Natural Product Research最新文献_第2页

Sesquiterpenoids from the Homalomena occulta (Lour.) Schott and their anti-osteoclast genesis activity. 半萜类化合物（来自Homalomena occulta）和它们的抗破骨细胞生成活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-11 DOI: 10.1080/14786419.2025.2512565

Bin Zhao, Yi Wu, Cheng Jiang, Tao Tang, Sicong Jiang, Yuping Jiang

引用次数: 0

Abietane diterpenoids and taraxerane-type triterpenes from Teucrium viscidum. 粘心铕中abie烷二萜和taraxer烷型三萜。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-10 DOI: 10.1080/14786419.2025.2514733

Tong Xue, Chun Gao, Hao Chen, Muhi Eldeen Hussien Ibrahim, Hongzheng Fu, Jianbin Wang

引用次数: 0

Extraction, purification, structural characterisation, and anti-glycolipid metabolism disorder activities of Alpinia officinarum Hance polysaccharide. 高寒多糖的提取、纯化、结构表征及抗糖脂代谢紊乱活性研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-10 DOI: 10.1080/14786419.2025.2509884

Wenzhao Wang, Qiuyun Li, Xinyu Chen, Jiayue Liang, Yiyang He, Yaowen Xing, Xubin Quan, Ningxin Yu, Peng Guo, Yanli Wu

{"title":"Extraction, purification, structural characterisation, and anti-glycolipid metabolism disorder activities of Alpinia officinarum Hance polysaccharide.","authors":"Wenzhao Wang, Qiuyun Li, Xinyu Chen, Jiayue Liang, Yiyang He, Yaowen Xing, Xubin Quan, Ningxin Yu, Peng Guo, Yanli Wu","doi":"10.1080/14786419.2025.2509884","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509884","url":null,"abstract":"Alpinia officinarum Hance is a traditional medicinal and edible plant, but research on its polysaccharides has been limited. In this study, a purified polysaccharide, named AOP-1-1, was successfully extracted. Its structure was meticulously analysed through techniques, such as NMR and HPLC. AOP-1-1 was determined to be an acidic heteropolysaccharide with high purity and uniformity. To further explore its potential medicinal value, its activity against glycolipid metabolism disorders was investigated. The results showed that AOP-1-1 could inhibit key enzymes involved in glucose metabolism and improve the abnormal levels of total cholesterol (TC) and triglycerides (TG) in oleic acid-induced HepG2 cells. Additionally, it demonstrated significant antioxidant activity. These findings provide a theoretical foundation for the further development and utilisation of A. officinarum Hance, opening up new possibilities for its application in the fields of medicine and health.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new cytotoxic stilbene from Paphiopedilum hirsutissimum (Lindl. ex Hook.) Stein. 一种新的细胞毒性二苯乙烯。例钩)。斯坦。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-09 DOI: 10.1080/14786419.2025.2514732

Nonthalert Lertnitikul, Cherdsak Boonyong, Rutt Suttisri

引用次数: 0

Secondary metabolites from Pometia pinnata leaves. 石榴树叶次生代谢物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-07 DOI: 10.1080/14786419.2025.2514736

Isti Istiqamah, Herliana Herliana, Agil Fadilah, Aih Diniresna, Rizki Fitriani, Muhamad Insanu, Elvira Hermawati, Nizar Happyana

引用次数: 0

Oleuropein protects against 5-fluorouracil-induced nephro-hepatotoxicity in animal model by focusing on preserving anti-oxidant defense, anti-inflammatory, and anti-apoptotic effects. 橄榄苦苷通过保持抗氧化防御、抗炎和抗凋亡的作用，对5-氟尿嘧啶引起的动物肾肝毒性具有保护作用。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-07 DOI: 10.1080/14786419.2025.2512576

Shokofeh Banaei, Vahid Asghariazar, Faraz Mahdizadeh, Mir-Mehdi Chinifroush-Asl, Elham Safarzadeh

