枸杞藤本植物中新8-O-4′木脂素和酚类葡萄糖苷的分离与结构分析。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-14 DOI:10.1080/14786419.2025.2571851

Truong Nhat Van Do, Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Thanh Thi Nguyen

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引用次数: 0

摘要

本研究在黄嘌呤氧化酶抑制作用的指导下，成功分离并鉴定了两种新的酚类化合物montanumgams A-B（1-2）和15种已知化合物（3-17）。通过核磁共振波谱（1D和2D-NMR）、ESI高分辨率质谱（hresms）分析以及与参考数据的对比，对它们的化学结构进行了鉴定。黄嘌呤氧化酶抑制活性表明，化合物1具有较强的抑制作用，IC50值为16.6µM，而阳性对照别嘌呤醇（IC50值为2.5µM）。

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Isolation and structural elucidation of new 8-O-4' neolignan and phenolic glucoside from the lianas of gnetum montanum markgr.

In this study, the bioactivity guided by xanthine oxidase inhibition successfully isolated and characterised two new phenolic compounds named montanumgams A-B (1-2) together with fifteen known compounds (3-17) from the lianas of Gnetum montanum Markgr. Their chemical structures were elucidated by analysing nuclear magnetic resonance spectroscopy (1D and 2D-NMR), ESI high-resolution mass spectrometry (HRESIMS), and comparison with reference data. The activity of xanthine oxidase inhibition revealed that compound 1 has potent inhibitory effects, exhibiting IC₅₀ values of 16.6 µM, compared to a positive control, allopurinol (IC₅₀, 2.5 µM).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.