Natural Product Research最新文献_第3页

A new aglycone derivative from the saprophytic fungus Tubeufia rubra.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-17 DOI: 10.1080/14786419.2024.2424391

Xin Li, Wen Zheng, Long Han, Zhang-Jiang He, Ji-Chuan Kang

引用次数: 0

Two new sesquiterpene eudesmanolides from the Croton cascarilloides Raeusch.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2442102

Tian-Yi Liu, Hong-Li Liu, Xi Jiang, Qiong Liu, Jing-Jie Bai, Ze-Ying Guo, Zheng Zhang, Ji-Hai Shang, Cheng-Shan Yuan

引用次数: 0

A new cadinane-type sesquiterpenoid glucoside from Centaurea alexandrina.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2440930

Ibrahim A Saleh, Wael M Elsayed, Taha A Hussien, Abdelsamed I Elshamy, Tarik A Mohamed, Mohamed-Elamir F Hegazy

引用次数: 0

Antimalarial and antimicrobial substances from the endophytic fungus Chaetomium globosum BCC71876. 内生真菌球茶菰 BCC71876 的抗疟和抗菌物质。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2440800

Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Wilunda Choowong, Pranee Rachtawee, Chitti Thawai, Pattama Pittayakhajonwut

{"title":"Antimalarial and antimicrobial substances from the endophytic fungus Chaetomium globosum BCC71876.","authors":"Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Wilunda Choowong, Pranee Rachtawee, Chitti Thawai, Pattama Pittayakhajonwut","doi":"10.1080/14786419.2024.2440800","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440800","url":null,"abstract":"Three previously undescribed compounds including 2',3'-dihydroxy-4,5',4″-trimethoxy-p-terphenyl (1), 5-methoxyhydroperoxyco-chliodinol (2), and 5-(3',3'-dimethylallyl)indole-3-oxoacetic acid (17), along with fifteen known compounds (3 - 16 and 18), were isolated from the endophytic fungus, Chaetomium globosum BCC71876. The chemical structures were determined by NMR spectral information as well as the comparison with those closely related compounds reported in the literature. The compounds isolated were evaluated for biological properties including antimalarial, anti-TB, anti-plant pathogenic fungal, antibacterial, and cytotoxicity. The isolated compounds exhibited a wide range of biological activities against the tested cell lines and showed very low cytotoxicity against both cancerous (MCF-7 and NCI-H187) and non-cancerous (Vero) cells, except for compounds 5, 10, 11, 17, and 18 (IC50 0.47 - 114.8 µM). Cochliodinol (5) had the strongest antimalarial activity (IC50 4.39 µM), whereas chaetomugilin J (11) showed the strongest anti-TB activity (MIC 3.13 µg/mL).","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imperatorin, a natural furanocoumarin alleviates chronic neuropathic pain by targeting GABAergic tone in an animal model of spinal cord injury.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2440533

Ayub Mohammed Butt, Manjeet Chopra, Ankita Bhagwani, Zarna Pathak, Kishori Jadhav, Rohini Jadhav, Pooja Tarde, Parusu Kavya Teja, Suraj Kutre, A Hariharan, Alisha Vartak, Siddheshwar K Chauthe, Hemant Kumar

{"title":"Imperatorin, a natural furanocoumarin alleviates chronic neuropathic pain by targeting GABAergic tone in an animal model of spinal cord injury.","authors":"Ayub Mohammed Butt, Manjeet Chopra, Ankita Bhagwani, Zarna Pathak, Kishori Jadhav, Rohini Jadhav, Pooja Tarde, Parusu Kavya Teja, Suraj Kutre, A Hariharan, Alisha Vartak, Siddheshwar K Chauthe, Hemant Kumar","doi":"10.1080/14786419.2024.2440533","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440533","url":null,"abstract":"Chronic neuropathic pain (CNP) caused by spinal cord injury (SCI) has long-term implications, that result in functional deficit. In this study, we explored imperatorin, a natural furanocoumarin isolated from the dried pulp of Aegle marmelos L. Imperatorin (10 mg/kg, i.p.) was administered to injured animals for seven consecutive days. It was discovered that imperatorin reduced the CNP by upregulating the expression of anti-inflammatory chemokines and cytokines like IL-10 and IL-12, and increasing the expression of GABA with p-value < 0.001 as compared to vehicle at DPI-28 and DPI-42. Also, GABA receptor expression was increased with p-value < 0.01 as compared to vehicle at DPI-28. Additionally, it downregulated the expression of various proinflammatory mediators like IL-6 (p-value < 0.01), CCL-2 (p-value < 0.01), IL-1β (p-value < 0.01), and CCL-3 (p-value < 0.001) as compared to vehicle at DPI-1. Furthermore, imperatorin reduced scar formation by decreasing fibrosis and gliosis post-SCI and also lessened pain behaviour, suggesting it helps reduce chronic neuropathic pain (CNP).","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids from the whole plants of limonium sinense and their anti-inflammatory activity. 从 limonium sinense 全株中提取的黄酮类化合物及其抗炎活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2440515

