Natural Product Research最新文献_第10页

Two undescribed constituents from Schisandra chinensis (Turcz.) Baill. and evaluation of their anti-oxidant activity. 中国五味子（Schisandra chinensis）的两种未描述成分Baill。并对其抗氧化活性进行评价。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-10 DOI: 10.1080/14786419.2025.2527870

Xiao-Yu Shi, Yao-Guang Huang, Xu-Peng Yang, Yan Xu, Jing-Ming Jia, An-Hua Wang

引用次数: 0

Physicochemical stability and toxicity assessment of cimitrypazepine, an azepino[5,4,3-cd]indole alkaloid. 氮平[5,4,3-cd]吲哚类生物碱cimitrypazepine的理化稳定性及毒性评价。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-10 DOI: 10.1080/14786419.2025.2528975

Regina Lis Gasparetto, Camila Esmerio Reginato-Couto, Guilherme Moreschi Gerhardt, Carlos Rafael Vaz, Márvia Cleysse Cunha Correia, Luiza Garcia de Souza, Amélia Teresinha Henriques, Fávero Reisdorfer Paula, Renata Biegelmeyer, Solange Cristina Garcia, Marcelo Dutra Arbo, José Roberto Santin, Tania Mari Bellé Bresolin, Luiz Carlos Klein-Junior

{"title":"Physicochemical stability and toxicity assessment of cimitrypazepine, an azepino[5,4,3-cd]indole alkaloid.","authors":"Regina Lis Gasparetto, Camila Esmerio Reginato-Couto, Guilherme Moreschi Gerhardt, Carlos Rafael Vaz, Márvia Cleysse Cunha Correia, Luiza Garcia de Souza, Amélia Teresinha Henriques, Fávero Reisdorfer Paula, Renata Biegelmeyer, Solange Cristina Garcia, Marcelo Dutra Arbo, José Roberto Santin, Tania Mari Bellé Bresolin, Luiz Carlos Klein-Junior","doi":"10.1080/14786419.2025.2528975","DOIUrl":"https://doi.org/10.1080/14786419.2025.2528975","url":null,"abstract":"Cimitrypazepine is an azepino[5,4,3-cd]indole alkaloid and is able to modulate CNS targets. However, there is a lack of information regarding the safety of this compound. Here, the chemical stability and toxicity of cimitrypazepine were assessed. In silico studies demonstrated that C-5, in the indole moiety, can undergo hydrolytic reactions; C-3, in the azepine moiety, is the most susceptible to oxidative degradation. Through in vitro assays, cimitrypazepine was unstable to acidic conditions, degrading by ∼50% in 3 h. Regarding toxicity, the alkaloid decreased HepG2 cells viability by 21% at 10 μM. It did not influence AST and LDH levels, but increased ALT levels. Genotoxicity, evaluated by the comet assay, was observed for concentrations above 2.5 mM. Finally, using zebrafish embryos, the LC50 at 96 h post-fertilization was estimated as 326 μM. This study highlights that care must be taken regarding cimitrypazepine concentration and formulation, to avoid toxicity and degradation.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory effects of arborside C pentaacetate- an iridoid glycoside acetate isolated from Nyctanthes arbor-tristis Linn. and in vitro and in silico studies. 香树苷C -五乙酸环烯醚萜苷醋酸酯的免疫调节作用。在体外和计算机研究中。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-09 DOI: 10.1080/14786419.2025.2526737

Talea Sana, Hira Noor Malik, Syeda Farah Shah, Komal Zia, Bina S Siddiqui, Zaheer Ul-Haq, Sabira Begum, Taibi B Hadda, Almas Jabeen

引用次数: 0

"Exploring flavonoids as potential therapeutics for diabetic neuropathy: ADMET predictions and molecular docking studies". 探索黄酮类化合物作为糖尿病神经病变的潜在治疗药物：ADMET预测和分子对接研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-09 DOI: 10.1080/14786419.2025.2529558

