Natural Product Research最新文献_第3页

A new sesquiterpene lactone isolated from Ainsliaea smithii and cytotoxic activity against the A549 cancer cell line 一种新的倍半萜内酯分离物及其对A549癌细胞的细胞毒活性研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-07 DOI: 10.1080/14786419.2025.2477810

Kishan Singh , Kaveri R. Washimkar , Divya Kushwaha , Madhav Nilakanth Mugale , Kapil Dev

引用次数: 0

Synthesis, anticancer activity and molecular docking study of triphenylphosphonium-linked derivatives of oleanolic acid 齐墩果酸三苯基膦衍生物的合成、抗癌活性及分子对接研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-10 DOI: 10.1080/14786419.2025.2477805

Deshang Li , Bo Wang , Rui Wang , Jianjun Huang , Ruofan Chen , Yi Li , Na Wang , Qianqian Wang , Chenmeng Xu , Wim Dehaen , Qiyong Huai

{"title":"Synthesis, anticancer activity and molecular docking study of triphenylphosphonium-linked derivatives of oleanolic acid","authors":"Deshang Li , Bo Wang , Rui Wang , Jianjun Huang , Ruofan Chen , Yi Li , Na Wang , Qianqian Wang , Chenmeng Xu , Wim Dehaen , Qiyong Huai","doi":"10.1080/14786419.2025.2477805","DOIUrl":"10.1080/14786419.2025.2477805","url":null,"abstract":"<div><div>Lung cancer and breast cancer both are extremely threatening to humans, so it is needed to develop safe and effective drugs for the treatment of these two ailments. To improve the activity and selectivity of bioactive natural product oleanolic acid (OA), triphenylphosphonium moieties were introduced at different sites of the OA core skeleton. The <em>in vitro</em> antiproliferative activity screening results displayed that the anticancer activity of all target compounds was significantly improved, and some derivatives displayed strong selectivity for breast cancer cells (MCF-7) and lung cancer cells (A549) over the human normal liver cells (QSG-7701 cells). Compounds <strong>6a</strong> (for A549 cells) and <strong>5g</strong> (for MCF-7 cells) demonstrated the best selectivity (with SI of 12.18 and 7.72, respectively). The docking results showed that <strong>5g</strong> and <strong>6c</strong> could bind to and interact with PI3K protein through hydrogen bonds and intermolecular hydrophobic forces. These compounds are potential anti-MCF-7 agents and deserve further study.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2556-2564"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential oil chemical composition of Lamium flexuosum Ten.: a wild accession from sicily (Italy) 屈叶草精油的化学成分。来自西西里岛（意大利）的野生植物。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-05-07 DOI: 10.1080/14786419.2025.2502856

Alessandro Vaglica , Natale Badalamenti , Antonella Porrello , Vincenzo Ilardi , Maurizio Bruno

引用次数: 0

A review on Arum palaestinum: phytochemical and biological aspects 巴勒斯坦魔芋的植物化学和生物学研究进展。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2024-12-16 DOI: 10.1080/14786419.2024.2443486

Ghassan Albarghouti , Baydaa’ Habash

{"title":"A review on Arum palaestinum: phytochemical and biological aspects","authors":"Ghassan Albarghouti , Baydaa’ Habash","doi":"10.1080/14786419.2024.2443486","DOIUrl":"10.1080/14786419.2024.2443486","url":null,"abstract":"<div><div><em>Arum palaestinum</em> is a wild edible, parietal, unisexual, perennial plant that grows in various parts of the Middle East, and frequently used in traditional Arabic Palestinian herbal medicine. The present review summarises information concerning <em>Arum palaestinum</em> including background information, historical records, phytochemical components, and biological activity which represents an important tool for further research studies. <em>Arum palaestinum</em> is thought to contain a wealth of rich bioactive compounds, such as terpinoids, polyphenols, flavonoids, and alkaloids. Long-term research on these compounds has demonstrated antioxidant, antibacterial, anti-inflammatory, and anticancer activities. Its aerial parts yielded the identification of over 180 chemicals, whereas its flowering part’s GC/MS study revealed the presence of twelve compounds. Its leaf extracts demonstrated toxicity against various cancer cell lines. Extracts from its flowers demonstrated potent anti-inflammatory and dose-dependent cytotoxic effects. The potential of GZ17-6.02, a promising combinatorial drug made from plant components, for clinical cancer treatment is still being investigated.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2578-2595"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromones from stems of Harrisonia perforata 花楸茎中的色素。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-03 DOI: 10.1080/14786419.2025.2462968

Sakunchai Khumsubdee , Vilailak Prachyawarakorn , Chulabhorn Mahidol , Poonsakdi Ploypradith , Somsak Ruchirawat , Phanruethai Pailee

引用次数: 0

Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents 天然生物活性物质来源——大叶龙胆根中总酚、总黄酮和标记环烯醚萜类化合物的提取与分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-04 DOI: 10.1080/14786419.2025.2475511

