Natural Product Research最新文献_第2页

Chemical constituents from the roots of Illigera celebica. 白屈根的化学成分。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-26 DOI: 10.1080/14786419.2025.2509882

Si-Feng Yang, Lin-Wen Yi, Qiu-Xia Huang, Xing-Meng Luo, Xiao-Bing Su, Lin Hu, Wen-Ting Li, Xiang-Zhong Huang, Meng-Yuan Jiang

引用次数: 0

Comparative phenolic profiling and antioxidant activity of Centaurea tougourensis Boiss. & Reut. and Centaurea dimorpha Viv. from Algeria. 半山腰酚类化合物的比较分析及抗氧化活性研究。& Reut。半人马座（centauria dimorpha Viv）。从阿尔及利亚。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-26 DOI: 10.1080/14786419.2025.2509881

Nabila Souilah, Nabila Adoui, Hamdi Bendif, Fatima Zohra Hechaichi, Hadjer Zaak, Ifriqya Medila, Abdulselam Ertaş, Mustafa Abdullah Yilmaz, Mehmet Öztürk, Gregorio Peron

{"title":"Comparative phenolic profiling and antioxidant activity of Centaurea tougourensis Boiss. & Reut. and Centaurea dimorpha Viv. from Algeria.","authors":"Nabila Souilah, Nabila Adoui, Hamdi Bendif, Fatima Zohra Hechaichi, Hadjer Zaak, Ifriqya Medila, Abdulselam Ertaş, Mustafa Abdullah Yilmaz, Mehmet Öztürk, Gregorio Peron","doi":"10.1080/14786419.2025.2509881","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509881","url":null,"abstract":"Centaurea L. plants are used in phytotherapy and as food. C. tougourensis (CT) and C. dimorpha (CD) are endemic of Algeria and have been scarcely studied up to now. Here, the phenolic content of their aerial parts was investigated using validated methods. Furthermore, the antioxidant properties of CT and CD were evaluated by performing DPPH, ABTS, FRAP, and phenanthroline assays. CD showed the highest total phenol (219.8 mg GAE/g) and total flavonoid (82.8 mg QE/g extract) contents. CT showed the highest flavonol content (46.3 mg QE/g). Chlorogenic acid, 4-OH-benzoic acid, and protocatechuic acid were the main compounds detected by LC-MS/MS. Several flavonoids were also detected in CD, while only hesperidin was detected in CT. Both the species showed antioxidant properties; however, radical scavenging activity and FRAP of CD were significantly higher than CT and were comparable with positive controls. Overall, this work affords a contribution to the characterisation and valorisation of the Algerian flora.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative hard tissue bone materials from natural sources: a study on silk sericin and ruthenium-based composites. 创新的天然硬组织骨材料：丝胶和钌基复合材料的研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-24 DOI: 10.1080/14786419.2025.2509887

Senthil Rethinam

引用次数: 0

New iridoids and phenolic glycosides from nuxia congesta R.Br. ex Fresen with potential inhibitors of SARS-CoV-2 main protease and spike RBD: an in silico approach. 茯苓中新的环烯醚萜和酚类苷类化合物。SARS-CoV-2主要蛋白酶和刺突RBD潜在抑制剂的ex Fresen：一种计算机方法。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-24 DOI: 10.1080/14786419.2025.2509883

Ali A El Gamal, Shaza M Al-Massarani, Lena W M Abdelmageed, Omer A Basudan, Md Tabish Rehman, Mohamed F AlAjmi, Maged S Abdel-Kader, Mehtab Parveen, Mohamed M Hefnawy

