{"title":"苍术茎叶提取物促生长作用及机制研究。尼罗罗非鱼。","authors":"Wei Tian, Ziying Wang, Dongdong Shi, Zhiwei Huang, Yuefei Liu, Xiumei Li","doi":"10.1080/14786419.2025.2570511","DOIUrl":null,"url":null,"abstract":"<p><p>Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated <i>Atractylodes lancea</i> DC. extract (ALE) on <i>Lactiplantibacillus plantarum</i> growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study on a growth promoting effect and mechanism of the extract of stem and leaf from <i>Atractylodes lancea</i> DC. on nile tilapia.\",\"authors\":\"Wei Tian, Ziying Wang, Dongdong Shi, Zhiwei Huang, Yuefei Liu, Xiumei Li\",\"doi\":\"10.1080/14786419.2025.2570511\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated <i>Atractylodes lancea</i> DC. extract (ALE) on <i>Lactiplantibacillus plantarum</i> growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2570511\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2570511","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Study on a growth promoting effect and mechanism of the extract of stem and leaf from Atractylodes lancea DC. on nile tilapia.
Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated Atractylodes lancea DC. extract (ALE) on Lactiplantibacillus plantarum growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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