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A review on pharmacological activities and phytochemical constituents of Zanthoxylum armatum DC. Zanthoxylum armatum DC 的药理活性和植物化学成分综述。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-03 DOI: 10.1080/14786419.2024.2409984
Syed Sadaqat Shah, Sajjad Ahmed, Bangwei Zhou, Lianxuan Shi
{"title":"A review on pharmacological activities and phytochemical constituents of <i>Zanthoxylum armatum</i> DC.","authors":"Syed Sadaqat Shah, Sajjad Ahmed, Bangwei Zhou, Lianxuan Shi","doi":"10.1080/14786419.2024.2409984","DOIUrl":"https://doi.org/10.1080/14786419.2024.2409984","url":null,"abstract":"<p><p><i>Zanthoxylum armatum,</i> a versatile plant known for its extensive pharmacological and phytochemical properties, has been traditionally utilised in various cultures for medicinal purposes. It is a widely recognised medicinal plant of the Rutaceae family, indigenous to Korea, China, Japan, and Pakistan, and thrives particularly in subtropical and temperate regions globally. Various parts of the plant hold medicinal significance: the seeds serve as a spice, condiment, and tonic; the wood finds application in dental care, crafting walking sticks, and timber; the fruit is utilised for oil extraction, water purification, and as an odontalgic, stomachic, and stimulant; the bark is valued as a tonic; while branches and thorns are utilised for their stimulant, stomachic, and odontalgic properties. The plant contains various bioactive compounds, including lignans, alkaloids, sterols, coumarins, phenolics, terpenoids, flavonoids, benzenoids, glycosides, alkenic acids, amino acids, fatty acids, armamide, L-sesamin, L-asarin, L-planinin, limonene, methyl cinnamate, linalool, linayl acetate, geraniol methyl cinnamate, citral, linalool and sabines. This review aims to comprehensively cover the pharmacological and phytochemical properties of <i>Z. armatum</i>, serving as a foundation for future research and potential applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenolic compounds from the aerial parts of Rhodiola rosea in Japan, and their antioxidant activity and chemical adaptation to alpine environment. 日本红景天气生部分的酚类化合物及其抗氧化活性和对高寒环境的化学适应性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-03 DOI: 10.1080/14786419.2024.2408662
Tsukasa Iwashina, Takahisa Nakane, Yuko Ishikawa-Takano, Hari Prasad Devkota
{"title":"Phenolic compounds from the aerial parts of <i>Rhodiola rosea</i> in Japan, and their antioxidant activity and chemical adaptation to alpine environment.","authors":"Tsukasa Iwashina, Takahisa Nakane, Yuko Ishikawa-Takano, Hari Prasad Devkota","doi":"10.1080/14786419.2024.2408662","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408662","url":null,"abstract":"<p><p>Twelve flavonoids (<b>1</b>-<b>12</b>) including a new flavonol glycoside, hibiscetin 3-<i>O</i>-glucopyranoside-8-<i>O</i>-glucuronopyranoside, ten known galloylglucoses (<b>13</b>-<b>22</b>) and three known phenolic acids (<b>23</b>-<b>25</b>) were isolated from the aerial parts of <i>Rhodiola rosea</i> growing in Japan. Their chemical structures were elucidated by UV-vis spectra, LC-MS, HR-MS, acid hydrolysis, NMR, and/or HPLC, and TLC comparisons with authentic samples. Antioxidant activity of major 14 compounds was measured by H-ORAC method, and two flavonols, herbacetin 3-<i>O</i>-glucoside-8-<i>O</i>-glucuronide, and gossypetin 3-<i>O</i>-glucuronide-8-<i>O</i>-glucoside, showed the strongest activity. Moreover, chemical adaptation to severe alpine environment of <i>R. rosea</i> was discussed.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosmarinus officinalis and Zataria multiflora extracts enhanced antibacterial activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus. 迷迭香和万年青提取物增强了环丙沙星对耐甲氧西林金黄色葡萄球菌的抗菌活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2409982
Zahra Samadi, Seyed Sadeq Mousavi Ghahfarrokhi, Hossein Jafari, Sepideh Nikrou, Mahdi Vazirian, Nasrin Samadi
