Natural Product Research最新文献_第2页

Effect of geographical origin on the chemical characteristics of Q. canariensis acorns: profiling fatty acids, tocopherols, and phenolic composition. 地理来源对加纳橡子化学特性的影响：脂肪酸、生育酚和酚类成分分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-04-01 DOI: 10.1080/14786419.2024.2335355

Sondes Fkiri, Bagues Mohamed, Mariem Khouja, Boutheina Stiti, Ridha Ben Salem, Zouhair Nasr, Lasâad Ben Slimane, Kamel Nagaz, Rigane Ghayth, Abdelhamid Khaldi

{"title":"Effect of geographical origin on the chemical characteristics of Q. canariensis acorns: profiling fatty acids, tocopherols, and phenolic composition.","authors":"Sondes Fkiri, Bagues Mohamed, Mariem Khouja, Boutheina Stiti, Ridha Ben Salem, Zouhair Nasr, Lasâad Ben Slimane, Kamel Nagaz, Rigane Ghayth, Abdelhamid Khaldi","doi":"10.1080/14786419.2024.2335355","DOIUrl":"10.1080/14786419.2024.2335355","url":null,"abstract":"The impact of geographical origin on the chemical composition of acorns from Quercus species has significant attention. This study aimed to explore the phenolic composition of methanolic extracts, tocopherol content, and fatty acid composition of acorn oils from six different populations of Q. canariensis acorns. The obtained results revealed that acorn oil from BniMtir exhibited high levels of α-tocopherol (58 mg/kg). The fatty acids identified across all samples were Z-vaccenic + oleic acids (38.44-58.58%). In addition, the data highlighted the presence of quinic (32.514-60.216 µg/g DW) and gallic acids (1.674-10.849 µg/g DW), as well as catechin (+) (0.096-12.647 µg/g DW) in all populations. These variations in chemical composition from different regions are likely linked to their geographical origin. In conclusion, this study's finding should significance for the industry, offering valuable insights into the potential production of bioactive compounds from Q. canariensis acorns, which could have various applications.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4247-4253"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new 3,4-dihydroisocoumarin and an antiinflammatory coumarin from the roots of Saposhnikovia divaricata (Turcz.) Schischk. 从Saposhnikovia divaricata (Turcz.) Schischk.的根中提取的一种新的3,4-二氢异香豆素和一种抗炎香豆素

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-04-02 DOI: 10.1080/14786419.2024.2334317

Yan Sun, Yan Liu, Peng Jiang, Si-Yi Wang, Juan Pan, Wei Guan, Yu-Xuan Wang, Hai-Xue Kuang, Yan-Hong Wang, Bing-You Yang

引用次数: 0

Phytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.). 用新鲜采摘的鸢尾（Mitragyna speciosa (Korth.)）叶片制备的水和乙醇液体提取物的植物化学分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-06-06 DOI: 10.1080/14786419.2024.2362428

Thiruventhan Karunakaran, Balasingam Vicknasingam, Marek C Chawarski

{"title":"Phytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.).","authors":"Thiruventhan Karunakaran, Balasingam Vicknasingam, Marek C Chawarski","doi":"10.1080/14786419.2024.2362428","DOIUrl":"10.1080/14786419.2024.2362428","url":null,"abstract":"Mitragyna speciosa, also known as kratom, has been reported to have a broad range of pharmacological properties. Freshly harvested leaves and their water extracts are consumed in Southeast Asia while preparations made from dried leaf material are consumed in Western countries. Our study evaluated the phytochemical composition of freshly harvested kratom leaves using LCMS/MS analysis of water and ethanol liquid extracts. Mitragynine and its congeners, including 7-hydroxymitragynine, speciocilliatine, speciogynine, paynantheine, as well as bioactive phenolics including chlorogenic acid, o-coumaric acid, quercitrin, and rutin were identified. However, 7-hydroxymitragynine was detected solely in the water-liquid extract. Currently, unknown compounds were also present in the chromatograms and mass spectra. The study results support that 7-hydroxymitragynine is a post-harvest oxidative derivative or metabolite of mitragynine. Further rigorous and comprehensive evaluations of the phytochemical composition of freshly harvested kratom leaves utilising advanced spectrometric methods are needed to establish the full spectrum of phytochemicals within the plant.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4480-4487"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical analysis of flotsam ambergris. 龙涎香浮渣的化学分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-07-01 DOI: 10.1080/14786419.2024.2361863