{"title":"Oleuropein protects against 5-fluorouracil-induced nephro-hepatotoxicity in animal model by focusing on preserving anti-oxidant defense, anti-inflammatory, and anti-apoptotic effects.","authors":"Shokofeh Banaei, Vahid Asghariazar, Faraz Mahdizadeh, Mir-Mehdi Chinifroush-Asl, Elham Safarzadeh","doi":"10.1080/14786419.2025.2512576","DOIUrl":"https://doi.org/10.1080/14786419.2025.2512576","url":null,"abstract":"The renal and liver dysfunction is considered to be a life-threatening side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the impact of oleuropein (OLE) against 5-FU-induced renal and liver toxicity. Twenty-four adult Sprague-Dawley rats were randomly divided into four groups (N = 6) including the control, 5-FU (100 mg/kg), OLE (200 mg/kg), and 5-FU + OLE. After treatment, blood and tissue samples were collected to assess the biochemical, inflammatory, oxidative stress, cell death associated parameters, and histological changes. 5-FU significantly increased biochemical parameters, TNF-α, and IL-6 concentration and were significantly related to histopathological complications. While the administration of oleuropein significantly decreased BUN-Cr, liver enzyme levels and inflammatory responses and improved pathological injuries. In addition, oleuropein ameliorated significantly the kidney and liver stress oxidative and apoptotic parameters. Conclusively, oleuropein exerted hepato-nephroprotective effects against 5-FU toxicity through its anti-oxidant, anti-apoptotic, and anti-inflammatory effects.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosmarinic acid attenuates photophobia, hyperalgesia and neuroinflammation during nitroglycerine induced migraine like headache in mice. 迷迭香酸减轻硝酸甘油诱导的小鼠偏头痛样头痛时的畏光、痛觉过敏和神经炎症。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-07 DOI: 10.1080/14786419.2025.2515274

Maira Anwar, Ismail Badshah, Babar Murtaza, Syed Muzzammil Masaud, Umair Ilyas, Amber Kiyani, Danish Patoli, Muhammad Tariq Khan

{"title":"Rosmarinic acid attenuates photophobia, hyperalgesia and neuroinflammation during nitroglycerine induced migraine like headache in mice.","authors":"Maira Anwar, Ismail Badshah, Babar Murtaza, Syed Muzzammil Masaud, Umair Ilyas, Amber Kiyani, Danish Patoli, Muhammad Tariq Khan","doi":"10.1080/14786419.2025.2515274","DOIUrl":"https://doi.org/10.1080/14786419.2025.2515274","url":null,"abstract":"Rosmarinic acid (RA) is a polyphenolic compound with considerable anti-inflammatory and neuroprotective activities. Migraine is characterised by neuroinflammation, oxidative stress, and pain hypersensitivity. This study evaluated effects of RA in a nitroglycerine (NG) induced model of migraine like headache with sumatriptan as a standard drug. Mice were divided into five groups namely: control, NG-treated, NG + RA (20 mg/kg), NG + RA (40 mg/kg), and NG + sumatriptan. It was observed that NG administration led to reduced pain thresholds, increased head-scratching, photosensitivity, elevated nitrite levels, oxidative stress, and upregulated neuroinflammatory markers (IL-6, TNF-α, COX-2, CGRP). RA, particularly at 40 mg/kg, significantly reversed these effects by enhancing antioxidant enzyme activity, reducing inflammation, and improving neuronal integrity. Histopathological analysis revealed reduced satellitosis and preserved cortical and trigeminal nucleus caudalis structures. These findings highlight RA's neuroprotective, anti-inflammatory, and antioxidant properties, suggesting its potential as a therapeutic agent for migraine.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) by compounds from fernandoa adenophylla (wall. ex G.Don) Steenis. 茶树提取物对外核苷酸焦磷酸酶/磷酸二酯酶1 （ENPP1）的抑制作用。don) Steenis。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-06 DOI: 10.1080/14786419.2025.2514730

Abdur Rauf, Rahaf Ajaj, Zafar Ali Shah, Giovanni Ribaudo

引用次数: 0

Unlocking nature's secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies. 解开大自然的秘密：植物性药物和草药的药代动力学综述。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-06 DOI: 10.1080/14786419.2025.2513583

