Natural Product Research最新文献_第9页

Flavonoids: the use in mental health and related diseases. 黄酮类化合物：用于心理健康和相关疾病。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-10 DOI: 10.1080/14786419.2023.2275275

Camilla Nicolucci, Milena Padovani, Fernanda de Castro Rodrigues, Laura Nagy Fritsch, Ana Cristina Santos, Denise Gonçalves Priolli, Juliana M Sciani

{"title":"Flavonoids: the use in mental health and related diseases.","authors":"Camilla Nicolucci, Milena Padovani, Fernanda de Castro Rodrigues, Laura Nagy Fritsch, Ana Cristina Santos, Denise Gonçalves Priolli, Juliana M Sciani","doi":"10.1080/14786419.2023.2275275","DOIUrl":"10.1080/14786419.2023.2275275","url":null,"abstract":"Given the current increase in mental and neurological disorders, there is an urgent need to develop alternative treatments for patients. Flavonoids exhibit diverse biological activities, including antioxidant, anti-inflammatory and neuroprotective, and has been considered potential therapies for central nervous system diseases, such as Alzheimer's disease, Parkinson's disease, drug addiction, and stroke. Studies have shown that flavonoids protect neurons from oxidative stress, reduce inflammation, improve brain blood flow and enhance cognitive function. Moreover, its modulation of neurotransmission, such as GABAergic, dopaminergic, serotoninergic, and noradrenergic, has been studied for the treatment of mental disorders that require sedative effects, antidepressants, sleep inducers and anxiety reduction. Although more research is needed to fully understand the mechanisms and potential benefits of these compounds, the use of flavonoids for neurological diseases is a promising avenue for future research and development. This review focuses on major flavonoid subclasses and their applications in central nervous system disorders.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4223-4233"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition, antimicrobial, and antioxidant activities of Opuntia stricta (Haw.) Haw. mucilage collected in Sicily, Italy. 严格仙人掌的化学成分、抗菌和抗氧化活性。在意大利西西里岛采集的粘液。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-01 DOI: 10.1080/14786419.2023.2272781

Michela Di Napoli, Natale Badalamenti, Giusy Castagliuolo, Rosalia Merra, Mario Varcamonti, Anna Zanfardino, Maurizio Bruno, Francesco Sottile

引用次数: 0

Therapeutic importance of Kigelia africana subsp. africana: an alternative medicine. 非洲基加利亚种的治疗重要性。非洲：一种替代药物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-03 DOI: 10.1080/14786419.2023.2273914

Zahra Abbas, Saad Mustafa, Mohd Faisal Khan, Mohammad Aasif Khan, Sheersh Massey, Kapil Dev, Asifa Khan, Shabana Parveen, Syed Akhtar Husain

{"title":"Therapeutic importance of Kigelia africana subsp. africana: an alternative medicine.","authors":"Zahra Abbas, Saad Mustafa, Mohd Faisal Khan, Mohammad Aasif Khan, Sheersh Massey, Kapil Dev, Asifa Khan, Shabana Parveen, Syed Akhtar Husain","doi":"10.1080/14786419.2023.2273914","DOIUrl":"10.1080/14786419.2023.2273914","url":null,"abstract":"Aim: To summarise a detailed up-to-date review of the traditional uses, phytoconstituents, and pharmacological activities of various parts of Kigelia africana.Materials and methods: Google Scholar, PubMed, PubChem, Elsevier, King Draw, indianbiodiversity.org.Result: The phytochemical analysis of Kigelia africana subsp. africana has revealed the presence of approximately 145 compounds extracted from different parts of the plant. These bioactive extracts of the plant possess anti-inflammatory, antioxidant, antimicrobial, antidiabetic, antineoplastic, and anti-urolithic activities. Due to its anti-inflammatory, antioxidant, and immune-booster properties, Kigelia can prove to be an essential source of drugs for treating various disorders.Conclusion: Knowledge of the phytoconstituents, non-medicinal and medicinal traditional uses, pharmacological activities, and products obtained from Kigelia is described in this review with the hope that the updated findings will promote research on its biological pathways.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4208-4222"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new furanone derivatives from the endophytic fungus Byssochlamys sp. and their cytotoxic activities. 内生真菌Byssochlamys sp.的两种新呋喃酮衍生物及其细胞毒性活性。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-27 DOI: 10.1080/14786419.2023.2275269

