Natural Product Research最新文献_第9页

First total synthesis of (±)-sanggenon F and its osteogenic differentiation promoting activity on human mesenchymal stem cells. 首次合成（±）-sanggenon F及其促人间充质干细胞成骨分化活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2565815

Ren-Fen Ma, Yue Jing, Hui Song, Bin Wang, Jian Li, Xiu-Shan Yin, Hua Zhang

引用次数: 0

Chemical analysis of Cannabis sativa L. roots from Northeastern Brazil and their potential in the development of new drugs. 巴西东北部大麻根的化学分析及其新药开发潜力。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2565259

Tarcísio Cícero de Lima Araújo, Nathália Andrezza Carvalho de Souza, Eduardo Anselmo Pereira, Pedro Guilherme Souza de Sá, Victória Laysna Dos Anjos Santos, Juliane Maria Dos Santos Silva, Larissa Araújo Rolim

{"title":"Chemical analysis of Cannabis sativa L. roots from Northeastern Brazil and their potential in the development of new drugs.","authors":"Tarcísio Cícero de Lima Araújo, Nathália Andrezza Carvalho de Souza, Eduardo Anselmo Pereira, Pedro Guilherme Souza de Sá, Victória Laysna Dos Anjos Santos, Juliane Maria Dos Santos Silva, Larissa Araújo Rolim","doi":"10.1080/14786419.2025.2565259","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565259","url":null,"abstract":"This study analyzes the chemical characteristics of a lyophilised aqueous extract of Cannabis sativa roots (AECsR) from northeastern Brazil using analytical techniques. Thermogravimetry was used for thermal analysis. Fourier transform infra-red spectroscopy (FTIR), high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS) and HPLC coupled to diode array detector (DAD) were used for the chemical analysis. Thermogravimetry analysis revealed two thermal events. FTIR analysis showed five bands of interest. HPLC-MS analysis suggested the presence of four compounds. HPLC-DAD confirmed the presence of N-trans-feruloyltyramine and identified and quantified p-coumaric acid for the first time in Cannabis roots from Vale do São Francisco - Brazil. This finding represents a step forward in the chemical standardisation of Cannabis root extracts, facilitating the use of this data for the development of new drugs derived from the Cannabis roots.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the anti-atherosclerotic effect and potential mechanism of Sanzi San in ApoE-defcient mice by UHPLC-ESI-QE-Orbitrap-MS based non-targeted metabonomics. 基于UHPLC-ESI-QE-Orbitrap-MS的非靶向代谢组学研究三子散对apoe缺陷小鼠的抗动脉粥样硬化作用及其潜在机制。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2565275

Shuai Liu, Hongyu Zheng, Jianye Wang, Jingmin Tian, Jianping Chen, Huimin Xia, Jiaqi Xu, Yuewu Wang, Yuanhong Liao, Chunlong He, Shikui Wu, Huiwen Zhang, Huanyun Wang, Jie Li

{"title":"Investigating the anti-atherosclerotic effect and potential mechanism of Sanzi San in ApoE-defcient mice by UHPLC-ESI-QE-Orbitrap-MS based non-targeted metabonomics.","authors":"Shuai Liu, Hongyu Zheng, Jianye Wang, Jingmin Tian, Jianping Chen, Huimin Xia, Jiaqi Xu, Yuewu Wang, Yuanhong Liao, Chunlong He, Shikui Wu, Huiwen Zhang, Huanyun Wang, Jie Li","doi":"10.1080/14786419.2025.2565275","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565275","url":null,"abstract":"CM), which is a well-known classic formula with an anti-atherosclerotic (AS) effect. However, the mechanism of SZS's anti-AS action remains to be further elucidated. This study went to check how well SZS works for AS and to dig deeper into how it might work. Our findings suggested that SZS significantly improved aortic lesion plaque areas of ApoE-/-mice. UHPLC-ESI-QE-Orbitrap-MS combined with pattern recognisable analysis, revealed a distinct separation between the model group and the control group, with the SZS-treated group being significantly closer to control than to model. This result was in line with the histopathological findings. Through metabolomics analysis, we found significantly different serum metabolites between groups, with 24 metabolites exhibiting significant regression. It is hypothesized that the anti-AS mechanism of SZS may be related to thiamine metabolism, arginine biosynthesis, and primary bile acid biosynthesis. The results of RT-qPCR showed that SZS alleviated AS by regulating the expression of Slc19a2, Tpk1, Ass1, Arg1, Cyp7a1 and Cyp8b1 in the pathway. Overall, these results provide initial support for the efficacy of SZS in the treatment of AS and investigate its potential pharmacological mechanisms, facilitating its rational development and application.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-MS/MS-based discovery of new cytochalasin from fungus Rosellinia sanctae-cruciana. 基于LC-MS/ ms的真菌Rosellinia sanctacrucana新细胞松弛素的发现

