In vitro and in silico evaluation of Turbinaria ornata-derived compounds: elucidating mechanisms of anticandidal and anticancer activities.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-14 DOI:10.1080/14786419.2025.2569808

Priyanka K R, Ramalingam Vaikundamoorthy, Rajaram Rajendran, Swathi Chandran Manimegalai, Kadalmani Balamuthu

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引用次数: 0

Abstract

Candida genera play a crucial role as infectious pathogens in humans and have the ability to form biofilms, which impede the efficacy of antifungal medications, thereby elevating resistance levels. In this present study, the extracts of Turbinaria ornata were used for the treatment of clinical isolates of Candida species, and UPLC-ESI-Q-TOF MSE was employed for the chemical profiling of macroalgae extracts. The methanol extract of T. ornata has excellent with MIC (125 mg/mL), particularly against C. krusei by reduction of adhesion compared with acetone and ethyl acetate extracts. The toxicity assay has been assessed by the nauplii stage in Artemia salina. The LC₅₀ value for cultured control and treated A549 and 3T3 cells was noted as ≥1000 µg/µL and 292.35 µg/µL, respectively. Isofucosterol exhibits the maximum docking score among the targeted protein molecules. The current study shows the efficient of Turbinaria ornata extract against candidiasis and lung cancer.

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刺鼻草衍生化合物的体外和计算机评价：阐明抗药和抗癌活性的机制。

念珠菌属在人类中作为感染性病原体发挥着至关重要的作用，并具有形成生物膜的能力，这阻碍了抗真菌药物的功效，从而提高了耐药性水平。本研究采用Turbinaria ornata提取物对临床分离的念珠菌进行治疗，并采用UPLC-ESI-Q-TOF MSE对大型藻类提取物进行化学分析。与丙酮和乙酸乙酯提取物相比，桔梗甲醇提取物（125 mg/mL）具有较好的MIC抑制作用，特别是对克鲁塞蝇的抑制作用。采用盐渍蒿（Artemia salina）的nauplii期进行毒性试验。A549和3T3细胞的LC50值分别为≥1000µg/µL和292.35µg/µL。异焦甾醇在靶蛋白分子中显示出最大的对接分数。目前的研究表明，鸟鼻藿提取物对念珠菌病和肺癌有有效的治疗作用。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.