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Volatiles organic compounds in craft beers produced in Basilicata (Southern Italy). 巴西利卡塔（意大利南部）生产的手工啤酒中的挥发性有机化合物。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2429117
Maurizio D'Auria, Rocco Racioppi
{"title":"Volatiles organic compounds in craft beers produced in Basilicata (Southern Italy).","authors":"Maurizio D'Auria, Rocco Racioppi","doi":"10.1080/14786419.2024.2429117","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429117","url":null,"abstract":"<p><p>The volatiles organic compounds of 21 samples of craft beers coming from Basilicata were detected, using a HS-SPME-GC-MS technique. The analysis showed the presence of various compounds (esters, alcohols, and terpenes), which were useful to determinate the aroma profiles of these beers. In addition, this profile was matched with the aroma profile of commercial beers, in order to establish the difference of the aroma profiles.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on medical plants Siegesbeckia based on diterpenoids and sesquiterpenoids: phytochemistry, pharmacology and clinical applications. 基于二萜和倍半萜的医用植物 Siegesbeckia 综述：植物化学、药理学和临床应用。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2426203
Tong Xue, Rongxin Liu, Hao Chen, Muhi Eldeen Hussien Ibrahim, Jiahui Dong, Wenjia Zhao, Li Chen, Hongzheng Fu, Jianbin Wang
{"title":"A review on medical plants <i>Siegesbeckia</i> based on diterpenoids and sesquiterpenoids: phytochemistry, pharmacology and clinical applications.","authors":"Tong Xue, Rongxin Liu, Hao Chen, Muhi Eldeen Hussien Ibrahim, Jiahui Dong, Wenjia Zhao, Li Chen, Hongzheng Fu, Jianbin Wang","doi":"10.1080/14786419.2024.2426203","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426203","url":null,"abstract":"<p><p>Natural products, owing to their chemical diversity, biological activity, and historical success, continue to be a precious source of lead compounds and potential candidates for drug discovery. <i>Siegesbeckia</i>, in particular, presents a promising avenue for drug discovery due to its long history of usage in traditional Chinese medicine and its well-established clinical applications. Diterpenoids and sesquiterpenoids, the characteristic metabolites of <i>Siegesbeckia</i>, have consistently attracted considerable attention in related scientific research because of their diverse structures and extensive range of bioactivities, including anti-inflammatory and anti-cancer properties. Herein, we provide an overview of the phytochemistry, biosynthesis, pharmacological action, as well as clinical applications of <i>Siegesbeckia</i>. This paper will provide a valuable reference for advancing further research and development of <i>Siegesbeckia</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UPLC-QTOF-MS based targeted metabolomics to unravel the hepatoprotective marker compounds of Swertia chirayita. 基于 UPLC-QTOF-MS 的靶向代谢组学揭示 Swertia chirayita 的保肝标志化合物。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2426063
Dhriti Verma, Saloni Thakur, Hitesh Shrimal, Satish Kumar, Joydeep Das, Biswatrish Sarkar, Deepak N Kapoor, Prashanta Kumar Deb
{"title":"UPLC-QTOF-MS based targeted metabolomics to unravel the hepatoprotective marker compounds of <i>Swertia chirayita</i>.","authors":"Dhriti Verma, Saloni Thakur, Hitesh Shrimal, Satish Kumar, Joydeep Das, Biswatrish Sarkar, Deepak N Kapoor, Prashanta Kumar Deb","doi":"10.1080/14786419.2024.2426063","DOIUrl":"10.1080/14786419.2024.2426063","url":null,"abstract":"<p><p><i>Swertia chirayita</i> is a popular hepatoprotective herb according to 'Ayurveda'. This study characterises the phytochemicals of <i>S. chirayita</i> responsible for hepatoprotective properties was executed using targeted metabolomics approach. Different fractions of hydro-alcoholic extract of <i>S. chirayita</i> were subjected