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Unveiling the therapeutic potential of neem flower: a phytochemical study for antidiabetic and anticancer properties.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 DOI: 10.1080/14786419.2024.2433194
Vibhavari P Jadhav, Yogeshwar R Suryawanshi, Sujatha Parameswaran, Nilesh N Wankhede
{"title":"Unveiling the therapeutic potential of neem flower: a phytochemical study for antidiabetic and anticancer properties.","authors":"Vibhavari P Jadhav, Yogeshwar R Suryawanshi, Sujatha Parameswaran, Nilesh N Wankhede","doi":"10.1080/14786419.2024.2433194","DOIUrl":"https://doi.org/10.1080/14786419.2024.2433194","url":null,"abstract":"<p><p>The study explores the medicinal properties of neem blossoms, highlighting their potential as less harmful and more beneficial than other plant parts, while also analysing extraction solvent effects. The Soxhlet extraction method was employed to extract phytochemicals using solvents based on their polarity, including chloroform, ethyl acetate, ethanol, and methanol. The study analysed four extracts for antidiabetic and anticancer properties. The ethanolic extract was found to be most effective against diabetes and cancer cells. It can actively inhibit the activity of (dipeptidyl peptidase 4) DPP-IV which leads to the decrease in sugar levels by increased activity of incretins. Similarly, extracts have shown good anticancer activity in [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide)] MTT assay. Among all extract studied ethanolic extract proved as the most active extract and was further qualitatively studied by using High-resolution mass spectra to analyse the chemical composition of the neem flower. 33 different compounds were identified from the most active extract of <i>Azadirachta Indica.</i></p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular properties, structure, neurotrophic and anti-inflammatory activities of cultured secondary metabolites from the cultures of the mushroom Cyathus striatus CBPFE A06. 蘑菇Cyathus striatus CBPFE A06培养次生代谢物的分子特性、结构、神经营养和抗炎活性
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-25 DOI: 10.1080/14786419.2023.2273911
Jing Wei, Mei-Yu Ye, Zhen-Xin Wang, Yi-Lin Zhang, Xuan-Sheng Hu, He-Ping Hui, Yi-Tong Liu, Jianzhao Qi
{"title":"Molecular properties, structure, neurotrophic and anti-inflammatory activities of cultured secondary metabolites from the cultures of the mushroom <i>Cyathus striatus</i> CBPFE A06.","authors":"Jing Wei, Mei-Yu Ye, Zhen-Xin Wang, Yi-Lin Zhang, Xuan-Sheng Hu, He-Ping Hui, Yi-Tong Liu, Jianzhao Qi","doi":"10.1080/14786419.2023.2273911","DOIUrl":"10.1080/14786419.2023.2273911","url":null,"abstract":"<p><p>Two previously undescribed natural cyathane diterpenoids Me-dentifragilin A (<b>1</b>) and Epi-neocyathin O (<b>2</b>), and three known cyathane diterpenoids <b>3</b>-<b>5</b>, cyathin O, neocyathin P, and cyathin I, were isolated from the rice medium of the <i>Cyathus striatus</i> CBPFE A06. Their structures were established by NMR spectra, and HR-ESI-MS. Compounds <b>1</b>-<b>5</b> displayed encouraging neurotrophic activity in PC-12 cells at doses of 5 µM. Meanwhile, <b>1</b>-<b>5</b> significantly inhibited LPS-induced NO generation in BV2 cells with the IC<sub>50</sub> values ranging from 2.44 ± 0.16 to 4.33 ± 0.32 μM. Western blot analysis showed that <b>2</b> and <b>4</b> inhibited the expression of genes involved in nitric oxide (NO) production. Molecular docking revealed that five residues of inducible NO synthase (iNOS) are key residues affecting the interaction of <b>2</b> and <b>4</b> with iNOS. This study enriches the structural diversity of cyathane diterpenes and adds to the evidence that cyathane diterpenes prevent and treat neurodegenerative diseases.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4280-4285"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the essential oil from Iphiona grantioides and investigation of its antibacterial and antioxidant properties. 颗粒硫醚精油的表征及其抗菌和抗氧化性能的研究。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-26 DOI: 10.1080/14786419.2023.2272782
Shah Iram Niaz, Muhammad Ali, Muhammad Saleem, Rubina Qaisrani, Kamran Safdar, Malik Muhammad Akram, Abdur Rauf, Maqbool Ahmad, Sanaullah Abbasi, Taghrid S Alomar, Najla AlMasoud, Giovanni Ribaudo
