Natural Product Research最新文献_第10页

Sustainable and eco-friendly packaging films based on poly vinyl alcohol incorporated with Chrysanthemum frutescens extract. 基于含有菊花提取物的聚乙烯醇的可持续环保包装薄膜。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-26 DOI: 10.1080/14786419.2025.2565267

Mona M AbdelMohsen, Hebat-Allah S Tohamy, Sally A Abdel-Halim, Hassan M Awad, Mohamed El-Sakhawy

引用次数: 0

Essential oil from Goniothalamus elegans Ast leaves in Vietnam: chemical composition, nitric oxide inhibition, and xanthine oxidase inhibition activities. 越南蓖麻叶精油：化学成分、一氧化氮抑制及黄嘌呤氧化酶抑制活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-26 DOI: 10.1080/14786419.2025.2559771

Trang Huyen Xuan Hoang, Tuan Quoc Doan, Dien Dinh, Anh Tuan Le, Hoai Thi Nguyen, Linh Thuy Thi Tran

{"title":"Essential oil from Goniothalamus elegans Ast leaves in Vietnam: chemical composition, nitric oxide inhibition, and xanthine oxidase inhibition activities.","authors":"Trang Huyen Xuan Hoang, Tuan Quoc Doan, Dien Dinh, Anh Tuan Le, Hoai Thi Nguyen, Linh Thuy Thi Tran","doi":"10.1080/14786419.2025.2559771","DOIUrl":"https://doi.org/10.1080/14786419.2025.2559771","url":null,"abstract":"Essential oils are renowned for their distinctive aromas and broad spectrum of bioactivities, particularly in managing inflammatory conditions and oxidative stress-related disorders. The genus Goniothalamus is well-known for its chemical diversity, yet its anti-inflammatory and anti-gout potential remains underexplored. In this study, the essential oil of Goniothalamus elegans Ast was analysed for the first time, revealing a complex profile of 48 compounds, accounting for 86.74% of its total composition. The primary constituents included guaiol (13.57%), bulnesol (8.78%), palmitic acid (5.89%), phytol (5.86%), and linalool (4.41%). The essential oil exhibited significant bioactivities, notably xanthine oxidase inhibition IC50 = 61.53 µg/mL and nitric oxide (NO) production suppression IC50 = 17.92 µg/mL. These findings highlight the potential of G. elegans essential oil as a promising natural source for developing anti-inflammatory agents or adjunctive treatments for gout.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-activity relationship of acetylcholinesterase inhibitory activity and neurite outgrowth promoting activity of homoisoflavans and related compounds. 同型异黄酮及其相关化合物抑制乙酰胆碱酯酶活性与促进神经突生长活性的构效关系。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-26 DOI: 10.1080/14786419.2025.2565707

Toshiro Noshita, Ayaka Saiki, Takeru Koga, Akihiro Tai

{"title":"Structure-activity relationship of acetylcholinesterase inhibitory activity and neurite outgrowth promoting activity of homoisoflavans and related compounds.","authors":"Toshiro Noshita, Ayaka Saiki, Takeru Koga, Akihiro Tai","doi":"10.1080/14786419.2025.2565707","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565707","url":null,"abstract":"Inhibitors of acetylcholinesterase (AChE) and agents that enhance neurite outgrowth are regarded as promising therapeutic strategies for addressing neurodegenerative disease including Alzheimer's disease. In this study, a series of homoisoflavonoid derivatives was rationally designed and synthesised, drawing on the structure of (±)-3',4'-dihydroxyhomoisoflavan, a compound previously reported to exhibit both potent AChE inhibitory activity and neurite outgrowth-promoting effects. The structure-activity relationship (SAR) analysis on the synthesised compounds indicated that the presence of a catechol moiety on the B ring is essential for neurite outgrowth-promoting activity. Conversely, modifications to the C-ring had a minimal impact on this activity. Moreover, AChE inhibitory potency was enhanced in analogues with increased lipophilicity compared to the parent compound, 3',4'-dihydroxyhomoisoflavan. Among the seven analogues evaluated, those featuring both a catechol B ring and a C ring in which the oxygen atom was substituted with a carbon atom have emerged as promising lead compounds. These findings underscore the potential of this class of homoisoflavonoid derivatives as candidates for further development as therapeutic agents for dementia.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition, in vitro and in silico evaluation of essential oil from Syzygium cumini L. for breast cancer. 芫荽精油治疗乳腺癌的化学成分、体外及体内评价。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-26 DOI: 10.1080/14786419.2025.2562599

Jyotirmayee Behera, Tushar Midha, Bhim Singh, Jare Shrikrushna Bharat, Somesh Baranwal, Vikas Jaitak

引用次数: 0

Hirsutane sesquiterpenoids from basidiomycete Pseudohydropus cf. parafunebris. 伪水担子菌的倍半萜类化合物。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-26 DOI: 10.1080/14786419.2025.2565269

Somporn Palasarn, Malipan Sappan, Kitlada Srichomthong, Thitiya Boonpratuang, Maneerat Pobkwamsuk, Masahiko Isaka, Taridaporn Bunyapaiboonsri

