Natural Product Research最新文献_第10页

Phytochemicals and health-promoting evaluations of Ophiorrhiza puffii, a chinese endemic plant. 一种中国特有的植物 Ophiorrhiza puffii 的植物化学成分和健康促进评估。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-12 DOI: 10.1080/14786419.2024.2425808

Qing Bu, Qi-Bin Yang, Zeng-Yue Ge, Ze-Xiong Shi, Lin-Fu Liang

{"title":"Phytochemicals and health-promoting evaluations of Ophiorrhiza puffii, a chinese endemic plant.","authors":"Qing Bu, Qi-Bin Yang, Zeng-Yue Ge, Ze-Xiong Shi, Lin-Fu Liang","doi":"10.1080/14786419.2024.2425808","DOIUrl":"https://doi.org/10.1080/14786419.2024.2425808","url":null,"abstract":"There has been no phytochemical or and pharmacological report of the Chinese endemic plant Ophiorrhiza puffii till now. At present, seven structurally diverse compounds were obtained, including six triterpenoids (1-6) and one anthraquinone (7). Interestingly, 1-6 furnished three distinct carbon skeletons. Additionally, these phytochemical constituents showed multiple health-promoting effects. Triterpene 3 displayed considerable tyrosinase inhibitory activity (IC50 = 5.42 μM). Components 4 and 5 demonstrated significant antioxidant activity (IC50 = 4.23 and 2.03 mM, respectively). Meanwhile, compounds 2 and 5 exhibited moderate α-glucosidase inhibitory activity (IC50 = 0.89 and 0.72 mM, respectively). Moreover, the binding mechanisms for bioactive compounds 2, 3 and 5 and the corresponding α-glucosidase and tyrosinase proteins were preliminarily inspected by molecular docking experiments. This study filled up the knowledge gap of the unexplored chemical and biological profiles of secondary metabolites from the plant O. puffii for the first time.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Madecassic acid analogues with a five-membered A-ring and their cytotoxic activity. 具有五元 A 环的麦地卡辛酸类似物及其细胞毒性活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-11 DOI: 10.1080/14786419.2024.2427811

Van Loc Tran, The Anh Nguyen, Nguyen Tran Dang, Thi Phuong Thao Tran, Tuan Anh Tran, Van Sung Tran, Van Chien Tran

{"title":"Madecassic acid analogues with a five-membered A-ring and their cytotoxic activity.","authors":"Van Loc Tran, The Anh Nguyen, Nguyen Tran Dang, Thi Phuong Thao Tran, Tuan Anh Tran, Van Sung Tran, Van Chien Tran","doi":"10.1080/14786419.2024.2427811","DOIUrl":"https://doi.org/10.1080/14786419.2024.2427811","url":null,"abstract":"The structural modification of madecassic acid focused on the contraction of the six-membered A-ring to a five-membered ring, combined with the dehydration of 6-OH to form a new double bond and formation of the esterification or amidation at C-28. The synthesised structures were identified based on the analysis of their NMR and EIS-MS data. Eighteen new madecassic acid analogues were tested in vitro for their cytotoxicity against three cancer cell lines, including human mouth carcinoma (KB), human hepatocellular carcinoma (HepG2), and human lung carcinoma (A549) using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Among them, compounds 5 and 12 exhibited potent and selective cytotoxic activity in KB and HepG2 cell lines, with IC50 values ranging from 3.57 to 6.32 µM. The results also indicated that analogues with a 5-membered A-ring containing an α,β-unsaturated aldehyde esterified at C-23 showed a decrease in their cytotoxic activity compared to precursors in the tested cancer cells.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How peptides from venomous and poisonous animals can be used to treat oral cancer: possible mechanisms of action. 如何利用来自毒液和有毒动物的肽来治疗口腔癌：可能的作用机制。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-11 DOI: 10.1080/14786419.2024.2423042

Karthikeyan Kandaswamy, Ajay Guru

引用次数: 0

Analysis of the components of Cassia nomame and their antioxidant activity. 决明子成分分析及其抗氧化活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-11 DOI: 10.1080/14786419.2024.2426060

