Jinqian Yu, Tong Niu, Tao Yue, Xiao Wang, Galabada Arachchige Sirimal Premakumara, Lei Zhao
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Anti-hyperuricemic triterpene saponins from the roots of Achyranthes bidentata.
Three new triterpene saponins (1-3) were obtained from Achyranthes bidentata, which were further assayed for the anti-hyperuricemic activities. Their structures were determined through HRESI-MS, NMR data and chemical method. As for the anti-hyperuricemic evaluation, 1-3 were evaluated against the adenosine/xanthine oxidase induced HK-2 cell model. Compound 1 showed the most effective activity at 50.0 μM, 2 and 3 showed moderate anti-hyperuricemic activities at 50.0 μM and 12.5 μM, respectively, with 1 and 2 concentration-dependent, while 3 on the contrary. Western blot analysis was carried out to investigate the mechanism of 1, demonstrating that 1 reduced uric acid levels partly by regulating the renal urate transporters (OAT1, URAT1 and GLUT9).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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