Natural Product Research最新文献_第9页

Biological activities of BY2-melanin, a plant-type eumelanin, isolated from cultured tobacco BY-2 cells. 植物型真黑色素BY2-melanin的生物学活性研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-16 DOI: 10.1080/14786419.2025.2505604

Abul Taher Mohammed Rafiqul Islam, Kenji Arakawa, Kenji Komaguchi, Kenji Kitamura, Nobukazu Tanaka

{"title":"Biological activities of BY2-melanin, a plant-type eumelanin, isolated from cultured tobacco BY-2 cells.","authors":"Abul Taher Mohammed Rafiqul Islam, Kenji Arakawa, Kenji Komaguchi, Kenji Kitamura, Nobukazu Tanaka","doi":"10.1080/14786419.2025.2505604","DOIUrl":"https://doi.org/10.1080/14786419.2025.2505604","url":null,"abstract":"BY2-melanin, a plant eumelanin distinct from nitrogen-free plant allomelanins, was previously isolated from cultured BY-2 tobacco cells. Herein, the biological activities of BY2-melanin, including its ability to protect against ultraviolet radiation (UVR) and antioxidant activity, were investigated. Based on the survival rate of Escherichia coli, the ability of BY2-melanin to protect against UVR was three and eight times higher than that of melanins isolated from fungi and bacteria, respectively. Its antioxidant activities, determined as ferrous iron-chelating activity and reducing power, were 1.7-4.9 and 0.3-0.4 times higher than those of animal melanins, respectively. Its 2,2-diphenyl-1-picrylhydrazyl and superoxide radical scavenging activities were similar to those of mushroom melanin, whereas its hydroxyl radical scavenging activity was one-fourth of that of melanins derived from mushroom and black tea. These findings shed light on the development of a class of melanin biopolymers that can be used as a broad-spectrum sunscreen with antioxidant activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico analysis of Chlorophytum borivilianum phytocompounds as a multi-targeted directed ligand (MTDL) against type 2 diabetes mellitus-induced Alzheimer's disease. 硼吊兰植物化合物作为多靶点定向配体（MTDL）抗2型糖尿病诱导的阿尔茨海默病的硅分析。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-16 DOI: 10.1080/14786419.2025.2503506

Kanika Khoba, Shivani Kumar, Ram Singh Purty

{"title":"In silico analysis of Chlorophytum borivilianum phytocompounds as a multi-targeted directed ligand (MTDL) against type 2 diabetes mellitus-induced Alzheimer's disease.","authors":"Kanika Khoba, Shivani Kumar, Ram Singh Purty","doi":"10.1080/14786419.2025.2503506","DOIUrl":"https://doi.org/10.1080/14786419.2025.2503506","url":null,"abstract":"Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder. A crosstalk between AD and hyperglycaemia has been observed where patients showed increased insulin resistance. Type 2 diabetes mellitus and its features, including hyperinsulinemia and chronic hyperglycaemia with an inflammatory response, are related to AD through insulin resistance. Here, aim was to identify a phytocompound that could be used as a potential drug candidate. GC-MS analysis of Chlorophytum borivilianum root extract provided a phytocompound library, of which 10 phytocompounds were selected for docking. Protein targets, namely acetylcholinesterase, butrylcholinesterase, Amyloid-β protein, BACE-1, N-methyl-D-aspartate, GSK-3β, APAF-1 and caspase-3, were used for docking. Based on pharmacokinetic and ADMET analysis, 25-Homo-24-Ketocholesterol, showed the lowest binding affinity with the targets, justified Lipinski's rule of 5, had high potency, good absorption and was less toxic to the human body. We conclude that 25-homo-24-ketocholesterol may act as a potential drug with multi-target directed ligand activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four new cytotoxic triterpenoids from Euphorbia fischeriana. 大戟属四种新的细胞毒性三萜。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-16 DOI: 10.1080/14786419.2025.2503015

Yuan-Biao He, Yan-Ni Ma, Yu-Ping Huang, Wen-Na Li, Ting-Xiang Shi, Jing Yang, Yong Zhao

引用次数: 0

A comprehensive study on chemical and biological profiles of Zygophyllum indicum (Burm.f.) Christenh. & Byng. 籼稻（Zygophyllum indicum, Burm.f.）化学生物学特性的综合研究Christenh。& Byng。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-15 DOI: 10.1080/14786419.2025.2503013

