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A new sesquiterpene and two new benzoic derivatives from the marine-derived fungus Aspergillus versicolour SCSIO41697. 海洋真菌杂色曲霉SCSIO41697的倍半萜和两个新的苯甲酸衍生物。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-04 DOI: 10.1080/14786419.2026.2666669
Qi Cheng, Feng Wu, Keyue Wu, Xumeng Ren, Yiran Lin, Shuhua Qi
{"title":"A new sesquiterpene and two new benzoic derivatives from the marine-derived fungus <i>Aspergillus versicolour</i> SCSIO41697.","authors":"Qi Cheng, Feng Wu, Keyue Wu, Xumeng Ren, Yiran Lin, Shuhua Qi","doi":"10.1080/14786419.2026.2666669","DOIUrl":"https://doi.org/10.1080/14786419.2026.2666669","url":null,"abstract":"<p><p>A new sesquiterpene (6 <i>R</i>,7<i>R</i>,10<i>S</i>)-14-hydroxy-epoxycupar-3-ene (<b>1</b>) and two new benzoic derivatives 2,2'-((oxybis(carbonyl))bis(4,1-phenylene))dipropionic acid (<b>2</b>) and 6-carboxy-3-methoxy-5-hydroxycoumarin (<b>3</b>) were obtained from the marine-derived fungus <i>Aspergillus versicolour</i> SCSIO 41697. Compound <b>1</b> is a rare natural sesquiterpene with a 5/5/6 spiral ring skeleton. Their structures were elucidated by comprehensive spectroscopic analysis, and the absolute configurations of <b>1</b> and <b>2</b> were established by quantum chemical calculations of ECD spectra. Bioassays showed that none of them had significant antibacterial activity and toxicity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implication of chemical pattern recognition method for quality control of Boerhavia diffusa L. in Indian markets using RP-HPLC fingerprint. 反相高效液相色谱指纹图谱化学模式识别方法在印度市场白花草质量控制中的意义。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-04 DOI: 10.1080/14786419.2026.2666670
Mridul Kant Chaudhary, Ankita Misra, Adarsh Tiwari, Sanjeev Kumar Lale, Nagayya Shiddamallayya, Rabinarayan Acharya, Sharad Srivastava
{"title":"Implication of chemical pattern recognition method for quality control of <i>Boerhavia diffusa</i> L. in Indian markets using RP-HPLC fingerprint.","authors":"Mridul Kant Chaudhary, Ankita Misra, Adarsh Tiwari, Sanjeev Kumar Lale, Nagayya Shiddamallayya, Rabinarayan Acharya, Sharad Srivastava","doi":"10.1080/14786419.2026.2666670","DOIUrl":"https://doi.org/10.1080/14786419.2026.2666670","url":null,"abstract":"<p><p>This study demonstrates the use of Chemical Pattern Recognition (CPR) for identifying and evaluating the quality of <i>Boerhavia diffusa</i> L., (<i>Punarnava</i>) collected from wild and market sources across India. RP-HPLC fingerprinting revealed 13 common peaks, with β-ecdysone (P3) and boeravinone B (P12) identified as major phytomarkers at Rt of 3.97 ± 0.09 and 17.01 ± 0.12 min. The concentration of β-ecdysone and boeravinone B varied from 0.76 ± 0.02 to 12.64 ± 0.16 µg mg<sup>-1</sup>, and 0.016 ± 0.002 to 5.52 ± 0.04 µg mg<sup>-1</sup>. To assess sample authenticity, CPR was implemented using multivariate chemometric tools, including HCA, PCA and OPLS-DA. HCA classified the 21 samples into two distinct clusters. PCA and OPLS-DA, effectively distinguished authentic from non-authentic samples. Peaks P12 (boeravinone B), P9, P13, P7 and P3 (β-ecdysone) emerged as key quality markers. The study establishes a scientific approach for authentication and quality control of <i>Punarnava</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical profiling and anti-inflammatory activity of Tetragonia tetragonoides in TNF-α/IFN-γ-stimulated keratinocytes. 在TNF-α/IFN-γ刺激的角质形成细胞中，类四角龙的植物化学特征和抗炎活性。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-04 DOI: 10.1080/14786419.2026.2666673
