Natural Product Research最新文献_第7页

Chemical composition and cytotoxic activities of Rhodomyrtus tomentosa (Aiton) Hassk. essential oil extracted by microwave-assisted hydrodistillation. 毛蕊红的化学成分及细胞毒活性研究。微波辅助加氢蒸馏提取精油。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-04 DOI: 10.1080/14786419.2025.2568943

Quoc-Trung Nguyen, Vu Le Nguyen, Duc-Hien Nguyen, Phu Hoang Dang

{"title":"Chemical composition and cytotoxic activities of Rhodomyrtus tomentosa (Aiton) Hassk. essential oil extracted by microwave-assisted hydrodistillation.","authors":"Quoc-Trung Nguyen, Vu Le Nguyen, Duc-Hien Nguyen, Phu Hoang Dang","doi":"10.1080/14786419.2025.2568943","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568943","url":null,"abstract":"Rhodomyrtus tomentosa (Aiton) Hassk. has been widely used in traditional medicine; however, limited attention has been paid to its essential oil's chemical profile and biological activities. In this study, essential oil was extracted from fresh leaves of R. tomentosa using microwave-assisted hydrodistillation. The oil yield was 0.72% (v/w), and gas chromatography-mass spectrometry (GC-MS) analysis revealed a composition highly enriched in monoterpene hydrocarbons, with α-pinene comprising approximately 79.73% of the total content. Minor constituents included β-caryophyllene, α-terpineol, and d-limonene. The cytotoxic potential of R. tomentosa essential oil (RtEO) was evaluated against three human cancer cell lines: breast adenocarcinoma (MCF-7), epidermoid carcinoma (KB), and lung carcinoma (A549) using the WST-1 assay. RtEO exhibited significant dose-dependent cytotoxicity, with IC50 values of 14.30 µg/mL, 19.91 µg/mL, and 20.63 µg/mL, respectively. These results suggest that RtEO possesses promising broad-spectrum anticancer activity, warranting further investigation as a potential natural source of bioactive compounds for cancer therapy.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(-)-Peniisocoumarin D, an unreported isocoumarin derivative isolated from the coculture of marine algicolous fungal strains Trichoderma flagellatum 12A1N and Fusarium proliferatum 1023F. （-）- peniisocoumarin D，一种未报道的从海藻真菌菌株鞭毛木霉12A1N和增殖镰刀菌1023F共培养中分离出来的异香豆素衍生物。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-03 DOI: 10.1080/14786419.2025.2567638

Sheng-Tao Fang, Xu-Liang Hou, Yin-Ping Song, Ji-Xue Zou, Nai-Yun Ji

引用次数: 0

Identification of phenolic compounds from the aerial parts of Holy basil (Ocimum tenuiflorum) cultivar 'Himalayan Sunset Blue', their anti-oxidant activity, and anthocyanin contribution to colour stability. 从圣罗勒（Ocimum tenuflorum）栽培“喜马拉雅日落蓝”的地上部分中鉴定酚类化合物，它们的抗氧化活性和花青素对颜色稳定性的贡献。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-03 DOI: 10.1080/14786419.2025.2565812

Takayuki Mizuno, Koji Sugimura, Tsukasa Iwashina, Yuko Ishikawa-Takano, Takahisa Nakane, Shoji Yahara, Haruka Seto, Fumi Tatsuzawa, Takashi Watanabe

