Natural Product Research最新文献_第10页

Pectin-like polysaccharide extracted from Cucumis melo pulp: physicochemical, antioxidant, and skin hydration efficacy. 从甜瓜果肉中提取的果胶样多糖：理化、抗氧化和皮肤保湿功效。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2434133

Tawanun Sripisut, Aunchayakorn Teja, Naphaporn Pengsuwan, Thapakorn Tree-Udom, Setinee Chanpirom

{"title":"Pectin-like polysaccharide extracted from Cucumis melo pulp: physicochemical, antioxidant, and skin hydration efficacy.","authors":"Tawanun Sripisut, Aunchayakorn Teja, Naphaporn Pengsuwan, Thapakorn Tree-Udom, Setinee Chanpirom","doi":"10.1080/14786419.2024.2434133","DOIUrl":"https://doi.org/10.1080/14786419.2024.2434133","url":null,"abstract":"Cucumis melo (currently accepted name of Luffa cylindrica) is a Cucurbitaceae vegetable with several biological activities. Polysaccharides from the fruit of C. melo were extracted and evaluated, producing a high extractive yield (17.20 ± 0.65%). The following physicochemical properties were provided: solubility and swelling capacity (99.51 ± 0.07% and 2.00 ± 0.00%, respectively), with a pH of 6.47 ± 0.02. The total polysaccharide content consisted of 0.23 ± 0.01 mg glucose/mg extract, while the total phenolic content was 19.99 ± 0.12 mg GAE/g extract, posing antioxidant activity on DPPH at IC50 of 214.38 ± 6.96 µg/mL. It was assumed from FT-IR that the extract consisted of pectin-like polysaccharides and other water-soluble polysaccharides. An in vivo study involving 20 volunteers showed that it did not cause skin irritation. A single application of the polysaccharide extract solutions (1.0 and 5.0% w/v) showed significantly greater short-term skin hydrating efficacy than the benchmark (p < 0.05), especially after 210 min, indicating its potential as a skin moisturising ingredient for cosmetics.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihydrosamidin: the basic khellactone ester derived from Phlojodicarpus komarovii and its impact on neurotrophic factors, energy and antioxidant metabolism after rat cerebral ischemia-reperfusion injury. Dihydrosamidin：从 Phlojodicarpus komarovii 提取的基本黄内酯及其对大鼠脑缺血再灌注损伤后神经营养因子、能量和抗氧化代谢的影响。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2433189

Anyuta A Toropova, Yanina G Razuvaeva, Daniil N Olennikov

{"title":"Dihydrosamidin: the basic khellactone ester derived from Phlojodicarpus komarovii and its impact on neurotrophic factors, energy and antioxidant metabolism after rat cerebral ischemia-reperfusion injury.","authors":"Anyuta A Toropova, Yanina G Razuvaeva, Daniil N Olennikov","doi":"10.1080/14786419.2024.2433189","DOIUrl":"https://doi.org/10.1080/14786419.2024.2433189","url":null,"abstract":"Dihydrosamidin (DHS), a khellactone 3'-O-isovaleroyl-4'-O-acetyl ester, is naturally found in Apiaceae plants yet remains underexplored in biomedical research. Employing HPLC-PDA-MS analysis, the profiling of coumarins in Phlojodicarpus komarovii revealed its significant presence, reaching DHS concentrations of 95 mg/g. DHS administering at a dosage of 80 mg/kg during bilateral transient occlusion of the common carotid artery in Wistar rats prevented neuronal death and decreased neuron-specific enolase levels in the blood serum, increases neurotrophic factors and vascular endothelial growth factor A levels in brain lysate. DHS influenced energy metabolism by reducing the lactate, enhancing the activity of pyruvate kinase and increasing the activities of NADH dehydrogenase and succinate dehydrogenase in brain cells. DHS reduced levels of malondialdehyde and increased activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, along with increased levels of reduced glutathione in brain homogenate. Thus, DHS administration promotes neuroplasticity, modulates glycolysis and oxidative phosphorylation and enhances antioxidant defences.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical screening and biological properties of Quintral flower polyphenolic fractions. 昆特兰花多酚组分的植物化学筛选和生物特性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2432609

Patricia Velásquez, Eduardo Muñoz-Carvajal, Marta Luengo, Daniela Bustos, Franco Galdames, Miguel Gómez, Gloria Montenegro, Ady Giordano