Sang-Yun Lee, Derrick Kakooza, Neil Patrick Uy, Su-Young Jung, Kyung Choi, Sung-Kwon Moon, Hoon Kim, Sanghyun Lee
{"title":"Phytochemical profiling and anti-inflammatory activity of <i>Tetragonia tetragonoides</i> in TNF-α/IFN-γ-stimulated keratinocytes.","authors":"Sang-Yun Lee, Derrick Kakooza, Neil Patrick Uy, Su-Young Jung, Kyung Choi, Sung-Kwon Moon, Hoon Kim, Sanghyun Lee","doi":"10.1080/14786419.2026.2666673","DOIUrl":"https://doi.org/10.1080/14786419.2026.2666673","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic inflammatory disorder characterised by immune dysregulation and impaired barrier function. This study aimed to perform phytochemical profiling of <i>Tetragonia tetragonoides</i> leaf extract (TTL) using LC-MS/MS and HPLC/PDA-based quantification, and to evaluate its anti-inflammatory potential in keratinocytes. Untargeted LC-MS/MS analysis tentatively identified 13 metabolites. HPLC/PDA analysis confirmed and quantified five major constituents using authentic standards, including caffeic acid (<b>1</b>), ferulic acid (<b>2</b>), rutin (<b>3</b>), <i>n</i>-<i>trans</i>-feruloyltyramine (<b>4</b>), and ferulic acid methyl ester (<b>5</b>). Among them, rutin (<b>3</b>) was identified as the predominant compound in TTL. In TNF-α/IFN-γ-stimulated HaCaT keratinocytes, the TTL extract exhibited no cytotoxicity and significantly attenuated inflammatory responses, as evidenced by reduced secretion of pro-inflammatory chemokines, including IL-8 and MCP-1. Gene expression analysis further demonstrated that TTL extract broadly suppressed inflammation-related mediators involved in AD pathogenesis. These findings suggest that TTL extract represents a promising natural anti-inflammatory agent with potential applicability in the management of AD.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpenoids from the flower of Chrysanthemum indicum L. and their anti-lung cancer cytotoxic activity. 菊花中倍半萜类化合物及其抗肺癌细胞毒活性。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-04 DOI: 10.1080/14786419.2026.2665765
Yonghao You, Caixia Ren, Chao Wang, Jinlong Shi, Chunliang Wang, Qibin Huang, Di Zhao, Jing Zeng
{"title":"Sesquiterpenoids from the flower of <i>Chrysanthemum indicum</i> L. and their anti-lung cancer cytotoxic activity.","authors":"Yonghao You, Caixia Ren, Chao Wang, Jinlong Shi, Chunliang Wang, Qibin Huang, Di Zhao, Jing Zeng","doi":"10.1080/14786419.2026.2665765","DOIUrl":"https://doi.org/10.1080/14786419.2026.2665765","url":null,"abstract":"<p><p>Chryejuindion A (<b>1</b>) and B (<b>2</b>), two undescribed sesquiterpenoids were separated from the flower of <i>Chrysanthemum indicum</i> L., as well as six known ones were identified as chrysanthemumin A (<b>3</b>), chrysanthemumin B (<b>4</b>), chrysanthemumin E (<b>5</b>), chrysanthemdiol A (<b>6</b>), respectively. Biologically, compound <b>1</b> showed significant cytotoxicity against lung cancer cells (A549, H1299 and Calu-1) with IC<sub>50</sub> values from 0.84 ± 0.47 to 1.39 ± 0.75 μM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and evaluation of rhoifolin: an anxiolytic flavonoid from Citrus paradisi Macfayden var. redblush leaves 从柑桔红叶中提取抗焦虑类黄酮——芦黄素的分离与评价。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-10 DOI: 10.1080/14786419.2025.2463120
Shaheena Sohi , Richa Shri , Varinder Singh
