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In vitro and in silico evaluation of Turbinaria ornata-derived compounds: elucidating mechanisms of anticandidal and anticancer activities. 刺鼻草衍生化合物的体外和计算机评价：阐明抗药和抗癌活性的机制。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2569808
Priyanka K R, Ramalingam Vaikundamoorthy, Rajaram Rajendran, Swathi Chandran Manimegalai, Kadalmani Balamuthu
{"title":"<i>In vitro</i> and <i>in silico</i> evaluation of <i>Turbinaria ornata</i>-derived compounds: elucidating mechanisms of anticandidal and anticancer activities.","authors":"Priyanka K R, Ramalingam Vaikundamoorthy, Rajaram Rajendran, Swathi Chandran Manimegalai, Kadalmani Balamuthu","doi":"10.1080/14786419.2025.2569808","DOIUrl":"https://doi.org/10.1080/14786419.2025.2569808","url":null,"abstract":"<p><p><i>Candida</i> genera play a crucial role as infectious pathogens in humans and have the ability to form biofilms, which impede the efficacy of antifungal medications, thereby elevating resistance levels. In this present study, the extracts of <i>Turbinaria ornata</i> were used for the treatment of clinical isolates of <i>Candida</i> species, and UPLC-ESI-Q-TOF MSE was employed for the chemical profiling of macroalgae extracts. The methanol extract of <i>T. ornata</i> has excellent with MIC (125 mg/mL), particularly against <i>C. krusei</i> by reduction of adhesion compared with acetone and ethyl acetate extracts. The toxicity assay has been assessed by the nauplii stage in <i>Artemia salina</i>. The LC<sub>50</sub> value for cultured control and treated A549 and 3T3 cells was noted as ≥1000 µg/µL and 292.35 µg/µL, respectively. Isofucosterol exhibits the maximum docking score among the targeted protein molecules. The current study shows the efficient of <i>Turbinaria ornata</i> extract against candidiasis and lung cancer.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural β-citronellol derivatives as potential dual enzyme inhibitors for the treatment of type 2 diabetes and Alzheimer's diseases. 天然β-香茅醇衍生物作为治疗2型糖尿病和阿尔茨海默病的潜在双酶抑制剂
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2572038
Ram Chander, Ritesh Sharma, Vijai K Agnihotri
{"title":"Natural <i>β</i>-citronellol derivatives as potential dual enzyme inhibitors for the treatment of type 2 diabetes and Alzheimer's diseases.","authors":"Ram Chander, Ritesh Sharma, Vijai K Agnihotri","doi":"10.1080/14786419.2025.2572038","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572038","url":null,"abstract":"<p><p>Effective strategies for treating type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) involve inhibition of <i>α</i>-amylase, <i>α</i>-glucosidase for T2DM and block acetylcholinesterase (AChE) enzymes for treating AD. To explore this potential natural <i>β</i>-citronellol, isolated from <i>Dracocephalum heterophyllum</i> Benth essential oil, was derivatized to yield three derivatives (Compounds 2-4), analysed using NMR and GC-MS techniques. The results showed that compounds 2 and 4 had the most significant <i>α</i>-glucosidase and AChE inhibition. Parent compound 1, along with 3 and 4, displayed the highest <i>α</i>-amylase inhibition. Network pharmacology identified CXCR4 (score: 14) and PIK3CA (score: 12) as top-ranked targets. These findings suggest that PIK3CA, which regulates glucose metabolism, insulin signalling, and cell survival, while CXCR4 suggests potential for neuroprotective and anti-inflammatory roles. Structure-activity relationship indicated that alkoxy group functionalization at <i>β</i>-carbon of <i>β</i>-citronellol is essential for activity. It highlights, a single <i>β</i>-citronellol derivative can manage dual T2DM and AD diseases.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new alkaloids identified from herb Delphinium trichophorum French, a famous Tibetan drug "Gebu Dilu".