Steven J Rowland, Paul A Sutton, C Anthony Lewis, Timothy Knowles, Michael J Wilde, Filipe Alves, Robert Clough

引用次数: 0

Multifaceted evaluation of Fumaria parviflora: from bioactive isolation to anticancer screening and computational drug design. 从生物活性分离到抗癌筛选和计算药物设计，对细小植物富米亚菌的多方面评价。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-31 DOI: 10.1080/14786419.2025.2538095

Rohan Singadi, Rahul Koli, Pooja Kagawad, Meenaxi M Maste

{"title":"Multifaceted evaluation of Fumaria parviflora: from bioactive isolation to anticancer screening and computational drug design.","authors":"Rohan Singadi, Rahul Koli, Pooja Kagawad, Meenaxi M Maste","doi":"10.1080/14786419.2025.2538095","DOIUrl":"https://doi.org/10.1080/14786419.2025.2538095","url":null,"abstract":"This study investigates the phytochemical composition and anticancer potential of Fumaria parviflora (F. parviflora) ethanolic extract. Preliminary screening confirmed the presence of multiple secondary metabolites, and chromatographic techniques led to the isolation of β-sitosterol, which was characterised by FT-IR, NMR, and LC-MS. However, in vitro cytotoxicity assessment against MCF-7 breast cancer cells revealed that β-sitosterol (RS-2) exhibited only moderate activity, with an IC50 of 639.2 µM. Molecular docking studies also indicated weak binding affinity of β-sitosterol towards selected breast cancer-related targets. In contrast, other constituents, particularly bidenlignaside A and B, showed stronger interactions in in silico, implicating them as more promising candidates. Drug-likeness and ADME predictions supported the pharmacokinetic suitability of these key compounds. Collectively, the results highlight F. parviflora as a valuable source of bioactive molecules, although β-sitosterol alone may have limited therapeutic potential, warranting further investigation of more potent constituents for breast cancer therapy.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Processing from natural products to effective pharmaceutical drugs: involvement of hot melt extrusion technique. 从天然产品到有效药物的加工：涉及热熔挤压技术。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-29 DOI: 10.1080/14786419.2025.2538096

Trung Hoang Trinh, Hiep Tuan Tran

引用次数: 0

Investigating the mechanism of anti-hepatic fibrosis action of Chiyin Heji based on network pharmacology, molecular docking and experimental validation. 基于网络药理学、分子对接和实验验证探讨赤阴合剂抗肝纤维化作用机制。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-29 DOI: 10.1080/14786419.2025.2537308

Manling Zhao, Yingjie Wang, Chao Fang, Wenbin Xu, Ziqi Yu, Junchen Zhu, Weibing Shi

{"title":"Investigating the mechanism of anti-hepatic fibrosis action of Chiyin Heji based on network pharmacology, molecular docking and experimental validation.","authors":"Manling Zhao, Yingjie Wang, Chao Fang, Wenbin Xu, Ziqi Yu, Junchen Zhu, Weibing Shi","doi":"10.1080/14786419.2025.2537308","DOIUrl":"https://doi.org/10.1080/14786419.2025.2537308","url":null,"abstract":"To unravel the pharmacological mechanisms and validate the efficacy of Chiyin Heji (the CYP) in anti-hepatic fibrosis, we analysed its components using UHPLC-Q-Orbitrap HRMS, screened drug targets through TCMSP, and identified disease targets using databases such as Genecard, OMIM, Drugbank and TTD. The intersection of these targets was analysed using GO and KEGG for PPI network analysis and target prediction. Molecular docking was simulated using AutoDock Vina. Design an in vitro cell experiment and verify using the CCK-8 assay, Transwell cell migration assay, qRT-PCR and Western blot. A comprehensive analysis led to the identification of 34 distinct chemical components in CYP. The PPI network identified 34 core targets linked to the PI3K/Akt, MAPK and IL-17 signalling pathways. Cell experiments show that the CYP can improve liver fibrosis by regulating the PTEN/PI3K/Akt/p70S6K signalling pathway, inhibiting the proliferation of HSCs, accelerating the degradation of collagen and alleviating inflammation.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition and biological activities of stolons methanolic extract and fractions from the Moroccan endemic species Searsia albida (Schousb.) Moffett. 摩洛哥特有种海苔（Searsia albida, Schousb.）匍匐茎甲醇提取物及其组分的化学成分和生物活性莫菲特。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-28 DOI: 10.1080/14786419.2025.2539332

