{"title":"刺鼻草衍生化合物的体外和计算机评价：阐明抗药和抗癌活性的机制。","authors":"Priyanka K R, Ramalingam Vaikundamoorthy, Rajaram Rajendran, Swathi Chandran Manimegalai, Kadalmani Balamuthu","doi":"10.1080/14786419.2025.2569808","DOIUrl":null,"url":null,"abstract":"<p><p><i>Candida</i> genera play a crucial role as infectious pathogens in humans and have the ability to form biofilms, which impede the efficacy of antifungal medications, thereby elevating resistance levels. In this present study, the extracts of <i>Turbinaria ornata</i> were used for the treatment of clinical isolates of <i>Candida</i> species, and UPLC-ESI-Q-TOF MSE was employed for the chemical profiling of macroalgae extracts. The methanol extract of <i>T. ornata</i> has excellent with MIC (125 mg/mL), particularly against <i>C. krusei</i> by reduction of adhesion compared with acetone and ethyl acetate extracts. The toxicity assay has been assessed by the nauplii stage in <i>Artemia salina</i>. The LC<sub>50</sub> value for cultured control and treated A549 and 3T3 cells was noted as ≥1000 µg/µL and 292.35 µg/µL, respectively. Isofucosterol exhibits the maximum docking score among the targeted protein molecules. The current study shows the efficient of <i>Turbinaria ornata</i> extract against candidiasis and lung cancer.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>In vitro</i> and <i>in silico</i> evaluation of <i>Turbinaria ornata</i>-derived compounds: elucidating mechanisms of anticandidal and anticancer activities.\",\"authors\":\"Priyanka K R, Ramalingam Vaikundamoorthy, Rajaram Rajendran, Swathi Chandran Manimegalai, Kadalmani Balamuthu\",\"doi\":\"10.1080/14786419.2025.2569808\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Candida</i> genera play a crucial role as infectious pathogens in humans and have the ability to form biofilms, which impede the efficacy of antifungal medications, thereby elevating resistance levels. In this present study, the extracts of <i>Turbinaria ornata</i> were used for the treatment of clinical isolates of <i>Candida</i> species, and UPLC-ESI-Q-TOF MSE was employed for the chemical profiling of macroalgae extracts. The methanol extract of <i>T. ornata</i> has excellent with MIC (125 mg/mL), particularly against <i>C. krusei</i> by reduction of adhesion compared with acetone and ethyl acetate extracts. The toxicity assay has been assessed by the nauplii stage in <i>Artemia salina</i>. The LC<sub>50</sub> value for cultured control and treated A549 and 3T3 cells was noted as ≥1000 µg/µL and 292.35 µg/µL, respectively. Isofucosterol exhibits the maximum docking score among the targeted protein molecules. The current study shows the efficient of <i>Turbinaria ornata</i> extract against candidiasis and lung cancer.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2569808\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2569808","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
In vitro and in silico evaluation of Turbinaria ornata-derived compounds: elucidating mechanisms of anticandidal and anticancer activities.
Candida genera play a crucial role as infectious pathogens in humans and have the ability to form biofilms, which impede the efficacy of antifungal medications, thereby elevating resistance levels. In this present study, the extracts of Turbinaria ornata were used for the treatment of clinical isolates of Candida species, and UPLC-ESI-Q-TOF MSE was employed for the chemical profiling of macroalgae extracts. The methanol extract of T. ornata has excellent with MIC (125 mg/mL), particularly against C. krusei by reduction of adhesion compared with acetone and ethyl acetate extracts. The toxicity assay has been assessed by the nauplii stage in Artemia salina. The LC50 value for cultured control and treated A549 and 3T3 cells was noted as ≥1000 µg/µL and 292.35 µg/µL, respectively. Isofucosterol exhibits the maximum docking score among the targeted protein molecules. The current study shows the efficient of Turbinaria ornata extract against candidiasis and lung cancer.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
