Natural Product Research最新文献_第3页

Characterisation of the essential oil from Iphiona grantioides and investigation of its antibacterial and antioxidant properties. 颗粒硫醚精油的表征及其抗菌和抗氧化性能的研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-26 DOI: 10.1080/14786419.2023.2272782

Shah Iram Niaz, Muhammad Ali, Muhammad Saleem, Rubina Qaisrani, Kamran Safdar, Malik Muhammad Akram, Abdur Rauf, Maqbool Ahmad, Sanaullah Abbasi, Taghrid S Alomar, Najla AlMasoud, Giovanni Ribaudo

引用次数: 0

In-vitro cytotoxic potential of aerial parts of Leutea avicennae Mozaff. in different Human cancer cell lines. 莫扎夫白茶地上部分的体外细胞毒性潜力。在不同的人类癌症细胞系中。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-27 DOI: 10.1080/14786419.2023.2275286

Mahsa Sabernavaei, Hamed Montazeri, Parastoo Mirzabeigi, Paria Sharafi-Badr, Mozhdeh Zamani, Abbas Hadjiakhoondi, Narguess Yassaa, Farzad Kobarfard

{"title":"In-vitro cytotoxic potential of aerial parts of Leutea avicennae Mozaff. in different Human cancer cell lines.","authors":"Mahsa Sabernavaei, Hamed Montazeri, Parastoo Mirzabeigi, Paria Sharafi-Badr, Mozhdeh Zamani, Abbas Hadjiakhoondi, Narguess Yassaa, Farzad Kobarfard","doi":"10.1080/14786419.2023.2275286","DOIUrl":"10.1080/14786419.2023.2275286","url":null,"abstract":"Medicinal plants such as Leutea avicennae Mozaff. (Apiaceae) have been shown some biological potential for preventing and treating diseases. Fractions and isolated compounds were tested on colon carcinoma (HT-29), cervical carcinoma (HeLa), breast carcinoma (MCF-7), and mouse embryonic fibroblast (NIH/3T3) cell lines. The BSLT method was used for the assessment of the general toxicity of the petroleum ether (PET), chloroform (CHCl3), ethyl acetate (EtOAc), and methanol (MeOH) fractions obtained from the aerial parts of L. avicennae. 1H-NMR and 13 C-NMR spectroscopy were used for structure elucidation. Five compounds, including two coumarins, osthole and umbelliferone, a diterpene phytol, β-sitosterol, and lauric acid, were isolated for the first time from L. avicennae. Osthole showed potent cytotoxic activity against MCF-7 and HT-29 cell lines with IC50 values of 4.23 ± 0.26 and 12.11 ± 0.13 µg/mL, respectively. Phytol demonstrated potent cytotoxic activity towards MCF-7 and HeLa cell lines with IC50 values of 6.80 ± 0.08 and 12.27 ± 0.18 µg/mL, respectively.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4098-4105"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54230235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin. 赤藓的镇痛作用及主要成分獐牙菜苦苷的分子对接研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-10 DOI: 10.1080/14786419.2023.2278160

Sarra Chabane, Amel Boudjelal, Souhila Bouaziz-Terrachet, Eleonora Spinozzi, Filippo Maggi, Riccardo Petrelli, Ghania Tail

{"title":"Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin.","authors":"Sarra Chabane, Amel Boudjelal, Souhila Bouaziz-Terrachet, Eleonora Spinozzi, Filippo Maggi, Riccardo Petrelli, Ghania Tail","doi":"10.1080/14786419.2023.2278160","DOIUrl":"10.1080/14786419.2023.2278160","url":null,"abstract":"Centaurium erythraea Rafn is employed in Algerian traditional medicine for treating pain. The analgesic activity of the ethanolic extract (EE) from the flowering aerial parts of this plant was examined, and molecular docking of the main bioactive compound was performed. The EE, characterised by the iridoid swertiamarin, was administered to Wistar albino rats in pain models. Peripheral analgesic activity was evaluated using the acetic acid-induced writhing test, and a hot plate test was performed for central antinociceptive activity evaluation. Treatment with EE significantly decreased rats' writhing induced by acetic acid suggesting peripheral analgesic activity. Furthermore, the elevation of mean basal reaction time in the hot plate method indicated central analgesic activity. Molecular docking studies showed good docking energy with acceptable binding interactions of swertiamarin with cyclooxygenase-2 protein. This supports the analgesic activity of C. erythraea EE, justifying the traditional use of the plant as an analgesic herbal remedy.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4511-4517"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells. 贯叶连翘橄榄油提取物对结直肠癌细胞和人骨髓干细胞的细胞毒性和抗转移作用。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-11 DOI: 10.1080/14786419.2023.2280715