Jie Wang, Wen-Bin Gao, Fan-Wei Liu, Qi Liu, Bo Song, Jin Ye, Ying Chen, Cai-Lin Zhao, Wei Dong, Li-Na Guo, Bo Song

引用次数: 0

Estimation of the phenolic content and in vivo evaluation of the anti-inflammatory and anti-ulcer activity of Rhus pentaphylla leaf and fruit extracts from Morocco.

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 DOI: 10.1080/14786419.2024.2436118

Agouram Fatimazahra, Hamid Kabdy, Khadija Oubella, Sara Oufquir, Abdelfatah Aitbaba, Hajar Azraida, Karima Raoui, Rachida Aboufatima, Zahra Sokar, Stefania Garzoli, Abderrahman Chait

{"title":"Estimation of the phenolic content and in vivo evaluation of the anti-inflammatory and anti-ulcer activity of Rhus pentaphylla leaf and fruit extracts from Morocco.","authors":"Agouram Fatimazahra, Hamid Kabdy, Khadija Oubella, Sara Oufquir, Abdelfatah Aitbaba, Hajar Azraida, Karima Raoui, Rachida Aboufatima, Zahra Sokar, Stefania Garzoli, Abderrahman Chait","doi":"10.1080/14786419.2024.2436118","DOIUrl":"https://doi.org/10.1080/14786419.2024.2436118","url":null,"abstract":"The present study aimed to estimate the phenolic compounds and evaluate the anti-inflammatory and anti-ulcer activity of Rhus pentaphylla leaf and fruit extracts in rodents. Phytochemical identification of the extracts was performed using HPLC technique. The anti-inflammatory property of the extracts was studied using three animal models of inflammation: xylene-induced ear swelling in Swiss albino mice, paw edoema and carrageenan-induced air pocketing in Sprague Dawley rats. The antiulcer activity of the extracts was evaluated through HCl/ethanol-induced acute gastric lesions in rats. HPLC results revealed the presence of epicatechin, caffeic acid and rutin in the leaf extract, while quercetin and kaempferol were identified in the fruit extract. Both leaf and fruit extracts demonstrated significant anti-inflammatory potential. Additionally, the extracts inhibited leukocyte migration and exhibited a strong gastroprotective effect. These remarkable in vivo pharmacological activities of Rhus pentaphylla extracts, linked to their bioactive compounds, demonstrate their potential for possible therapeutic applications.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lathyrane diterpenoids from Euphorbia lathyris induce cell-cycle arrest and apoptosis in human hypertrophic scar cells. 大戟中的Lathyrane二萜类化合物诱导人增生性瘢痕细胞的细胞周期停滞和凋亡。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-10 DOI: 10.1080/14786419.2023.2280736

