Truong Nhat Van Do, Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Thanh Thi Nguyen
{"title":"Isolation and structural elucidation of new 8-<i>O</i>-4' neolignan and phenolic glucoside from the lianas of <i>gnetum montanum</i> markgr.","authors":"Truong Nhat Van Do, Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Thanh Thi Nguyen","doi":"10.1080/14786419.2025.2571851","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571851","url":null,"abstract":"<p><p>In this study, the bioactivity guided by xanthine oxidase inhibition successfully isolated and characterised two new phenolic compounds named montanumgams A-B (<b>1</b>-<b>2</b>) together with fifteen known compounds (<b>3</b>-<b>17</b>) from the lianas of <i>Gnetum montanum</i> Markgr. Their chemical structures were elucidated by analysing nuclear magnetic resonance spectroscopy (1D and 2D-NMR), ESI high-resolution mass spectrometry (HRESIMS), and comparison with reference data. The activity of xanthine oxidase inhibition revealed that compound <b>1</b> has potent inhibitory effects, exhibiting IC<sub>50</sub> values of 16.6 µM, compared to a positive control, allopurinol (IC<sub>50</sub>, 2.5 µM).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring aroma profiles of <i>gardenia jasminoides</i> flowers and leaves by HS-gC-MS.","authors":"Xiangyang Guo","doi":"10.1080/14786419.2025.2570892","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570892","url":null,"abstract":"<p><p>The aroma characteristics of flowers and leaves from <i>G. jasminoides</i> were comprehensively explored using HS-GC-MS technology, coupled to relative odour activity value (rOAV) determination and PCA analysis. A total of 116 volatiles were identified in <i>G. jasminoides</i>, with 71 common volatiles detected in both the leaves (GJ-L) and flowers (GJ-F). Alkenes were found to be the most abundant volatiles in both samples, both in terms of quantity and relative abundance. Notably, 2,3-butanedione (rOAV = 100) was identified as the key contributor to buttery aroma in GJ-F, while 3-methylbutanal (rOAV = 100) was the principal contributor to fruity odour in GJ-L. PCA further revealed significant differences in the aroma characteristics between GJ-F and GJ-L. This study enhances our understanding of the volatile compositions and odour characteristics of different parts (flowers and leaves) of <i>G. jasminoides</i>, providing a theoretical basis for the development and utilisation of products derived from <i>G. jasminoides</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gehan F Abdel Raoof, Eman A Younis, Hanan F Aly, Hala M Mohamed Nagy
{"title":"Pancake evaluation, phytochemical characterization, and therapeutic potential of <i>Cichorium intybus</i> L. herb: a focus on antioxidant, antidiabetic, and anticholinesterase activities.","authors":"Gehan F Abdel Raoof, Eman A Younis, Hanan F Aly, Hala M Mohamed Nagy","doi":"10.1080/14786419.2025.2572534","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572534","url":null,"abstract":"<p><p>The current research evaluated the different extracts of <i>Cichorium intybus</i> L. (chicory) herbs for their antioxidant, anticholinesterase and antidiabetic activities. It investigated the phytoconstituents of the most active fraction. In addition, pancake samples of chicory were prepared and evaluated for their nutritional values and sensory scores. The result revealed that the <i>n</i>-butanol fraction exhibited the highest biological activities. Moreover, LC-ESI-MS/MS analysis of the <i>n</i>-butanol fraction revealed the identification of 17 phenolic compounds. Furthermore, gallic and pyrogallic acids were isolated and identified from the <i>n</i>-butanol fraction. In addition, glutamic and aspartic acids were the major amino acids in chicory herbs. Furthermore, HPLC analysis of the vitamins revealed that vitamins B6 and E constituted the greatest concentration. In addition, the panellists found that supplementing chicory herb powder to oats was most acceptable. In conclusion, chicory herbs may be used in the food industry due to their safety, high nutritional value and acceptability.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juanjuan Liu, Ya Gao, Hu Chen, Guoyong Luo, Shaoping Yang
