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One undescribed glycoside benzofuran derivative and a new p-hydroxybenzoate glycoside from the leaves of Illicium dunnianum Tutcher 从 Illicium dunnianum Tutcher 的叶子中提取出一种未曾描述过的苷类苯并呋喃衍生物和一种新的对羟基苯甲酸苷。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2216348
{"title":"One undescribed glycoside benzofuran derivative and a new p-hydroxybenzoate glycoside from the leaves of Illicium dunnianum Tutcher","authors":"","doi":"10.1080/14786419.2023.2216348","DOIUrl":"10.1080/14786419.2023.2216348","url":null,"abstract":"<div><div>One undescribed benzofuran derivative (illiciumphenolicacid A, <strong>1</strong>) and one new phenolic glycoside (illiciumphenolicacid B, <strong>2</strong>), together with six known compounds (<strong>3–8</strong>) were isolated from the leaves of <em>Illicium dunnianum</em> Tutcher. Their structures were elucidated by detailed spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR). In addition, we determined the <em>α</em>-glucosidase inhibitory activity of the isolates <em>in vitro</em> using spectrophotometric methods. Compared with the positive control acarbose (IC<sub>50</sub> 306.2 ± 4.1 <em>μ</em>M), compounds <strong>1–8</strong> were shown to be moderate potential <em>α</em>-glucosidase inhibitory activity with IC<sub>50</sub> values in the range 380–655 <em>μ</em>M.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9933968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid molecularly imprinted polymers for targeted separation and enrichment of 10-hydroxycamptothecin in Camptotheca acuminata Decne 杂化分子印迹聚合物用于定向分离和富集喜树中的 10-羟基喜树碱。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2228981
{"title":"Hybrid molecularly imprinted polymers for targeted separation and enrichment of 10-hydroxycamptothecin in Camptotheca acuminata Decne","authors":"","doi":"10.1080/14786419.2023.2228981","DOIUrl":"10.1080/14786419.2023.2228981","url":null,"abstract":"<div><div>The molecularly imprinted polymer was synthesized using 3-aminopropylthiosilane-methacrylic acid monomer (APTES-MAA) as the functional monomer and 10-hydroxycamptothecin (HCPT) as the template, based on computer simulation. The hybrid molecularly imprinted polymers (HMIPs) were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, particle size measurement, scanning electron microscopy and energy dispersive X-ray spectroscopy. It has been shown that HMIPs are irregularly shaped and porous, with particle sizes ranging mainly from 130 to 211 nm. At 298 K, the HMIPs exhibit a maximum adsorption capacity of 8.35 mg·g<sup>−1</sup> for HCPT and demonstrate good adsorption specificity (<em>α</em> = 5.38). The pseudo-second-order reaction mechanism suggests that the equilibrium adsorption capacity of HCPT on HMIPs is 8.11 mg·g<sup>−1</sup>. Finally, HCPT was successfully separated and enriched from the extract of <em>Camptotheca acuminata</em> Decne. seeds using HMIPs.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl 从 Mezonevron sinense Hemsl.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2219821
{"title":"Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl","authors":"","doi":"10.1080/14786419.2023.2219821","DOIUrl":"10.1080/14786419.2023.2219821","url":null,"abstract":"<div><div>Two new norcassane-type diterpenoids, named 6<em>β</em>-hydroxy-bisnorcass-13-en-12-one (<strong>1</strong>) and 6<em>β</em>-hydroxy-bisnorcassan-12-one (<strong>2</strong>), were isolated from the seeds of <em>Mezonevron sinense</em> Hemsl. The structures of compounds <strong>1</strong>-<strong>2</strong> were determined by extensive spectroscopic analysis. Two compounds exhibited immunosuppressive activity with the IC<sub>50</sub> values of 19.35 ± 0.87 μM and 18.69 ± 0.88 μM in the ConA induced T cell model and 65.04 ± 0.83 <em>μ</em>M and 48.06 ± 0.76 μM in LPS induced B cell model, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9602181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on 2-arylbenzo[b]furans from Itea omeiensis and their fragmentation patterns with Q-Orbitrap mass spectrometry 用 Q-Orbitrap 质谱法研究峨嵋杉中的 2-芳基苯并[b]呋喃及其碎片模式。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2216344