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2566909
Siyuan Liu, Yuansheng Zou, Zeren Dawa, Fangle Liu, Meiqi Wang, Chenchen Zhu, Chaozhan Lin
{"title":"Two new alkaloids identified from herb <i>Delphinium trichophorum</i> French, a famous Tibetan drug \"Gebu Dilu\".","authors":"Siyuan Liu, Yuansheng Zou, Zeren Dawa, Fangle Liu, Meiqi Wang, Chenchen Zhu, Chaozhan Lin","doi":"10.1080/14786419.2025.2566909","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566909","url":null,"abstract":"<p><p>A new benzamide derivative alkaloid (<b>1</b>) and a new hetisine-type diterpenoid alkaloid (<b>2</b>) were isolated from <i>D. trichophorum</i> Franch with fourteen known alkaloids compounds (<b>3</b>∼<b>16</b>, including twelve hetisine-type diterpenoid alkaloids), in which three compounds were discovered firstly from genus <i>Delphinium</i> (<b>10</b>, <b>15</b>, <b>16</b>) and three compounds were discovered firstly from species <i>D. -trichophorum</i> (<b>7</b>, <b>9</b>, <b>11</b>). Their structures were elucidated by -extensive spectroscopic analyses, including 1D NMR, 2D NMR and ESI-MS/HR ESI-MS techniques, along with their anti-inflammatory activities were evaluated by measuring NO production in LPS-stimulated RAW264.7 cells.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LC-MSn analysis, antioxidant activity and in-vivo toxicology of methanolic extract of aerial parts from Calendula aegyptiaca. 埃及金盏菊空中部位甲醇提取物的LC-MSn分析、抗氧化活性及体内毒理学研究。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2571079
Wafa Grati, Amal Tahri, Bouthaina Bouzayani, Sonda Samet, Amani Ayachi, Dana Jallouli, Fatma Ayadi, Lobna Ben Mahmoud, Khaled Mounir Zeghal, Tarek Rebai, Michel Treilhou, Nathan Téné, Zouhair Sahnoun, Raoudha Mezghani-Jarraya
{"title":"LC-MS<sup>n</sup> analysis, antioxidant activity and <i>in-vivo</i> toxicology of methanolic extract of aerial parts from <i>Calendula aegyptiaca</i>.","authors":"Wafa Grati, Amal Tahri, Bouthaina Bouzayani, Sonda Samet, Amani Ayachi, Dana Jallouli, Fatma Ayadi, Lobna Ben Mahmoud, Khaled Mounir Zeghal, Tarek Rebai, Michel Treilhou, Nathan Téné, Zouhair Sahnoun, Raoudha Mezghani-Jarraya","doi":"10.1080/14786419.2025.2571079","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571079","url":null,"abstract":"<p><p>Antioxidant activity of several organ and total aerial part extracts from <i>Calendula aegyptiaca</i> was investigated. Flavonoids and total phenol contents as well as ferric reducing power assay (FRAP), total antioxidant capacity (TAC), 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay revealed that methanolic extracts were richer in phenolics and flavonoids than Dichloromethane (DCM) and <i>n-</i>hexane extracts. The methanolic extract of the plant's aerial part (MEAP) was found to have the highest phenolic content (385.06 ± 0.92 mg of Gallic acid equivalent/g of dried extract). The chemical profile of MEAP was explored through high-performance liquid chromatography combined with negative electrospray ionisation mass spectrometry (HPLC-HESI-MS). Twenty-nine compounds were identified, mostly composed of flavonoids (<b>32.4</b>%), phenolic acids (<b>10.5</b>%), and saponins (<b>46.8</b>%). By administering the MEAP to Wistar female rats in drinking water, its subacute toxicity was examined. Hematological, biochemical, histological and oxidative stress parameters were evaluated. Doses of <b>0.125</b>, <b>0.250</b>, <b>0.500</b>, and <b>1.000 </b>g of plant per kg of body weight did not cause damage in rats receiving this treatment. Nevertheless, a decrease in serum uric acid level was observed following extract administration. So, this extract may have antihyperuricemic activity which should be confirmed by using an animal model of hyperuricaemia.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new alkaloids were isolated from Portulaca oleracea L. and their bioactivities. 从马齿苋中分离到了两个新的生物碱，并对它们的生物活性进行了研究。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2572535
Jing Liu, Xiaoqian Zhang, Hongzhe Zhang, Junjie Yao, Shengnan Guo, Aijing Leng, Xixiang Ying