{"title":"Identification of phenolic compounds from the aerial parts of Holy basil (Ocimum tenuiflorum) cultivar 'Himalayan Sunset Blue', their anti-oxidant activity, and anthocyanin contribution to colour stability.","authors":"Takayuki Mizuno, Koji Sugimura, Tsukasa Iwashina, Yuko Ishikawa-Takano, Takahisa Nakane, Shoji Yahara, Haruka Seto, Fumi Tatsuzawa, Takashi Watanabe","doi":"10.1080/14786419.2025.2565812","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565812","url":null,"abstract":"Two anthocyanins, eight flavones, and four phenolic compounds were isolated from the aerial parts of Holy basil (Ocimum tenuiflorum) cultivar 'Himalayan Sunset Blue'. They were identified as cyanidin 3-O-[(6''″-E-p-coumaroylglucopyranosyl)-(1→4)-(6″-E-p-coumaroylglucopyranoside)]-5-O-(6″'-malonylglucopyranoside) and cyanidin 3-O-[glucopyranosyl-(1→4)-(6″-E-p-coumaroylglucopyranoside]-5-O-(6'″-malonylglucopyranoside) for anthocyanins, apigenin, luteolin, chrysoeriol and their 7-O-glycosides for flavones, and rosmarinic acid, globoidnans A and B, and rabdosiin for phenolic compounds. In this survey, antioxidant activity of selected six compounds was measured. Moreover, two anthocyanins which are main pigments in the sky-blue herb tea 'Tulsi', were dissolved the buffer solutions and were measured their absorption spectra under interval measurement over 8 h. It was suggested that the chain structure of p-coumaric acid and glucose in anthocyanins contributes to stable colour expression.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new triterpenoid pentaglycoside from Olax imbricata: isolation and in vitro, in silico studies on α-glucosidase. 油菜籽中一个新的三萜五糖苷：分离及α-葡萄糖苷酶的体外研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-03 DOI: 10.1080/14786419.2025.2565705

Nham-Linh Nguyen, Thi Trang Nguyen, Thanh Tan Mai, Minh Hao Hoang, Thi Anh Tuyet Nguyen, Nguyen Kim Tuyen Pham, Thi Nga Vo

{"title":"A new triterpenoid pentaglycoside from Olax imbricata: isolation and in vitro, in silico studies on α-glucosidase.","authors":"Nham-Linh Nguyen, Thi Trang Nguyen, Thanh Tan Mai, Minh Hao Hoang, Thi Anh Tuyet Nguyen, Nguyen Kim Tuyen Pham, Thi Nga Vo","doi":"10.1080/14786419.2025.2565705","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565705","url":null,"abstract":"Extensive fractionation of methanol extract from the dried powdered roots of Olax imbricata (Olacaceae) led to the isolation of a new oleanane-skeleton triterpene pentaglycoside, olaximpentaose (1). The chemical structure was elucidated using 1D and 2D NMR and HR-ESI-MS data analysis. The sugar subunits of olaximpentaose (1) were determined by acidic hydrolysis and 1H NMR chemical shifts, coupling constants, and integral ratios of the anomeric signals. Compound 1 exhibited the higher inhibition against α-glucosidase, with the IC50 = 97.19 ± 12.29 µM when compared with acarbose (IC50 = 126.62 ± 5.57 µM). In addition, the docking results revealed that structure 1 and acarbose were bound to the enzyme with docking scores of -8.960 kcal/mol and -7.966 kcal/mol, respectively. Molecular dynamics (MD) simulations provided insights into the action of 1 on α-glucosidase. Following the production MD run for 100 ns, the resultant trajectories revealed that the α-glucosidase/1 complex displayed overall stability during simulations. These results might be responsible for the promising activity of 1 against α-glucosidase.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Corchorus olitorius L. on osteogenic differentiation of MC3T3-E1 pre-osteoblast cells by increasing alkaline phosphatase and hydroxyproline. 通过增加碱性磷酸酶和羟脯氨酸对MC3T3-E1前成骨细胞成骨分化的促进作用。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-03 DOI: 10.1080/14786419.2025.2568205