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2565279

Nisha Sharma, Poonam Choudhary, Priya Kumari, Mohd Murtaza, Vidushi Abrol, Chetan Kumar, Rohit Singh, Sundeep Jaglan, Manoj Kushwaha

引用次数: 0

Phyto-pharmacognostical characterisation, residual analysis of unexplored high altitude Himalayan species Iris kashmiriana Baker rhizome and antimicrobial potential of essential oil. 高海拔喜马拉雅地区未开发物种克什米尔鸢尾根茎的植物生药学特征、残留分析及精油的抑菌潜力。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2566467

Susmita Roy, Sreya Dutta, Deepak Kumar, Ayan Samadder, Rajosik Bose, Shyam Baboo Prasad, Ajay Kumar Meena, Gajji Babu, Kalyan Hazra

{"title":"Phyto-pharmacognostical characterisation, residual analysis of unexplored high altitude Himalayan species Iris kashmiriana Baker rhizome and antimicrobial potential of essential oil.","authors":"Susmita Roy, Sreya Dutta, Deepak Kumar, Ayan Samadder, Rajosik Bose, Shyam Baboo Prasad, Ajay Kumar Meena, Gajji Babu, Kalyan Hazra","doi":"10.1080/14786419.2025.2566467","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566467","url":null,"abstract":"There is growing demand for plant-derived essential oils as alternative antimicrobial agents to synthetic drugs. The study investigated the phyto-pharmacognostic properties and safety of Iris kashmiriana Baker's rhizome, including the isolation, characterisation, and antibacterial evaluation of its essential oil. Phyto-pharmacognostic characterisation, residual analyses were done by Pharmacopoeial guidelines. The essential oil, isolated through hydro-distillation, was analysed using GC-MS for composition and tested for antimicrobial activity against Staphylococcus aureus and Escherichia coli through MIC and MBC assays. Study established a blueprint for identification of the rhizome and residual analyses ensured the safety. The isolated oil (yield 1.03%, w/w) which was found to be contained a few major bioactive terpenoids, alcohol, esters showed antibacterial activity on both the strains with greater effect on Gram positive strain. The study confirmed the identity, purity, safety, and efficacy of the plant rhizome, paving the way for its use as moderately effective antimicrobial agent in phyto-pharmaceuticals.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiolytics and antidepressants properties of roasted agung banana peel: a potential therapeutic approach. 烤香蕉皮的抗焦虑和抗抑郁特性：一种潜在的治疗方法。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2566462

Lannie Hadisoewignyo, Jefri Prasetyo, Kuncoro Foe, Kevin Owen Santoso, Eka Pramyrtha Hestianah, Ida Ayu Andri Parwitha, Ivonne Soeliono

引用次数: 0

Heterologous expression of Pyrenocine A from Colletotrichum gloeosporioides CGMCC 3.17371. 炭疽菌CGMCC 3.17371株pyrecinine A的异源表达。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2568206

Chao Chen, Yuxin Shi, Haizhifei Ding, Lina Yu, Wei Lin, Jianbin Xiao, Huaidong Zhang, Qin Li, Mingliang Zhang, Li Li

引用次数: 0

Phenolic profile, in vitro bioactivities, and in silico inhibition of α-amylase and trypsin by Thymelaea hirsuta (L.) Endl. 百里菊酚谱、体外生物活性及对α-淀粉酶和胰蛋白酶的抑制作用Endl。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2562600

Kamal Nedjari Benhadj Ali, Mohammed Bouzouina, Djilali Benabdelmoumene, Souheyla Mekraf, Mohammed Cheurfa, Abdelaziz Merouane