{"title":"Isolation and evaluation of rhoifolin: an anxiolytic flavonoid from Citrus paradisi Macfayden var. redblush leaves","authors":"Shaheena Sohi ,&nbsp;Richa Shri ,&nbsp;Varinder Singh","doi":"10.1080/14786419.2025.2463120","DOIUrl":"10.1080/14786419.2025.2463120","url":null,"abstract":"<div><div><em>Citrus</em> species have a history of use in treating neurological conditions like insomnia, anxiety, and nervousness, though these claims lack exhaustive validation. This study evaluated the anxiolytic activity of <em>Citrus paradisi</em> Macfayden var. redblush leaves, aiming to isolate and characterise the bioactive constituent. Four leaf extracts (petroleum ether (60–80 °C), chloroform, methanol and aqueous) were evaluated for anxiolytic activity using elevated plus maze (EPM) in mice. The methanol extract showed anxiolytic activity and was subjected to bioactivity guided isolation using solvent partitioning, column chromatography and preparative HPLC to isolate the anxiolytic compound, CP-1, characterised as rhoifolin (based on spectroscopic analysis). Rhoifolin, at 0.705% w/w in leaves, was confirmed as anxiolytic compound through additional tests (light-dark box and social interaction tests) and holds promise as a potential treatment for anxiety disorders.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2316-2324"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversification of structurally significant cycloartane-type triterpenes: exploiting beddomeilactone 结构上重要的环artan型三萜的多样化：利用床内酯。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-08 DOI: 10.1080/14786419.2025.2477222
Chetan Paul Singh , Aliya Tabassum , Ravindra S. Phatake , Yogesh P. Bharitkar
{"title":"Diversification of structurally significant cycloartane-type triterpenes: exploiting beddomeilactone","authors":"Chetan Paul Singh ,&nbsp;Aliya Tabassum ,&nbsp;Ravindra S. Phatake ,&nbsp;Yogesh P. Bharitkar","doi":"10.1080/14786419.2025.2477222","DOIUrl":"10.1080/14786419.2025.2477222","url":null,"abstract":"<div><div>The cycloartane-type triterpenes are a structurally important class of natural products with diverse biological activity. Here, we present synthetic strategies and chemical modifications for obtaining a number of recently reported cycloartane-type triterpenes, along with various close-to-natural novel derivatives. The naturally abundant beddomeilactone (<strong>1</strong>) serves as the key resource for most transformations. Notably, the linear sequences we put forward for synthesising three natural products from <strong>1</strong>, include the selective reduction of <strong>1</strong> to generate the <strong>2</strong> with desired stereochemistry, the lactonization of <strong>2</strong> gives <strong>3</strong> qualitatively, and a selective olefin reduction of <strong>3</strong> gives <strong>11</strong>. Further selective olefin reduction of <strong>1</strong> and <strong>2</strong> was carried out in order to produce dihydro-analogues (<strong>15</strong> and <strong>17</strong>). Acid-catalyzed esterification of <strong>1</strong> led to retro-aldol, forming novel analogue <strong>18</strong>; also synthesised the expected ester derivative <strong>5</strong>. Subsequent transformations, such as epoxidation, lactone ring opening, and amidation, produced diverse synthetic analogues (<strong>19–21</strong>). We also efficiently converted compound <strong>4</strong> into 2,4-<em>epi</em>-­binectarilactone (<strong>22</strong>), a structural analogue of <strong>3</strong>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2538-2547"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two undescribed iridoids from the flowers of Sesamum indicum L. 芝麻花中两种未描述环烯醚萜类化合物。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-03 DOI: 10.1080/14786419.2025.2475509
Qing Shu , Yujun Tang , Yayu Wu , Miao Wang , Yifan Yuan , Wei Xu , Guangxiong Zhou
