Natural Product Research最新文献

{"title":"Ganodermanic acid, a new steroidal compound derived from the marine fungus <i>Aspergillu</i>s sp. ZJUT223.","authors":"Youmin Ying, Xiaoxiao Chen, Shijie Zhan, Si Yang, Jinli Liu, Weiguang Shan, Yuhao Lin, Rong Wang","doi":"10.1080/14786419.2025.2573887","DOIUrl":"https://doi.org/10.1080/14786419.2025.2573887","url":null,"abstract":"<p><p>A new steroid ganodermanic acid (<b>1</b>) and seventeen known compounds <b>2</b>-<b>18</b> were isolated from the marine fungus <i>Aspergillus</i> sp. ZJUT223. Extensive spectroscopic data (1D/2D NMR and HR-ESI-MS) established the planar structure of <b>1</b>. Its stereochemistry was assigned using NOESY, density functional theory (DFT)-calculated NMR with DP4+ analysis, and calculated electrical circular dichroism (ECD). In the quorum sensing (QS) inhibition assay, aspergilol I (<b>17</b>) dose-dependently inhibited violacein production in <i>Chromobacterium violaceum</i> CV026, suggesting that it interfered with quorum sensing signalling in this reporter strain. This is the first report of aspergilol I (<b>17</b>) as a potential quorum sensing inhibitor.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, synthesis and preclinical evaluation of naringenin and its semi-synthetic derivatives in postmenopausal osteoporosis.","authors":"Shaheen Jabbar, Faraha Ahmed, Syed Sufian Ahmad, Bushra Parveen, Syed Arman Rabbani, Mohamed El-Tanani, M Shaquiquzzaman, Mohammad Ahmed Khan","doi":"10.1080/14786419.2025.2568204","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568204","url":null,"abstract":"&lt;p&gt;&lt;p&gt;In this study, a derivative of Naringenin (NRG-D), a naturally occurring flavonoid was designed by modifying its structure at the 4th carbonyl position, guided by structure-activity relationship analysis. The binding affinity of NRG-D for bone marker proteins was initially assessed through in-silico studies. The therapeutic effects of both NRG and NRG-D were then evaluated in a rat model of postmenopausal osteoporosis induced by vinyl cyclohexene diepoxide (VCD). Female Wistar rats received VCD (160 mg/kg) for 15 days, followed by a 30-day drug-free period. Animals were subsequently divided into seven groups: control, VCD, alendronate, NRG and NRG-D (both at 10 and 25 mg/kg), administered for four weeks. Serum biochemical analyses were conducted to evaluate bone turnover markers, and micro-computed tomography (microCT) and histopathological assessments were performed on femur bones and lumbar vertebrae. The findings revealed that both NRG and NRG-D significantly attenuated osteoporotic changes, evidenced by a reduction in the bone resorption marker RANKL and an increase in the bone formation marker BALP. Additionally, treated animals exhibited improved bone microarchitecture and repaired trabecular bone structures. These results suggest that NRG and its derivative NRG-D exert beneficial bone regenerative effects and may offer a promising phytochemical-based therapeutic approach for the treatment of postmenopausal osteoporosis.Naringenin (NRG), a naturally occurring flavonoid, possesses potent antioxidant and anti-inflammatory properties and has shown potential benefits in managing osteoporosis. In this study, a derivative of NRG (NRG-D) was designed by modifying its structure at the 4th carbonyl position, guided by structure-activity relationship analysis. The binding affinity of NRG-D for bone marker proteins was initially assessed through &lt;i&gt;in-silico&lt;/i&gt; studies. The therapeutic effects of both NRG and NRG-D were then evaluated in a rat model of postmenopausal osteoporosis induced by vinyl cyclohexene diepoxide (VCD). Female Wistar rats received VCD (160 mg/kg) for 15 days to simulate postmenopausal conditions, followed by a 30-day drug-free period. Animals were subsequently divided into seven groups: control, VCD, alendronate, NRG (10 and 25 mg/kg), and NRG-D (10 and 25 mg/kg), with treatment administered for four weeks. Serum biochemical analyses were conducted to evaluate bone