Chun-Yan Zhang, Shun Xu, Lei Yu, Yi-Wen Nie, Si-Bo Li, Jian-Yong Zhu

{"title":"Lathyrane diterpenoids from Euphorbia lathyris induce cell-cycle arrest and apoptosis in human hypertrophic scar cells.","authors":"Chun-Yan Zhang, Shun Xu, Lei Yu, Yi-Wen Nie, Si-Bo Li, Jian-Yong Zhu","doi":"10.1080/14786419.2023.2280736","DOIUrl":"10.1080/14786419.2023.2280736","url":null,"abstract":"One new lathyrane-type diterpenoid, euphlathin A (1), and 11 known analogues (2-12), were isolated from the fruits of Euphorbia lathyris. Their structures were elucidated by spectroscopic data. The absolute configurations of 1 were established by single-crystal X-ray crystallography. All diterpenoids (1-12) were evaluated for antiproliferative activity against the human hypertrophic scar (HTS) cells. Compound 1 exhibited significantly against HTS cells growth with an IC50 value of 6.33 μM. Morphological features of apoptosis were evaluated in 1-treated HTS cells. Wound healing assays indicated that 1 significantly inhibited the migration of HTS at 24 h and 48 h. Compound 1 effectively induced apoptosis of HTS, which was associated with G2/M or S phase cell cycle arrest. Flow cytometric analysis showed that the treatment by 1 significantly induced HTS cell apoptosis in a dose-dependent manner. Overall, euphlathin A (1) has the potential to be a therapeutic agent for the treatment of hyperplastic scar therapy.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4181-4190"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Costunosides A-C: cytotoxic sesquiterpene lactones from the rhizomes of Aucklandia costus Falc. Costunosides A-C：来自Aucklandia costus Falc根状茎的细胞毒性倍半萜内酯。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-06 DOI: 10.1080/14786419.2023.2275743

Anil Bhushan, Dixhya Rani, Bashir A Lone, Misbah Tabassum, Ajai P Gupta, Dilip M Mondhe, Sumeet Gairola, Prem Narayan Gupta, Prasoon Gupta

引用次数: 0

Nutritional value and therapeutic potential of Moringa oleifera: a short overview of current research. 辣木的营养价值和治疗潜力:目前研究的简要概述。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-12-03 DOI: 10.1080/14786419.2023.2284862

Nabila Bibi, Nadia Rahman, Muhammad Qasim Ali, Noormazlinah Ahmad, Farzana Sarwar

引用次数: 0

Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida. 来自 Picralima nitida 的抗疟和抗锥虫病单萜吲哚生物碱。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-28 DOI: 10.1080/14786419.2024.2434710

Michael Konney Laryea, Kofi Mensah Wonder Abotsi, Eric Woode, Rita Akosua Dickson, Lauren Webster, Edmund Ekuadzi

引用次数: 0

An integrated analysis of network pharmacology and GEO database to decode the active component and the underlying mechanism of Yiwei decoction in non-small cell lung cancer. 通过网络药理学和 GEO 数据库的综合分析，解读益卫煎对非小细胞肺癌的有效成分和内在机制。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-27 DOI: 10.1080/14786419.2024.2432610

Lei Zhang, Wei Zhu

{"title":"An integrated analysis of network pharmacology and GEO database to decode the active component and the underlying mechanism of Yiwei decoction in non-small cell lung cancer.","authors":"Lei Zhang, Wei Zhu","doi":"10.1080/14786419.2024.2432610","DOIUrl":"https://doi.org/10.1080/14786419.2024.2432610","url":null,"abstract":"Treating non‑small‑cell lung cancer (NSCLC) is challenging and demands therapies with minimal side effects to enhance patient quality of life. Yiwei Decoction (YWD) shows potential for NSCLC treatment,but further research is necessary for full comprehension about active compounds, molecular targets, and mechanisms. Using TCMSP and BATMAN‑TCM, the study identified YWD's active components and targets, and analyzed NSCLC differential genes from the GEO database.NSCLC targets from GeneCard, NCBI, and DisGeNET were combined with differential genes to identify component targets. A PPI network showed overlapping targets, while GO and KEGG analyses assessed relevant pathways. Molecular docking validated the connection between the main compound and core target in the \"active ingredient‑target‑pathway\" network. The study identified 193 targets for 20 active YWD components and 197 NSCLC‑related targets, with 14 overlaps.GO analysis revealed that YWD affects 146 biological processes, including cell proliferation and protein kinase binding. KEGG analysis identified 58 pathways related to inflammation, cell survival, and cancer, clarifying YWD's role in NSCLC treatment. Network analysis and molecular docking indicated that n‑coumaroyltyramine and quercetin effectively bind to CCND1 and EGFR, underscoring their therapeutic contributions. The study suggests that YWD may target CCND1, EGFR, and TP53, impacting HIF‑1, JAK‑STAT, and other stress‑related pathways in NSCLC.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0