引用次数: 0

Cutibacterium acnes growth and biofilm formation is inhibited by flavonoids. 黄酮类化合物抑制痤疮表皮杆菌的生长和生物膜的形成。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-25 DOI: 10.1080/14786419.2025.2565276

Marija Ivanov, Nikoleta Đorđevski, Jelena Dabić, Dejan Stojković

{"title":"Cutibacterium acnes growth and biofilm formation is inhibited by flavonoids.","authors":"Marija Ivanov, Nikoleta Đorđevski, Jelena Dabić, Dejan Stojković","doi":"10.1080/14786419.2025.2565276","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565276","url":null,"abstract":"Cutibacterium acnes is the cause of inflammatory acne and implanted devices associated infections. This study investigated flavonoids belonging to the 4 classes: flavanones (hesperidin, neohesperidin, naringenin, naringin, and eriodictyol), flavones (diosmetin, diosmin), isoflavone (genistein), and flavonols (kaempferol, galangin) as inhibitors of C. acnes growth in planktonic and biofilm form and assessed its potential to impact the integrity of cell membrane. Flavonoids could inhibit C. acnes growth, minimal inhibitory concentration (MIC) was in range 50-200 mg/L, with the lowest MIC (50 mg/L) for neohesperidin and eriodictyol. Minimal biofilm inhibitory concentrations were in range 25-200 mg/L, with the lowest values and highest antibiofilm potential recorded for eriodictyol, genistein, and kaempferol. Impact on cell membrane was significant in the presence of almost all examined flavonoids, as determined by crystal violet uptake assay. Flavonoids, especially eriodictyol, represent promising underexplored agents for combating infections and processes linked with the presence of C. acnes.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four new fluorenones isolated from the mycelia of medicinal mushroom Piptoporus soloniensis (Dubois:Fr.) Pilat and their anti-inflammatory activity. 从药用蘑菇Piptoporus soloniensis （Dubois:Fr.）菌丝体中分离到的4个新的芴酮类化合物和它们的抗炎活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-25 DOI: 10.1080/14786419.2025.2565702

Lan Yao, Yi-Fan Sun, Ren-Ya Ji, Zi-Chen Tian, Shu-Han Zhang, Gen-Wei Zhang, Jian-Hua Lv

引用次数: 0

Anti-hyperuricemic triterpene saponins from the roots of Achyranthes bidentata. 牛膝根抗高尿酸三萜皂苷。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-24 DOI: 10.1080/14786419.2025.2559775

Jinqian Yu, Tong Niu, Tao Yue, Xiao Wang, Galabada Arachchige Sirimal Premakumara, Lei Zhao

引用次数: 0

One novel sesquiterpenoid from the fungus Pestalotiopsis clavata JSQ 12 isolated from the mushroom Lanmaoa asiatica. 一种新的倍半萜类化合物——拟盘多毛孢JSQ - 12。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-24 DOI: 10.1080/14786419.2025.2565708

Zi-Lin Wang, Shuai-Ming Zhu, Yu Yang, Rui Xu, Xue Zhao, Chen Sun, Qian Luo, You-Zhi Zhang, Guo-Gang Zhang, Chang-Wei Li

引用次数: 0

The phytochemical characteristics of Swertia mussotii Franch. and the potential for treating neuroinflammation in vitro through the NF-κB pathway. 法国獐牙菜的植物化学特性。以及通过NF-κB途径在体外治疗神经炎症的潜力。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-24 DOI: 10.1080/14786419.2025.2565264

Yating Zheng, Jiajing Yu, Yanan Li, Hong Zhou, Guobiao Dai, Lijiao Yang, Rui Tan, Hezhong Jiang

{"title":"The phytochemical characteristics of Swertia mussotii Franch. and the potential for treating neuroinflammation in vitro through the NF-κB pathway.","authors":"Yating Zheng, Jiajing Yu, Yanan Li, Hong Zhou, Guobiao Dai, Lijiao Yang, Rui Tan, Hezhong Jiang","doi":"10.1080/14786419.2025.2565264","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565264","url":null,"abstract":"Microglial activation is a key driver of neuroinflammation, rendering it a critical therapeutic target. This study explored the neuroprotective potential of compounds derived from Swertia mussotii Franch. against lipopolysaccharide (LPS)-induced microglial activation. Eleven compounds were isolated from this plant. Screening using an LPS-stimulated BV2 microglial cell model identified amarogentin (AMG) as exhibiting significant protective effects. Subsequent mechanistic investigations revealed that AMG effectively mitigated LPS-induced morphological changes associated with microglial activation and suppressed the release of nitric oxide (NO) (p < 0.01) and pro-inflammatory cytokines (TNF-α, IL-1β) (p < 0.05). Moreover, AMG markedly downregulated the mRNA expression of inducible nitric oxide synthase (iNOS) (p < 0.01), TNF-α (p < 0.01), and IL-1β (p < 0.05). At the protein level, AMG inhibited the expression of phosphorylated p65 (p-p65) (p < 0.01). These results indicate that AMG confers robust neuroprotective effects against microglial activation-induced injury, likely via suppression of the NF-κB signalling pathway.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0