Sudharsan Parthasarathy, Shaza H Aly, Siva Vijayakumar Tharumasivam, Bupesh Giridharan, Janani Chandran, Purushothaman Thirumurthy, Mohamed S Abd El Hafeez, Mohamed El-Shazly

{"title":"Unlocking nature's secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies.","authors":"Sudharsan Parthasarathy, Shaza H Aly, Siva Vijayakumar Tharumasivam, Bupesh Giridharan, Janani Chandran, Purushothaman Thirumurthy, Mohamed S Abd El Hafeez, Mohamed El-Shazly","doi":"10.1080/14786419.2025.2513583","DOIUrl":"https://doi.org/10.1080/14786419.2025.2513583","url":null,"abstract":"Herbal and plant-based medicines have been used for centuries for their therapeutic properties. However, understanding their pharmacokinetics is essential for optimising their efficacy, ensuring their safety and guiding appropriate dosing regimens. Herbal and plant-based medications can be ingested, inhaled, applied topically or injected. Factors such as solubility, formulation and interactions with gut enzymes and transporters influence their absorption characteristics. Distribution of these compounds involves their movement throughout the body, influenced by factors like blood flow, tissue permeability and plasma protein binding. Herbal and plant-based medications are metabolised in the liver by cytochrome P450 enzymes and conjugation routes. Metabolism can vary by genetics and gut microbiome. These compounds can be excreted by the kidneys, liver, faeces, lungs, sweat and saliva. This review aims to decode the pharmacokinetics of herbal and plant-based medicines by providing a comprehensive overview of their absorption, distribution, metabolism and elimination processes.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-25"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new ursane-type triterpene and potent antibacterial alkylbenzoquinones from the aerial parts of M aesa balansae. 一种新的熊烷型三萜和有效抗菌的烷基苯醌。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-06-05 DOI: 10.1080/14786419.2025.2512574

Hieu Nguyen-Ngoc, Bui Thi Thu Trang, Cuong Quoc Nguyen, Quang De Tran, Dang Ngoc Quang, Vu Dinh Hoang, Nguyen Huu Tung, Ngoc Binh Vo, Duc Trong Nghiem, Minh Thi Tran, Hun Kim, Nguyen Van Minh, Gyung Ja Choi, Quang Le Dang

{"title":"A new ursane-type triterpene and potent antibacterial alkylbenzoquinones from the aerial parts of M aesa balansae.","authors":"Hieu Nguyen-Ngoc, Bui Thi Thu Trang, Cuong Quoc Nguyen, Quang De Tran, Dang Ngoc Quang, Vu Dinh Hoang, Nguyen Huu Tung, Ngoc Binh Vo, Duc Trong Nghiem, Minh Thi Tran, Hun Kim, Nguyen Van Minh, Gyung Ja Choi, Quang Le Dang","doi":"10.1080/14786419.2025.2512574","DOIUrl":"https://doi.org/10.1080/14786419.2025.2512574","url":null,"abstract":"A new ursane-type triterpene (1) alongside two known alkylbenzoquinones, dihydromaesanin (2) and embeliquinone (3), were isolated from the aerial parts of Maesa balansae. The structure of 1 was elucidated based on 1D-, 2D-NMR, and HRESI-MS data. The two alkylbenzoquinones were tested on 13 phytopathogenic bacterial strains. Compound 2 displayed exceptional antibacterial activity against Acidovorax avenae subsp. cattleyae, Xanthomonas arboricola pv. pruni, X. campestris pv. campestris, and Ralstonia solanacearum with MIC values in a range of 1.6-100 µg/mL. Additionally, compound 3 exhibited antibacterial activity against A. avenae subsp. cattleyae with a MIC value of 50 µg/mL. Notably, the antibacterial activities of compounds 2 and 3 against various phytopathogenic bacteria were evaluated for the first time. Furthermore, the antibacterial mechanisms of compounds 2 and 3 against tested phytobacteria were elucidated via molecular docking studies, demonstrating strong binding with the active site of RpfF and DNA gyrase B (binding energies below -5.6 kcal/mol).","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0