Fatima-Ezzahra Derdar, Manal Zefzoufi, Kaouthar ELBirgui, Said Broudi, Hanane Ennaji, Anas El Ouaddari, Rabiaa Fdil, Hafida Bouamama, Samir Ibenmoussa

{"title":"Chemical composition and biological activities of stolons methanolic extract and fractions from the Moroccan endemic species Searsia albida (Schousb.) Moffett.","authors":"Fatima-Ezzahra Derdar, Manal Zefzoufi, Kaouthar ELBirgui, Said Broudi, Hanane Ennaji, Anas El Ouaddari, Rabiaa Fdil, Hafida Bouamama, Samir Ibenmoussa","doi":"10.1080/14786419.2025.2539332","DOIUrl":"https://doi.org/10.1080/14786419.2025.2539332","url":null,"abstract":"Due to its rich phenolic content, Searsia albida (Schousb.) Moffett, a medicinal plant from Essaouira, Morocco, holds the potential to combat microbial resistance. This study is the first to profile S. albida using UHPLC-MS/MS and assess its biological activities. Antimicrobial effects were tested on Gram-negative (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Staphylococcus aureus, Enterococcus hirae), and Candida albicans. The methanolic extract, dichloromethane, and ethyl acetate fractions' antioxidant activity was determined using DPPH, FRAP, ABTS, and TAC tests, and cytotoxicity was tested on P3 myeloma cells. The plant's extracts revealed 20 distinct compounds. PCA analysis highlighted that the ethyl acetate fraction, rich in chlorogenic acid (45.36%), showed strong antioxidant, cytotoxic, and antimicrobial effects, especially against Gram-positive bacteria. The dichloromethane fraction containing galloylhexose derivatives (30.71%) displayed significant antimicrobial activity, especially against Gram-negative bacteria and C. albicans. This work provides insights into the bioactive compounds of S. albida, opening doors for further exploration.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatographic separation and isolation of bioactive compounds, 1H, 13C nuclear magnetic resonance analysis, antioxidant, antimicrobial and antiulcer potential of isolates from Olax psittacorum extract. 油葵提取物的色谱分离、生物活性化合物分离、1H、13C核磁共振分析、抗氧化、抗菌和抗溃疡活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-28 DOI: 10.1080/14786419.2025.2536635

Pragyan Parimita Mansingh, Lopamudra Adhikari, Moonmun Dhara

{"title":"Chromatographic separation and isolation of bioactive compounds, 1H, 13C nuclear magnetic resonance analysis, antioxidant, antimicrobial and antiulcer potential of isolates from Olax psittacorum extract.","authors":"Pragyan Parimita Mansingh, Lopamudra Adhikari, Moonmun Dhara","doi":"10.1080/14786419.2025.2536635","DOIUrl":"https://doi.org/10.1080/14786419.2025.2536635","url":null,"abstract":"The herb Olax psittacorum (Lam.) Vahl. has been used traditionally for treating various ailments. The current research reports the isolation, identification, and characterisation of bioactive compounds from O. psittacorum leaf ethanolic extract and assessing their antioxidant as well as antimicrobial properties. Chromatographic separation of bioactive compounds was performed by thin layer chromatography and column chromatography, and were identified using proton (1H), carbon (13 C) Nuclear Magnetic Resonance spectroscopy along with Gas Chromatography-Mass Spectrometry analysis. Potential functional groups within the isolates were characterised by Fourier transform-infra-red spectroscopy Analysis. The isolate Pra-a demonstrated good antioxidant properties against 2,2'-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay. The isolated compounds exhibited good antibacterial properties with the Zone of inhibition ranging from 3 to 15 mm. The compounds exhibited good docking score as compared to the standard ofloxacin. The isolates from O. psittacorum leaf possess considerable antioxidant, antibacterial, antiulcer properties, suggesting potential pharmaceutical utilisation through purification and characterisation.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous determination of stigmasterol and β-sitosterol in Justicia adhatoda leaves using reverse-phase high-performance liquid chromatography (RP-HPLC). 反相高效液相色谱法（RP-HPLC）同时测定黑枣叶中豆甾醇和β-谷甾醇的含量。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-07-28 DOI: 10.1080/14786419.2025.2537306

Satyajit Mohanty, Tuhin Mukherjee, Nikita Nayak, Ashok Pattnaik, Sumel Ashique

引用次数: 0