{"title":"Phenolic profile, in vitro bioactivities, and in silico inhibition of α-amylase and trypsin by Thymelaea hirsuta (L.) Endl.","authors":"Kamal Nedjari Benhadj Ali, Mohammed Bouzouina, Djilali Benabdelmoumene, Souheyla Mekraf, Mohammed Cheurfa, Abdelaziz Merouane","doi":"10.1080/14786419.2025.2562600","DOIUrl":"https://doi.org/10.1080/14786419.2025.2562600","url":null,"abstract":"Research on plants like Thymelaea hirsuta (L.) Endl. is increasingly crucial for identifying alternative therapies for chronic diseases. This study investigated the n-butanol leaf fraction (NBF) of T. hirsuta for its antioxidant, anti-diabetic, and anti-inflammatory properties through in vitro experiments, including 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), Ferric Reducing Antioxidant Power (FRAP), Ferrous Ion Chelating (FIC), α-amylase inhibition, and anti-inflammatory assays. In silico study was also conducted against α-amylase and trypsin enzymes. Eighteen (18) compounds, including various phenolic acids and flavonoids, were identified by HPLC-PDA-MS/MS. The NBF demonstrated potent antioxidant activity, exhibiting 99.60% inhibition against ABTS•+, 92.85% against DPPH•, and 88.05% for FIC. It also showed significant α-amylase inhibition (85.40% at 5 mg/mL; IC50: 0.37 ± 0.08 mg/mL). Furthermore, the NBF displayed notable anti-inflammatory activities, with 95.37% inhibition of protein denaturation (IC50: 1.83 ± 0.06 mg/mL), 79.14% inhibition of heat-induced haemolysis (IC50: 0.026 mg/mL), and 77.72% inhibition of proteinase (IC50: 0.81 ± 0.95 mg/mL). In silico molecular docking studies against α-amylase and trypsin enzymes revealed feruloyl apigenin as a promising dual inhibitor. This novel compound exhibited a binding affinity comparable to acarbose and diclofenac sodium. These findings highlight the NBF of T. hirsuta as a potential source of bioactive compounds for future anti-inflammatory and anti-diabetic pharmaceutical development.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The essential oil chemical composition of aerial parts of a new chemotype of Scutellaria altissima growing wild in North Macedonia. 北马其顿野生黄芩一个新化学型地上部挥发油的化学成分。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2566910

Natale Badalamenti, Antonella Porrello, Vincenzo Ilardi, Maurizio Bruno

{"title":"The essential oil chemical composition of aerial parts of a new chemotype of Scutellaria altissima growing wild in North Macedonia.","authors":"Natale Badalamenti, Antonella Porrello, Vincenzo Ilardi, Maurizio Bruno","doi":"10.1080/14786419.2025.2566910","DOIUrl":"https://doi.org/10.1080/14786419.2025.2566910","url":null,"abstract":"The genus Scutellaria L. (Lamiaceae) has a very wide geographical distribution across all temperate regions. Due to the potential medicinal value of Scutellaria, especially as antifeedant and anti-cancer, a very large number of phytochemical and pharmacology investigations have been carried out. Scutellaria altissima L. is a perennial herbaceous plant native to East Central Europe to Caucasus. Chemical composition of the essential oil from the aerial parts of S. altissima (Sa), collected in North Macedonia, and investigated for the first time in this study, was evaluated by gas chromatography (GC-MS). Sa (yield 0.01%), was characterised by good amounts of phenylpropanoids phenylpropanoids (54.2%), with myristicin (47.8%) as the principal metabolites of the oil. Other abundant compounds were linalool (13.1%), apiol (6.4%), and 1-octen-3-ol (4.9%). The chemical profile of Sa was compared with the composition all other essential oils (EOs) of Scutellaria species showing some peculiar characteristics.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition and biological activities of Piper divaricatum G.Mey (Piperaceae) essential oil from different locations: an analysis of the literature. 不同产地胡椒精油的化学成分及生物活性：文献分析。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-09-29 DOI: 10.1080/14786419.2025.2565260

Anderson de Santana Botelho, Oberdan Oliveira Ferreira, Ravendra Kumar, Pooja Bargali, Eliza de Jesus Barros Dos Santos, Karyme do Socorro de Souza Vilhena, Marcilene Paiva Da Silva, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade

{"title":"Chemical composition and biological activities of Piper divaricatum G.Mey (Piperaceae) essential oil from different locations: an analysis of the literature.","authors":"Anderson de Santana Botelho, Oberdan Oliveira Ferreira, Ravendra Kumar, Pooja Bargali, Eliza de Jesus Barros Dos Santos, Karyme do Socorro de Souza Vilhena, Marcilene Paiva Da Silva, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade","doi":"10.1080/14786419.2025.2565260","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565260","url":null,"abstract":"Piper divaricatum is an aromatic plant native to South America which has an essential oil with a rich chemical composition and promising biological activities. The main compounds found include phenylpropanoids such as methyl eugenol and eugenol, as well as monoterpenes and sesquiterpenes, the concentrations of which vary according to the geographical location of the specimens. These compounds are known to have relevant therapeutic properties, such as antioxidant, antimicrobial, anti-inflammatory, anaesthetic and insecticidal activities, which contribute to the activities observed in the oils in various studies. However, these studies are still in their infancy and further research is needed to better understand the possible applications of P. divaricatum essential oil. In this context, this mini-review seeks to provide information on the chemical and biological potential of the essential oil of the species, gathering data from studies carried out to date and demonstrating its potential, which is still little explored.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0