to assess <i>in-vitro</i> antioxidant and hepatoprotective properties in HepG2 cells. Furthermore, active fraction was further subjected to UPLC-QTOF-MS based targeted metabolomics to identify the phytochemicals linked to bioactivity. A complementary <i>in-silico</i> experiment was also performed to understand the interactions of identified molecules with CYP2E1 enzyme. It was observed that, n-butanol fraction deciphers significant (<i>p</i> < .05) and maximum antioxidant and hepatocyte protection compared to other fractions. UPLC-QTOF-HRMS analysis reveals that it contains 17 secondary metabolites various classes. Identified molecules showed potential interactions with the crucial amino acid residues in the active site of CYP2E1 protein indicate the possibility of inhibition which may counter APAP induced toxicity in HepG2 cells.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new dammarane-type triterpenoid saponin from the leaves of sour jujube. 从酸枣叶中提取的一种新的达玛烷型三萜类皂甙。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-13 DOI: 10.1080/14786419.2024.2427814
Jin-Yan Tan, Pei Li, Si-Qi Yang, Jia-Ning Zhang, Yan-Gang Cheng
{"title":"A new dammarane-type triterpenoid saponin from the leaves of sour jujube.","authors":"Jin-Yan Tan, Pei Li, Si-Qi Yang, Jia-Ning Zhang, Yan-Gang Cheng","doi":"10.1080/14786419.2024.2427814","DOIUrl":"https://doi.org/10.1080/14786419.2024.2427814","url":null,"abstract":"<p><p>A new dammarane-type triterpenoid saponin, suanzaoside A (<b>1</b>) along with one known analogue 3-<i>O</i>-[<i>α</i>-L-rhamnopyranosyl(1→2)-<i>α</i>-L-arabinopyranosyl-]-30-<i>O</i>-[<i>β</i>-D-glucopyranosyl-(1→2)-<i>β</i>-D-glucopyranosyl]-3<i>β</i>,25,30-trihydroxy-16-one-20<i>R</i>,24<i>R</i>-epoxydammarane (<b>2</b>), were isolated from the leaves of sour jujube. The structure of these isolated compounds was elucidated by HRESIMS, 1D and 2D NMR spectroscopy, and literature comparison. In addition, the anti-inflammatory activities were further tested in LPS-induced RAW264.7 macrophage.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of new isoflavonoids derivatives from Genista carinalis Griseb. and biological activity. 从Genista carinalis Griseb.中分离出新的异黄酮衍生物及其生物活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-13 DOI: 10.1080/14786419.2024.2427806
Hilmican Caliskan, Temine Sabudak, H Hulya Orak, Merve Argon, Cansel Cakir, Mehmet Ozturk
{"title":"Isolation of new isoflavonoids derivatives from <i>Genista carinalis</i> Griseb. and biological activity.","authors":"Hilmican Caliskan, Temine Sabudak, H Hulya Orak, Merve Argon, Cansel Cakir, Mehmet Ozturk","doi":"10.1080/14786419.2024.2427806","DOIUrl":"https://doi.org/10.1080/14786419.2024.2427806","url":null,"abstract":"<p><p>The genus <i>Genista</i> L. has been used in the treatment of rheumatic, diabetic and ulcerous diseases. Herein, the antioxidant, anticholinesterase, and antidiabetic activities of <i>Genista carinalis</i> Griseb. extracts were determined. The antioxidant activity was performed FRAP, DPPH, CUPRAC, and TEAC assays, while anticholinesterase activity was performed against acetylcholinesterase and butyrylcholinesterase, and antidiabetic activity against α-amylase and α-glucosidase, spectrophotometrically. The activity results allowed for the study of the phytochemistry of the ethyl acetate extract that exhibited the best activity. Three new isoflavonoids, 5-methyl-7-methoxy-4'-hydroxy isoflavone <b>(3)</b>, 7-acetyl-5-hydroxy-4'-methoxy isoflavone <b>(4)</b> and 7-O-[β-D-glucopyranosyl-(6''→6''')-β-D-glucopyranosyl]-5-4'-dihydroxy isoflavone <b>(5)</b>, together with two known compounds, isoprunetin <b>(1)</b> and 6-hydroxy biochanin A <b>(2)</b> were isolated from the ethyl acetate extract. Their structures were elucidated by extensive 1D-, 2D-NMR, and MS data analyses. Compound <b>(3)</b> showed the highest antioxidant potential in TEAC, FRAP, and CUPRAC assays, while <b>(2)</b> exhibited higher butyrylcholinesterase enzyme inhibitory activity among the isolated compounds.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient directional biosynthesis of isoquercitrin from quercetin by Bacillus subtilis CD-2 and its anti-inflammatory activity. 枯草芽孢杆菌 CD-2 从槲皮素高效定向生物合成异槲皮素及其抗炎活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-13 DOI: 10.1080/14786419.2024.2425802
