Natural Product Research最新文献_第8页

Exploring hesperidin: an effective naturalphytomedicine for combating breast cancer. 探索橙皮甙：抗击乳腺癌的有效天然药物

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429120

Chitra Shivalingam, Saheb Ali

引用次数: 0

Crystal structure and the degradation products of Tenvermectin B. 天维菌素 B 的晶体结构和降解产物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429110

Zhen-Yu Wang, Chun-Hui Wu, Xiao-Han Ren, Wei Zhang, Shao-Yong Zhang, Huan Qi, Jun Huang, Ji-Dong Wang, Hui Zhang

引用次数: 0

Synthesis of epoxyazadiradione-thiazole hybrid derivatives and evaluation of their cytotoxic activities. 环氧偶氮二酮噻唑杂化衍生物的合成及其细胞毒性活性评估。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429130

Gaja Swarna Kumari, Sai Balaji Andugulapati, Vaikundamoorthy Ramalingam, K Suresh Babu

{"title":"Synthesis of epoxyazadiradione-thiazole hybrid derivatives and evaluation of their cytotoxic activities.","authors":"Gaja Swarna Kumari, Sai Balaji Andugulapati, Vaikundamoorthy Ramalingam, K Suresh Babu","doi":"10.1080/14786419.2024.2429130","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429130","url":null,"abstract":"In an attempt to develop natural product-based anticancer agents, a series of novel epoxyazadiradione-thiazole hybrids (6a-j) were synthesised and evaluated for their anticancer activity. All the synthesised derivatives were assessed for in vitro cytotoxic activity against a panel of human cancer and normal cell lines and the results showed that most of the compounds exhibited significant cytotoxic activity against cancer cells and as well some of the compounds showed less cytotoxicity against normal cells. In particular, compound 4 showed potent cytotoxic activity against tongue cancer cell lines. In consideration of the potent activity, the compound 4 was further assessed for cell cycle analysis and the results showed that the compound arrests the cell cycle progression at the G0/G1 phase in the tongue cancer cell lines. Consequently, the annexin V/PI staining assay demonstrated that compound 4 induced early apoptosis against tongue cancer. Taken together, the results inferred that the epoxyazadiradione is promising anticancer candidate for developing novel anticancer drugs against tongue cancer.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition and biological activities of essential oils from Cymbopogon schoenanthus (L.) Spreng.: a Saharan plant from Ghardaïa region (Algeria). Cymbopogon schoenanthus (L.) Spreng.精油的化学成分和生物活性：来自 Ghardaïa 地区（阿尔及利亚）的一种撒哈拉植物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-15 DOI: 10.1080/14786419.2024.2425811

Hanane BenZetta, Faiza Baali, Nadjette Djemouai, Sofia Ayari-Guentri, Somia Saad, Kathia Belaid, Elyes Kelai

{"title":"Chemical composition and biological activities of essential oils from Cymbopogon schoenanthus (L.) Spreng.: a Saharan plant from Ghardaïa region (Algeria).","authors":"Hanane BenZetta, Faiza Baali, Nadjette Djemouai, Sofia Ayari-Guentri, Somia Saad, Kathia Belaid, Elyes Kelai","doi":"10.1080/14786419.2024.2425811","DOIUrl":"https://doi.org/10.1080/14786419.2024.2425811","url":null,"abstract":"The essential oils (EOs) of Cymbopogon schoenanthus (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while Bacillus cereus was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20th day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that C. schoenanthus is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of myristicin and gymnemasaponins in modern oncology: bridging natural products and cancer therapeutics. 肉豆蔻皂苷和钩藤皂苷在现代肿瘤学中的作用：天然产品与癌症疗法的桥梁。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-15 DOI: 10.1080/14786419.2024.2429518

Vibala B V

引用次数: 0

Harnessing gene-encoded antioxidant peptides from amphibian skin secretions as a novel therapeutic strategy against influenza a virus. 利用两栖动物皮肤分泌物中的基因编码抗氧化肽作为抗甲型流感病毒的新型治疗策略。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-15 DOI: 10.1080/14786419.2024.2427839

Omar Farooq Burhanuddin Mohammed, Jayalakshmi Somasundaram, Ajay Guru

引用次数: 0

Omphalotin peptide from Omphalotus olearius as a natural preservative against Fusarium mold contamination. 从 Omphalotus olearius 中提取的 Omphalotin 肽是一种天然防腐剂，可防止镰刀菌霉菌污染。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-15 DOI: 10.1080/14786419.2024.2427813