{"title":"<i>Rosmarinus officinalis</i> and <i>Zataria multiflora</i> extracts enhanced antibacterial activity of ciprofloxacin against methicillin-resistant <i>Staphylococcus aureus</i>.","authors":"Zahra Samadi, Seyed Sadeq Mousavi Ghahfarrokhi, Hossein Jafari, Sepideh Nikrou, Mahdi Vazirian, Nasrin Samadi","doi":"10.1080/14786419.2024.2409982","DOIUrl":"https://doi.org/10.1080/14786419.2024.2409982","url":null,"abstract":"<p><p>The study investigates the antibacterial potential of hydroalcoholic extracts from <i>Rosmarinus officinalis</i> and <i>Zataria multiflora</i>, combined with ciprofloxacin, against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Initial screening showed promising results, leading to further exploration of the synergistic effect of the extracts and ciprofloxacin. The combination of the two extracts had an additive effect, while the combination of each extract with ciprofloxacin resulted in partial synergism. The most significant synergistic effect was observed against MRSA 9, with a 3200-fold reduction in the MIC value of ciprofloxacin. The similar inhibitory concentration of the extracts for all MRSA strains suggests these non-antibiotic agents have a broad spectrum of activity against MRSA. This offers a promising avenue for developing new therapeutic approaches to tackle drug-resistant bacterial infections. The results highlight the potential of combining <i>R. officinalis</i> and <i>Z. multiflora</i> extracts with ciprofloxacin to enhance antibacterial efficacy against MRSA strains.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scutellaria baicalensis baicalein as a novel therapeutic agent to treat SARS-CoV-2 infections. 黄芩黄芩素作为治疗 SARS-CoV-2 感染的新型治疗剂。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2407512
Vinothini Gunasekaran, Palanivel Sathishkumar
{"title":"<i>Scutellaria baicalensis</i> baicalein as a novel therapeutic agent to treat SARS-CoV-2 infections.","authors":"Vinothini Gunasekaran, Palanivel Sathishkumar","doi":"10.1080/14786419.2024.2407512","DOIUrl":"https://doi.org/10.1080/14786419.2024.2407512","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antifungal talaroenamine L with unusual leptosphaeronyl moiety from marine-derived Talaromyces sp. HDN17-428 via HDACi elicitation. 通过 HDACi 诱导，从海洋来源的塔拉酵母菌 HDN17-428 中提取出具有不寻常钩端基的新型抗真菌塔拉烯胺 L。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2407503
Komal Anjum, Luning Zhou, Khizar Hayyat, Xiaofei Huang, Jiaxiang Wang, Guojian Zhang, Tianjiao Zhu, Qian Che, Dehai Li
{"title":"Novel antifungal talaroenamine L with unusual leptosphaeronyl moiety from marine-derived <i>Talaromyces</i> sp. HDN17-428 via HDACi elicitation.","authors":"Komal Anjum, Luning Zhou, Khizar Hayyat, Xiaofei Huang, Jiaxiang Wang, Guojian Zhang, Tianjiao Zhu, Qian Che, Dehai Li","doi":"10.1080/14786419.2024.2407503","DOIUrl":"https://doi.org/10.1080/14786419.2024.2407503","url":null,"abstract":"<p><p>Vorinostat elicitation of the deep-sea fungus <i>Talaromyces</i> sp. HDN17-428 resulted in the isolation of one new compound, talaroenamine L (<b>1</b>) with unusual leptosphaeronyl moiety and three known compounds (<b>2</b>-<b>4</b>). Structures of <b>1</b>-<b>4</b> were confirmed by extensive NMR, HRESIMS and OR calculations. Antimicrobial activities of all compounds were tested in which compounds <b>1</b>-<b>4</b> showed substantial antifungal activities with MIC values ranged from 3.1 to 12.5 <i>μ</i>M.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of emodin in oral cancer therapy: from traditional medicine to modern nanotechnology. 大黄素在口腔癌治疗中的作用：从传统医学到现代纳米技术。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2408410
Chinnasamy Ragavendran
{"title":"The role of emodin in oral cancer therapy: from traditional medicine to modern nanotechnology.","authors":"Chinnasamy Ragavendran","doi":"10.1080/14786419.2024.2408410","DOIUrl":"https://doi.org/10.1080/14786419.2024.2408410","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combating dental biofilms using plant-derived flavonoids: a simple and potential therapeutic approach. 利用植物黄酮类化合物对抗牙科生物膜：一种简单而有潜力的治疗方法。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2406991
Lekha Sree Venkatesan, Vinothini Gunasekaran, Palanivel Sathishkumar
{"title":"Combating dental biofilms using plant-derived flavonoids: a simple and potential therapeutic approach.","authors":"Lekha Sree Venkatesan, Vinothini Gunasekaran, Palanivel Sathishkumar","doi":"10.1080/14786419.2024.2406991","DOIUrl":"https://doi.org/10.1080/14786419.2024.2406991","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant, antibacterial and antibiofilm activities of Pittosporum napaulense (DC.) against drug-resistant Staphylococcus aureus and Shigella sp. 海桐（DC.）对耐药金黄色葡萄球菌和志贺氏杆菌的抗氧化、抗菌和抗生物膜活性
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2410422
Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y R, Rabinarayan Acharya, Pradeep Kumar Naik
