Alessandro Vaglica, Natale Badalamenti, Antonella Porrello, Vincenzo Ilardi, Maurizio Bruno
{"title":"Essential oil chemical composition of <i>Lamium flexuosum</i> Ten.: a wild accession from sicily (Italy).","authors":"Alessandro Vaglica, Natale Badalamenti, Antonella Porrello, Vincenzo Ilardi, Maurizio Bruno","doi":"10.1080/14786419.2025.2502856","DOIUrl":"https://doi.org/10.1080/14786419.2025.2502856","url":null,"abstract":"<p><p><i>Lamium flexuosum</i> Ten. is a perennial species, belonging to the Lamiaceae family, that primarily thrives in temperate biomes. Its natural distribution includes Italy, Spain, France, Morocco, Algeria, and Tunisia. In this study, the chemical profile of the essential oil extracted from the aerial parts of the Sicilian accession of this plant, which had never been previously analysed, was assessed using GC-MS. The essential oil (<b>Lf</b>) was found to be rich in sesquiterpene hydrocarbons (65.3%) with <i>β</i>-caryophyllene (21.9%), <i>β</i>-copaene (16.9%) and <i>α</i>-humulene (8.0%) as the predominant compounds. A comparison with other previously studied essential oils of the <i>Lamium</i> genus is discussed. Additionally, a review of the traditional medicine of <i>Lamium</i> species has been conducted.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuejun Wang, Jun Chen, Han Lin, Changli Min, Li Zhang, Zhimou Gao
{"title":"Exploring biosynthetic potential of the endophytic <i>Penicillium turbatum</i> BLH34 using whole-genome sequence analysis and molecular networking.","authors":"Xuejun Wang, Jun Chen, Han Lin, Changli Min, Li Zhang, Zhimou Gao","doi":"10.1080/14786419.2025.2500738","DOIUrl":"https://doi.org/10.1080/14786419.2025.2500738","url":null,"abstract":"<p><p>An in-depth genomic and metabolomic investigation was conducted on the endophytic fungus <i>Penicillium turbatum</i> BLH34, isolated from <i>Macleaya cordata</i>. Hybrid sequencing (Illumina-Nanopore) generated a high-quality 27.9 Mb genome (GC 48.6%) encoding 9798 proteins, with functional annotation linking 5350 genes to the NCBI non-redundant database and 3404 to KEGG pathways. AntiSMASH analysis uncovered 35 biosynthetic gene clusters (BGCs), 23 of which lacked homology to known pathways, highlighting BLH34's potential for novel metabolite discovery. Molecular networking (GNPS) and LC-MS/MS identified 19 specialised metabolites, including antimicrobial polyketides. Bioassays demonstrated potent inhibition against <i>Staphylococcus aureus</i> (36 mm), <i>Bacillus subtilis</i> (28 mm) and <i>Escherichia coli</i> (24 mm), underscoring its pharmaceutical relevance.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen-Qing Du, Can Liu, Ruo-Mei Li, Ning-Ning Shi, Yan-Nan Ji, Jin-Long Qi, Yu-Cheng Gu, Chun-Hui Liang, Man-Li Zhang
{"title":"New ecdysteroids with anticomplementary activity from roots of <i>Leuzea uniflora</i> (L.) holub.","authors":"Wen-Qing Du, Can Liu, Ruo-Mei Li, Ning-Ning Shi, Yan-Nan Ji, Jin-Long Qi, Yu-Cheng Gu, Chun-Hui Liang, Man-Li Zhang","doi":"10.1080/14786419.2025.2502855","DOIUrl":"https://doi.org/10.1080/14786419.2025.2502855","url":null,"abstract":"<p><p>Phytochemical investigation on roots extract of <i>Leuzea uniflora</i> (L.) Holub led to the isolation of two novel ecdysteroids, 11<i>α</i>-hydroxy-25<i>R</i>-inokosterone (1) and 11<i>α</i>-hydroxy-24<i>R</i>, 25 <i>R</i>-amarasterone A (2), along with 20 known constituents. The structures of novel compounds were confirmed by NMR and ECD spectroscopy. Compounds <b>2</b> and <b>9</b> exhibited anticomplementary activity with classical pathway, their CH<sub>50</sub> values were 138.4 ± 0.07 µg·mL<sup>-1</sup> and 158.3 ± 0.09 µg·mL<sup>-1</sup>, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emodin ameliorates dopaminergic neuron loss in the MPP<sup>+</sup> induced parkinson's disease model: significant inhibition of ferroptosis by activating UQCRC1 protein.","authors":"Ayiguzhali Yusun, Hong-Mei Wan, Hua-Xian Chen, Mo Sun, Chen-Ning Zhang, Xu-Dong Ding","doi":"10.1080/14786419.2025.2502155","DOIUrl":"https://doi.org/10.1080/14786419.2025.2502155","url":null,"abstract":"<p><p>Emodin, a naturally occurring compound derived from anthraquinone, demonstrates notable efficacy in combating oxidative stress, protecting neural tissues, and inhibiting malignant cell proliferation. This bioactive phytochemical has garnered significant scientific attention due to its multifaceted therapeutic potential, particularly in the context of oncological interventions and neurodegenerative