{"title":"New iridoids and phenolic glycosides from nuxia congesta R.Br. ex Fresen with potential inhibitors of SARS-CoV-2 main protease and spike RBD: an in silico approach.","authors":"Ali A El Gamal, Shaza M Al-Massarani, Lena W M Abdelmageed, Omer A Basudan, Md Tabish Rehman, Mohamed F AlAjmi, Maged S Abdel-Kader, Mehtab Parveen, Mohamed M Hefnawy","doi":"10.1080/14786419.2025.2509883","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509883","url":null,"abstract":"The aerial parts of Nuxia congesta R.Br. ex Fresen were chromatographically purified, yielding five new compounds: two iridoids (1,2), one phenylpropanoid glycoside (3), and two rhamnosyl esters (4,5). The compounds were characterised via NMR and HRESIMS. The isolated compounds inhibitory action towards the COVID-19 major protease (Mpro) and receptor-binding domain (RBD) enzymes was evaluated. Comparative molecular docking and binding free energy analyses were conducted based on the binding affinities of the ligand binding domains of the therapeutic targets Mpro and RBD. The results indicated that all compounds effectively interacted with the binding sites of Mpro and RBD receptors, exhibiting a greater affinity for the Mpro receptor. The binding energy to Mpro ranged between -7.8 and -8.1 kcal/mol, however for RBD receptors it ranged from -7.0 to -7.3 kcal/mol. This research supports the efficacy of isolated compounds as antiviral medications, especially in the context of COVID-19.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jatropha tanjorensis J.L.Ellis & Saroja inhibited carbon tetrachloride-induced fibrogenesis in Wistar rats. 麻疯树（Jatropha tanjorensis J.L.Ellis & Saroja）抑制四氯化碳诱导的Wistar大鼠纤维生成。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-24 DOI: 10.1080/14786419.2025.2509137

Ifeoluwa T Oyeyemi, Ifeoluwa T Ajayi, Enivwenaye E W Nabofa

{"title":"Jatropha tanjorensis J.L.Ellis & Saroja inhibited carbon tetrachloride-induced fibrogenesis in Wistar rats.","authors":"Ifeoluwa T Oyeyemi, Ifeoluwa T Ajayi, Enivwenaye E W Nabofa","doi":"10.1080/14786419.2025.2509137","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509137","url":null,"abstract":"Jatropha tanjorensis has been employed to treat various diseases. This study aimed to investigate the mode of action of J. tanjorensis against liver fibrogenesis induced by carbon tetrachloride (CCl4). Liver fibrosis was induced in male Wistar rats by exposing them to CCl4 for nine weeks. From weeks 7 to 9, J. tanjorensis extract was administered. The study evaluated the activities of antioxidant enzymes and lipid peroxidation (LPO) levels, expression of TGFβ1 and fibrosis-associated proteins, and liver histology. J. tanjorensis significantly increased the depleted antioxidant activities induced by CCl4 while significantly reducing the elevated LPO levels caused by CCl4. Furthermore, it downregulated the upregulation of TGFβ1 and fibrosis-associated proteins induced by CCl4 and mitigated the liver lesions and collagen deposits resulting from CCl4 exposure. Overall, J. tanjorensis alleviated liver injury and fibrogenesis by exerting its antioxidant effect and inhibition of TGFβ1.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the glucan profile: a comparative study of Lion's Mane and Shiitake mushrooms. 揭示葡聚糖谱：狮鬃和香菇的比较研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-23 DOI: 10.1080/14786419.2025.2509142

C S Keerthana, Rozy Kumari, Muskan Beura, Sumit Sharan, Susheel Kumar Sharma, Ananta Ganjoo, Anil Dahuja, Veda Krishnan

引用次数: 0

Anti-inflammatory and anti-proliferative activities of secondary metabolites isolated from the leaves of Gymnosporia chevalieri. 雪氏裸子孢子叶次生代谢产物的抗炎和抗增殖活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-23 DOI: 10.1080/14786419.2025.2509886

Nghia Ai Thi Doan, Hanh Nhu Thi Hoang, Anh Tuan Le, Hoai Thi Nguyen, Thi Hong Van Le, Duc Viet Ho

{"title":"Anti-inflammatory and anti-proliferative activities of secondary metabolites isolated from the leaves of Gymnosporia chevalieri.","authors":"Nghia Ai Thi Doan, Hanh Nhu Thi Hoang, Anh Tuan Le, Hoai Thi Nguyen, Thi Hong Van Le, Duc Viet Ho","doi":"10.1080/14786419.2025.2509886","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509886","url":null,"abstract":"A new triterpenoid, 3,4-seco-29-hydroxyfriedelan-3-oic acid (1), was obtained from the leafy parts of Gymnosporia chevalieri, along with eighteen previously identified compounds. These included four pentacyclic triterpenoids (2-5), two carotenoids (6 and 7), one flavanol dimer (8), nine flavonoids (9-17), one megastigmane glycoside (18), and one pentose (19). A combination of spectroscopic techniques was employed for structural identification. Thirteen isolates (2, 4, 7-12, 14, 15 and 17-19) showed inhibitory activity in the macrophage NO production model, with IC50 values in the range (13.0 and 95.2 µM). Compound 14 had the most potent effect (IC50 = 13.0 µM), which was comparable to that of dexamethasone. Compounds 1, 3 and 6 exerted pronounced anti-proliferative effects against Hep-G2, A549 and MCF-7 cell lines with IC50 values in the range (9.3 and 23.6 µM). This is the first phytochemical investigation of G. chevalieri.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(±)-Rhodaulision A and B, two pairs of meroterpenoids from branches and leaves of Rhododendron dauricum L. and their anti-osteoarthritis activity. （±）-杜鹃花（rhodaulision） A和B，从杜鹃花枝叶中提取的两对萜类化合物及其抗骨关节炎活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-23 DOI: 10.1080/14786419.2025.2509297