{"title":"Phytochemical screening and biological properties of Quintral flower polyphenolic fractions.","authors":"Patricia Velásquez, Eduardo Muñoz-Carvajal, Marta Luengo, Daniela Bustos, Franco Galdames, Miguel Gómez, Gloria Montenegro, Ady Giordano","doi":"10.1080/14786419.2024.2432609","DOIUrl":"https://doi.org/10.1080/14786419.2024.2432609","url":null,"abstract":"Tristerix corymbosus flower is used in traditional medicine for its antioxidant and antibacterial properties, which are attributed to phenolic compounds. These compounds present different grades of associations with the plant matrix (free, esterified, and insoluble). This study aimed to determine which fraction contributes the most to total phenolic and flavonoid contents and bioactive properties. The total phenolic content was higher in the free fraction. In contrast, the esterified fraction exhibited the highest total flavonoid content and the greatest number of characterised compounds (chlorogenic, coumaric, and sinapic acids). All fractions exhibited antioxidant capacity against FRAP, DPPH, and ABTS assays. The free and esterified fractions presented antibacterial capacity against E. coli, S. typhi, and S. aureus. Chlorogenic and sinapic acids were correlated with the antibacterial capacity against E. coli and S. typhi. While coumaric acid correlated with the antibacterial capacity against S. aureus. These findings enable the exploration of potential applications for the different fractions.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monosaccharide composition, physicochemical characteristics, and prebiotic activity of purified polysaccharides from red Ganoderma mushroom prepared using ultrasonic-assisted extraction. 利用超声波辅助提取法制备的红灵芝纯化多糖的单糖组成、理化特性和益生活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2432606

Bo Jie Chen, Cong Xia, Peiling Wu, Yang Liu, Jing Li, Tiemin Jiang, Xia Li, Biyu Peng, Hock Eng Khoo

{"title":"Monosaccharide composition, physicochemical characteristics, and prebiotic activity of purified polysaccharides from red Ganoderma mushroom prepared using ultrasonic-assisted extraction.","authors":"Bo Jie Chen, Cong Xia, Peiling Wu, Yang Liu, Jing Li, Tiemin Jiang, Xia Li, Biyu Peng, Hock Eng Khoo","doi":"10.1080/14786419.2024.2432606","DOIUrl":"10.1080/14786419.2024.2432606","url":null,"abstract":"The objective of this study was to develop a purified Ganoderma polysaccharide for use in prebiotic research. The monosaccharide composition, physicochemical characteristics, and prebiotic activities of the Ganoderma polysaccharides were determined. Additionally, the total protein, total sugar, antioxidant activities, and molecular weights of the polysaccharides were subjected to analysis. The results demonstrated that the purified polysaccharide sample was predominantly composed of short-chain dextrans. The sample was found to comprise trehalose and trace amounts of protein. The Brunauer-Emmet-Teller (BET) analysis revealed that the polysaccharides exhibited a multiporous structure. The polysaccharide structure was found to consist of hydroxyl groups, along with the other common functional groups typically observed in sugar molecules. The polysaccharide sample exhibited moderate thermal stability, and its antioxidant activities were observed to be concentration-dependent. Furthermore, the Ganoderma polysaccharides were observed to facilitate the growth of probiotic strains. Therefore, the polysaccharides are potential nutraceuticals and prebiotics.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative analysis of chemical constituents and study on the biological activity of Polygonum perfoliatum L. 何首乌化学成分定性分析及生物活性研究

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2430327

Chaochen Yue, Ya Zhang, Juan Xue, Tian Lu, Lei Li, Yanjie Wang, Rui Zhou, Di Gao, Huifang Chai

引用次数: 0

Emerging role of natural product-derived phytochemicals in the green synthesis of metal nanoparticles: a paradigm shift in sustainable nanotechnology. 源自天然产品的植物化学物质在绿色合成金属纳米粒子中的新作用：可持续纳米技术的范式转变。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-26 DOI: 10.1080/14786419.2024.2432012

Priyadharsan Arumugam

引用次数: 0

In vitro and in silico anti-inflammatory effect of minor constituents from the roots of Polygala arillata Buch.-Ham. ex D. Don. 远志根部次要成分的体外和体内抗炎作用

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-26 DOI: 10.1080/14786419.2024.2429121

Bui Thi Thuy Luyen, Tran Anh Quang, Le Xuan Duy, Bui Huu Tai, Nguyen Viet Phong, Do Huu Nghi, Nguyen Minh Khoi, Nguyen Van Chinh, Nguyen Cao Cuong, Trinh Thi Thuy, Tran Thu Huong, Le Ba Vinh, Nguyen Hong Anh, Nguyen Tuan Hiep

