从马齿苋中分离到了两个新的生物碱，并对它们的生物活性进行了研究。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-14 DOI:10.1080/14786419.2025.2572535

Jing Liu, Xiaoqian Zhang, Hongzhe Zhang, Junjie Yao, Shengnan Guo, Aijing Leng, Xixiang Ying

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引用次数: 0

摘要

马齿苋在中国古代常用于治疗结肠炎，但其治疗物质尚不清楚。由于生物碱是该植物的主要化学成分，因此本研究对其进行了研究。从马蹄苋中分离得到化合物oleraglycerolpyridin(1)和olerapyrrolidinone(2)，通过NMR和HR-MS对其结构进行了验证，并分别采用ELISA法测定IL-1β、TNF-α和改良Ellman法测定其乙酰胆碱酯酶活性。

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Two new alkaloids were isolated from Portulaca oleracea L. and their bioactivities.

Portulaca oleracea L. was commonly used to treat colitis in ancient China, but the therapeutic substances were unclear. As alkaloids are the major chemical compositions of the plant, they were therefore investigated in this research. The compounds oleraglycerolpyridin (1) and olerapyrrolidinone (2) were separated from the Portulaca oleracea L. The structures were verified by NMR and HR-MS, subsequently, their bioactivities were respectively evaluated by determination of IL-1β, TNF-α by ELISA method, and acetylcholinesterase activities by modified Ellman's method.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.