{"title":"Two undescribed iridoids from the flowers of Sesamum indicum L.","authors":"Qing Shu ,&nbsp;Yujun Tang ,&nbsp;Yayu Wu ,&nbsp;Miao Wang ,&nbsp;Yifan Yuan ,&nbsp;Wei Xu ,&nbsp;Guangxiong Zhou","doi":"10.1080/14786419.2025.2475509","DOIUrl":"10.1080/14786419.2025.2475509","url":null,"abstract":"<div><div>From the flowers of <em>Sesamum indicum</em> L., two novel iridoid compounds sesamiridol (<strong>1</strong>) and sesamiridoside (<strong>2</strong>) have been successfully isolated. Alongside these, five known iridoids were identified: lamiolactone (<strong>3</strong>), sesamoside (<strong>4</strong>), lamalbide (<strong>5</strong>), shanzhiside methyl ester (<strong>6</strong>), phloyoside III (<strong>7</strong>). The two-dimensional structures of compounds <strong>1</strong> and <strong>2</strong> were ascertained by means of IR, UV, NMR, and HR-ESI-MS, corroborated by comparison with relevant literature data. The configurations of these novel compounds were clarified <em>via</em> NOESY spectroscopy, ECD calculations, and acid hydrolysis. Moreover, an evaluation of the antioxidant activities of all compounds were conducted.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2462-2472"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sources of variation of the chemical composition of Lippia origanoides Kunth (Verbenaceae) 马鞭草科马鞭草化学成分变异的来源。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-04 DOI: 10.1080/14786419.2025.2463119
Gabriela Parolin Trindade , Guilherme Perez Pinheiro , Alex Aparecido Rosini Silva , Andréia de Melo Porcari , Alexandra Christine Helena Frankland Sawaya
{"title":"Sources of variation of the chemical composition of Lippia origanoides Kunth (Verbenaceae)","authors":"Gabriela Parolin Trindade ,&nbsp;Guilherme Perez Pinheiro ,&nbsp;Alex Aparecido Rosini Silva ,&nbsp;Andréia de Melo Porcari ,&nbsp;Alexandra Christine Helena Frankland Sawaya","doi":"10.1080/14786419.2025.2463119","DOIUrl":"10.1080/14786419.2025.2463119","url":null,"abstract":"<div><div><em>Lippia origanoides</em> Kunth is a perennial shrub widely used in Brazilian folk medicine while extracts of its leaves have been shown to possess several therapeutic properties. We investigated this species’ non-volatile compounds through a LC-MS-based untargeted metabolomics approach to evaluate the influence of genetic and developmental factors on <em>L. origanoides</em> metabolism. We compared five adult plants and eight leaf developmental stages separately; the chemical analyses were performed <em>via</em> UHPLC-ESI-QTOF-MS/MS and the resulting data were processed in Progenesis QI 2.0 and in MetaboAnalyst 6.0 for statistical analysis. Luteolin-7-<em>O</em>-glucoside and kaempferol/luteolin were the most intense components in the negative and positive ion modes, respectively. A subtle chemical variation between individuals was found while the leaf development, conversely, strongly affected the chemical profile, which may ultimately result in variation in bioactivity. Altogether, we reported herein new perspectives on <em>L. origanoides</em> non-volatile components and the impact of intraspecific factors on this species’ metabolism.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2306-2315"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects 芍药根中两个新化合物的研究。以及它们的抗炎作用。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-01 DOI: 10.1080/14786419.2025.2462114
Bo Fu , Jin-Ling Zhang , Jia-Tong Wu , Si-Yi Wang , Yi-Qiang Zhang , Juan Pan , Wei Guan , Zhi-Chao Hao , Hai-Xue Kuang , Qing-shan Chen , Li-Li Zhang , Bing-You Yang , Yan Liu