{"title":"Two new alkaloids were isolated from <i>Portulaca oleracea</i> L. and their bioactivities.","authors":"Jing Liu, Xiaoqian Zhang, Hongzhe Zhang, Junjie Yao, Shengnan Guo, Aijing Leng, Xixiang Ying","doi":"10.1080/14786419.2025.2572535","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572535","url":null,"abstract":"<p><p><i>Portulaca oleracea</i> L. was commonly used to treat colitis in ancient China, but the therapeutic substances were unclear. As alkaloids are the major chemical compositions of the plant, they were therefore investigated in this research. The compounds oleraglycerolpyridin (<b>1</b>) and olerapyrrolidinone (<b>2</b>) were separated from the <i>Portulaca oleracea</i> L. The structures were verified by NMR and HR-MS, subsequently, their bioactivities were respectively evaluated by determination of IL-1<i>β</i>, TNF-<i>α</i> by ELISA method, and acetylcholinesterase activities by modified Ellman's method.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and structural elucidation of new 8-O-4' neolignan and phenolic glucoside from the lianas of gnetum montanum markgr. 枸杞藤本植物中新8-O-4′木脂素和酚类葡萄糖苷的分离与结构分析。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2571851
Truong Nhat Van Do, Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Thanh Thi Nguyen
{"title":"Isolation and structural elucidation of new 8-<i>O</i>-4' neolignan and phenolic glucoside from the lianas of <i>gnetum montanum</i> markgr.","authors":"Truong Nhat Van Do, Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Thanh Thi Nguyen","doi":"10.1080/14786419.2025.2571851","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571851","url":null,"abstract":"<p><p>In this study, the bioactivity guided by xanthine oxidase inhibition successfully isolated and characterised two new phenolic compounds named montanumgams A-B (<b>1</b>-<b>2</b>) together with fifteen known compounds (<b>3</b>-<b>17</b>) from the lianas of <i>Gnetum montanum</i> Markgr. Their chemical structures were elucidated by analysing nuclear magnetic resonance spectroscopy (1D and 2D-NMR), ESI high-resolution mass spectrometry (HRESIMS), and comparison with reference data. The activity of xanthine oxidase inhibition revealed that compound <b>1</b> has potent inhibitory effects, exhibiting IC<sub>50</sub> values of 16.6 µM, compared to a positive control, allopurinol (IC<sub>50</sub>, 2.5 µM).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring aroma profiles of gardenia jasminoides flowers and leaves by HS-gC-MS. 用HS-gC-MS研究栀子花和叶的香气特征。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-14 DOI: 10.1080/14786419.2025.2570892
Xiangyang Guo
{"title":"Exploring aroma profiles of <i>gardenia jasminoides</i> flowers and leaves by HS-gC-MS.","authors":"Xiangyang Guo","doi":"10.1080/14786419.2025.2570892","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570892","url":null,"abstract":"<p><p>The aroma characteristics of flowers and leaves from <i>G. jasminoides</i> were comprehensively explored using HS-GC-MS technology, coupled to relative odour activity value (rOAV) determination and PCA analysis. A total of 116 volatiles were identified in <i>G. jasminoides</i>, with 71 common volatiles detected in both the leaves (GJ-L) and flowers (GJ-F). Alkenes were found to be the most abundant volatiles in both samples, both in terms of quantity and relative abundance. Notably, 2,3-butanedione (rOAV = 100) was identified as the key contributor to buttery aroma in GJ-F, while 3-methylbutanal (rOAV = 100) was the principal contributor to fruity odour in GJ-L. PCA further revealed significant differences in the aroma characteristics between GJ-F and GJ-L. This study enhances our understanding of the volatile compositions and odour characteristics of different parts (flowers and leaves) of <i>G. jasminoides</i>, providing a theoretical basis for the development and utilisation of products derived from <i>G. jasminoides</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancake evaluation, phytochemical characterization, and therapeutic potential of Cichorium intybus L. herb: a focus on antioxidant, antidiabetic, and anticholinesterase activities. 菊苣的煎饼评价、植物化学特性和治疗潜力：重点研究抗氧化、抗糖尿病和抗胆碱酯酶活性。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-13 DOI: 10.1080/14786419.2025.2572534