Safdar Ali Amur , Quratulain Khuhro , Najaf Ali Soomro , Aiman Amur , Guang Chen

{"title":"Extraction and analysis of total phenolics, flavonoids and marker iridoids from Gentiana macrophylla Pall roots: a natural source of bioactive agents","authors":"Safdar Ali Amur , Quratulain Khuhro , Najaf Ali Soomro , Aiman Amur , Guang Chen","doi":"10.1080/14786419.2025.2475511","DOIUrl":"10.1080/14786419.2025.2475511","url":null,"abstract":"<div><div>This study focused on the quality control (QC) of roots of <em>Gentiana macrophylla</em> Pall. from Hebei An-Guo Medicine Market, China. Plant roots were extracted using 70% aqueous ethanol with soxhlation and sonication extraction technologies. The extracts were then condensed, dried, and solubilised in methanol, ethanol, and water for chemical analysis. The sonication extract yielded higher amounts of total phenolics (33.12 mg/gDW) and flavonoids (17.59 mg/gDW) in ethanol compared to water and methanol. HPLC analysis showed a high concentration of gentiopicroside (588.48 μg/mL) in the ethanol fraction of the sonication extract, with loganic acid (283.58 μg/mL) and sweroside (9.49 μg/mL) in the water fraction. The soxhlation extract had lower concentrations of these compounds. The root extract (sonication extraction) of <em>G. macrophylla</em> Pall. demonstrated dose-dependent antioxidant (DPPH, NBTs, FRAP) and outstanding antibacterial activities against <em>Escherichia coli</em> and <em>Staphylococcus aureus</em> at lower concentrations.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2478-2487"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality control and spectrum–effect relationship of Crataegus pinnatifida polysaccharide from different habitats 不同产地山楂多糖的质量控制及光谱效应关系。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-03-07 DOI: 10.1080/14786419.2025.2476200

Yongshuai Jing , Qiyuan Han , Ziyan Li , Yingqi Li , Xiaoyu Chang , Beibei Hu , Lanfang Wu

引用次数: 0

Semisynthesis and biological activities of derivatives of cyclocommunol from Artocarpus altilis fruit peel 山茱萸果皮环共甲醚衍生物的半合成及生物活性研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-02-24 DOI: 10.1080/14786419.2025.2472277

Syamsurizal , Arash Samadi , Samuel Tanoeyadi , Muhammad Amin , Leigh E. Skala , Taifo Mahmud

{"title":"Semisynthesis and biological activities of derivatives of cyclocommunol from Artocarpus altilis fruit peel","authors":"Syamsurizal , Arash Samadi , Samuel Tanoeyadi , Muhammad Amin , Leigh E. Skala , Taifo Mahmud","doi":"10.1080/14786419.2025.2472277","DOIUrl":"10.1080/14786419.2025.2472277","url":null,"abstract":"<div><div><em>Artocarpus altilis</em> (breadfruit) is an economically important species of the Moraceae family found throughout the tropics. While breadfruit pulp is widely used and processed into various food products, the peel waste is currently underutilised. Our chemical study of breadfruit peel has led to the isolation of the major constituent cyclocommunol (<strong>1</strong>). Using <strong>1</strong> as the starting material, we synthesised nine cyclocommunol derivatives (<strong>2</strong>–<strong>10</strong>) and tested their antibacterial and antitumor activities. Compounds <strong>1</strong>, <strong>3, 4</strong>, and <strong>9</strong> have weak antibacterial activity against several Gram-(+) and Gram-(–) bacteria. In addition, compounds <strong>7</strong> and <strong>9</strong> showed moderate cytotoxicity against the MCF-7 breast cancer cell line, whereas compound <strong>4</strong> showed comparable cytotoxicity against the NCI-H460 lung cancer cell line. The study showed that the underutilised breadfruit peel waste may be used as a source of compounds with pharmaceutical potential.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2402-2409"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of cannabinoids and triterpenoids from Rhododendron anthopogon D.Don (Ericaceae) Leaves anthopogon d.d don （Ericaceae）杜鹃叶片中大麻素和三萜的分离。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 Epub Date: 2025-05-12 DOI: 10.1080/14786419.2025.2505601

Maroof Shah , Hassan Sher , Haidar Ali , Melanie-Jayne R. Howes , Moses K. Langat , Eliot Jan-Smith

{"title":"Isolation of cannabinoids and triterpenoids from Rhododendron anthopogon D.Don (Ericaceae) Leaves","authors":"Maroof Shah , Hassan Sher , Haidar Ali , Melanie-Jayne R. Howes , Moses K. Langat , Eliot Jan-Smith","doi":"10.1080/14786419.2025.2505601","DOIUrl":"10.1080/14786419.2025.2505601","url":null,"abstract":"<div><div><em>Rhododendron anthopogon</em> D.Don (Ericaceae) is a medicinal plant that occurs in the Swat District, Pakistan. Column chromatography was used to isolate cannabichromeorcinic acid (<strong>1</strong>), cannabigerorcinic acid (<strong>2</strong>), ursolic acid (<strong>3</strong>), friedelin (<strong>4</strong>) and 2-phenylethyl 4-methoxybenzoate (<strong>5</strong>) from the methylene chloride extract of <em>R. anthopogon</em> leaves that were collected from the Daral region in the Swat District, Pakistan. The structures of the isolated compounds were elucidated using nuclear magnetic resonance spectroscopy and mass spectrometry, and by comparison of the experimental data with those reported in the literature. The occurrence of cannabinoids (<strong>1</strong>) and (<strong>2</strong>), triterpenoids (<strong>3</strong>) and (<strong>4</strong>), and 2-phenylethyl 4-methoxybenzoate (<strong>5</strong>) in <em>R. anthopogon</em> leaves, as reported in this study, may shed some light on this species’ traditional medicinal uses.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 9","pages":"Pages 2623-2626"},"PeriodicalIF":1.6,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated affinity ultrafiltration UHPLC-QE-Orbitrap-MS and molecular docking for efficient screening of aurora kinase a inhibitors from Eomecon chionantha Hance. 结合亲和超滤法UHPLC-QE-Orbitrap-MS和分子对接高效筛选光激酶a抑制剂。

IF 1.6 3区化学

Natural Product Research Pub Date : 2026-05-03 DOI: 10.1080/14786419.2026.2666381

Jieyao Ma, Yalan Wu, Yufeng Zou, Huiling Liu, Lian Zhu, Wei Cai

引用次数: 0