Hirsutane sesquiterpenoids from basidiomycete Pseudohydropus cf. parafunebris.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-09-26 DOI:10.1080/14786419.2025.2565269

Somporn Palasarn, Malipan Sappan, Kitlada Srichomthong, Thitiya Boonpratuang, Maneerat Pobkwamsuk, Masahiko Isaka, Taridaporn Bunyapaiboonsri

引用次数: 0

Abstract

Two undescribed hirsutane-type sesquiterpenes, hydropusins A (1) and B (2), along with two known hirsutanes, 6,7-epoxy-4(15)-hirsutene-5-ol (3) and 6,7-epoxy-4(15)-hirsutene-1,5-diol (4), were isolated from the basidiomycete Pseudohydropus cf. parafunebris TBRC-BCC 55386, cultivated in the presence of the epigenetic regulator nicotinamide. The absolute configuration of compound 1 was determined using the modified Mosher method. Compounds 1 and 3 showed weak cytotoxicity towards NCI-H187 cancer cells, with IC₅₀ values of 161 and 144 µM, respectively.

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伪水担子菌的倍半萜类化合物。

从担子菌Pseudohydropus cf. parafunebris TBRC-BCC 55386中分离出两种未描述的hirsutin型倍半萜，hydropusins A(1)和B(2)，以及两种已知的hirsutin， 6,7-环氧-4(15)-hirsutene-5-ol(3)和6,7-环氧-4(15)-hirsutene-1,5-diol(4)，在表观遗传调节剂烟酰胺的存在下培养。用改进的Mosher法确定了化合物1的绝对构型。化合物1和3对NCI-H187癌细胞具有较弱的细胞毒性，IC50值分别为161和144µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.