Anne Katherine C Gomes, Rodolfo Goetze Fiorot, Anne Caroline C Gomes, Naomi Kato Simas

{"title":"\"Exploring flavonoids as potential therapeutics for diabetic neuropathy: ADMET predictions and molecular docking studies\".","authors":"Anne Katherine C Gomes, Rodolfo Goetze Fiorot, Anne Caroline C Gomes, Naomi Kato Simas","doi":"10.1080/14786419.2025.2529558","DOIUrl":"10.1080/14786419.2025.2529558","url":null,"abstract":"Neuropathic pain is a type of chronic pain that occurs as a direct consequence of an injury or diseases that affect the somatosensory system, such as diabetes, which characterises diabetic neuropathy. Conventional treatments, including opioids, tricyclic antidepressants and anticonvulsants, are not fully effective and can cause severe side effects such as respiratory depression and cardiotoxicity. Natural products, particularly flavonoids, emerge as promising alternatives. This study reviewed flavonoids from literature as potential diabetic neuropathy treatments and evaluated their pharmacokinetics, toxicity, and structure-activity relationships (SAR). Isoflavones and flavones showed the most favourable profiles in cytotoxicity tests, hERG channel safety, and Ames test. These flavonoids exhibited high affinity for NMDA receptors, with significant interaction energy (-8.5 to -10.6 kcal mol-1) involving key amino acids. These findings highlight isoflavones and flavones as potential candidates for further research into alternative treatments for neuropathic pain, offering hope for effective and safer therapies for this debilitating condition.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPLC-QTOF-MS/MS-Guided phytochemical characterization and molecular docking of Rosa rusoga extract for Keap1-Nrf2 modulation. UPLC-QTOF-MS/ ms引导下玫瑰提取物Keap1-Nrf2调控的植物化学表征及分子对接

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-09 DOI: 10.1080/14786419.2025.2528151

Vu Thanh Nguyen, Van Bui Thị Thu, Thao Vo Thi Minh, Khang Huynh Vinh, Nguyen Lam Vy, Vy Nguyen Hoang Thuy, Thanh Luu Pham, Tong Xuan Nguyen, Dinh Thi Thuy, Huu Duc Huynh, Truong Giang Nguyen

{"title":"UPLC-QTOF-MS/MS-Guided phytochemical characterization and molecular docking of Rosa rusoga extract for Keap1-Nrf2 modulation.","authors":"Vu Thanh Nguyen, Van Bui Thị Thu, Thao Vo Thi Minh, Khang Huynh Vinh, Nguyen Lam Vy, Vy Nguyen Hoang Thuy, Thanh Luu Pham, Tong Xuan Nguyen, Dinh Thi Thuy, Huu Duc Huynh, Truong Giang Nguyen","doi":"10.1080/14786419.2025.2528151","DOIUrl":"https://doi.org/10.1080/14786419.2025.2528151","url":null,"abstract":"Rosa rugosa extract (RRE) is traditionally used for its antioxidant properties, but its molecular mechanisms remain unclear. This study investigated the ability of RRE to activate the Keap1-Nrf2 pathway, a key regulator of oxidative stress defense. UPLC-QTOF-MS/MS identified 91 phytochemicals, with 10 major compounds, including flavonoids, triterpenoids, and alkaloids. Molecular docking revealed that 3-trans-p-coumaroylrotundic acid, gallocatechin-(4→8)-epicatechin, and ginsenoside Rf interact with the Kelch domain of Keap1, potentially preventing Nrf2 degradation. Functional validation via Nrf2-knockout zebrafish (nfe2l2adl703/dl703) confirmed that RRE enhances oxidative stress resistance and upregulates the expression of antioxidant genes (gstp1 and prdx1) in an Nrf2-dependent manner. These findings suggest that RRE acts as a natural Keap1 inhibitor, supporting Nrf2-driven cytoprotection. This study provides a mechanistic basis for the traditional use of RRE in oxidative stress management, highlighting its potential for nutraceutical and therapeutic applications.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unsaturated lactones from Aspergillus ochraceopetaliformis. 从赭曲霉中提取的不饱和内酯。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-08 DOI: 10.1080/14786419.2025.2529564