Gehan F Abdel Raoof, Eman A Younis, Hanan F Aly, Hala M Mohamed Nagy
{"title":"Pancake evaluation, phytochemical characterization, and therapeutic potential of <i>Cichorium intybus</i> L. herb: a focus on antioxidant, antidiabetic, and anticholinesterase activities.","authors":"Gehan F Abdel Raoof, Eman A Younis, Hanan F Aly, Hala M Mohamed Nagy","doi":"10.1080/14786419.2025.2572534","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572534","url":null,"abstract":"<p><p>The current research evaluated the different extracts of <i>Cichorium intybus</i> L. (chicory) herbs for their antioxidant, anticholinesterase and antidiabetic activities. It investigated the phytoconstituents of the most active fraction. In addition, pancake samples of chicory were prepared and evaluated for their nutritional values and sensory scores. The result revealed that the <i>n</i>-butanol fraction exhibited the highest biological activities. Moreover, LC-ESI-MS/MS analysis of the <i>n</i>-butanol fraction revealed the identification of 17 phenolic compounds. Furthermore, gallic and pyrogallic acids were isolated and identified from the <i>n</i>-butanol fraction. In addition, glutamic and aspartic acids were the major amino acids in chicory herbs. Furthermore, HPLC analysis of the vitamins revealed that vitamins B6 and E constituted the greatest concentration. In addition, the panellists found that supplementing chicory herb powder to oats was most acceptable. In conclusion, chicory herbs may be used in the food industry due to their safety, high nutritional value and acceptability.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, and molecular docking study of isopimaroyl 1,2,4-triazole-thioether derivatives as anti-tumor agents. 异松烷基1,2,4-三唑硫醚抗肿瘤衍生物的设计、合成及分子对接研究。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-13 DOI: 10.1080/14786419.2025.2566472
Juanjuan Liu, Ya Gao, Hu Chen, Guoyong Luo, Shaoping Yang
{"title":"Design, synthesis, and molecular docking study of isopimaroyl 1,2,4-triazole-thioether derivatives as anti-tumor agents.","authors":"Juanjuan Liu, Ya Gao, Hu Chen, Guoyong Luo, Shaoping Yang","doi":"10.1080/14786419.2025.2566472","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566472","url":null,"abstract":"<p><p>To develop highly effective natural anti-tumor agents, 12 isopimaroyl 1,2,4-triazole-thioether compounds were designed and synthesised. Anti-tumor activity tests showed that the majority of these target compounds exhibited moderate to excellent inhibitory effects against HepG2, K562, and PC-3 cells, with a particular selectivity for PC-3 cells. Compound <b>5 g</b> demonstrated promising anticancer activity against HepG2 cells, surpassing the reference drug 5-FU. Compound <b>5k</b> exhibited comparable activity to 5-FU against K562 cells. Additionally, the <i>p</i>-NO<sub>2</sub> substituted compounds <b>5h</b> and <b>5l</b> displayed the most significant anti-tumor activity, with IC<sub>50</sub> values of 7.42 ± 1.45 μmol/L and 8.38 ± 1.67 μmol/L, respectively. Molecular docking studies further revealed a docking model of compound <b>5h</b> with 5ds3 protein, suggesting its potential as a promising anti-PC-3 drug.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on a growth promoting effect and mechanism of the extract of stem and leaf from Atractylodes lancea DC. on nile tilapia. 苍术茎叶提取物促生长作用及机制研究。尼罗罗非鱼。
IF 1.6 3区 化学
Natural Product Research Pub Date : 2025-10-13 DOI: 10.1080/14786419.2025.2570511
Wei Tian, Ziying Wang, Dongdong Shi, Zhiwei Huang, Yuefei Liu, Xiumei Li
{"title":"Study on a growth promoting effect and mechanism of the extract of stem and leaf from <i>Atractylodes lancea</i> DC. on nile tilapia.","authors":"Wei Tian, Ziying Wang, Dongdong Shi, Zhiwei Huang, Yuefei Liu, Xiumei Li","doi":"10.1080/14786419.2025.2570511","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570511","url":null,"abstract":"<p><p>Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated <i>Atractylodes lancea</i> DC. extract (ALE) on <i>Lactiplantibacillus plantarum</i> growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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