Natural Product Research最新文献_第2页

Chrydintins A and B, two new sesquiterpenoids from Chrysanthemum indicum with cardioprotective activities.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-23 DOI: 10.1080/14786419.2024.2444570

Guanghui Zhang, Chunxiang Zhou, Donglin Wang, Junxia Liu, Xinyong Zhao

引用次数: 0

Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2440537

Beibei Geng, Man Zhao, Jun Wang, Tian Zhong, Chaoyan Kang, Zizhen Wang, Xin Ma, Ting Xia

{"title":"Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.","authors":"Beibei Geng, Man Zhao, Jun Wang, Tian Zhong, Chaoyan Kang, Zizhen Wang, Xin Ma, Ting Xia","doi":"10.1080/14786419.2024.2440537","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440537","url":null,"abstract":"T-cell acute lymphoblastic leukaemia (T-ALL) is a common childhood malignant tumour, which has poor prognosis and high recurrence rate. Ginsenoside Rh2 (GRh2), a bioactive ingredient of Panax ginseng has significant anti-tumour effect. In this study, we found that gene expressions of Jurkat cells were significantly changed in the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signalling pathways after 35 µm GRh2 treatment, involving in JUN, PIEN, AKT3 and MAPK8IP2. Target proteins including PI3K, AKT, ASK, caspase 8 and caspase 9 were bind tightly with GRh2 by molecular docking. Moreover, the protein expression ratios of p-PI3K/PI3K and p-AKT/AKT were significantly reduced, and the expression ratios of p-ASK1/ASK1, p-JNK/JNK and p-c-JUN/c-JUN, Bax/Bcl-2, and the levels of cleaved caspase 8, 9, 3 were increased significantly in GRh2-treated Jurkat cells. The results imply that GRh2 induced T-ALL apoptosis by activating the MAPK pathway and inhibiting the PI3K-AKT pathway.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2438269

Lakmal Gonawala, Maheehsa Madhumaali, Hanouf Ismail, Nishara Jayasooriya, Nalaka Wijekoon, Shanuk Rajapakshe, Harshanie Erangika, Dhammika Amaratunga, Rajitha Gunaratna, Harry W M Steinbusch, Chandra Mohan, Yu-Chung Chiang, Priyani Paranagama, K Ranil D de Silva

{"title":"Phytochemistry and nutraceutical potential of Ceylon Cinnamomum species native to Sri Lanka.","authors":"Lakmal Gonawala, Maheehsa Madhumaali, Hanouf Ismail, Nishara Jayasooriya, Nalaka Wijekoon, Shanuk Rajapakshe, Harshanie Erangika, Dhammika Amaratunga, Rajitha Gunaratna, Harry W M Steinbusch, Chandra Mohan, Yu-Chung Chiang, Priyani Paranagama, K Ranil D de Silva","doi":"10.1080/14786419.2024.2438269","DOIUrl":"https://doi.org/10.1080/14786419.2024.2438269","url":null,"abstract":"Cinnamon is a spice that is renowned for its several medicinal and cosmetic benefits. The research study examined the essential oil content, antioxidant, and anti-inflammatory properties of seven Cinnamomum species native to Sri Lanka. Cinnamon bark and leaf samples were used to extract essential oils, methanol, and hexane. Essential oil extracts underwent GC-MS analysis, while all extracts were subjected to antioxidant and anti-inflammatory assays. The bark of Sri Vijaya and C. rivulorum, along with the leaves of Sri Vijaya and C. sinharajaense, exhibited remarkable antioxidant properties. The cinnamaldehyde percentage of Sri Gemunu was the highest at 61.63%, while the bark of C. sinharajaense contained 59.19%. The leaves of Sri Gemunu had the highest eugenol content, determining at 91.45%. C. zeylanicum and its strains have been found to exhibit the highest antioxidant and anti-inflammatory properties. C. sinharajaense and C. rivulorum are two wild cinnamon species that show potential for potential medicinal uses. Thus, these species have great potential for further research on their biological properties and their possible applications in various fields, such as pharmaceuticals.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical profile and biological screening of two Amaranthaceae plants: Atriplex halimus and Haloxylon scoparium.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-22 DOI: 10.1080/14786419.2024.2443489

Amani Amamra, Yassine Reggami, Ihcene Bouasla, Houneida Benbouzid, Imene Becheker, Hajira Berredjem

{"title":"Phytochemical profile and biological screening of two Amaranthaceae plants: Atriplex halimus and Haloxylon scoparium.","authors":"Amani Amamra, Yassine Reggami, Ihcene Bouasla, Houneida Benbouzid, Imene Becheker, Hajira Berredjem","doi":"10.1080/14786419.2024.2443489","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443489","url":null,"abstract":"In this study, phytochemical and biological properties of Atriplex halimus and Haloxylon scoparium leaves, collected in Algeria, were evaluated. The aqueous extract of the studied plants was subjected to phytochemical screening by biochemical analysis and HPLC. The diffusion assay was assessed to investigate the antimicrobial effect against clinical and reference strains. Moreover, we investigated DPPH and FRAP, as well as the haemolytic activity. The results showed abundance in the phytochemical and mineral components. Notably, A. halimus exhibited the highest DPPH and FRAP values with IC50 = 1.69 ± 0.67 and IC50 = 3.20 ± 0.04 mg/g, respectively. The antibacterial activity was better at the concentration of 25 mg/mL, compared to the standard antibiotics. The inhibition zones varied between 8 and 40 mm. The haemolytic activity did not depict any toxicity. The investigated plants exhibited interesting antioxidant and antibacterial properties and may serve as a valuable source for novel antimicrobial drugs.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia. 安纳托利亚东黑海地区恰耶利-里泽蜂胶的化学分析和生物活性评估。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-20 DOI: 10.1080/14786419.2024.2443500