Pinar Ertugruloglu, Elif Baris, Gaye Sumer Okkali, Nazli Boke Sarikahya

{"title":"Enhancement of Corchorus olitorius L. on osteogenic differentiation of MC3T3-E1 pre-osteoblast cells by increasing alkaline phosphatase and hydroxyproline.","authors":"Pinar Ertugruloglu, Elif Baris, Gaye Sumer Okkali, Nazli Boke Sarikahya","doi":"10.1080/14786419.2025.2568205","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568205","url":null,"abstract":"Corchorus olitorius L. (jute mallow or molehiya) belongs to the Malvaceae family valued for its nutritional and medicinal properties. In this study, the potential to enhance osteogenesis in MC3T3-E1(Murine Calvaria-derived 3T3 Subclone E1) pre-osteoblastic cells was investigated to support bone formation and mineralisation. Leaf ethanolic extract was prepared and applied to MC3T3-E1 cells. Osteogenic effects were evaluated through three methods: MTT assays for cell viability, Alizarin Red S staining for calcium deposition, enzymatic analyses for alkaline phosphatase (ALP) and hydroxyproline (HYP). A non-cytotoxic concentration of C. olitorius extract (0.5 mg/mL) significantly increased ALP and HYP levels, promoting osteogenic differentiation in both undifferentiated and differentiated cells. HYP levels were notably elevated in differentiated cells. The findings suggested that C. olitorius extract may be a promising natural agent for enhancing bone health, warranting further in vivo and clinical studies to confirm its therapeutic potential.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitex polygama extract and the flavonoid orientin alleviates vincristine-induced neuropathic pain in mice: possible role of muscarinic and opioid receptors and nitric oxide. 黄荆提取物和黄酮类东方苷减轻长春新碱引起的小鼠神经性疼痛：毒蕈碱和阿片受体和一氧化氮的可能作用。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-03 DOI: 10.1080/14786419.2025.2565261

Igor Frederico de Oliveira Ramos, Evelynn Dalila do Nascimento Melo, Claudio Mello Evangelista De Mendonça, Paula Lima do Carmo, Shaft Corrêa Pinto, Juliana Montani Raimundo, Michelle Frazão Muzitano, André Gustavo Calvano Bonavita

{"title":"Vitex polygama extract and the flavonoid orientin alleviates vincristine-induced neuropathic pain in mice: possible role of muscarinic and opioid receptors and nitric oxide.","authors":"Igor Frederico de Oliveira Ramos, Evelynn Dalila do Nascimento Melo, Claudio Mello Evangelista De Mendonça, Paula Lima do Carmo, Shaft Corrêa Pinto, Juliana Montani Raimundo, Michelle Frazão Muzitano, André Gustavo Calvano Bonavita","doi":"10.1080/14786419.2025.2565261","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565261","url":null,"abstract":"Neuropathic pain affects 7-10% of the global population and is often poorly managed by current pharmacological treatments, which can cause significant adverse effects. This study evaluated the hydroalcoholic extract of Vitex polygama (VPE) and its flavonoid orientin in a vincristine-induced neuropathic pain model. Neuropathic pain was induced by vincristine and assessed using the hot plate test (for thermal hyperalgesia) and von Frey test (for mechanical allodynia). Atropine, naloxone, and L-NAME were used to investigate the mechanism of action of VPE. Antinociceptive effects of VPE were observed at a dose of 30 mg/kg, reversed by muscarinic and opioid receptor antagonists and a nitric oxide synthase inhibitor, indicating the involvement of multiple pathways. Orientin (30 mg/kg) also demonstrated novel antinociceptive activity, inhibited by atropine, indicating muscarinic receptor involvement. This study demonstrated the newsworthy antinociceptive activity of V. polygama and its flavonoid orientin in a vincristine-induced neuropathic pain model.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of the bioactive compounds and potential mechanisms of fingerroot (Boesenbergia rotunda) as an anti-breast cancer by bioinformatics. 用生物信息学方法研究指根抗乳腺癌活性物质及其潜在机制。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-01 DOI: 10.1080/14786419.2025.2559753

