Resveratrol synergistically enhances anti-lung cancer efficacy with myricetin and dihydromyricetin on A549 cells by increasing their intracellular concentrations.
{"title":"Resveratrol synergistically enhances anti-lung cancer efficacy with myricetin and dihydromyricetin on A549 cells by increasing their intracellular concentrations.","authors":"Yuexing Chang, Yufeng Liu, Ailing Guo, Liangfeng Wang, Zhihuan Wu, Haodong Jiang, Fangli Wang, Yinyin Xiang, Feng Jin, Yun Deng","doi":"10.1080/14786419.2025.2566912","DOIUrl":null,"url":null,"abstract":"<p><p>The present study aimed to investigate the synergistic cytotoxic effects and related mechanism of resveratrol and myricetin or dihydromyricetin in A549 cells. Cell viability, scratch wound, clone formation, cell apoptosis and cycle test were operated to confirm the synergistic anti-lung cancer effects. The effects of resveratrol on the efflux of myricetin, dihydromyricetin and rhodamine 123 were determined to discover the synergistic mechanism. The combination of resveratrol of 25 µg/mL and myricetin or dihydromyricetin of 25 µg/mL had the best synergistic anti-lung cancer effect. Resveratrol combined with myricetin or dihydromyricetin caused A549 cells to exit the S- and G2/M-phase. Resveratrol enhanced the myricetin, dihydromyricetin and rhodamine 123 concentrations in A549 cells. Resveratrol and myricetin or dihydromyricetin exert a synergistic effect, but not <i>via</i> a suppression of P-glycoprotein.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2566912","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The present study aimed to investigate the synergistic cytotoxic effects and related mechanism of resveratrol and myricetin or dihydromyricetin in A549 cells. Cell viability, scratch wound, clone formation, cell apoptosis and cycle test were operated to confirm the synergistic anti-lung cancer effects. The effects of resveratrol on the efflux of myricetin, dihydromyricetin and rhodamine 123 were determined to discover the synergistic mechanism. The combination of resveratrol of 25 µg/mL and myricetin or dihydromyricetin of 25 µg/mL had the best synergistic anti-lung cancer effect. Resveratrol combined with myricetin or dihydromyricetin caused A549 cells to exit the S- and G2/M-phase. Resveratrol enhanced the myricetin, dihydromyricetin and rhodamine 123 concentrations in A549 cells. Resveratrol and myricetin or dihydromyricetin exert a synergistic effect, but not via a suppression of P-glycoprotein.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
