从海洋真菌曲霉sp. ZJUT223中提取的一种新的甾体化合物——灵芝酸。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-16 DOI:10.1080/14786419.2025.2573887

Youmin Ying, Xiaoxiao Chen, Shijie Zhan, Si Yang, Jinli Liu, Weiguang Shan, Yuhao Lin, Rong Wang

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引用次数: 0

摘要

从海洋真菌曲霉（Aspergillus sp. ZJUT223）中分离到一个新的甾类灵芝酸(1)和17个已知化合物2 ~ 18。广泛的光谱数据（1D/2D NMR和HR-ESI-MS）确定了1的平面结构。通过NOESY、密度泛函理论(DFT)- DP4+分析计算核磁共振（NMR）和计算电圆二色性（ECD）确定其立体化学性质。在群体感应（quorum sensing， QS）抑制实验中，曲霉醇I（17）剂量依赖性地抑制了violaceum CV026中紫罗兰素的产生，表明它干扰了该报告菌株的群体感应信号。这是首次报道曲霉醇I（17）作为潜在的群体感应抑制剂。

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Ganodermanic acid, a new steroidal compound derived from the marine fungus Aspergillus sp. ZJUT223.

A new steroid ganodermanic acid (1) and seventeen known compounds 2-18 were isolated from the marine fungus Aspergillus sp. ZJUT223. Extensive spectroscopic data (1D/2D NMR and HR-ESI-MS) established the planar structure of 1. Its stereochemistry was assigned using NOESY, density functional theory (DFT)-calculated NMR with DP4+ analysis, and calculated electrical circular dichroism (ECD). In the quorum sensing (QS) inhibition assay, aspergilol I (17) dose-dependently inhibited violacein production in Chromobacterium violaceum CV026, suggesting that it interfered with quorum sensing signalling in this reporter strain. This is the first report of aspergilol I (17) as a potential quorum sensing inhibitor.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.