Ju Han, Jingru Ma, Ruiqi He, Fan Yang, Jingyi Meng, Jiaqi Liu, Fanxing Shi, Jinao Duan, Liangliang Chen, Sen Zhang
{"title":"Efficient directional biosynthesis of isoquercitrin from quercetin by <i>Bacillus subtilis</i> CD-2 and its anti-inflammatory activity.","authors":"Ju Han, Jingru Ma, Ruiqi He, Fan Yang, Jingyi Meng, Jiaqi Liu, Fanxing Shi, Jinao Duan, Liangliang Chen, Sen Zhang","doi":"10.1080/14786419.2024.2425802","DOIUrl":"https://doi.org/10.1080/14786419.2024.2425802","url":null,"abstract":"<p><p>Isoquercetin, as the sole product, was directionally biosynthesized from quercetin in a non-aqueous system using <i>Bacillus subtilis</i> CD-2 (1 g/L quercetin), and its structure was identified by LC-MS and NMR analysis. CCK8 assays showed no cytotoxicity and good cell proliferation. The anti-inflammatory experiments demonstrated strong inhibition of NO release, transcriptional downregulation of classical effective cellular factors tumour necrosis factor-α, interleukin-6, interleukin-1β, and transcriptional upregulation of interleukin-10 in LPS-induced RAW264.7 cells. Its stronger anti-inflammatory activity than quercetin provided a reference for modifying the structure of quercetin to obtain more compounds with better pharmacological activities for medical industry.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pimarane diterpenoids: sources, structures and biological activities. Pimarane diterpenoids：来源、结构和生物活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-13 DOI: 10.1080/14786419.2024.2426071
Haiqiang Zhang, Meng Li, Ayi Lvha, Shengming Zhang
{"title":"Pimarane diterpenoids: sources, structures and biological activities.","authors":"Haiqiang Zhang, Meng Li, Ayi Lvha, Shengming Zhang","doi":"10.1080/14786419.2024.2426071","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426071","url":null,"abstract":"<p><p>The pimarane diterpenoids, a widespread class of secondary metabolites, have been found in several dozens of plant species from various families and in organisms from other taxonomic groups. According to the different chiral centres, pimarane diterpenes can be divided into four types, including pimarane, isopimarane, <i>ent</i>-pimarane, and <i>ent</i>-isopimarane. Meanwhile, these compounds possessed many pharmacological activities, such as cytotoxic, anti-inflammatory, and antibacterial activities. Due to their notable structure and biological activities these substances have attracted interest in recent years. A comprehensive account of the structural diversity (368 structures, 117 references) and biological activities of pimarane diterpenes discovered from 2000 until 2023 is given in this review.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of different processing treatments to active ingredients, nutrients, volatile components and antioxidant activity in Poria cocos wolf. 不同加工处理对茯苓有效成分、营养成分、挥发性成分和抗氧化活性的影响。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-12 DOI: 10.1080/14786419.2024.2421905
Chuqian Gao, Miaofen Chen, Xiang Wei, Jianguo Zeng, Hongqi Xie