{"title":"Characterisation of the essential oil from <i>Iphiona grantioides</i> and investigation of its antibacterial and antioxidant properties.","authors":"Shah Iram Niaz, Muhammad Ali, Muhammad Saleem, Rubina Qaisrani, Kamran Safdar, Malik Muhammad Akram, Abdur Rauf, Maqbool Ahmad, Sanaullah Abbasi, Taghrid S Alomar, Najla AlMasoud, Giovanni Ribaudo","doi":"10.1080/14786419.2023.2272782","DOIUrl":"10.1080/14786419.2023.2272782","url":null,"abstract":"<p><p><i>Iphiona grantioides</i> (Boiss) Anderb. is a medicinal plant featuring several traditional uses. Nevertheless, this plant has not been widely investigated by modern medicinal chemistry yet, as also the properties of its extracts.In this study, we report the extraction of the essential oil by hydrodistillation from the leaves of <i>I. grantioides</i>. This was characterised by GC-MS analysis and ten chemical constituents were identified.Our findings demonstrate that the essential oil is effective in inhibiting the growth of bacterial strains, and of <i>Klebsiela pneumonia</i> and <i>S</i>taphylococcus <i>aureus</i> in particular. Additionally, its antioxidant properties were evaluated, and it showed radical scavenging activity <i>in vitro</i>.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4086-4091"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-vitro cytotoxic potential of aerial parts of Leutea avicennae Mozaff. in different Human cancer cell lines. 莫扎夫白茶地上部分的体外细胞毒性潜力。在不同的人类癌症细胞系中。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-27 DOI: 10.1080/14786419.2023.2275286
Mahsa Sabernavaei, Hamed Montazeri, Parastoo Mirzabeigi, Paria Sharafi-Badr, Mozhdeh Zamani, Abbas Hadjiakhoondi, Narguess Yassaa, Farzad Kobarfard
{"title":"<i>In-vitro</i> cytotoxic potential of aerial parts of <i>Leutea avicennae</i> Mozaff. in different Human cancer cell lines.","authors":"Mahsa Sabernavaei, Hamed Montazeri, Parastoo Mirzabeigi, Paria Sharafi-Badr, Mozhdeh Zamani, Abbas Hadjiakhoondi, Narguess Yassaa, Farzad Kobarfard","doi":"10.1080/14786419.2023.2275286","DOIUrl":"10.1080/14786419.2023.2275286","url":null,"abstract":"<p><p>Medicinal plants such as <i>Leutea avicennae</i> Mozaff. (Apiaceae) have been shown some biological potential for preventing and treating diseases. Fractions and isolated compounds were tested on colon carcinoma (HT-29), cervical carcinoma (HeLa), breast carcinoma (MCF-7), and mouse embryonic fibroblast (NIH/3T3) cell lines. The BSLT method was used for the assessment of the general toxicity of the petroleum ether (PET), chloroform (CHCl<sub>3</sub>), ethyl acetate (EtOAc), and methanol (MeOH) fractions obtained from the aerial parts of <i>L. avicennae.</i> 1H-NMR and 13 C-NMR spectroscopy were used for structure elucidation. Five compounds, including two coumarins, osthole and umbelliferone, a diterpene phytol, β-sitosterol, and lauric acid, were isolated for the first time from <i>L. avicennae.</i> Osthole showed potent cytotoxic activity against MCF-7 and HT-29 cell lines with IC<sub>50</sub> values of 4.23 ± 0.26 and 12.11 ± 0.13 µg/mL, respectively. Phytol demonstrated potent cytotoxic activity towards MCF-7 and HeLa cell lines with IC<sub>50</sub> values of 6.80 ± 0.08 and 12.27 ± 0.18 µg/mL, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4098-4105"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54230235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells. 贯叶连翘橄榄油提取物对结直肠癌细胞和人骨髓干细胞的细胞毒性和抗转移作用。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-11 DOI: 10.1080/14786419.2023.2280715
Hatice Yildirim, Burcu Efe Daşkan
{"title":"Cytotoxic and anti-metastatic effects of <i>Hypericum perforatum</i> olive oil extract in colorectal cancer cells and human bone marrow derived stem cells.","authors":"Hatice Yildirim, Burcu Efe Daşkan","doi":"10.1080/14786419.2023.2280715","DOIUrl":"10.1080/14786419.2023.2280715","url":null,"abstract":"<p><p>This study is aimed to investigate the effects of <i>Hypericum perforatum</i> olive oil extract on the cytotoxic and metastatic properties of human colorectal cancer cells and human bone marrow-derived mesenchymal stem cells. In addition, ALDH3A1 and Vimentin expressions were evaluated by qRT-PCR and western blot analysis. Total phenolic and flavonoid contents and antioxidant activity of methanol extracts prepared with oil enrichment were measured using spectrophotometry-based methods. The cytotoxic effects of the extracts on SW-480 and bone marrow-derived mesenchymal stem cells were evaluated by MTT assay, resulting in IC<sub>50</sub> values of 4.8 mg/ml and 4.9 mg/ml, respectively. It was determined that cell migration and colony formation were significantly reduced at the IC<sub>50</sub> values determined for SW-480 and human bone marrow-derived mesenchymal stem cells.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4166-4174"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89718998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective role of polysaccharide from the roots of Millettia speciosa Champ in mice with ulcerative colitis induced by dextran sulphate sodium.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 DOI: 10.1080/14786419.2024.2435535