turnover markers, and micro-computed tomography (microCT) and histopathological assessments were performed on femur bones and lumbar vertebrae. The findings revealed that both NRG and NRG-D significantly attenuated osteoporotic changes, evidenced by a reduction in the bone resorption marker RANKL and an increase in the bone formation marker BALP. Additionally, treated animals exhibited improved bone microarchitecture and repaired trabecular bone structures. These results suggest that NRG and its derivative NRG-D exert beneficial bone regenerative effects and may","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiproliferative effects and mitochondrial dysfunction of α-mangostin extracted from the pericarp of the mangosteen fruit (<i>Garcinia mangostana</i> L.) on rat C6 glioma cells.","authors":"Huyen Thi Do, Anh Kim Nguyen, Nhung Huyen Nguyen, Anh Thi Mai Dao, Lien Thi Ha Nghiem, Tru Van Nguyen, Linh Khanh Nguyen, Phuong Khanh Pham, Duong Thi Thuy Le","doi":"10.1080/14786419.2025.2571853","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571853","url":null,"abstract":"<p><p>Glioblastoma is a brain tumour with limited therapeutic options, prompting the exploration of novel treatments. This study evaluates the effects of α-mangostin, a xanthone derived from the pericarp of mangostin (<i>Garcinia mangostana</i> L), on C6 glioma cells. α -mangostin was successfully purified with a purity of ≥ 97%, and its chemical structure was confirmed. This study evaluated the antioxidant and anticancer activities of α-mangostin isolated from <i>G. mangostana</i>. The compound showed moderate antioxidant capacity (DPPH• IC₅₀ = 67.55 ± 0.91 μg/mL) and potent cytotoxicity against C6 glioma cells (IC₅₀ = 4.67 μg/mL). Mitochondrial membrane potential dropped to 34.27 ± 1.24% and 25.77 ± 0.98% at 5 and 8 μg/mL, respectively. DNA fragmentation increased from 2.17 ± 1.543% (control) to 17.95 ± 6.277% at 5 μg/mL. These findings suggest that α-mangostin induces glioma cell death <i>via</i> mitochondrial dysfunction and genotoxic stress, supporting its potential as a therapeutic lead for glioblastoma.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-Oxo-triterpenoids of ursane, oleanane and dammarane types and their α-glucosidase inhibitory properties.","authors":"Liana Zakirova, Alexander Poptsov, Oxana Kazakova, Irina Smirnova, Yury Gatilov, Dmitriy Polovyanenko, Irina Bagryanskaya, Denis Babkov, Roman Danilov, Andrey Lukyanov","doi":"10.1080/14786419.2025.2565286","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565286","url":null,"abstract":"<p><p>New 2-oxo-triterpenoids of ursane, dammarane and oleanane types were synthesised from the corresponding 3-oxo-derivatives by Willgerodte-Kindler reaction with yields of 31-42%. It was shown that their C2-oximes are formed as the equimolar mixtures of <i>syn/anti</i>-isomers in contrast to literature data for C3-oximes giving a single <i>E</i>-isomer due to the steric factors. The structures of 2-oxo- and 3-oxo-28-oxo-allobetulones as well as allobetulone 2<i>E</i>-oxime were confirmed by X-ray diffraction analysis. A regioisomer of natural erythrodiol - olean-12(13)-ene-2β,28-diol <b>19</b> was firstly synthesised by the reduction of methyl 2-oxo-oleanoate. The tested triterpenoids were more potent in α-glucosidase (from <i>S. cerevisia</i>) inhibition than acarbose (from 5 to 20 times). Erythrodiol <b>20</b> showed IC₅₀ value of 8.35 μM, while it's regioisomer <b>19</b> was found as the most active and non-cytotoxic in terms of enzyme inhibition with an IC₅₀ value of 14.19 μM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scytonemin extracted from <i>Lyngbya aestuarii</i> exhibits anti-cancer activity: involvement of c-Myc pathway inhibition.","authors":"Animesh Sen, Arpan Dey Bhowmik, Sikha Mandal, Paritosh Mondal, Ansuman Chattopadhyay, Jnanendra Rath","doi":"10.1080/14786419.2025.2571860","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571860","url":null,"abstract":"<p><p>The increasing incidence of cancer-related morbidity and