{"title":"Design, synthesis, and molecular docking study of isopimaroyl 1,2,4-triazole-thioether derivatives as anti-tumor agents.","authors":"Juanjuan Liu, Ya Gao, Hu Chen, Guoyong Luo, Shaoping Yang","doi":"10.1080/14786419.2025.2566472","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566472","url":null,"abstract":"<p><p>To develop highly effective natural anti-tumor agents, 12 isopimaroyl 1,2,4-triazole-thioether compounds were designed and synthesised. Anti-tumor activity tests showed that the majority of these target compounds exhibited moderate to excellent inhibitory effects against HepG2, K562, and PC-3 cells, with a particular selectivity for PC-3 cells. Compound <b>5 g</b> demonstrated promising anticancer activity against HepG2 cells, surpassing the reference drug 5-FU. Compound <b>5k</b> exhibited comparable activity to 5-FU against K562 cells. Additionally, the <i>p</i>-NO<sub>2</sub> substituted compounds <b>5h</b> and <b>5l</b> displayed the most significant anti-tumor activity, with IC<sub>50</sub> values of 7.42 ± 1.45 μmol/L and 8.38 ± 1.67 μmol/L, respectively. Molecular docking studies further revealed a docking model of compound <b>5h</b> with 5ds3 protein, suggesting its potential as a promising anti-PC-3 drug.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on a growth promoting effect and mechanism of the extract of stem and leaf from <i>Atractylodes lancea</i> DC. on nile tilapia.","authors":"Wei Tian, Ziying Wang, Dongdong Shi, Zhiwei Huang, Yuefei Liu, Xiumei Li","doi":"10.1080/14786419.2025.2570511","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570511","url":null,"abstract":"<p><p>Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated <i>Atractylodes lancea</i> DC. extract (ALE) on <i>Lactiplantibacillus plantarum</i> growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Bellal Hoque, Md Abdul Hannan, Papia Haque, Sushanta Tappo
{"title":"Multi-solvent extraction, quantification and characterisation of tannin from <i>Neltuma juliflora</i> bark: a pathway to sustainable utilisation.","authors":"Mohammad Bellal Hoque, Md Abdul Hannan, Papia Haque, Sushanta Tappo","doi":"10.1080/14786419.2025.2572037","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572037","url":null,"abstract":"<p><p>This research investigates the extraction, quantification and characterisation of tannin from the bark of <i>Neltuma juliflora</i> (Sw.) Raf. (<i>N. juliflora</i>, formerly known as <i>Prosopis juliflora</i> (Sw.) DC.), an invasive species that is widely available but underutilised. Various solvent extraction techniques, including single-phase, combined and sequential extractions, were evaluated. The highest tannin yield (85%) was obtained with 4% NaOH in single-phase extraction, while combined extraction resulted in the highest tannin purity (85.91%). Sequential extraction demonstrated solvent selectivity, with methanol producing the highest extract (93.6%) and acetone yielding a highly purified fraction (83.14%). The presence of essential tannin functional groups was validated by Fourier Transform Infra-red (FTIR) spectroscopy. The analysis of band gap energy indicated values between 4.00 and 5.09 eV, varying with the extraction method. These findings underscore <i>N. juliflora</i> as a promising sustainable tannin source, which offers an eco-friendly alternative to conventional sources and supports invasive species control efforts.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander S Tikhomirov, Svetlana E Solov'eva, Tatiana S Shkuratova, Natalya M Malyutina, Daria V Andreeva, George V Zatonsky, Natalia E Grammatikova, Andrey E Shchekotikhin
{"title":"Isolation of cyclic decapeptide antibiotics related to gramicidin S.","authors":"Alexander S Tikhomirov, Svetlana E Solov'eva, Tatiana S Shkuratova, Natalya M Malyutina, Daria V Andreeva, George V Zatonsky, Natalia E Grammatikova, Andrey E Shchekotikhin","doi":"10.1080/14786419.2025.2568953","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568953","url":null,"abstract":"<p><p>Natural products remain to be an important source for the development of antibacterial agents. In this study, we isolated and evaluated the key biological properties of minor components of the gramicidin S (GS) antibiotic complex produced by <i>Bacillus brevis</i> var. G-B R<sup>+</sup>. Using HPLC techniques, we obtained highly pure samples of GS and its five major related components in individual form. Structures of isolated compounds were assigned as GS homologues, featuring several amino acid residue substitutions, two of which are previously undescribed. Antibacterial activity of new cyclic decapeptides was close to GS, while two of five isolated compounds demonstrated up to 4 times reduced haemolysis. Circular dichroism spectra of GS homologues and the parental antibiotic exhibited the same β-structure conformation. Taken together, this study demonstrates that analysis of minor components of antibiotic complexes could result in the discovery of new antibacterial compounds with better efficacy or favourable therapeutic profile.