Yanfei Lu, Rihui Wu, Jiaquan Liu, Jinwen Huang, Qiu Liu, Min Yao, Jingyu Wu, Jiming Ye, Dongli Li, Lishe Gan, Jingwei Jin
{"title":"Protective role of polysaccharide from the roots of <i>Millettia speciosa</i> Champ in mice with ulcerative colitis induced by dextran sulphate sodium.","authors":"Yanfei Lu, Rihui Wu, Jiaquan Liu, Jinwen Huang, Qiu Liu, Min Yao, Jingyu Wu, Jiming Ye, Dongli Li, Lishe Gan, Jingwei Jin","doi":"10.1080/14786419.2024.2435535","DOIUrl":"https://doi.org/10.1080/14786419.2024.2435535","url":null,"abstract":"<p><p>This study investigated the therapeutic mechanism of Millettia Speciosa Champ. polysaccharide (MSCP), also known as Niu Dali polysaccharide, in treating ulcerative colitis (UC) using a dextran sulphate sodium (DSS) induced colitis model in C57BL/6 mice. Mice were randomly assigned to four groups: control, DSS model, and low- and high-dose MSCP treatment groups (50, 100 mg/kg/day, respectively). MSCP administration began concurrently with DSS induction. Throughout the intervention, changes in body weight and disease activity index were monitored. On day 44, colonic tissues were collected for analysis after measuring their lengths. Results demonstrated that MSCP effectively ameliorated DSS-induced chronic colitis by suppressing proinflammatory cytokine secretion, enhancing anti-inflammatory cytokine production, restoring intestinal epithelial barrier integrity, and downregulating TLR4 expression.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of Hypericum perforatum L. with antiangiogenic activities. 从贯叶连翘枝和叶中提取的具有抗血管生成活性的三种新酰基间苯三酚。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-12-05 DOI: 10.1080/14786419.2023.2278176
Hao Zhang, Kunling Wang, Fan Chen
{"title":"Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of <i>Hypericum perforatum</i> L. with antiangiogenic activities.","authors":"Hao Zhang, Kunling Wang, Fan Chen","doi":"10.1080/14786419.2023.2278176","DOIUrl":"10.1080/14786419.2023.2278176","url":null,"abstract":"<p><p>Three new acylphloroglucinols were isolated from the branches and leaves of <i>Hypericum perforatum</i> L., named as hyperipersions A-C (<b>1-3</b>), together with three known compounds which were identified as elegaphenone (<b>4</b>), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (<b>5</b>) and 2,3-methylenedioxyxanthone (<b>6</b>), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC<sub>50</sub> value of compound <b>3</b> was 2.39 ± 0.21 <i>μ</i>M against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4134-4140"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginase inhibitory activities of chemical constituents from Macaranga hurifolia Beille leaves. 山核桃叶化学成分对精氨酸酶的抑制活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-05 DOI: 10.1080/14786419.2023.2275267
Andy Zedet, Yao Kanga, Marc Pudlo, François Senejoux, Corine Girard
{"title":"Arginase inhibitory activities of chemical constituents from <i>Macaranga hurifolia</i> Beille leaves.","authors":"Andy Zedet, Yao Kanga, Marc Pudlo, François Senejoux, Corine Girard","doi":"10.1080/14786419.2023.2275267","DOIUrl":"10.1080/14786419.2023.2275267","url":null,"abstract":"<p><p>The methanolic extract of the leaves of <i>Macaranga hurifolia</i> Beille showed arginase inhibitory activity (40% at 100 µg/mL) and was then fractionated to obtain nine polyphenolic compounds. Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in the literature, as gallic acid (<b>1</b>), 3,4-dihydroxybenzoic acid (<b>2</b>), chlorogenic acid, (<b>3</b>), corilagin (<b>4</b>), cynaroside (<b>5</b>), cosmosiin (<b>6</b>), hyperoside (<b>7</b>) isoquercitrin (<b>8)</b> and guajaverin (<b>9</b>). These compounds have been evaluated as arginase inhibitors. Compounds <b>4</b>, <b>7</b>, <b>8</b> and <b>9</b> showed varying arginase inhibitory activities with IC<sub>50</sub> values ranging from 102 to 302 μM. All the isolated compounds were previously identified in this species but their activities on arginase are reported here for the first time.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4286-4291"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of Entada abyssinica (Fabaceae) constituents. uhplc - q - tof - hesi -MS/MS分析及其抗菌性能。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-17 DOI: 10.1080/14786419.2023.2280171