Jing-Jie Bai, Hong-Qian Pan, Qiong Liu, Duo-Xiu Li, Bai-Chuan Zhu, Ying-Ming Zhang, Ai-Hong Zhao, Cheng-Shan Yuan

引用次数: 0

Assessment of antifungal and anti-biofilm potential of essential oil active constituents alone and in combinatorial mode of limonene and linalool against Candida albicans and Candida tropicalis. 精油活性成分单独及柠檬烯和芳樟醇联合抗白色念珠菌和热带念珠菌的抗真菌和抗生物膜潜力评价。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-07 DOI: 10.1080/14786419.2025.2526731

Pankaj Kumar Chaudhary, Deepika Saini, Amit Kumar Srivastava, Ramasare Prasad

{"title":"Assessment of antifungal and anti-biofilm potential of essential oil active constituents alone and in combinatorial mode of limonene and linalool against Candida albicans and Candida tropicalis.","authors":"Pankaj Kumar Chaudhary, Deepika Saini, Amit Kumar Srivastava, Ramasare Prasad","doi":"10.1080/14786419.2025.2526731","DOIUrl":"https://doi.org/10.1080/14786419.2025.2526731","url":null,"abstract":"Opportunistic Candidiasis is rising among immunocompromised and elderly patients, with increasing antifungal resistance. This study evaluated five essential oil-derived compounds against Candida albicans and Candida tropicalis. Limonene showed the strongest antifungal activity, with minimum inhibitory concentration (MICs) of 32-64 µg/mL. Similarly, biofilm inhibition/eradication concentration (BIC/BEC) was found in followed the order: limonene > linalool > 1,8-cineole = 2-undecanone = borneol. Notably, the combination of limonene and linalool showed additive effects, with fractional inhibitory concentration index (FICI) values of 0.79 for C. albicans and 0.98 for C. tropicalis. This combinatorial approach, investigated for the first time, showed no significant cytotoxicity on human embryonic kidney (HEK-293) and human keratinocyte (HaCaT) cell lines. A co-culture model of Candida spp. and HaCaT cells was developed to study host-pathogen interactions and antifungal efficacy. Results highlight EO-ACs, especially limonene and linalool, as promising alternatives against resistant Candida infections.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of a novel glycoside from the inner bark of Sclerocarya birrea: insights into antibiotic and anticancer activity. 从硬核树皮中分离和表征一种新的糖苷：抗生素和抗癌活性的见解。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-05 DOI: 10.1080/14786419.2025.2524608

Mokgadi Precious Mphahlele, Armand Mallé Lando, Michael Hermann Kamdem Kengne, Jordan Tonga Lembe, Pangaman Jiyane, Thierry Fonkui Youmbi, Vusani Mandiwana, Lerato Hlekelele, Marthe Carine Djuidje Fotsing, Edwin Mpho Mmutlane, Stéphane Zingue, Derek Tantoh Ndinteh