disorder management. The neuroprotective capacity of emodin in preventing dopaminergic neuronal demise through ferroptosis modulation requires further exploration. Our experimental approach employed Erastin and MPP<sup>+</sup>-activated cellular systems to systematically evaluate this anthraquinone's therapeutic potential in counteracting iron-dependent programmed cell death mechanisms. Experimental data revealed that emodin effectively suppressed iron-dependent cell death through upregulation of mitochondrial complex III component UQCRC1. In MPP<sup>+</sup>-challenged Parkinsonian models, this compound substantially reduced degeneration of dopamine-producing neurons. Mechanistic investigations demonstrated that ferroptotic pathway activation contributes to MPP<sup>+</sup>-mediated neurotoxicity, while emodin counteracts this process <i>via</i> UQCRC1-mediated cytoprotection. These findings establish a novel regulatory axis linking UQCRC1 activation with ferroptosis inhibition, proposing emodin as a dual-function agent capable of both attenuating neuronal demise and modulating programmed cell death pathways. The pharmacological profile of emodin suggests clinical potential for intervening in ferroptosis-associated neurodegeneration.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alline L B Dias, Cassia C Fernandes, Suzana M L O Marcionilio, Daniela S Gonçalves, Gabriel G Calefi, Carlos H G Martins, Yan R Nobles, Antônio E M Crotti, Mayker L D Miranda
{"title":"<i>In vitro</i> biocontrol of phytopathogenic bacteria using floral essential oils and their synergistic blends.","authors":"Alline L B Dias, Cassia C Fernandes, Suzana M L O Marcionilio, Daniela S Gonçalves, Gabriel G Calefi, Carlos H G Martins, Yan R Nobles, Antônio E M Crotti, Mayker L D Miranda","doi":"10.1080/14786419.2025.2500734","DOIUrl":"https://doi.org/10.1080/14786419.2025.2500734","url":null,"abstract":"<p><p>Chemical compositions of essential oils (EOs) from <i>Pelargonium graveolens</i> (EO-PG), <i>Lavandula angustifolia</i> (EO-LA) and <i>Cananga odorata</i> (EO-CO) flowers were determined by GC-MS and GC-FID. Antibacterial activities were determined by the microdilution broth method in 96-well culture plates and MIC and MBC values were expressed as mg/mL. EOs were assayed individually and showed to be active against <i>Xanthomonas citri, X. euvesicatoria, X. vasicola, X. campestris, Pseudomonas fluorescens, Xylella fastidiosa, Burkholderia cepacia, Pantoea ananatis, Pectobacterium carotovorum</i> and <i>Ralstonia solanacearum</i> at concentrations between 0.31 and 10 mg/mL. Blend 2 (EO-PG: EO-LA: EO-CO 3:1:1), out of the three blends prepared by this study, was the most promising one since it exhibited the lowest values of MIC and MBC, i.e., between 0.31 and 1 mg/mL. In short, this study showed, for the first time, that EOs and their blends may be promising tools in agricultural defense to prevent severe bacterial diseases in plants.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carla Buzzanca, Angela D'Amico, Paolo Gabrielli, Alessandra Durazzo, Massimo Lucarini, Vita Di Stefano
{"title":"Alfalfa (<i>Medicago sativa</i> L.): literature quantitative research analysis.","authors":"Carla Buzzanca, Angela D'Amico, Paolo Gabrielli, Alessandra Durazzo, Massimo Lucarini, Vita Di Stefano","doi":"10.1080/14786419.2025.2486335","DOIUrl":"https://doi.org/10.1080/14786419.2025.2486335","url":null,"abstract":"<p><p><i>Medicago sativa</i> L., also known as alfalfa, is a perennial crop native of the Mediterranean area. It is one of the most widely cultivated plants due to its adaptability to diverse environments. This communication aims at giving an updated picture of <i>Medicago sativa</i> L.; a literature quantitative research analysis was carried out based on the Scopus database content. The resulting research gives 20,565 documents, which cover a time range between 1866 and 2025. The main subject areas are as follows: <i>Agricultural and Biological Sciences</i>, <i>Biochemistry</i>, <i>Genetics and Molecular Biology</i>, <i>Environmental Science</i>, and others. The main relevant research directions, challenges, and emerging applications are explored.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing Zhao, Shu-Yue Song, Han Fang, Yao-Yao Zheng, Meng-Qi Zhang, Xia Ren, Ya-Hui Zhang, Xiu-Mei Fu, Xin Li, Chang-Yun Wang