Khadim Ali Gishkori, Saba Naz, Aftab Ahmed Kandhro

{"title":"A comprehensive study on chemical and biological profiles of Zygophyllum indicum (Burm.f.) Christenh. & Byng.","authors":"Khadim Ali Gishkori, Saba Naz, Aftab Ahmed Kandhro","doi":"10.1080/14786419.2025.2503013","DOIUrl":"https://doi.org/10.1080/14786419.2025.2503013","url":null,"abstract":"This study aimed to determine the chemical and biological composition of Zygophyllum indicum (Burm.f.) Christenh. & Byng. Phenolic compounds were analysed via HPLC-PDA, essential oils/volatiles using GC-MS, and fatty acid profiling through GC-FID. Antioxidant activity was assessed using the DPPH scavenging assay, while antibacterial screening was performed by evaluating the inhibition capability of the extract against four organisms: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Six phenolic compounds were detected, i.e. vanillin being the dominant one. A total of 52 volatile compounds were identified in the plant's essential oil, and 13 fatty acids were detected via GC-FID, with unsaturated fatty acids present in higher concentrations. The ethanol extract exhibited considerable antioxidant activity. These findings highlight Z. indicum as a valuable natural source of nutritionally significant compounds and antioxidants. Additionally, the data provide useful insights for industries that utilise this medicinal plant as raw material for therapeutic formulations.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential oil study of Artemisia herba Alba (asso.): antifungal activity against Fusarium oxysporum f. sp. ciceri and phytochemical analysis by gC/mS. 白蒿精油对镰刀菌的抑菌活性及gC/mS分析。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-15 DOI: 10.1080/14786419.2025.2494634

Fatiha Lazreg, Zohra Benaouf, Aoumaria Merzoug, Leila Si Moussa, Asmaa Guessab, José Sanchez, Edwardo Gallego, Oussama Djorf

{"title":"Essential oil study of Artemisia herba Alba (asso.): antifungal activity against Fusarium oxysporum f. sp. ciceri and phytochemical analysis by gC/mS.","authors":"Fatiha Lazreg, Zohra Benaouf, Aoumaria Merzoug, Leila Si Moussa, Asmaa Guessab, José Sanchez, Edwardo Gallego, Oussama Djorf","doi":"10.1080/14786419.2025.2494634","DOIUrl":"https://doi.org/10.1080/14786419.2025.2494634","url":null,"abstract":"This study investigated on the Artemisia herba-alba (Asso.) essential oil antifungal activity; (EO) against Fusarium oxysporum f. sp. ciceri (FOC), the causal agent of chickpea wilt. Distillation of leaves parts of Artemisia herba-alba (Asso.) using Clevenger apparatus, yielded 1.7 ± 0.17% essential oil. The extracted essential oil demonstrated significant antifungal activity against mycelial growth. The inhibition rates were 72.08 and 100% observed by using sterile paper disc containing 15 and 20 µl of EO, respectively. Scanning electron microscopy (SEM) images showed structural damage to fungal cells, including collapsed conidia with micro-fissures and cell wall destruction. Phytochemical analysis of A. herba alba essential oil using CPG/SM allowed us to identify 26 compounds, with major components being: Camphor (22.893%), Chrysanthenone (22.235%), β-Thujone (7.686%) and α-Thujone (7.316%).","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterisation of two new malonylated rare ginsenosides by acid hydrolysis and their anti-hepatoma activities. 两种新型丙二酸水解人参皂苷的制备、表征及其抗肝癌活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-14 DOI: 10.1080/14786419.2025.2503505

Ya-Qian Lu, Xiao-Man Jin, Fu-Rui Zhang, Mei-Hui Li, Wen-Wen Li, Wei Li, Chun-Su Yuan, Zhi Liu

引用次数: 0

The undescribed alkaloids from Jacobaea cannabifolia (less.) E. Wiebe and their anti-inflammatory activities. 大麻雅花中未描述的生物碱（少。）E. Wiebe及其抗炎活性

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-14 DOI: 10.1080/14786419.2025.2502145

Jian-Zhe Li, Juan Pan, Yu Bi, Zhi-Chao Hao, Wei Guan, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Xin-Yue Wu, Da-Lin Li, Bing-You Yang, Yan Liu

