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C19-diterpenoid alkaloids from Aconitum refractum var. circinatum 毛乌头中C19二萜生物碱。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2223736
{"title":"C19-diterpenoid alkaloids from Aconitum refractum var. circinatum","authors":"","doi":"10.1080/14786419.2023.2223736","DOIUrl":"10.1080/14786419.2023.2223736","url":null,"abstract":"<div><div>Two unprecedented aconitine-type C19-diterpenoid alkaloids, refractines A–B (<strong>1</strong>–<strong>2</strong>), along with 12 known compounds (<strong>3</strong>–<strong>14</strong>) were isolated from the roots of <em>Aconitum refractum</em> (Finet et Gagnep.) Hand. -Mazz. Their structures were elucidated based on extensive spectroscopic analyses, including 1D and 2D NMR, IR, and HR-ESI-MS data. All compounds were tested for inhibitory activities against NO production in LPS induced RAW 264.7 macrophages, compounds <strong>10</strong> and <strong>14</strong> had slight inhibited NO production with rate of 29.4% and 22.1% at the concentration of 30 μM, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9643233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from the roots of Dolomiaea souliei 来自 Dolomiaea souliei 根部的化学成分。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2215902
{"title":"Chemical constituents from the roots of Dolomiaea souliei","authors":"","doi":"10.1080/14786419.2023.2215902","DOIUrl":"10.1080/14786419.2023.2215902","url":null,"abstract":"<div><div>A new benzofuran-type neolignan (<strong>1</strong>), two new phenylpropanoids (<strong>2</strong> - <strong>3</strong>), and one new C<sub>21</sub> steroid (<strong>4</strong>) were isolated from the ethyl acetate extract of the roots of <em>Dolomiaea souliei</em> by chromatographic methods, including silica gel, ODS column chromatography, MPLC, and semi-preparative HPLC. Their structures were identified as dolosougenin A (<strong>1</strong>), (<em>S</em>)-3-isopropylpentyl (<em>E</em>)-3-(4-hydroxy-3-methoxyphenyl) acrylate (<strong>2</strong>), (<em>S</em>)-3-isopropylpentyl (<em>Z</em>)-3-(4-hydroxy-3-methoxyphenyl) acrylate (<strong>3</strong>) and dolosoucin A (<strong>4</strong>) through various spectroscopic techniques including 1D NMR, 2D NMR, IR, UV, HR ESI MS, ORD, and computational ORD methods.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of extraction and dyeing conditions of the Parkia roxburghii pod’s peel as a natural substantive silk dye 优化朴树荚果皮作为天然真丝绸染料的提取和染色条件。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2225124
{"title":"Optimization of extraction and dyeing conditions of the Parkia roxburghii pod’s peel as a natural substantive silk dye","authors":"","doi":"10.1080/14786419.2023.2225124","DOIUrl":"10.1080/14786419.2023.2225124","url":null,"abstract":"<div><div>Natural dyes are soft, eco-friendly, and non-toxic colours for silk fabric, imparting high compatibility with the environment. Among the different natural dyestuffs derived from different parts of plants, the peel of the <em>Parkia roxburghii</em> pod is thriving as one of the potential natural substantive dyes. The study reveals optimization of dye extraction for dyeing silk fabric. Colour strength (K/S) and absorbance of dye extract were evaluated for optimization of extraction and dyeing parameters. The optimized ML ratio (material and solvent proportions) was 1:30 for 60 min of boiling at 80 °C under acidic medium. Use of natural and synthetic mordants produced different colour patterns giving two classes, YR, light to dark brownish colour. CuSO<sub>4</sub>, lime juice and <em>Terminalia chebula</em> mordants produced better wash fastness and light fastness in meta-mordant conditions. Dyeing silk with <em>parkia</em> peel without mordant also produces better fastness properties, thus acts as a natural substantive silk dye.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous quantitation of nine carbazole alkaloids from Murraya koenigii (L.) Spreng by 1H qNMR spectroscopy 利用 1H qNMR 光谱同时定量 Murraya koenigii (L.) Spreng 中的九种咔唑生物碱。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2219819