{"title":"In vitro and in silico anti-inflammatory effect of minor constituents from the roots of Polygala arillata Buch.-Ham. ex D. Don.","authors":"Bui Thi Thuy Luyen, Tran Anh Quang, Le Xuan Duy, Bui Huu Tai, Nguyen Viet Phong, Do Huu Nghi, Nguyen Minh Khoi, Nguyen Van Chinh, Nguyen Cao Cuong, Trinh Thi Thuy, Tran Thu Huong, Le Ba Vinh, Nguyen Hong Anh, Nguyen Tuan Hiep","doi":"10.1080/14786419.2024.2429121","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429121","url":null,"abstract":"Vietnamese traditional medicine has utilised the roots of Polygala arillata Buch.-Ham. ex D. Don to treat acute arthritis, rheumatism, pain, and as a tonic ingredient. In this study, phytochemical analysis of the roots of P. arillata resulted in the isolation of one novel compound, named polygarinolide A (1), along with six known compounds (2-7). High-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy were among the spectroscopic techniques used to identify their structures. Additionally, the absolute configuration of compound 1 was determined through ECD calculation. The NO inhibitory activity of purified substances was evaluated. Interestingly, compound 2 exhibited inhibitory activity on NO production in LPS-stimulated RAW264.7 cells (IC50 = 25.37 μM). Moreover, interactions and binding mechanisms of the most active chemical with cyclooxygenase-2 inhibitor (COX-2) and nitric oxide synthase (iNOS) proteins were investigated by molecular docking simulations. Our findings add to our understanding of the secondary metabolites generated by P. arillata and provide a sound scientific basis for future research into the plant's potential anti-inflammatory properties.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic potential of four species of Termitomyces mushrooms from Nepal. 尼泊尔四种鸡枞的抗糖尿病潜力

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-26 DOI: 10.1080/14786419.2024.2431985

Achut Parajuli, Hari Prasad Aryal, Mukti Ram Paudel, Maan Bahadur Rokaya

{"title":"Antidiabetic potential of four species of Termitomyces mushrooms from Nepal.","authors":"Achut Parajuli, Hari Prasad Aryal, Mukti Ram Paudel, Maan Bahadur Rokaya","doi":"10.1080/14786419.2024.2431985","DOIUrl":"https://doi.org/10.1080/14786419.2024.2431985","url":null,"abstract":"People use mushrooms to treat diabetes mellitus. We studied the antidiabetic potential of four Termitomyces mushrooms using porcine pancreatic α-amylase inhibitory activity and alloxan-induced diabetic mice. Methanolic extracts of all Termitomyces mushrooms were effective in inhibiting α-amylase activity. T. striatus forma ochraceus showed the highest α-amylase inhibitory activity of 61.4% (200 g/ml). When we administered intraperitoneal doses of Termitomyces extracts (250 and 500 mg/kg) to alloxan-induced diabetes mice (30-35 g), we observed a weight loss in diabetic control mice compared to diabetic mice. At the end of the 15 days, diabetic control mice lost more weight with the administration dose of 500 mg/kg than that of 250 mg/kg Termitomyces extracts. Monitoring blood glucose levels for 15 days revealed that 500 mg/kg significantly reduced blood glucose levels compared to 250 mg/kg. In conclusion, Termitomyces species were effective in decreasing α-amylase activity and reducing blood sugar levels in alloxan-induced diabetic mice.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New bioactive mono-acyl glycerol ester from the Red Sea marine coral Sclerophytum levi. 来自红海海洋珊瑚 Sclerophytum levi 的新型生物活性单酰基甘油酯。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-26 DOI: 10.1080/14786419.2024.2432614

Basma H Farouk, Asmaa M Abdel-Tawab, Mohamed E Mostafa, Fawzia Z El-Ablack, El Sayed A E Hamed, Seif-Eldin N Ayyad

引用次数: 0

Analysis of minerals and phytochemicals in the leaves of the Ocimum kilimandscharicum plant using spectroscopic methods and screening of antibacterial activity. 利用光谱法分析千金藤植物叶片中的矿物质和植物化学物质并筛选抗菌活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-25 DOI: 10.1080/14786419.2024.2432607

P Sakuntala, A Ch Pradyutha, R Selvaraju

{"title":"Analysis of minerals and phytochemicals in the leaves of the Ocimum kilimandscharicum plant using spectroscopic methods and screening of antibacterial activity.","authors":"P Sakuntala, A Ch Pradyutha, R Selvaraju","doi":"10.1080/14786419.2024.2432607","DOIUrl":"https://doi.org/10.1080/14786419.2024.2432607","url":null,"abstract":"This study presents an innovative X-ray diffraction (XRD) application to identify minerals in the medicinal plant Ocimum kilimandscharicum. Additionally, this study includes the analysis of chemical compounds and screening antibacterial activity in the leaf extract, using Gas Chromatography-Mass Spectrometry (GC-MS) and UV-visible spectroscopy. The results of X-ray diffraction showed that the leaves are a rich source of minerals such as oxides of Potassium, Magnesium, and Calcium. The GC-MS analysis revealed that the leaf extract of Ocimum kilimandscharicum possesses Eugenol (27.53%), Camphor (16.91%), Thujopsene (13.53%) as major components and UV-visible studies showed the existence of Phytochemicals such as chromophores, carotenoids, and chlorophyll. The ethanol extract of leaves showed antimicrobial activity against four microorganisms. It significantly inhibited Bacillus subtilis, E.Coli, and Staphylococcus aureus, surpassing the positive control streptomycin. These findings suggest the potential of using leaves of Ocimum kilimandscharicum for curing infectious diseases and can be used as a mineral supplement.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0