Ban-Ban Li, Shao-Wei Sun, Shuang Miao, Li-Juan Yang, Xin-Yu Meng, Kai-Kai Gong, Shi-Zhou Qi, Jin-Jie Zhang

引用次数: 0

Polyhydroxyalkanes from Pachysandra terminalis Sieb. et Zucc. Pachysandra terminalis Sieb. et Zucc.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-16 DOI: 10.1080/14786419.2024.2441497

Yuying Zhang, Chenwang Liu, Chuanming Gong, Yao Wu, Yu Sun, Yuze Li, Wei Wang, Xiaomei Song, Dongdong Zhang

引用次数: 0

Cotteslosin D, a new cyclopentapeptide from a sponge-derived fungus Aspergillus versicolour 2-18. Cotteslosin D，一种来自海绵真菌 Aspergillus versicolour 2-18 的新型环戊肽。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-14 DOI: 10.1080/14786419.2024.2441495

Maokun Zheng, Zheng Huang, Yanxiu Zheng, Yukun Tang, Jun Wang, Shengpu Yang

引用次数: 0

New α-glucosidase inhibitors and antioxidants in optimized Psychotria malayana Jack leaves extract identified by gC-MS-based metabolomics and in silico molecular docking. 通过基于 gC-MS 的代谢组学和硅学分子对接，在优化的 Psychotria malayana Jack 叶提取物中发现新的α-葡萄糖苷酶抑制剂和抗氧化剂。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-14 DOI: 10.1080/14786419.2024.2440789

Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat So'ad, Qamar Uddin Ahmed, Zalikha Ibrahim, Mohd Zuwairi Saiman, Dewi Melani Hariyadi, Agus Susilo, Mohammad Shahzad Samdani, Syed Atif Abbas, Mahibub Mahamadsa Kanakal, Abdullah Khan, Mohammad Kashif

{"title":"New α-glucosidase inhibitors and antioxidants in optimized Psychotria malayana Jack leaves extract identified by gC-MS-based metabolomics and in silico molecular docking.","authors":"Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat So'ad, Qamar Uddin Ahmed, Zalikha Ibrahim, Mohd Zuwairi Saiman, Dewi Melani Hariyadi, Agus Susilo, Mohammad Shahzad Samdani, Syed Atif Abbas, Mahibub Mahamadsa Kanakal, Abdullah Khan, Mohammad Kashif","doi":"10.1080/14786419.2024.2440789","DOIUrl":"https://doi.org/10.1080/14786419.2024.2440789","url":null,"abstract":"Our earlier research demonstrated α-glucosidase inhibitory (AGI) and antioxidant activities of the optimised extract of Psychotria malayana leaves. It was reported having numerous compounds, although it was unclear which compounds exhibit the bioactivities as well as their binding interaction to the enzyme. This study aimed to identify the compounds possessing AGI and antioxidant activities in the extract utilising GC-MS-based metabolomics, and to analyse the ligand-enzyme binding interactions via in-silico molecular docking. A partial least square was employed to correlate the metabolite profile and bioactivities. The loading plot reveals the bioactive compounds in this extract. The AGI activity of 1-cyclohexene-1-carboxylic, propanoic, butanedioic and D-gluconic acid together with the antioxidant activity of some compounds were reported for the first time through this study. The docking study reveals that all compounds, except for 1-cyclohexene-1-carboxylic acid, exhibit binding to the enzyme's catalytic site. This discovery demonstrates the potential of this plant for diabetes therapy.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from a new source, Haplanthodes tentaculatus: characterization and anticancer activity. 从一种新资源 Haplanthodes tentaculatus 中分离出 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone: 特征和抗癌活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-14 DOI: 10.1080/14786419.2024.2441491

Parth B Trivedi, Madhavi Badole

引用次数: 0