{"title":"Simultaneous quantitation of nine carbazole alkaloids from Murraya koenigii (L.) Spreng by 1H qNMR spectroscopy","authors":"","doi":"10.1080/14786419.2023.2219819","DOIUrl":"10.1080/14786419.2023.2219819","url":null,"abstract":"<div><div><em>Murraya koenigii</em> leaves are widely used as a spice and also have several biological activities. The major active constituents are carbazole alkaloids. Quantitation by HPLC or HPTLC requires pure marker compounds, whereas nuclear magnetic resonance spectroscopy can be used as a quantitative technique without the requirement of a pure marker compound. An alkaloid-rich fraction was prepared from the leaves and a validated qNMR method was developed for the quantitation of nine carbazole alkaloids, namely mahanimbine, girinimbine, koenimbine, koenine, kurrayam, mukonicine, isomahanimbine, euchristine B and bismahanine. One of the major compounds, koenimbine, was isolated and quantified by HPTLC to compare the results. The results obtained by qNMR were compared with the reported yields of these compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new feruloylfriedelinol from the stems of Bridelia stipularis and its α–glucosidase inhibition 一种新的阿魏酰弗里德硒醇，产自布里黛拉（Bridelia stipularis）的茎及其α-葡萄糖苷酶抑制作用。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2222218
{"title":"A new feruloylfriedelinol from the stems of Bridelia stipularis and its α–glucosidase inhibition","authors":"","doi":"10.1080/14786419.2023.2222218","DOIUrl":"10.1080/14786419.2023.2222218","url":null,"abstract":"<div><div>Phytochemical investigation of the stems of <em>Bridelia stipularis</em> led to the isolation of a new triterpene, 3<em>β</em>-<em>O</em>-<em>trans</em>-feruloylfriedelinol (<strong>1</strong>), together with five known compounds, friedelin (<strong>2</strong>), 3<em>β</em>-friedelinol (<strong>3</strong>), lupeol (<strong>4</strong>), stigmasterol (<strong>5</strong>), and 4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid (<strong>6</strong>). Their structures were identified by intensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance, infrared, and mass spectrometry. Compound <strong>1</strong> showed significant α-glucosidase inhibitory activity (IC<sub>50</sub> = 337.49 ± 0.59 µM) close to the standard, acarbose. Furthermore, the structure activity relationship of <strong>1</strong> was analyzed by molecular docking studies. In addition, the molecular docking results showed that the interaction between <strong>1</strong> and the active site occurred through hydrophobic forces and hydrogen bonds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9646281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New cyclic dipeptide discovered from deep-sea derived Aspergillus sp. HDN20-1401 从源自深海的曲霉菌 HDN20-1401 中发现新的环状二肽。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2227754
{"title":"New cyclic dipeptide discovered from deep-sea derived Aspergillus sp. HDN20-1401","authors":"","doi":"10.1080/14786419.2023.2227754","DOIUrl":"10.1080/14786419.2023.2227754","url":null,"abstract":"<div><div>A new alkaloid named aspergilalkaloid A (<strong>1</strong>) with pyridoindole hydroxymethyl piperazine dione structure along with six known compounds <strong>2-7</strong> were isolated from deep-sea derived fungus <em>Aspergillus</em> sp. HDN20-1401. The structure including absolute configuration was elucidated by extensive NMR analyses, HRESIMS, ECD calculation, and theoretical NMR calculation with DP4+ analysis. All isolated compounds were tested for antimicrobial and anticancer activity. Aspergilalkaloid A (<strong>1</strong>) showed inhibitive activity against <em>Bacillus cereus</em> with MIC value of 12.5 <em>μ</em>M and weak activity against MRCNS.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical composition and anti-inflammatory activity of flower essential oil from Forsythia koreana Nakai 中井连翘花精油的化学成分和抗炎活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2223748
{"title":"Chemical composition and anti-inflammatory activity of flower essential oil from Forsythia koreana Nakai","authors":"","doi":"10.1080/14786419.2023.2223748","DOIUrl":"10.1080/14786419.2023.2223748","url":null,"abstract":"<div><div><em>Forsythia koreana</em> Nakai is an ornamental plant widely cultivated in East Asia. The essential oil of <em>F. koreana</em> flowers (FEO) was extracted by hydrodistillation process and the volatile components were determined with gas chromatography coupled with mass spectrometry. The anti-inflammatory activity of FEO was investigated by using TPA-induced mouse ear inflammation model. The major components of FEO were identified as <em>n</em>-tetracosane (29.85%), <em>n</em>-heneicosane (17.45%), myristic acid (8.46%) and palmitaldehyde (6.22%). The TPA-induced mouse ear edema, water content, dermis thickness, epidermis thickness and nitric oxide production were decreased by FEO. Our findings suppose that the flower essential oil of <em>F. koreana</em> exerted anti-inflammatory activity, and may be used in the development of anti-inflammatory products in future.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical, ethnomedicinal uses and pharmacological profile of Juncus decipiens (Buchenau) Nakai (common rush) Juncus decipiens (Buchenau) Nakai（普通蔺草）的植物化学成分、民族药用价值和药理学特征。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2223749