{"title":"Isolation and characterization of a novel glycoside from the inner bark of Sclerocarya birrea: insights into antibiotic and anticancer activity.","authors":"Mokgadi Precious Mphahlele, Armand Mallé Lando, Michael Hermann Kamdem Kengne, Jordan Tonga Lembe, Pangaman Jiyane, Thierry Fonkui Youmbi, Vusani Mandiwana, Lerato Hlekelele, Marthe Carine Djuidje Fotsing, Edwin Mpho Mmutlane, Stéphane Zingue, Derek Tantoh Ndinteh","doi":"10.1080/14786419.2025.2524608","DOIUrl":"10.1080/14786419.2025.2524608","url":null,"abstract":"Phytochemical analysis of the dichloromethane-methanol (1:1) extract from Sclerocarya birrea inner bark led to the identification of three compounds: a novel glycoside, 3α-sorbithoxyglucose (1), and two known compounds, retusasterol (2) and β-sitosterol-3-O-D-glycoside (3), isolated for the first time from this plant. Structural elucidation via NMR confirmed their identities. Cytotoxicity studies against MCF7 breast cancer and DU145, PC3, LNCaP prostate cancer cell lines revealed that compounds 1 and 2 lacked inhibitory effects on cell proliferation, while retusasterol exhibited cytotoxicity with CC50 values of 38 μg/mL (DU145), 40 μg/mL (PC3), and 32 μg/mL (LNCaP). However, further analysis indicated that retusasterol promoted tumour cell proliferation. Antimicrobial screening of 3α-sorbithoxyglucose against Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Mycobacterium smegmatis, Enterobacter cloacae, Proteus vulgaris, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli, and Pseudomonas aeruginosa revealed MIC values of 15.625-250 μg/mL, suggesting potential as an antimicrobial agent compared to standard antibiotics.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New sesquiterpene derivatives from stems and leaves of Smallanthus sonchifolius. 小红花茎叶的倍半萜新衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-05 DOI: 10.1080/14786419.2025.2528154

Pham Thi Mai Huong, Do Hoang Anh, Le Thi Vien, Tran Thi Hong Hanh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam

引用次数: 0

A new acylated triterpene glycoside and cytotoxic constituents from Dolichandrone serrulata (Wall. ex DC.) Seem Dolichandrone serrulata (Wall. ex DC.) Seem.A new acylated triterpene glycoside and cytotoxic constituents from Dolichandrone serrulata (Wall. ex DC.) Seem.

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-07-03 DOI: 10.1080/14786419.2024.2306173

Watcharapa Jitkaroon , Wirunya Sutassanawichanna , Roongtiwa Srisuphan , Pawaris Wongprayoon , Purin Charoensuksai , Kanok-on Rayanil

{"title":"A new acylated triterpene glycoside and cytotoxic constituents from Dolichandrone serrulata (Wall. ex DC.) Seem","authors":"Watcharapa Jitkaroon , Wirunya Sutassanawichanna , Roongtiwa Srisuphan , Pawaris Wongprayoon , Purin Charoensuksai , Kanok-on Rayanil","doi":"10.1080/14786419.2024.2306173","DOIUrl":"10.1080/14786419.2024.2306173","url":null,"abstract":"<div><div>In this study, a new acylated triterpene glycoside, 3α-O-stearoyl-28-[2′-stearoyl-α-l-arabinopyranosyl]-olean-12-en-28-oic acid (1), was isolated from the flowers of Dolichandrone serrulata. In addition to this compound, eleven known compounds were also isolated, including a related pentacyclic triterpenoid: ursolic acid (2), two cycloartane triterpenoids: 24-methylenecycloartanol (3) and 24-methylenecycloartane-3,28-diol (4), three cyclohexylethane derivatives: (-)-rengyolone (5), (-)-cleroindicin C (6) and (-)-cleroindicin D (7), an iridoid: 6-O-trans-feruloyl catalpol (8), two phenylethanoid glycosides: salidroside (9) and verbascoside (10), and two steroids: β-sitosterol (11) and β-sitosterol-3-O-β-d-glucopyranoside (12). The chemical structures of these compounds were determined by analysing their HRMS and NMR spectroscopic data. Additionally, their cytotoxic activities against NH22, HCT116, MCF7, MDA-MB-231, and HeLa cell lines were evaluated for all the compounds. Ursolic acid exhibited moderate cytotoxic activity against all cancer cell lines tested, particularly against HN22, MDA-MB-231, MCF-7, and HCT116 cells with IC50 values of approximately 19–34 µM.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 13","pages":"Pages 3657-3664"},"PeriodicalIF":1.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0