Hatice Yildirim, Burcu Efe Daşkan

引用次数: 0

Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of Hypericum perforatum L. with antiangiogenic activities. 从贯叶连翘枝和叶中提取的具有抗血管生成活性的三种新酰基间苯三酚。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-12-05 DOI: 10.1080/14786419.2023.2278176

Hao Zhang, Kunling Wang, Fan Chen

引用次数: 0

Structure-based virtual screening, ADMET analysis, and molecular dynamics simulation of Moroccan natural compounds as candidates for the SARS-CoV-2 inhibitors. 基于结构的虚拟筛选、ADMET分析和摩洛哥天然化合物作为SARS-CoV-2抑制剂候选物的分子动力学模拟

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-15 DOI: 10.1080/14786419.2023.2281002

Oussama Abchir, Hassan Nour, Ossama Daoui, Imane Yamari, Souad ElKhattabi, Mhammed El Kouali, Mohammed Talbi, Abdelkbir Errougui, Samir Chtita

{"title":"Structure-based virtual screening, ADMET analysis, and molecular dynamics simulation of Moroccan natural compounds as candidates for the SARS-CoV-2 inhibitors.","authors":"Oussama Abchir, Hassan Nour, Ossama Daoui, Imane Yamari, Souad ElKhattabi, Mhammed El Kouali, Mohammed Talbi, Abdelkbir Errougui, Samir Chtita","doi":"10.1080/14786419.2023.2281002","DOIUrl":"10.1080/14786419.2023.2281002","url":null,"abstract":"The lack of treatments and vaccines effective against SARS-CoV-2 has forced us to explore natural compounds that could potentially inhibit this virus. Additionally, Morocco is renowned for its rich plant diversity and traditional medicinal uses, which inspires us to leverage our cultural heritage and the abundance of natural resources in our country for therapeutic purposes. In this study, an extensive investigation was conducted to gather a collection of phytoconstituents extracted from Moroccan plants, aiming to evaluate their ability to inhibit the proliferation of the SARS-CoV-2 virus. Molecular docking of the studied compounds was performed at the active sites of the main protease (6lu7) and spike (6m0j) proteins to assess their binding affinity to these target proteins. Compounds exhibiting high affinity to the proteins underwent further evaluation based on Lipinski's rule and ADME-Tox analysis to gain insights into their oral bioavailability and safety. The results revealed that the two compounds demonstrated strong binding affinity to the target proteins, making them potential candidates for oral antiviral drugs against SARS-CoV-2. The molecular dynamics results from this computational analysis supported the overall stability of the resulting complex.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4347-4354"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134647915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arginase inhibitory activities of chemical constituents from Macaranga hurifolia Beille leaves. 山核桃叶化学成分对精氨酸酶的抑制活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-05 DOI: 10.1080/14786419.2023.2275267

Andy Zedet, Yao Kanga, Marc Pudlo, François Senejoux, Corine Girard

引用次数: 0

Chemical composition of essential oil from Lindera subumbelliflora Kosterm and its effect on the susceptibility and biofilm activities of Candida albicans and Streptococcus mutans. 潜花Lindera submbelliflora Kosterm精油的化学成分及其对白色念珠菌和变形链球菌易感性和生物膜活性的影响。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-07 DOI: 10.1080/14786419.2023.2278164

Nur Nabilah Mohd Zaini, Wan Mohd Nuzul Hakimi Wan Salleh, Mohd Hafiz Arzmi, Abubakar Siddiq Salihu, Nurunajah Ab Ghani