Ali Disli, Nurdan Akdogan, Selinay Ozel, Levent Nuralin, Senem Akkoc, Hatice Ogutcu, Dogukan Doyduk, Gulay Dilek

引用次数: 0

Cell death by apoptosis induced by Ocotea indecora (Schott) Mez essential oil in different cancer cell lines. Ocotea indecora (Schott) Mez 精油在不同癌细胞系中诱导细胞凋亡。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-20 DOI: 10.1080/14786419.2024.2443492

Francisco Paiva Machado, Ana Caroline Diniz-Dos-Santos, Lucas Nicolau de Queiroz, Caio Pinho Fernandes, Leandro Rocha, Bruno Kaufmann Robbs

{"title":"Cell death by apoptosis induced by Ocotea indecora (Schott) Mez essential oil in different cancer cell lines.","authors":"Francisco Paiva Machado, Ana Caroline Diniz-Dos-Santos, Lucas Nicolau de Queiroz, Caio Pinho Fernandes, Leandro Rocha, Bruno Kaufmann Robbs","doi":"10.1080/14786419.2024.2443492","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443492","url":null,"abstract":"Cancer is the second leading cause of death in the world. Plants from Ocotea genus have been studied for their biological activities. Here we evaluated the antitumor activity of Ocotea indecora essential oil in several cancer cell lines and its phytochemical composition. We performed cell viability using MTT (1000-31.25 μg/mL) using DMSO (negative) and carboplatin (positive) controls. Cytometric and morphological assays analysed cell death pathway. In vivo acute toxicity was assessed in mice (150, 300, and 900 mg/kg) and GCMC for phytochemical analysis. The oil showed sesquirosefuran as the main metabolite and was cytotoxic against all cell lines tested, mainly HEPG2 (human hepatoblastoma cell) (IC50=44.9 µg/mL), was selective (SI = 1.69) and tolerated in mice. Apoptosis is the main cell death pathway as indicated by the presence of active caspase 3/7 and morphological characteristics. In conclusion, the oil was effective against HEPG2 cells and could be considered for future cancer studies.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-metabolomic investigation of biologically active fraction of Phanera vahlii (Wight & Arn.) Benth. leaf.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-19 DOI: 10.1080/14786419.2024.2443490

V Sushma, A Niranjana Kumar, J Kotesh Kumar, K V N Satya Srinivas, Shashikanta Sau, Rachana Patwari, M Sujitha, Nitin Pal Kalia, M Mohana Krishna Reddy, Nishant Jain

{"title":"Phyto-metabolomic investigation of biologically active fraction of Phanera vahlii (Wight & Arn.) Benth. leaf.","authors":"V Sushma, A Niranjana Kumar, J Kotesh Kumar, K V N Satya Srinivas, Shashikanta Sau, Rachana Patwari, M Sujitha, Nitin Pal Kalia, M Mohana Krishna Reddy, Nishant Jain","doi":"10.1080/14786419.2024.2443490","DOIUrl":"https://doi.org/10.1080/14786419.2024.2443490","url":null,"abstract":"Phanera vahlii (Wight & Arn.) Benth., leaves are used traditionally in variety of diseases. Chemical examination of the leaves yielded Davinvolunol B (1) and Quercetin-3-O-rhamnoside (2). Compared with the other extracts, the aqueous methanol extract significantly inhibited Streptococcus aureus with an IC50 of 8 µg/mL. In the anticancer activity assay, the ethyl acetate extract was effective against HeLa cells (IC50 19 µg/mL), the methanol extract was effective against A549 cells (IC50 of 19 µg/mL), the aqueous methanol extract was effective against PANC-1 cells (IC50 of 17 µg/mL) and the chloroform extract was effective against HT1080 cells (IC50 of 19 µg/mL). The polar extracts which showed good antioxidant activity exhibited strong bioactivity. This finding was supported by untargeted phytometabolite profiling of extracts using UPLC-ESI-Q-TOF-MSE. The PCA score plot and the Ven diagram revealed that the extracts had a distinctive and adequate number of polar molecules that likely contributed to their observed inhibitory activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four new flavonoids from Sophora flavescens and their antibacterial activities.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-17 DOI: 10.1080/14786419.2024.2440797

Yun Gao, Xin-Min Li, Fan-Fan Cao, Guo-Qing Long, Jing-Ming Jia, An-Hua Wang

引用次数: 0

Plant-part chemical composition of essential oils of Crithmum maritimum L. from Montenegro. 黑山 Crithmum maritimum L. 植物精油的部分化学成分。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-17 DOI: 10.1080/14786419.2024.2440514

Danijela Vuković, Mijat Božović, Danka Caković, Dragana Petrović, Vladimir Živković

引用次数: 0

The essential oil chemical composition of the aerial parts of Asparagus pastorianus Webb & Berthel growing wild in Sicily (Italy). 意大利西西里岛野生芦笋气生部分的精油化学成分。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-17 DOI: 10.1080/14786419.2024.2442103

Antonella Porrello, Maddalena Cerasola, Natale Badalamenti, Giuseppe Bazan, Maurizio Bruno

引用次数: 0