{"title":"The effects of different processing treatments to active ingredients, nutrients, volatile components and antioxidant activity in <i>Poria cocos</i> wolf.","authors":"Chuqian Gao, Miaofen Chen, Xiang Wei, Jianguo Zeng, Hongqi Xie","doi":"10.1080/14786419.2024.2421905","DOIUrl":"https://doi.org/10.1080/14786419.2024.2421905","url":null,"abstract":"<p><p>The study compared the triterpenoid ingredients, polysaccharide, protein, amino acid, and volatile components of PC. The PC was treated with traditional sweating (TST), steaming sweating for 1 to 4 h (SS1h-SS4h, <i>Δ</i> = 1 h) and non-sweating (NS). The results showed the content of six triterpenoids (1.03 mg/g), water-soluble protein (0.33 mg/g) and total triterpenoid (3.81 mg/g) were the highest in NS; the content of alkali-soluble polysaccharide (51.96 mg/g) was the highest in SS1h; the content of crude protein (16.18 mg/g) and total amino acid (53.07 mg/g) were highest in TST. Moreover, the predominant volatile component of SS1h was hexanal, SS2h-SS4h and TST were Linalool, NS was D-limonene. Ulteriorly, the correlation analysis showed antioxidant effect of PC may be related to the content of alkali-soluble polysaccharide, Furan-2-pentyl, and 2-Octenal, PCA result indicated the score of SS1h-treated PC was the highest. This study could provide a new solution for the industrial production of PC.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the therapeutic potential of cyclopeptides from Stachys geobombycis in Alzheimer's disease. 探索环肽对阿尔茨海默病的治疗潜力。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-12 DOI: 10.1080/14786419.2024.2426065
Vanitha Marunganathan, Ajay Guru
{"title":"Exploring the therapeutic potential of cyclopeptides from <i>Stachys geobombycis</i> in Alzheimer's disease.","authors":"Vanitha Marunganathan, Ajay Guru","doi":"10.1080/14786419.2024.2426065","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426065","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Portulaca oleracea L.: literature quantitative research analysis. 马齿苋：文献定量研究分析。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-11-12 DOI: 10.1080/14786419.2024.2426204
Maria Mattera, Niccolò Pilla, Altero Aguzzi, Paolo Gabrielli, Gabriella Di Lena, Alessandra Durazzo, Massimo Lucarini
{"title":"<i>Portulaca oleracea</i> L.: literature quantitative research analysis.","authors":"Maria Mattera, Niccolò Pilla, Altero Aguzzi, Paolo Gabrielli, Gabriella Di Lena, Alessandra Durazzo, Massimo Lucarini","doi":"10.1080/14786419.2024.2426204","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426204","url":null,"abstract":"<p><p>Purslane (<i>Portulaca oleracea</i> L.) has always been considered a plant with excellent qualities; in fact, it has been consumed for centuries as an edible plant but also used in folk medicine. This work aims to give an updated shot of the main features and potentialities of purslane. A literature quantitative research analysis was carried out. Besides the botanical and geographical aspects, we have explored the nutritional properties and possible beneficial effects on human health due to the presence of bioactive compounds, indicating their traditional use in food and medicine preparation as well as proposing possible future applications. Purslane is a rich source of vitamins, flavonoids, organic acids, lignans, alkaloids, terpenoids, cerebrosides, sterols and minerals; in particular, it is considered a good vegetable source of unsaturated fatty acids, especially linoleic and alpha-linolenic acids. Due to its profile of bioactive components, several potential beneficial effects on humans have been reported, i.e. hepatoprotective, neuroprotective, anti-inflammatory, antimicrobial and antioxidant. Purslane finds several applications: enhancing the nutritional and sensory properties of bread, stabilising yoghurt, improving fish sausages' quality and shelf-life, acting as a natural additive due to its antibacterial, antifungal, and antioxidant properties. Additionally, it can be utilised for phytoremediation and recycling drainage water in saline environments.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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