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Cascabela thevetia</i> (L.) lippold.- a review on its phytochemistry, pharmacology and toxicity.","authors":"Bhagya N","doi":"10.1080/14786419.2025.2572039","DOIUrl":"https://doi.org/10.1080/14786419.2025.2572039","url":null,"abstract":"<p><p><i>Cascabela thevetia</i> (L.) Lippold. is an ornamental plant with traditional medicinal uses to treat oedema, diuretic, and cardiac disorders. The current review investigate the methods involved in the extraction and characterisation of phytochemicals from different parts of <i>C. thevetia.</i> In addition, the pharmacological potential, safety and toxicity of isolated pure phytochemicals from this plant were discussed in detail. The current review lists out a total of 81 phytochemicals that belong to terpenes, phenolics and flavonoids. The pharmacological potential of cardiac glycosides and flavonoids isolated from <i>C. thevetia</i> exhibited potent cytotoxic, antiviral and insecticidal activities under <i>in vitro</i> conditions. However, other pharmacological potentials and toxic effects of the isolated phytochemicals are not thoroughly investigated.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design, synthesis, and biological activities of novel camphoric acid derivatives bearing <i>α</i>-aminophosphonate moiety.","authors":"Yunfeng Shen, Wanli Zheng, Mingjun Zhu, Xianli Ma, Caina Jiang, Fangyao Li","doi":"10.1080/14786419.2025.2566464","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566464","url":null,"abstract":"<p><p>In light of the broad-spectrum biological activities of camphor and α-aminophosphonate, a series of camphor acid derivatives incorporating α-aminophosphonate moieties were rationally designed, synthesised, and evaluated for their biological activities. The target compounds were characterised using IR,<sup>1</sup>H NMR,<sup>13</sup>C NMR, and ESI-MS techniques. Preliminary bioassays revealed compound <b>5a</b> displayed a 93.7% inhibitory effect, while compound <b>5i</b> showed a 96.2% inhibitory effect against <i>B. dothidea</i> when tested at a concentration of 50 mg/L, much better than that of the positive control Chlorothalonil. Herbicidal evaluations revealed that at 100 mg/L, the growth inhibition rates of compounds <b>5a</b>, <b>5c</b>, <b>5f</b>, and <b>5h</b> on the roots of rape (Brassica campestris) were 81.5%, 82.8%, 81.2%, and 96.6%, respectively, much better than that of the positive control Flumioxazin. Preliminary insecticidal assays suggested that the introduction of α-aminophosphonate significantly enhanced the insecticidal activity of the parent compound. This investigation establishes a proof-of-concept foundation, indicating that the drug design strategy could be effectively applied in agrochemical research.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolation and identification of diverse steroids as <i>Escherichia coli β</i>-glucuronidase inhibitors from the Submerge-cultured mycelia of <i>Hirsutella sinensis</i>.","authors":"Youmin Ying, Xiaoxiao Chen, Ling Li, Jianwei Wang, Yun Zhang, Wei Mao, Weiguang Shan, Sha Xu","doi":"10.1080/14786419.2025.2571857","DOIUrl":"https://doi.org/10.1080/14786419.2025.2571857","url":null,"abstract":"<p><p>The ethanol extract of the submerge-cultured mycelia of <i>Hirsutella sinensis</i> (SCMHS) inhibited the <i>Escherichia coli β</i>-glucuronidase (EcGUS) <i>in vitro</i>. In-depth chemical investigation furnished 26 steroids, including a new compound hirsusterol A (<b>1</b>) featuring a rare 14,15-<i>seco</i> steroidal moiety and 25 known compounds with varied chemical diversity. The plausible biosynthetic pathway for hirsusterol A (<b>1</b>) was proposed. Except for ergosterol (<b>22</b>) and ergosterol peroxide (<b>23</b>), all the other compounds have never been obtained from <i>H. sinensis</i> previously. Compounds <b>8</b> and <b>23</b> were found to be potent uncompetitive inhibitors of EcGUS. This is the first report of these two steroids as EcGUS inhibitors. The findings of this study preliminary clarified the active ingredient underlying the EcGUS inhibition activity of SMCHS and provided potential drug leads for the development of new EcGUS inhibitors.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}