Four new fluorenones isolated from the mycelia of medicinal mushroom Piptoporus soloniensis (Dubois:Fr.) Pilat and their anti-inflammatory activity.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-09-25 DOI:10.1080/14786419.2025.2565702

Lan Yao, Yi-Fan Sun, Ren-Ya Ji, Zi-Chen Tian, Shu-Han Zhang, Gen-Wei Zhang, Jian-Hua Lv

引用次数: 0

Abstract

Medicinal mushroom is a prolific source of secondary metabolites with excellent biological activities. In this study, four new fluorenone derivatives, soloniensis A - D (1 - 4) were isolated from the rice-fermented mycelia of the medicinal mushroom Piptoporus soloniensis (Dubois:Fr.) Pilat. Their structures were established through extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR. The anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells demonstrated that fluorenones 1-4 exhibited significant anti-inflammatory activity with IC₅₀ values ranging from 7.92 ± 0.61 to 18.15 ± 0.71 μM.

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从药用蘑菇Piptoporus soloniensis （Dubois:Fr.）菌丝体中分离到的4个新的芴酮类化合物和它们的抗炎活性。

药用菌是次生代谢产物的丰富来源，具有良好的生物活性。本研究从药用蘑菇茄茄Piptoporus soloniensis （Dubois:Fr.）的稻谷发酵菌丝体中分离得到4个新的芴酮衍生物，茄茄A - D（1 - 4）。Pilat。通过广泛的光谱分析，包括HR-ESI-MS， 1D和2D NMR，确定了它们的结构。脂多糖刺激RAW264.7巨噬细胞的抗炎活性表明，氟酮1-4具有显著的抗炎活性，IC50值为7.92±0.61 ~ 18.15±0.71 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.