Tetsuya Saito, Yuria Kurosu, Hajime Sato, Etsuko Katoh, Takahiro Hosoya

{"title":"Analysis of the components of Cassia nomame and their antioxidant activity.","authors":"Tetsuya Saito, Yuria Kurosu, Hajime Sato, Etsuko Katoh, Takahiro Hosoya","doi":"10.1080/14786419.2024.2426060","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426060","url":null,"abstract":"Cassia nomame, an annual herb belonging to the Leguminosae family, is traditionally consumed as tea in the form of dried whole herbs or beans. To deepen our understanding of the chemical constituents of C. nomame, we isolated 16 compounds, categorised as flavone derivatives (1-4), including a novel compound nomameflavone A (4), a chalcone derivative (5), an aurone derivative (6), a chromone derivative (7), a juglone derivative (8), anthraquinone derivatives (9-11), phenolic compounds (12-14), and sterol derivatives (15, 16). The structure of each compound was elucidated using NMR and MS. Compounds 2, 6, 7, 8, 12, 13, and 14 were successfully isolated from C. nomame for the first time. Furthermore, compounds 1, 3, 5, and 6 exhibited DPPH radical scavenging activities, and the bioactivity of 3 was discovered. The elucidation of the diverse chemical constituents of C. nomame underscores its potential functional ingredients.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allelopathic and phytotoxic activity of essential oil of Elaeagnus angustifolia flowers and its major constituents on Amaranthus retroflexus and Lolium perenne. Elaeagnus angustifolia 花精油及其主要成分对反折苋和欧洲旱金莲的异位和植物毒性活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-10 DOI: 10.1080/14786419.2024.2424402

Caixia Han, Yu Mei, Nigora Kuchkarova, Zokir Toshmatov, Shijie Fang, Hua Shao

{"title":"Allelopathic and phytotoxic activity of essential oil of Elaeagnus angustifolia flowers and its major constituents on Amaranthus retroflexus and Lolium perenne.","authors":"Caixia Han, Yu Mei, Nigora Kuchkarova, Zokir Toshmatov, Shijie Fang, Hua Shao","doi":"10.1080/14786419.2024.2424402","DOIUrl":"https://doi.org/10.1080/14786419.2024.2424402","url":null,"abstract":"This study investigated the allelopathic and phytotoxic effects of Elaeagnus angustifolia flower essential oil (EO) and its major constituents. Forty-one compounds were identified by GC-MS, accounting for 96.93% of the total oil, with the main compounds being ethyl cinnamate and methyl cinnamate. The allelopathic assay of the EO completely suppressed the seed germination of Lolium perenne and Amaranthus retroflexus at 22.22 mg/mL air treatment. Phytotoxic activities of ethyl cinnamate and methyl cinnamate were much stronger than those of the EO against L. perenne, with IC50 values of 0.386, 0.396, and 7.159 mg/mL, respectively. The strength of the phytotoxic activity of the major constituent ethyl cinnamate, and the mixture of ethyl cinnamate and methyl cinnamate was comparable to that of the commercial herbicide glyphosate in terms of suppressing root elongation in A. retroflexus, with IC50 values of 0.049, 0.076, and 0.017 mg/mL, respectively, indicating a possible synergistic effect of the major compounds.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential role of lumazine peptide penilumamide E from Aspergillus terreus in head and neck cancer treatment. 来自土曲霉的鲁马嗪肽青霉酰胺 E 在头颈癌治疗中的潜在作用。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-10 DOI: 10.1080/14786419.2024.2426062

Karthikeyan Kandaswamy, Ajay Guru

引用次数: 0

A new benzodioxole derivative from the marine-derived Streptomyces sp. SYPHU 0002. 一种来自海洋链霉菌 SYPHU 0002 的新型苯并二恶茂衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-09 DOI: 10.1080/14786419.2024.2425058

Pengyun Mou, Yuan Peng, Bangyan Zhang, Pengze Wang, Xianpu Ni, Huanzhang Xia

引用次数: 0

Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae). 通过气相色谱-质谱（GC-MS）和液相色谱-质谱/质谱（LC-MS/MS）进行植物化学评价：对地方物种 Centaurea amanicola Hub.-Mor. 和 C. antitauri Hayek（菊科）提取物的抗糖尿病、抗菌、抗氧化和基因毒性活性的综合研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-09 DOI: 10.1080/14786419.2024.2425798

