hanouf Ismail, Nishara Jayasooriya, Nalaka Wijekoon, Shanuk Rajapakshe, Harshanie Erangika, Dhammika Amaratunga, Rajitha Gunaratna, Harry W M Steinbusch, Chandra Mohan, Yu-Chung Chiang, Priyani Paranagama, K Ranil D de Silva","doi":"10.1080/14786419.2024.2438269","DOIUrl":"https://doi.org/10.1080/14786419.2024.2438269","url":null,"abstract":"<p><p>Cinnamon is a spice that is renowned for its several medicinal and cosmetic benefits. The research study examined the essential oil content, antioxidant, and anti-inflammatory properties of seven <i>Cinnamomum</i> species native to Sri Lanka. Cinnamon bark and leaf samples were used to extract essential oils, methanol, and hexane. Essential oil extracts underwent GC-MS analysis, while all extracts were subjected to antioxidant and anti-inflammatory assays. The bark of Sri Vijaya and <i>C. rivulorum</i>, along with the leaves of Sri Vijaya and <i>C. sinharajaense</i>, exhibited remarkable antioxidant properties. The cinnamaldehyde percentage of Sri Gemunu was the highest at 61.63%, while the bark of <i>C. sinharajaense</i> contained 59.19%. The leaves of Sri Gemunu had the highest eugenol content, determining at 91.45%. <i>C. zeylanicum</i> and its strains have been found to exhibit the highest antioxidant and anti-inflammatory properties. <i>C. sinharajaense</i> and <i>C. rivulorum</i> are two wild cinnamon species that show potential for potential medicinal uses. Thus, these species have great potential for further research on their biological properties and their possible applications in various fields, such as pharmaceuticals.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical profile and biological screening of two Amaranthaceae plants: Atriplex halimus and Haloxylon scoparium.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2443489
Amani Amamra, Yassine Reggami, Ihcene Bouasla, Houneida Benbouzid, Imene Becheker, Hajira Berredjem
{"title":"Phytochemical profile and biological screening of two Amaranthaceae plants: <i>Atriplex halimus</i> and <i>Haloxylon scoparium</i>.","authors":"Amani Amamra, Yassine Reggami, Ihcene Bouasla, Houneida Benbouzid, Imene Becheker, Hajira Berredjem","doi":"10.1080/14786419.2024.2443489","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443489","url":null,"abstract":"<p><p>In this study, phytochemical and biological properties of <i>Atriplex halimus</i> and <i>Haloxylon scoparium</i> leaves, collected in Algeria, were evaluated. The aqueous extract of the studied plants was subjected to phytochemical screening by biochemical analysis and HPLC. The diffusion assay was assessed to investigate the antimicrobial effect against clinical and reference strains. Moreover, we investigated DPPH and FRAP, as well as the haemolytic activity. The results showed abundance in the phytochemical and mineral components. Notably, <i>A. halimus</i> exhibited the highest DPPH and FRAP values with IC<sub>50</sub> = 1.69 ± 0.67 and IC<sub>50</sub> = 3.20 ± 0.04 mg/g, respectively. The antibacterial activity was better at the concentration of 25 mg/mL, compared to the standard antibiotics. The inhibition zones varied between 8 and 40 mm. The haemolytic activity did not depict any toxicity. The investigated plants exhibited interesting antioxidant and antibacterial properties and may serve as a valuable source for novel antimicrobial drugs.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia. 安纳托利亚东黑海地区恰耶利-里泽蜂胶的化学分析和生物活性评估。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-20 DOI: 10.1080/14786419.2024.2443500
Ali Disli, Nurdan Akdogan, Selinay Ozel, Levent Nuralin, Senem Akkoc, Hatice Ogutcu, Dogukan Doyduk, Gulay Dilek
{"title":"Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia.","authors":"Ali Disli, Nurdan Akdogan, Selinay Ozel, Levent Nuralin, Senem Akkoc, Hatice Ogutcu, Dogukan Doyduk, Gulay Dilek","doi":"10.1080/14786419.2024.2443500","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443500","url":null,"abstract":"<p><p>The constituents of the aqueous, ethanol, hexane, and methanol extracts of Anatolian propolis collected from the Eastern Black Sea Region (Çayeli-Rize) were investigated by GC-MS, HPLC and AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic acid, rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin and gallic acid were determined. The contents of phenolic acids and flavonoids varied between 17.04-642.59 and 1.18-2749.20 ppm, respectively. Minerals found in propolis were Na, K, Ca, Mg and Zn. The methanol extract had the highest antiproliferative activity against the A549 cell line with an IC<sub>50</sub> value of 0.1821 µL/mL. The extracts showed higher antibacterial activity against Gram-negative bacteria compared to Gram-positive bacteria.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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