mortality underscores the urgent need for novel, less toxic therapeutic options. In this study, we isolated scytonemin from the marine cyanobacterium <i>Lyngbya aestuarii</i>. Its identification was confirmed through an absorption peak at 384 nm and MALDI-TOF MS analysis showing a [M + H]⁺ ion at m/z 545.838, consistent with its oxidised form (C₃₆H₂₀N₂O₄). Scytonemin demonstrated significant cytotoxicity against breast cancer cell lines MDA-MB-231 and MCF-7, with IC₅₀ values of 8 μM and 4 μM, respectively, while remaining non-toxic to human peripheral blood lymphocytes (HPBLs). The compound rapidly induced caspase-dependent intrinsic apoptosis within 2 h, with apoptotic effects magnifying at 24 and 48 h. Molecular docking and reporter gene assays revealed that scytonemin inhibits two critical proteins associated with cancer progression c-Myc and Polo-like kinase 1 (PLK1). These results suggest that scytonemin holds promise as a lead compound for the development of targeted anti-cancer therapies.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile profiling of forty-two white turmeric (<i>Curcuma zedoaria</i> Rosc.) accessions revealed its drug yielding potential with quality constituents.","authors":"Nikita Panda, Jyotirmayee Lenka, Suprava Sahoo, Basudeba Kar","doi":"10.1080/14786419.2025.2570897","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570897","url":null,"abstract":"<p><p>White turmeric (<i>Curcuma zedoaria</i>) of the family <i>Zingiberaceae</i> is a medicinal plant used in Ayurveda to treat various ailments. Despite having immense therapeutic properties, identification of elite accessions with high oil yield and quality constituents remains an issue. So, in this study forty-two accessions of <i>C. zedoaria</i> have been collected from Eastern India (Odisha and West Bengal) and their essential oil (EO) yield was studied. Their yield varied from 0.2% - 0.82% (v/w on fresh weight basis). Seventy-seven constituents were identified by gas chromatography and mass spectrometry (GC-MS) analysis with area percentage varying from 90.97-99.92%. The predominant constituents found in majority of accessions were Curzerenone followed by 1,8-cineole, curzerene, germacrene-B, germacrone, curdione, γ-eudesmol acetate in <i>C. zedoaria</i> essential oil. In this study, Cz42 was identified as the elite accession with high oil yield (0.82 ± 0.06%) and quality constituents that could be used commercially for cultivation and development of potential drug molecules.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new isoflavone glycoside from the stems of <i>Eclipta prostrata</i> (L.) L. with glycosidase inhibitory activity.","authors":"Yuan Gao, Ying-Xiao Xiao, Hao Xu, Xue-Feng Wu, Yi-Lin Li, Hyun-Sun Lee, Long Cui","doi":"10.1080/14786419.2025.2572536","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572536","url":null,"abstract":"<p><p>A new isoflavone glycoside, prostratanoside A (<b>1</b>), along with four known compounds (<b>2-5</b>), was isolated from the stems of <i>Eclipta prostrata</i> (L.) L. Their structures were elucidated through comprehensive spectroscopic (NMR and MS) and physicochemical analyses. All isolated compounds were evaluated for their <i>in vitro</i> α-glucosidase inhibitory activity. Notably, compound <b>1</b> displayed the most potent inhibition, with an IC₅₀ value of 10.3 ± 1.2 μM. Besides, the potential binding sites of <b>1</b> were predicted by molecular docking.