引用次数: 0

Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities. 本文研究了黄杨（dasymaschalon filipes, ridl.）茎、枝次生代谢产物。以及它们的生物活动。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-14 DOI: 10.1080/14786419.2025.2503016

Tanapol Bunpan, Phansuang Udomputtimekakul, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Anan Athipornchai

{"title":"Secondary metabolites from the twigs and stems of dasymaschalon filipes (ridl.) ban. and their biological activities.","authors":"Tanapol Bunpan, Phansuang Udomputtimekakul, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Anan Athipornchai","doi":"10.1080/14786419.2025.2503016","DOIUrl":"https://doi.org/10.1080/14786419.2025.2503016","url":null,"abstract":"Investigation of the crude hexane and ethyl acetate extracts of the twigs and stems of D. filipes (Annonaceae) led to the discovery of five compounds: desmosdumotin D (1), a mixture of stigmasterol and β-sitosterol (2), unonal (3), isounonal (4), and cepharadione B (5). The structural elucidation of the compounds was accomplished using 1H,13C, and 2D NMR techniques. The three crude extracts of D. filipes showed weak activity versus the HIV-1 virus. The cytotoxicity assays showed that the crude hexane extract was particularly effective against A549 cell lines, with an ED50 of 15.24 mg/mL. Meanwhile, the crude ethyl acetate and methanol extracts inhibited KKU-M213 cell lines, demonstrating ED50 values of 13.42 and 10.92 mg/mL, respectively. D. filipes is a rich source of potential compounds with anti-HIV-1RT or cytotoxicity activities. This is the first report on the phytochemistry and bioactivity study of D. filipes.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory metabolites from the mangrove endophytic fungus Diaporthe pseudooculi HHUF 30617. 红树林内生真菌Diaporthe pseudoculi HHUF 30617的抗炎代谢物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-14 DOI: 10.1080/14786419.2025.2503508

Runxin Yang, Leshi Yu, Xiaoting Xie, Gang Chen, Lu Wen

引用次数: 0

Callus initiation and regeneration of Curculigo orchioides Gaertn. and its untargeted metabolomic profiles using UHPLC-Q-Orbitrap HRMS compared to the parent plant. 兰花愈伤组织的形成与再生。利用UHPLC-Q-Orbitrap HRMS分析其非靶向代谢组学特征。

IF 1.9 3区化学

Natural Product Research Pub Date : 2025-05-13 DOI: 10.1080/14786419.2025.2503011

Abdul Halim Umar, Diah Ratnadewi, Mohamad Rafi, Yohana Caecilia Sulıstyanıngsıh, Hamim Hamım

{"title":"Callus initiation and regeneration of Curculigo orchioides Gaertn. and its untargeted metabolomic profiles using UHPLC-Q-Orbitrap HRMS compared to the parent plant.","authors":"Abdul Halim Umar, Diah Ratnadewi, Mohamad Rafi, Yohana Caecilia Sulıstyanıngsıh, Hamim Hamım","doi":"10.1080/14786419.2025.2503011","DOIUrl":"https://doi.org/10.1080/14786419.2025.2503011","url":null,"abstract":"Curculigo orchioides Gaertn. is a traditional medicinal plant widely used in Asia. However, it is often collected from the wild without replanting efforts. Additionally to its slow growth, its availability is further threatened by natural disasters and land-use shifting, putting its future supply at risk. This work aimed to obtain an efficient method for callus initiation and plant multiplication, investigate whether propagules produce secondary metabolites found in the mother plant. Combinations of plant growth regulators were used to initiate callus and/or shoots from leaf explants, and UHPLC-Q-Orbitrap HRMS identified metabolites. The explants cultured on MS medium supplemented with a combination of BAP (5 mg L-1) and IBA (3 mg L-1) initiated callus and regenerated plantlets. Through LC-HRMS analysis, several compounds with pharmacological effects were found in the in vitro propagules. In callus and plantlet leaves, 24 and 27 compounds were identified respectively, dominated by phenolics. Principal component analysis and hierarchical cluster discriminated the metabolites in the propagules and mother plant organs. The essential compounds, (1S,2R)-O-methylnyasicoside, curculigoside B, orcinol glucoside, 2,4-dichloro-5-methoxy-3-methylphenol were determined in callus at a higher concentration than in the mother plant. Conclusively, in vitro propagules of C. orchioides is a valuable alternative source of bioactive compounds.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0