{"title":"Chemical composition of essential oil from Lindera subumbelliflora Kosterm and its effect on the susceptibility and biofilm activities of Candida albicans and Streptococcus mutans.","authors":"Nur Nabilah Mohd Zaini, Wan Mohd Nuzul Hakimi Wan Salleh, Mohd Hafiz Arzmi, Abubakar Siddiq Salihu, Nurunajah Ab Ghani","doi":"10.1080/14786419.2023.2278164","DOIUrl":"10.1080/14786419.2023.2278164","url":null,"abstract":"The chemical composition of the essential oil of Lindera subumbelliflora (Lauraceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The antifungal activity of L. subumbelliflora essential oil was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. A total of 28 components (99.6%) were successfully identified, which were characterised by β-eudesmol (14.6%), cis-α-bergamotene (11.0%), α-copaene (8.5%), dodecen-1-ol (8.5%), and (E)-nerolidol (8.3%). The essential oil exhibited activity against Candida albicans and Streptococcus mutans with MIC values of 250 and 500 µg/mL, respectively. The essential oil increased the biofilm of Candida albicans by 38.25%, however, decreased the biofilm of Streptococcus mutans by 47.89% when treated with 500 µg/mL. Thus, the essential oil has a promising application in dentistry via inhibition of the growth of Candida albicans and Streptococcus mutans. However, the antibiofilm activity of the essential oil is only applicable for cariogenic Streptococcus mutans.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4518-4523"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico analysis, isolation, and cytotoxicity evaluation of the coumestans from Cullen corylifolium (L.) Medik. Cullen corylifolium (L.)中古美斯坦类化合物的硅分析、分离及细胞毒性评价Medik。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-27 DOI: 10.1080/14786419.2023.2285875

Nancy Tripathi, Himisa Shah, Nivedita Bhardwaj, Ruma Sarkar, Shreyans K Jain

{"title":"In silico analysis, isolation, and cytotoxicity evaluation of the coumestans from Cullen corylifolium (L.) Medik.","authors":"Nancy Tripathi, Himisa Shah, Nivedita Bhardwaj, Ruma Sarkar, Shreyans K Jain","doi":"10.1080/14786419.2023.2285875","DOIUrl":"10.1080/14786419.2023.2285875","url":null,"abstract":"Cullen corylifolium is well known for diverse phytoconstituents that possess multifaceted pharmacology, and one such less explored class is coumestans, which have not been well explored for their anticancer activities. One of the popular cancer targets is the Epidermal Growth Factor Receptor, a tyrosine kinase involved in various cancers, especially breast and lung cancer hence, a crucial cancer target. This work is focussed on molecular docking and molecular simulation studies on coumestans against EGFR. The rigorous docking studies resulted in two coumestans (1 and 5) with binding energy less than Gefitinib and Erlotinib. Compounds 1 and 5 were subjected to molecular simulation, binding free energy calculation, per-residue energy decomposition, and in silico ADMET prediction. The best hit, compound 1 was evaluated for its cytotoxicity against MDA-MB-231 and A549 cells via in vitro assay. The ligand-protein complex exhibited good stability, binding free energies, better in silico pharmacokinetics, low toxicity, and good cytotoxicity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4419-4426"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of Entada abyssinica (Fabaceae) constituents. uhplc - q - tof - hesi -MS/MS分析及其抗菌性能。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-17 DOI: 10.1080/14786419.2023.2280171

Larissa M Magnibou, Steven C N Wouamba, Abel J G Yaya, Judith F Mbougnia, Guy S S Njateng, Ghislain W Fotso, Celine Henoumont, Sophie Laurent, Talla Emmanuel

{"title":"Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of Entada abyssinica (Fabaceae) constituents.","authors":"Larissa M Magnibou, Steven C N Wouamba, Abel J G Yaya, Judith F Mbougnia, Guy S S Njateng, Ghislain W Fotso, Celine Henoumont, Sophie Laurent, Talla Emmanuel","doi":"10.1080/14786419.2023.2280171","DOIUrl":"10.1080/14786419.2023.2280171","url":null,"abstract":"A rapid untargeted UHPLC-Q-TOF-ESI-MS/MS-Based metabolomic profiling of the medicinal plant Entada abyssinica was performed. A total of 18 metabolites were detected, of which 10 could not be identified. Based on this result, an extensive chemical investigation of the CH2Cl2-MeOH (1:1) extract of this plant was carried out, leading to the isolation of a new ceramide, named entadamide (1), together with nine known compounds: monomethyl kolavate (2), 24-hydroxytormentic acid (3) chondrillasterol (4), 3-O-β-D glucopyranosylstigmasterol (5), 3-O-β-D glucopyranosylsitosterol (6), quercetin 3'-methylether (7), 2,3-dihydroxypropyl icosanoate (8), 2,3-dihydroxy-propyl 23-hydroxytricosanoate (9) and 2,3-dihydroxy-propyl 24-hydroxytetracosanoate (10). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1D and 2D NMR, and HRESI-MS) in comparison with those reported in the literature. Furthermore, the crude extract and some isolated compounds were tested against non-ciprofloxacin resistant strains viz, Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Samonella thyphi (ATCC 19430) and Samonella enterica (NR4294). The tested samples demonstrated significant activity against all the tested bacteria (MIC values: 3.12-12.5 μg/mL).","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4155-4165"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0