{"title":"Deciphering the effective substances of mangrove plant <i>Acanthus ilicifolius</i> Linn. against liver injury.","authors":"Qing Zhao, Shu-Yue Song, Han Fang, Yao-Yao Zheng, Meng-Qi Zhang, Xia Ren, Ya-Hui Zhang, Xiu-Mei Fu, Xin Li, Chang-Yun Wang","doi":"10.1080/14786419.2025.2503012","DOIUrl":"https://doi.org/10.1080/14786419.2025.2503012","url":null,"abstract":"<p><p>The mangrove plant <i>Acanthus ilicifolius</i> Linn. has been recorded to treat liver injury diseases, but its active ingredients are unclear. In the present study, chemical compounds in the ethanol extract of <i>A. ilicifolius</i> were isolated, and their anti-liver injury, anti-inflammatory and anti-oxidant activities were evaluated to decipher the effective substances. In total, 42 compounds (<b>1-42</b>) were obtained, including two new naphthalene compounds (<b>1-2</b>). Moreover, the anti-liver injury, anti-inflammatory and anti-oxidant activities of compounds were evaluated. In CCl<sub>4</sub>-induced HepG2 cellular model, compound <b>33</b> showed significant anti-liver injury activity at 50, 25, 12.5 and 6.25 μM, while <b>1</b>, <b>9</b>, <b>13-16</b>, <b>33</b> showed significant activity at 50 and 25 μM. Overall, naphthalenes (<b>1-2</b>), phenylethanoid glycosides (<b>12-16</b>), alkaloid (<b>3</b>), flavonoid (<b>9</b>) and lignin (<b>33</b>) could be the main effective substances in <i>A. ilicifolius</i> against liver injury.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuan Wang, Guanglong Zhang, Xiaohui Jiang, Liangmin Yu
{"title":"Design and synthesis of amide derivatives inspired by capsaicin as potential antibacterial and antitumor agents.","authors":"Xuan Wang, Guanglong Zhang, Xiaohui Jiang, Liangmin Yu","doi":"10.1080/14786419.2025.2502852","DOIUrl":"https://doi.org/10.1080/14786419.2025.2502852","url":null,"abstract":"<p><p>Nine amide derivatives inspired by capsaicin (ADICs) were synthesised and evaluated for antibacterial and antitumor activities by a series of standard methods in this study. The results showed that ADICs had good antibacterial and antitumor activity. In the antibacterial assay, their inhibitory rates were over 76.70% at 20 μg/mL, the MIC values were not more than 32 μg/mL, and they exhibited healthy characteristics with MBC values exceeding 128 μg/mL. In antitumor assay, the inhibition rates of the products a3, b3, and c3 with chloroacetamide exceeded 55.00% at 10 μM, and their IC<sub>50</sub> values were all less than 8.61 μM; furthermore, injection of products a3 and b3 suppressed the growth of A549 and HCT116 tumour cells transplanted subcutaneously into nude mice. As benign and healthy antibacterial and antitumor agents, the research and development of ADICs are of important realistic significance to their application in the food and pharmaceutical industries.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Liu, Wei-Wei Tian, Ying-Chao Wang, Can Ren, Dong-Mei Yu, Jian-Bo Wang, Jun-Ning Zhao, Hua Hua
{"title":"Three phloridzin derivatives capable of anti-oxidant from <i>Malus toringoides</i> (Rehd) Hughes.","authors":"Li Liu, Wei-Wei Tian, Ying-Chao Wang, Can Ren, Dong-Mei Yu, Jian-Bo Wang, Jun-Ning Zhao, Hua Hua","doi":"10.1080/14786419.2025.2494623","DOIUrl":"https://doi.org/10.1080/14786419.2025.2494623","url":null,"abstract":"<p><p>Two new phloridzin derivatives 6″-<i>O</i>-(4-hydroxytrans cinnamoyl) phloridzin (1) and 6″-<i>O</i>-(4-hydroxycis-cinnamoyl) phloridzin (3) and one known dihydrochalcones 6″-<i>O</i>-feruloyl phloroside (2) were isolated from the leaves of <i>Malus toringoides</i> (Rehd) Hughes. Their structures were elucidated on the basis of extensive spectroscopic data. The results of zebrafish and FRAP antioxidant kit showed that compound 1-3 had antioxidant effects.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New phenazines from Taibai mountain-derived <i>Streptomyces xanthophaeus</i> A54.","authors":"Lukuan Hou, Xue Yang, Shuyao Wang, Wenli Li","doi":"10.1080/14786419.2025.2502141","DOIUrl":"https://doi.org/10.1080/14786419.2025.2502141","url":null,"abstract":"<p><p>Four phenazineswere isolated from the Taibai mountain-derived <i>Streptomyces xanthophaeus</i> A54, among which Taibphenazine A (<b>1</b>) and Taibphenazine B (<b>2</b>) are new compounds. Comprehensive spectroscopic analyses, including HRESIMS, NMR, ECD calculations, and optical rotation value, were employed to elucidate the structures of these compounds. Taibphenazine B showed considerable anti-influenza A virus activity (IC<sub>50</sub>=27.07 μM), which was similar to the positive control ribavirin (IC<sub>50</sub>=24.20 μM).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}