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel arneomas A-B and other naphthoquinone active components in <i>Arnebia euchroma</i> I. M. Johnst.","authors":"Li-Li Han, Yibanuer Reheman, Reyilanmu Maisaidi, Cong-Zhao Fan, Lei-Ling Shi, Sheng-Jie Jia","doi":"10.1080/14786419.2025.2568209","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568209","url":null,"abstract":"<p><p><i>Arnebia euchroma</i> I. M. Johnst., a famous traditional medicine in China, is widely used in TCM clinic. As the purpose to dig bioactive constituents, silica gel, preparative High-Performance Liquid Chromatography and other manners were used to analyse its components. As a result, two new compounds arneomas A-B (<b>1-2</b>), and four known ones deoxyalkannin (<b>3</b>), shikonin (<b>4</b>), arnebifuranone (<b>5</b>), heliotropin one A (<b>6</b>) were obtained. Their structures were determined by spectral data and physical and chemical properties. The CCK-8 method was used to assess the cytotoxicity of the compounds towards the human cervical cancer cell line (Hela cells). Compounds <b>2</b> and <b>4</b> show apparent antitumor activity with median inhibition concentration IC₅₀ of 6.07, 8.37 μM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High resolution-mass spectrometry (hR-MS) profiling of <i>Apamarga Ksharodaka</i> (herbal alkaline water from <i>Achyranthes aspera</i> Linn.) and computational screening of bioactive phytochemicals for wound healing applications.","authors":"Ayush Kumar Garg, Preeti Chouhan, Binay Sen","doi":"10.1080/14786419.2025.2568949","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568949","url":null,"abstract":"<p><p><i>Apamarga Ksharodaka,</i> an ayurvedic formulation made from the herb <i>Achyranthes aspera</i> Linn, is renowned for its wound healing properties. This study aimed to evaluate its wound-healing activity through in-vitro and in-silico methods. High-Resolution Mass Spectrometry (HR-MS) was used to analyse the phytochemical composition, identifying 25 compounds. These were screened for wound-healing potential using literature and bioinformatics databases. Molecular docking studies were conducted on six wound-progressing receptors (Interleukin-1 Receptor, Peroxisome Proliferator-Activated Receptor Gamma, Tumour Necrosis Factor, Proteinase-Activated Receptor 1, Angiotensin II Type 1 Receptor, and Endothelin Receptors) using CB-Dock software, visualising interactions in Chimaera and Biovia Discovery Studio. Among the identified compounds, Homovanillic acid and Biochanin A demonstrated significant binding affinities to these targets, with Biochanin A showing the highest affinity (-8.3 to -9 kcal/mol). These findings confirm the efficacy of <i>Apamarga Ksharodaka</i> in wound management, highlighting Homovanillic acid and Biochanin A as key bioactive components.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel aliphatic glycoside and a new lignan glycoside from <i>Siraitia grosvenorii</i> and their hepatoprotective activities.","authors":"Jia-Nan Mao, Hua-Xue Huang, Guang-Yu Chen, Juan-Jiang Wu, Qing-Ling Xie, Shi-Qi Liu, Shuang Zhan, Zhi Peng, Xu-Dong Zhou, Wei Wang","doi":"10.1080/14786419.2025.2566911","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566911","url":null,"abstract":"<p><p>Five glycosides (<b>1</b>-<b>5</b>) containing one novel aliphatic glycoside Luohanguonoside G (<b>1</b>), one new lignan glycoside Luohanguonoside H (<b>2</b>) and three known ones (<b>3</b>-<b>5</b>) were isolated from the fresh fruit extract of <i>Siraitia grosvenorii</i> (<i>S. grosvenorii</i>). Structurally, according to various spectroscopic techniques analysis, the new compounds <b>1</b> and <b>2</b> were elucidated as a rare seven-carbon heptane glucose glycoside and a lignan glycoside, respectively. Among <b>1</b>-<b>5</b>, the lignan glycosides <b>3</b> and <b>4</b> have been reported in other plants but separated from <i>S. grosvenorii</i> for the first time. Additionally, a cytotoxicity and a hepatoprotective activity experiment were performed on compounds <b>1</b>-<b>5</b> to evaluate their preventing ability for liver disease. The results indicate that compound <b>5</b> exhibited significant hepatoprotective activities in comparison with bicyclol and compound <b>1</b>-<b>4</b> exhibited moderate activity for liver protection compared to model control group. This research firstly assessed the hepatic protection competence of the isolates from <i>S. grosvenorii in vitro</i>, providing evidence for the further investigation on the preventing potential of liver diseases of this plant.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}