{"title":"Antioxidant, antibacterial and antibiofilm activities of <i>Pittosporum napaulense</i> (DC.) against drug-resistant <i>Staphylococcus aureus</i> and <i>Shigella</i> sp.","authors":"Sajna Sameekshya Hota, Dibya Ranjan Sahoo, Subhaswaraj Pattnaik, Monika Mishra, Tapasa Mishra, Tanuja Sahu, Baishali Basundhara Naik, Malayamarutham Kalyankumarraju, Amit Kumar Dixit, Deepak Lamba, Sanjaya Kumar Y R, Rabinarayan Acharya, Pradeep Kumar Naik","doi":"10.1080/14786419.2024.2410422","DOIUrl":"https://doi.org/10.1080/14786419.2024.2410422","url":null,"abstract":"<p><p>Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, <i>Pittosporum napaulense</i> (DC.) Rehder & E. H. Wilson is an important medicinal plant with widespread pharmacological importance. The antioxidant potential, antibacterial and antibiofilm activities of <i>P. napaulense</i> (DC.) were evaluated. The ethanolic extract showed the highest share of phenolic and flavonoid contents responsible for DPPH and ABTS radical scavenging activity with an IC50 of 5.58 and 5.28 µg/ml, respectively. In addition, the extracts also showed antibacterial and antibiofilm properties against multidrug-resistant bacterial strains, <i>Staphylococcus aureus</i> and <i>Shigella</i> sp. The biological activities of <i>P. napaulense</i> (DC.) bark could be attributed to the presence of phytoconstituents such as Malabaricone C, Borapetoside B, Kanzonol R. as evident from UPLC-Q-TOF-MS analysis. Based on the bioactivities; this plant could be explored for the development of potential therapeutic drug candidates against severe bacterial diseases.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro anti-inflammatory, anticancer effects and phytochemical characterisation of organic extracts from Aristolochia olivieri Colleg. ex Boiss. 体外抗炎、抗癌作用以及马兜铃科植物橄榄的有机提取物的植物化学特征。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2407504
Fuad O Abdullah
{"title":"In vitro anti-inflammatory, anticancer effects and phytochemical characterisation of organic extracts from <i>Aristolochia olivieri</i> Colleg. ex Boiss.","authors":"Fuad O Abdullah","doi":"10.1080/14786419.2024.2407504","DOIUrl":"https://doi.org/10.1080/14786419.2024.2407504","url":null,"abstract":"<p><p>Natural extract plays a crucial role in our lives, major compound in the n-hexane (AR-H) and the ethyl acetate (AR-E) <i>Aristolochia olivieri</i> extracts was n-hexadecanoic acid, and of the methanol extract (AR-M) was pentacosane. The AR-M extract had a strong ability to induce mRNA expression of an inflammatory cytokine, IL-6, as an M1-like macrophage subset compared to the negative control (DMSO-treated cells). In contrast, AR-E treatment showed strong anti-inflammatory activity against macrophages. The AR-H extract had a moderate inflammatory effect against macrophages. The IC50 results of the anticancer assays ranged from 58.29 to 451.03 μg/mL for the three extracts. The anticancer action of the AR-E extract against U-87MG cells was higher (58.29 μg/mL) than that of AR-H and AR-M (156.38 and 196.14 μg/mL, respectively). The greater cytotoxicity effect observed with the AR-E extract against U-87MG can be linked to its high content of hexadecanoic acid (32.49%) and linolenic acid (12.90%).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraction of camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata fruits by natural deep eutectic solvent. 用天然深共晶溶剂萃取喜树果实中的喜树碱和 10-羟基喜树碱。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-10-01 DOI: 10.1080/14786419.2024.2411363
Beibei Fang, Qing Liu, Chengli Yang, Kaixuan Liu, Guanya He, Xuchun Zhai, Kaishun Hu, Zulekha, Dali Li
{"title":"Extraction of camptothecin and 10-hydroxycamptothecin from <i>Camptotheca acuminata</i> fruits by natural deep eutectic solvent.","authors":"Beibei Fang, Qing Liu, Chengli Yang, Kaixuan Liu, Guanya He, Xuchun Zhai, Kaishun Hu, Zulekha, Dali Li","doi":"10.1080/14786419.2024.2411363","DOIUrl":"https://doi.org/10.1080/14786419.2024.2411363","url":null,"abstract":"<p><p>A natural deep eutectic solvent-based ultrasound-assisted simultaneous extraction (NADES-UAE) of camptothecin (CPT) and 10-hydroxycamptothecin (10-HCPT) was established. The 1.31 mg of CPT and 1.66 mg of 10-HCPT were obtained from each gram of the fruit powder of <i>Camptotheca acuminata</i> under the optimum conditions with a water content of 20%, a liquid-solid ratio of 12 mL/g and an ultrasound time of 20 min. The recovery efficiencies of CPT and 10-HCPT after AB-8 resin enrichment were 70.5% and 74.8%, respectively. The stronger interaction between NADES3 which was screened from 12 kinds of NADES and target components compared with methanol or water was demonstrated using molecular dynamics simulation. Moreover, the recovered NADES3 could be reused at least 4 times. The present research provided an efficient, environment-friendly, and sustainable method for extracting and recovering CPT and 10-HCPT from the fruits of <i>C. acuminata</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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