Larissa M Magnibou, Steven C N Wouamba, Abel J G Yaya, Judith F Mbougnia, Guy S S Njateng, Ghislain W Fotso, Celine Henoumont, Sophie Laurent, Talla Emmanuel
{"title":"Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of <i>Entada abyssinica</i> (Fabaceae) constituents.","authors":"Larissa M Magnibou, Steven C N Wouamba, Abel J G Yaya, Judith F Mbougnia, Guy S S Njateng, Ghislain W Fotso, Celine Henoumont, Sophie Laurent, Talla Emmanuel","doi":"10.1080/14786419.2023.2280171","DOIUrl":"10.1080/14786419.2023.2280171","url":null,"abstract":"<p><p>A rapid untargeted UHPLC-Q-TOF-ESI-MS/MS-Based metabolomic profiling of the medicinal plant <i>Entada abyssinica</i> was performed. A total of 18 metabolites were detected, of which 10 could not be identified. Based on this result, an extensive chemical investigation of the CH<sub>2</sub>Cl<sub>2</sub>-MeOH (1:1) extract of this plant was carried out, leading to the isolation of a new ceramide, named entadamide (<b>1</b>), together with nine known compounds: monomethyl kolavate (<b>2</b>), 24-hydroxytormentic acid (<b>3</b>) chondrillasterol (<b>4</b>), 3-<i>O</i>-<i>β</i>-D glucopyranosylstigmasterol (<b>5</b>), 3-<i>O</i>-<i>β</i>-D glucopyranosylsitosterol (<b>6</b>), quercetin 3'-methylether (<b>7</b>), 2,3-dihydroxypropyl icosanoate (<b>8</b>), 2,3-dihydroxy-propyl 23-hydroxytricosanoate (<b>9</b>) and 2,3-dihydroxy-propyl 24-hydroxytetracosanoate (<b>10</b>). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1D and 2D NMR, and HRESI-MS) in comparison with those reported in the literature. Furthermore, the crude extract and some isolated compounds were tested against non-ciprofloxacin resistant strains <i>viz, Pseudomonas aeruginosa</i> (ATCC 27853), <i>Escherichia coli</i> (ATCC 25922), <i>Samonella thyphi</i> (ATCC 19430) and <i>Samonella enterica</i> (NR4294). The tested samples demonstrated significant activity against all the tested bacteria (MIC values: 3.12-12.5 μg/mL).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4155-4165"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antifungal activity of citronellal against Trichophyton rubrum and its predictive mechanism of action by CYP51 inhibition through molecular docking. 香茅醛对红色毛癣菌的抗真菌活性及其通过分子对接抑制CYP51的预测作用机制。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-07 DOI: 10.1080/14786419.2023.2277352
Francisco Patricio de Andrade Júnior, Rawny Galdino Gouveia, Cássio Ilan Soares Medeiros, Bráulio de Almeida Teixeira, Brenda Kercya da Silva Farias, Nayana da Rocha Oliveira, Daniele de Figuerêdo Silva, Edeltrudes de Oliveira Lima
{"title":"Antifungal activity of citronellal against <i>Trichophyton rubrum</i> and its predictive mechanism of action by CYP51 inhibition through molecular docking.","authors":"Francisco Patricio de Andrade Júnior, Rawny Galdino Gouveia, Cássio Ilan Soares Medeiros, Bráulio de Almeida Teixeira, Brenda Kercya da Silva Farias, Nayana da Rocha Oliveira, Daniele de Figuerêdo Silva, Edeltrudes de Oliveira Lima","doi":"10.1080/14786419.2023.2277352","DOIUrl":"10.1080/14786419.2023.2277352","url":null,"abstract":"<p><p>The present study aimed to investigate the antifungal activity of citronellal (CIT) against clinical isolates of <i>T. rubrum</i> and to show the possible mechanism of action involved. The antifungal potential of CIT was evaluated from the Minimum Inhibitory Concentration (MIC), Minimum Fungicide Concentration (MFC) and assays with ergosterol and sorbitol, to elucidate the possible mechanisms of action, and molecular docking. MIC and MFC values ranged from 4 to 512 µg/mL. Regarding the mechanism of action, the monoterpene demonstrated interaction with fungal ergosterol. In addition, it is possible to observe that CIT acts on crucial enzymes for the biosynthesis and maintenance of the fungal cell membrane, due to the ability of the monoterpene to bind to CYP51. The results obtained in this research demonstrate that CIT has the potential to become, in the future, a product for the treatment of dermatophytosis.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4125-4133"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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