{"title":"Phytochemical, ethnomedicinal uses and pharmacological profile of Juncus decipiens (Buchenau) Nakai (common rush)","authors":"","doi":"10.1080/14786419.2023.2223749","DOIUrl":"10.1080/14786419.2023.2223749","url":null,"abstract":"<div><div><em>Juncus decipiens</em> is a member of the Juncaceae family and has culinary, medicinal, and decorative properties. It is also used in traditional Chinese Medicines for many years that promotes diuresis for strangury and clears out heart fire. This species has recently gained medicinal attention as a source of phenanthrenes, phenolic compounds, glycerides, flavonoids, and cycloartane triterpenes. This plant was also shown to be active, and researchers explored its antioxidant, anti-inflammatory, antialgal, antibacterial, and psychological behaviour-boosting properties. Preliminary research suggests that this species might be used for skin protection and brain disorders if proper clinical trials are conducted. The ethnomedicinal, phytochemistry, biological potencies, dangers, and scopes of <em>Juncus decipiens</em> have been examined in this respect.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9627843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient preparation of hyperoside and quercitrin from Zanthoxylum bungeanum Maxim leaves using an integrated surfactant-based aqueous two-phase system, back-extraction and adsorption separation 利用基于表面活性剂的综合水基两相体系、反萃取和吸附分离，从 Zanthoxylum bungeanum Maxim 叶子中高效制备金丝桃苷和槲皮素。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2219822
{"title":"Efficient preparation of hyperoside and quercitrin from Zanthoxylum bungeanum Maxim leaves using an integrated surfactant-based aqueous two-phase system, back-extraction and adsorption separation","authors":"","doi":"10.1080/14786419.2023.2219822","DOIUrl":"10.1080/14786419.2023.2219822","url":null,"abstract":"<div><div><em>Zanthoxylum bungeanum</em> leaves (ZBL) are of great medicinal value for being rich in hyperoside and quercitrin. In this study, a novel, efficient and economical continuous process was established. First, aqueous two-phase system (ATPS) composed of Triton X-100/(NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> was employed to enrich hyperoside and quercitrin from ZBL extracts and the recoveries reached 98.53% and 99.12%. Then back-extraction with dichloromethane-water system was adopted to separate hyperoside and quercitrin from Triton X-100 micelles which were recycled and the recoveries reached 86.58% and 85.19%. Finally, S-8 macroporous resin was used for removing the salt introduced in ATPS and the final recoveries reached 82.38% and 81.81%, much higher than the total flavonoids recovery as 69.08%. Furthermore, scale-up experiment certified that the continuous process was feasible for industrial production. Efficiently and economically, this method achieved a great breakthrough in purity and provided a novel reference for further purification and phase-forming component recycle.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9645653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enrichment and qualitative analysis of flavonoid glycosides from the aerial parts of Glycyrrhiza uralensis Fisch 甘草气生部分黄酮苷的富集和定性分析
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-09-16 DOI: 10.1080/14786419.2023.2226296
{"title":"Enrichment and qualitative analysis of flavonoid glycosides from the aerial parts of Glycyrrhiza uralensis Fisch","authors":"","doi":"10.1080/14786419.2023.2226296","DOIUrl":"10.1080/14786419.2023.2226296","url":null,"abstract":"<div><div>Our previous study found that the aerial parts of Chinese liquorice (<em>Glycyrrhiza uralensis</em> Fisch.) had pharmacological effects against chronic non-bacterial prostatitis in rats, however the pharmacologically active compounds remain unclear. Here, a method based on UPLC-Q-Exactive Orbitrap-MS was established to qualitatively analyse the flavonoid glycosides rich fraction extracted from the aerial part of <em>G. uralensis</em> Fisch., after pretreatment with <em>n</em>-butanol and enrichment using AB-8 macroporous resin. Using both positive and negative ion modes, 52 compounds were identified or tentatively characterised by comparison with standards and the literature: 40 flavonoids, 8 organic acids, 2 chromones, 1 coumarin, and 1 phenylethanoid glycoside. This study provides not only an approach to enrich flavonoid glycosides but also a methodology for quickly determining the relevant bioactive components in the aerial parts of <em>G. uralensis</em> Fisch.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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