Muhammad Hermawan Widyananda, Lailil Muflikhah, Siti Mariyah Ulfa, Nashi Widodo

{"title":"Exploration of the bioactive compounds and potential mechanisms of fingerroot (Boesenbergia rotunda) as an anti-breast cancer by bioinformatics.","authors":"Muhammad Hermawan Widyananda, Lailil Muflikhah, Siti Mariyah Ulfa, Nashi Widodo","doi":"10.1080/14786419.2025.2559753","DOIUrl":"https://doi.org/10.1080/14786419.2025.2559753","url":null,"abstract":"This research explored the active compounds in Boesenbergia rotunda and predicted its anti-breast cancer mechanism. The Boesenbergia rotunda rhizome was extracted using microwave-assisted extraction (MAE) with ethanol solvent, and the active compound was identified using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Drug-likeness, bioactivity, and membrane permeability were used to select active compounds with high potential for anti-breast cancer effects. Molecular docking and dynamic simulations were performed to study the interactions between active compounds and target proteins. The ethanol extract contained various active compounds, predominantly flavonoids, with pinostrobin being the most abundant (24.061%). Six compounds (chrysin, pinostrobin, pinocembrin, formononetin, desmethoxyyangonin, and zearalenone) showed the highest potential as anti-breast cancer agents, targeting proliferation-related and angiogenesis-associated proteins (CDK1, JAK3, ADORA1, PI3K, MMP13, VEGFR1). These findings suggest that Boesenbergia rotunda ethanol extract has promising anti-breast cancer capabilities by inhibiting proliferation, angiogenesis, and tumour invasion.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undescribed isoprenoids obtained from Dictamnus dasycarpus Turcz and their cytotoxic activities. 未描述的异戊二烯类化合物及其细胞毒活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-01 DOI: 10.1080/14786419.2025.2565265

Sun Ye, Si-Yi Wang, Yang Xu, Jia-Tong Wu, Juan Pan, Zhi-Chao Hao, Wei Guan, Zhen-Peng Xu, Yuan-Yuan Zhou, Shao-Wa Lv, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang

引用次数: 0

Evaluation of phytochemical profiling, antioxidant and antimicrobial activities of Cionura erecta latex: the first report of the therapeutic potential of a natural exudate. 植物化学特征、抗氧化和抗菌活性的评价：首次报道天然渗出物的治疗潜力。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-01 DOI: 10.1080/14786419.2025.2567640

Selda Dogan Calhan, Pelin Eroglu, Zehra Oksuz, Ece Cobanoglu, Ozlem Nekuk, Mustafa Gundogan, Nefise Ozlen Sahin

{"title":"Evaluation of phytochemical profiling, antioxidant and antimicrobial activities of Cionura erecta latex: the first report of the therapeutic potential of a natural exudate.","authors":"Selda Dogan Calhan, Pelin Eroglu, Zehra Oksuz, Ece Cobanoglu, Ozlem Nekuk, Mustafa Gundogan, Nefise Ozlen Sahin","doi":"10.1080/14786419.2025.2567640","DOIUrl":"https://doi.org/10.1080/14786419.2025.2567640","url":null,"abstract":"This study provides the first detailed evaluation of C. erecta latex, an uncharacterised exudate of the Apocynaceae family, focusing on its phytochemical composition and bioactivity. HPLC analysis revealed nine phenolic compounds, mainly sinapic acid (4876.2 µg/g), ferulic acid (902.6 µg/g), and epicatechin (386.5 µg/g). Although the total phenolic content was relatively low (2.27 ± 4.2 mg GAE/g), DPPH assay indicated moderate antioxidant activity (IC50 = 114 µg/mL), suggesting contributions from other bioactive constituents. Volatile profiling via HS-SPME-GC-MS and solvent-assisted GC-MS identified compounds such as p-cymene (14.05%), 2-hexanol (12.52%), and kaur-16-ene (72.06%). The latex exhibited antimicrobial activity against bacteria and yeasts, with MIC values ranging from 62.5 to 250 µg/mL, showing higher effectiveness against Acinetobacter baumannii, Candida parapsilosis, and Candida glabrata. Overall, the findings highlight C. erecta latex as a phenol- and terpenoid-rich natural product with promising antioxidant and antimicrobial potential, supporting its traditional dermatological use and future pharmaceutical relevance.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(±)-Harmansenoids A and B, two pairs of new phloroglucinols with cardioprotective effects from Hypericum monogynum L. (Hypericaceae). （±）-Harmansenoids A和B，两对具有心脏保护作用的新间苯三酚。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-01 DOI: 10.1080/14786419.2025.2567636

Silian Zhou, Junhui Du

引用次数: 0