Bei Wang, Wei Liu, Qiming Lu, Liang Xiang

引用次数: 0

Effects of monoterpenes on digestive enzymatic activities and some constituents involved in intermediary metabolism of Trogoderma granarium (Everts) (Coleoptera: Dermestidae). 单萜烯对谷物Trogoderma （Trogoderma granarium）消化酶活性及部分中间代谢成分的影响

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-23 DOI: 10.1080/14786419.2025.2507818

Meriem Soltani, Ibtissem Fatima Zahra Abes, Mouatez Djabri, Rifka Mahieddine, Chafia Saadi, Fouzia Tine-Djebbar, Samir Tine, Noureddine Soltani

{"title":"Effects of monoterpenes on digestive enzymatic activities and some constituents involved in intermediary metabolism of Trogoderma granarium (Everts) (Coleoptera: Dermestidae).","authors":"Meriem Soltani, Ibtissem Fatima Zahra Abes, Mouatez Djabri, Rifka Mahieddine, Chafia Saadi, Fouzia Tine-Djebbar, Samir Tine, Noureddine Soltani","doi":"10.1080/14786419.2025.2507818","DOIUrl":"https://doi.org/10.1080/14786419.2025.2507818","url":null,"abstract":"Our study aims to evaluate the repellency and fumigant toxicity profiles of 3 essential oil components (EOCs) namely Limonene, Menthol and Linalool against Trogoderma granarium last instar larvae. Limonene is the most toxic chemical tested. Various parameters are examined, including digestive enzymes, enzymes of intermediary metabolism (alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST)), and oxidative stress biomarker (esterase). The results highlight the insecticidal efficacy and repellent activity of three EOCs, which is correlated with the applied concentrations and the exposure time. Furthermore, the biochemical analyses indicate that the treatment significantly decreases the activity of digestive enzymes such as protease, α-amylase, chitinase and lipase, and triglyceride levels. The specific activity of enzymes related to intermediary metabolism reveals an increase in the level of ALT, ALP and AST in treated T. granarium larvae compared to controls. Finally, EOCs also increase the esterase activity in treated larvae compared to controls.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyllosticta capitalensis: a novel source of Guignardone A, a high-affinity ligand for penicillin-binding proteins. 毛缕虫：桂树酮a的新来源，桂树酮a是青霉素结合蛋白的高亲和力配体。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-22 DOI: 10.1080/14786419.2025.2509879

Dhilna Sunny Chingath, Usha Bhagirathan, Leyon Varghese

{"title":"Phyllosticta capitalensis: a novel source of Guignardone A, a high-affinity ligand for penicillin-binding proteins.","authors":"Dhilna Sunny Chingath, Usha Bhagirathan, Leyon Varghese","doi":"10.1080/14786419.2025.2509879","DOIUrl":"https://doi.org/10.1080/14786419.2025.2509879","url":null,"abstract":"Endophytic fungi from Pleurolobus gangeticus were isolated, clone purified, identified and subjected to liquid state fermentation. Ethyl acetate extracts of the fermentation product was prepared for antibacterial testing against gram-negative and gram-positive bacteria. Out of the four endophytes isolated, Phyllosticta capitalensis (DLa) showed strong antibacterial activity in the disc diffusion assay with maximum zone of inhibition (27.3 ± 0.6 mm). DLa also had a very low value for Minimum Inhibitory Concentration (10 µg/mL) against all the tested bacteria, indicating its strong broad-spectrum activity. The phytochemical characterisation of DLa showed a meroterpenoid named Guignardone A and three Cyclic dipeptides. In silico studies indicated strong binding affinity between Guignardone A and various penicillin-binding proteins (PBP1, PBP2, PBP2a, PBP3, PBP4 and PBP5) of the above tested bacteria. Further studies are ongoing for optimising the fermentation conditions of P. capitalensis for the enhanced production of Guignardone A.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0