{"title":"Study on 2-arylbenzo[b]furans from Itea omeiensis and their fragmentation patterns with Q-Orbitrap mass spectrometry","authors":"","doi":"10.1080/14786419.2023.2216344","DOIUrl":"10.1080/14786419.2023.2216344","url":null,"abstract":"<div><div>One new 2-arylbenzo[<em>b</em>]furan named iteafuranal F (<strong>1</strong>) as well as two known analogues (<strong>2–3</strong>) were isolated from the 95% EtOH extract of aerial parts of <em>Itea omeiensis</em>. Their chemical structures were constructed based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. Antioxidant assays revealed significant superoxide anion radical scavenging capacity of <strong>1</strong> with IC<sub>50</sub> value of 0.66 mg/mL, which was comparable to the efficiency of positive control of luteolin. In addition, the preliminary MS fragmentation patterns in negative ion mode were established to distinguish 2-arylbenzo[<em>b</em>]furans with C-10 in different oxidation states: the characteristic loss of CO molecule [M-H-28]<sup>-</sup> was observed for 3-formyl-2-arylbenzo[<em>b</em>]furans, and the loss of CH<sub>2</sub>O fragment [M-H-30]<sup>-</sup> for 3-hydroxymethyl-2-arylbenzo[<em>b</em>]furans, and the loss of CO<sub>2</sub> fragment [M-H-44]<sup>-</sup> for 2-arylbenzo[<em>b</em>]furan-3-carboxylic acids.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9898509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, isolation, characterization of C3-C11 bridge-bond isomer of paclitaxel and its antitumor effect via inducing A549 cells pyroptosis 紫杉醇 C3-C11 桥键异构体的合成、分离、表征及其通过诱导 A549 细胞热休克产生的抗肿瘤作用。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2218011
{"title":"Synthesis, isolation, characterization of C3-C11 bridge-bond isomer of paclitaxel and its antitumor effect via inducing A549 cells pyroptosis","authors":"","doi":"10.1080/14786419.2023.2218011","DOIUrl":"10.1080/14786419.2023.2218011","url":null,"abstract":"<div><div>During the chemical manufacturing control processing of new paclitaxel formulations, a photodegradation impurity called C3-C11 bridge-bond isomer appeared. Our work describes the synthesis, isolation, purification, and structural characterization methods using four spectroscopies: FT-IR, UV, NMR (1H and 13 C), and LC-MS. In addition, we discovered that the C3-C11 bridge-bond isomer can promote A549 cells pyroptosis, and increase pyroptosis-related proteins, including cleaved-caspase 3, cleaved-PARP, GSDME-N, and lactate dehydrogenase, thus making it anti-tumor effects. The study offered data suggesting that the C3-C11 bridge bond isomer may be used as an anti-tumour drug in the future.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9919084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Streptomyces from desert environments: a treasure trove of next-generation natural compounds 沙漠环境中的链霉菌：新一代天然化合物的宝库
IF 2.2 3区 化学
Natural Product Research Pub Date : 2024-09-12 DOI: 10.1080/14786419.2024.2403032
Periyasamy Sivalingam
{"title":"Streptomyces from desert environments: a treasure trove of next-generation natural compounds","authors":"Periyasamy Sivalingam","doi":"10.1080/14786419.2024.2403032","DOIUrl":"https://doi.org/10.1080/14786419.2024.2403032","url":null,"abstract":"Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats. 穿心莲（burm.f.）叶提取物可减轻睾酮诱导的 Wistar 大鼠良性前列腺增生。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-12 DOI: 10.1080/14786419.2024.2401494
Imaobong Christopher Etti, Erimimoh Eba Unoh, Mary Richard Akpan, Ubong Uduak Umanah, Rebecca Emmanuel Agbonika, Arifah Abdul Kadir, Chukwuemeka Nwafor
{"title":"Attenuation of testosterone-induced benign prostatic hyperplasia with <i>Andrographis paniculata</i> (burm.f.) leaf extract in Wistar rats.","authors":"Imaobong Christopher Etti, Erimimoh Eba Unoh, Mary Richard Akpan, Ubong Uduak Umanah, Rebecca Emmanuel Agbonika, Arifah Abdul Kadir, Chukwuemeka Nwafor","doi":"10.1080/14786419.2024.2401494","DOIUrl":"https://doi.org/10.1080/14786419.2024.2401494","url":null,"abstract":"<p><p><i>Andrographis paniculata</i> (Burm.f.) Nees has been used traditionally in treating many diseases. This study investigated its potential to attenuate benign prostatic hyperplasia (BPH) in male rats. Rats were castrated, divided into five groups and orally treated for 14 days with: normal saline,10 mg/kg testosterone propionate sc, finasteride (0.5 mg/kg), 500 mg, and 1500 mg/kg of <i>Andrographis paniculata</i>. Relative prostate weights, the correlation between prostatic index and volume and the prostates' histopathology as well as Prostate Specific Antigen (PSA) were evaluated. Following treatment with <i>Andrographis paniculata</i>, the prostate weights were significantly reduced (<i>p</i> < 0.05) and the lost correlation observed in the untreated group was restored. Histopathological assessment showed reduced epithelial hyperplasia following treatment with a resultant thin layer of epithelial cells, similar to the healthy normal control group. The level of PSA was also reduced. <i>Andrographis paniculata,</i> thus, has the potential to inhibit the proliferation observed in testosterone-induced BPH.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2-Arylbenzofurans from the stems and leaves of Artocarpus tonkinensis and their potential antiproliferative activities 来自朝鲜蓟茎和叶的 2-芳基苯并呋喃及其潜在的抗增殖活性