{"title":"Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects","authors":"Bo Fu ,&nbsp;Jin-Ling Zhang ,&nbsp;Jia-Tong Wu ,&nbsp;Si-Yi Wang ,&nbsp;Yi-Qiang Zhang ,&nbsp;Juan Pan ,&nbsp;Wei Guan ,&nbsp;Zhi-Chao Hao ,&nbsp;Hai-Xue Kuang ,&nbsp;Qing-shan Chen ,&nbsp;Li-Li Zhang ,&nbsp;Bing-You Yang ,&nbsp;Yan Liu","doi":"10.1080/14786419.2025.2462114","DOIUrl":"10.1080/14786419.2025.2462114","url":null,"abstract":"<div><div>Two new compounds (<strong>1</strong>-<strong>2</strong>), together with six known ones (<strong>3-8</strong>), were isolated from the roots of <em>Paeonia lactiflora</em> Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds <strong>1-8</strong> were determined using LPS-induced RAW 264.7 cells. Compounds <strong>2, 6,</strong> and <strong>8</strong> showed the most potent inhibitory activities on NO production with <em>IC<sub>50</sub></em> values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds <strong>4</strong> and <strong>7</strong> showed moderate inhibitory activities. Compounds <strong>3</strong> and <strong>5</strong> showed relatively weak inhibitory activities.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2291-2298"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenolic constituents from the roots of Strobilanthes sarcorrhiza C. Ling and their bioactivity 石斛根中酚类成分及其生物活性研究。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-17 DOI: 10.1080/14786419.2025.2469316
Mingjie Xu , Yiwei Wu , Taohong Han , Yajing Chen , Lingxia Qu , Yuyan Xu , Yunhan Zhang , Huizhen Yang , Jiaping Fan , Xueli Huang , Ke Yang , Tunhai Xu , Yindi Zhu
{"title":"Phenolic constituents from the roots of Strobilanthes sarcorrhiza C. Ling and their bioactivity","authors":"Mingjie Xu ,&nbsp;Yiwei Wu ,&nbsp;Taohong Han ,&nbsp;Yajing Chen ,&nbsp;Lingxia Qu ,&nbsp;Yuyan Xu ,&nbsp;Yunhan Zhang ,&nbsp;Huizhen Yang ,&nbsp;Jiaping Fan ,&nbsp;Xueli Huang ,&nbsp;Ke Yang ,&nbsp;Tunhai Xu ,&nbsp;Yindi Zhu","doi":"10.1080/14786419.2025.2469316","DOIUrl":"10.1080/14786419.2025.2469316","url":null,"abstract":"<div><div>This research is the first to report the phytochemical investigation of <em>Strobilanthes sarcorrhiza</em> C. Ling. Thirty-three compounds were isolated and characterised (<strong>1 to 32</strong>), including a pair of undescribed isomers (<strong>1a</strong> and <strong>1b</strong>), one undescribed phenolics (<strong>16</strong>), and 30 known compounds. Their structures were assessed <em>via</em> spectroscopic and chemical data. The protective effect of all compounds (62.5–500 nM) against lipopolysaccharide (LPS)-induced cytotoxicity in RAW 264.7 was tested. Compounds <strong>1a</strong>, <strong>1b</strong>, <strong>10</strong>, <strong>11</strong>–<strong>17</strong>, <strong>21</strong>, <strong>24</strong>, and <strong>28</strong>–<strong>32</strong> showed a significant increase in viability. The <strong>1b</strong> potential targets against inflammatory diseases were predicted by network pharmacology, 43 pathways were identified, and chemokine signalling was significantly enriched. The <strong>1b</strong> anti-inflammatory activities were further assessed <em>in vitro</em> in LPS-activated RAW 264.7 cells, which indicated that <strong>1b</strong> exhibits an anti-inflammatory character by repressing p-AKT, p-PI3K, and p-NF-κB nuclear translocation and IL-6, TNF-α, and IL-1β expression. This research provides the basis for the application of <em>S. sarcorrhiza</em> as a natural anti-inflammatory agent.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2338-2346"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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