Omar Farooq Burhanuddin Mohammed, Jayalakshmi Somasundaram, Ajay Guru

引用次数: 0

Discovery of two new tirucallane-type triterpenes anomers from Toona ciliata. 从 Toona ciliata 发现两种新的 tirucallane 型三萜异构体。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2429115

Aliya Tabassum, Harshad B Bhore, Jayanta Samanta, Anil Kumar Katare, Yogesh P Bharitkar

引用次数: 0

Unveiling the antibacterial and antioxidant capabilities of Diospyros buxifolia leaf and stem extracts via GC-MS analysis. 通过气相色谱-质谱分析揭示欧鼠李叶和茎提取物的抗菌和抗氧化能力。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2425804

Praveen Kumar Basivi, Jayaletchumi Raman, Anitha Tippana, Vijay Kakani, Reetesh Kumar, Pasupuleti Visweswara Rao, Chang Woo Kim

{"title":"Unveiling the antibacterial and antioxidant capabilities of Diospyros buxifolia leaf and stem extracts via GC-MS analysis.","authors":"Praveen Kumar Basivi, Jayaletchumi Raman, Anitha Tippana, Vijay Kakani, Reetesh Kumar, Pasupuleti Visweswara Rao, Chang Woo Kim","doi":"10.1080/14786419.2024.2425804","DOIUrl":"10.1080/14786419.2024.2425804","url":null,"abstract":"Drug-resistant microorganisms pose a significant threat to public health as they can undermine the effectiveness of existing antibiotics and other medications. Additionally, the formation of free radicals, can contribute to various health problems. Diospyros buxifolia (D. buxifolia) belonging to Ebenaceae family is a large tropical evergreen tree utilised in traditional medicine to cure several health ailments. The present study was set out to separate bioactive speciation of aqueous and methanolic extracts of stem and leaves from D. buxifolia by using Gas Chromatography-Mass Spectrometry (GC-MS) followed by evaluation of its antimicrobial and antioxidant capabilities. GC-MS identified 14 different bioactive compounds, with four compounds common for both (leaf and stem) extracts. The methanolic extracts of leaf demonstrated significant antibacterial activity) while stem extracts exhibited notable antioxidant potential. Thus, D. buxifolia is proved source of natural antimicrobial and antioxidant agent, that could address the challenges posed by drug-resistant microorganisms and oxidative stress in global health.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical analysis on the female cone of Araucaria bidwillii Hook. Araucaria bidwillii Hook雌锥体的植物化学分析

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-14 DOI: 10.1080/14786419.2024.2426213

Claudio Frezza, Alessandro Venditti, Ottavia Giampaoli, Chiara Dal Bosco, Marco Franceschin, Claudio Scintu, Fabio Sciubba, Mauro Serafini, Daniela De Vita, Fabio Attorre

{"title":"Phytochemical analysis on the female cone of Araucaria bidwillii Hook.","authors":"Claudio Frezza, Alessandro Venditti, Ottavia Giampaoli, Chiara Dal Bosco, Marco Franceschin, Claudio Scintu, Fabio Sciubba, Mauro Serafini, Daniela De Vita, Fabio Attorre","doi":"10.1080/14786419.2024.2426213","DOIUrl":"10.1080/14786419.2024.2426213","url":null,"abstract":"In this work, the first phytochemical analysis ever performed on a whole cone of Araucaria bidwillii Hook. is presented. This was carried out by means of column chromatography, NMR spectroscopy and MS spectrometry on the female cone, evidencing the presence of forty metabolites, thirty-three of which are primary whilst the remaining are non-volatile secondary. A chemophenetic evaluation was also performed reporting seven new compounds for the species i.e. β-sitosterol (5), 15-agathic acid methyl ester (6), methyl (E)-communate (7), shikimic acid (8), gallic acid (9), p-hydroxy-benzoic acid (10) and quinic acid (11). Throughout this evaluation some important qualitative phytochemical differences among this female cone, its seeds and the few other studied cones of the species comprised in the family, were evidenced. These whole results provide more information on the phytochemistry of this organ and of the species, in general, but also underline the need to perform more studies.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0