IF 2.2 3区 化学
Natural Product Research Pub Date : 2024-09-12 DOI: 10.1080/14786419.2024.2402462
Jia-Ming Guo, Lin-Xuan Li, Xin-Yi Li, Tian-Yu Wang, En-Ning Zhu, An-Jiao Wu, Shu-Ri Li, Hui- Yang, Yan-Ping Liu, Yan-Hui Fu
{"title":"2-Arylbenzofurans from the stems and leaves of Artocarpus tonkinensis and their potential antiproliferative activities","authors":"Jia-Ming Guo, Lin-Xuan Li, Xin-Yi Li, Tian-Yu Wang, En-Ning Zhu, An-Jiao Wu, Shu-Ri Li, Hui- Yang, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/14786419.2024.2402462","DOIUrl":"https://doi.org/10.1080/14786419.2024.2402462","url":null,"abstract":"Phytochemical study on the stems and leaves of Artocarpus tonkinensis led to the isolation of a new 2-arylbenzofuran, artocartone (1), as well as seven known 2-arylbenzofurans (2–8). The chemical s...","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive phenolic profiling and biological evaluation of Centaurea glastifolia L. (Asteraceae). 菊科植物仙人掌（Centaurea glastifolia L.）的综合酚类分析和生物学评价。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-12 DOI: 10.1080/14786419.2024.2403028
Sefa Gözcü, Zeynep Akşit, Ali Aydın, Mustafa Abdullah Yılmaz, Samed Şimşek
{"title":"Comprehensive phenolic profiling and biological evaluation of <i>Centaurea glastifolia</i> L. (Asteraceae).","authors":"Sefa Gözcü, Zeynep Akşit, Ali Aydın, Mustafa Abdullah Yılmaz, Samed Şimşek","doi":"10.1080/14786419.2024.2403028","DOIUrl":"https://doi.org/10.1080/14786419.2024.2403028","url":null,"abstract":"<p><p>The present investigation focused on the comprehensive analysis of the phenolic profile of <i>Centaurea glastifolia</i> L. (Asteraceae) and the assessment of its diverse biological activities. Utilising LC-MS/MS, the phytochemical composition of the 70% methanol extract of <i>Centaurea glastifolia</i> (CG-ME) was thoroughly elucidated, revealing the presence of 30 distinct phytochemical compounds. Notably, major phenolic constituents identified in the extract included quinic acid, chlorogenic acid, luteolin-7-<i>O</i>-glucoside, kaempferol-3-<i>O</i>-glucoside, luteolin, and apigenin-7-<i>O</i>-glucoside. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities of CG-ME were investigated. The CG-ME exhibited a moderate capacity for scavenging DPPH radicals (IC<sub>50</sub>: 50.05 ± 1.58 µg/mL) and FRAP (63.96 ± 0.39 mg TE/g extract), indicating a moderate level of antioxidant activity. Moreover, CG-ME demonstrated significant antiproliferative effects (GI<sub>50</sub>: 1.10 and 1.30 µg/mL) on cancer cells (C6 and HTC cancer cell lines, respectively) while displaying low cytotoxicity towards normal cells (LC<sub>50</sub>: >1000 µg/mL). In terms of antibacterial activity, CG-ME was found to be inactive against tested both Gram-positive and Gram-negative bacterial strains (MIC > 500 µg/mL). The extracts had a promising antiproliferative effect on C6, HeLa, and HT29 cancer cell lines with a less cytotoxic effect (10.5-14.2%) against normal cells.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical analysis of the methanolic extract from the mangrove species Avicennia marina plant species inhabited in coastal water 栖息于沿海水域的红树林物种 Avicennia marina 植物甲醇提取物的植物化学分析
IF 2.2 3区 化学
Natural Product Research Pub Date : 2024-09-12 DOI: 10.1080/14786419.2024.2402474
Perumal Govindhan
{"title":"Phytochemical analysis of the methanolic extract from the mangrove species Avicennia marina plant species inhabited in coastal water","authors":"Perumal Govindhan","doi":"10.1080/14786419.2024.2402474","DOIUrl":"https://doi.org/10.1080/14786419.2024.2402474","url":null,"abstract":"The mangrove, a vital ecosystem, faces significant threats from climate change, human actions, and pollution. This study aims to evaluate the presence and distribution of trace metals (Cu, Cd, Ni, ...","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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