Mohaddeseh Nobarirezaeyeh, Hafize Yuca, Bilge Aydın, Ayşe Civaş, Songül Karakaya, Mehmet Karadayı, Abdussamed Yasin Demir, Mehmet Bona, Bilal Yılmaz, Gamze Göger, Muhammed Ziya Şahinöz, Elif Beyza Özer, Enes Tekman, Zühal Güvenalp, Ayşe Mine Gençler Özkan

{"title":"Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae).","authors":"Mohaddeseh Nobarirezaeyeh, Hafize Yuca, Bilge Aydın, Ayşe Civaş, Songül Karakaya, Mehmet Karadayı, Abdussamed Yasin Demir, Mehmet Bona, Bilal Yılmaz, Gamze Göger, Muhammed Ziya Şahinöz, Elif Beyza Özer, Enes Tekman, Zühal Güvenalp, Ayşe Mine Gençler Özkan","doi":"10.1080/14786419.2024.2425798","DOIUrl":"https://doi.org/10.1080/14786419.2024.2425798","url":null,"abstract":"The study investigated the antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from Centaurea amanicola and C. antitauri (Asteraceae). Methanol extracts were analysed for phenolic and fatty oil contents. Major components of fatty oils were identified, including methyl hexadecanoate (48.30%) and heptacosane (22.13%) in C. antitauri, and methyl hexadecanoate (16.29%) and methyl linoleate (13.55%) in C. amanicola. The highest α-amylase inhibition was observed in hexane extracts of both species with 55.53% and 41.57% inhibition values, respectively. Antioxidant activity, measured by ABTS•+ and DPPH• scavenging, varied among extracts, with notable efficacy in C. antitauri dichloromethane extract and C. amanicola ethyl acetate extract. The dichloromethane extract of C. antitauri demonstrated effectiveness against Candida albicans with MIC= 156.25 µg/mL. Importantly, all extracts were found to be genotoxicity-safe. Overall, the findings highlight the potential of these extracts for various medicinal applications, particularly in managing diabetes and combating microbial infections.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycosparvine A, a new indole alkaloid from the leaves of Glycosmis parviflora. Glycosparvine A，一种来自 Glycosmis parviflora 叶子的新吲哚生物碱。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-09 DOI: 10.1080/14786419.2024.2426210

Jing-Ling Ren, Pei-Lian Liu, Hong-Yan Yang, Zhong-Liu Zhou, Zi-Ming Chen, Shou-Yuan Wu

引用次数: 0

Laccase purification and azo dye decolorization potential of Sparassis latifolia. Laccase purification and azo dye decolorization potential of Sparassis latifolia.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-09 DOI: 10.1080/14786419.2024.2411713

Abdul Rehman Niazi, Tehreem Fatima, Aneeqa Ghafoor, Munir Ahmad, Muhammad Asad Ghafoor, Abdulaziz Bentalib, Muhammad Bilawal Junaid, Imran Haider

{"title":"Laccase purification and azo dye decolorization potential of Sparassis latifolia.","authors":"Abdul Rehman Niazi, Tehreem Fatima, Aneeqa Ghafoor, Munir Ahmad, Muhammad Asad Ghafoor, Abdulaziz Bentalib, Muhammad Bilawal Junaid, Imran Haider","doi":"10.1080/14786419.2024.2411713","DOIUrl":"https://doi.org/10.1080/14786419.2024.2411713","url":null,"abstract":"Sparassis latifolia often referred to as Cauliflower mushroom possess both medicinal and edibility values. In this research work, first time laccase purification and dye colourisation efficacy of Sparassis latifolia's purified laccase were assessed. Optimal laccase potential was noted after 12th day of incubation with 4 pH of medium at 45 °C. As supplementary nutritional source, sucrose and ammonium sulphate were unveiled as most effective synthetic carbon and nitrogen sources while wheat straw found as proficient lignocellulosic biomass for enhanced laccase production. Following optimisation of laccase production parameters, laccase was purified to 14.2 fold by ammonium sulphate precipitation, dialysis and anion exchange chromatography. Laccase molecular weight determined through SDS PAGE was found to be of 65 KDa. This purified laccase was tested for its ability to decolourise the Congo red at definite pH and temperature. It was found that this fungus has capability to decolourise up to 98.6% of Congo-red dye.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0