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Antibacterial ent-trachyloban-19-oic acid and other constituents from Croton kinondoensis G.W. Hu, Ngumbau & Q.F. Wang.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 DOI: 10.1080/14786419.2024.2434132
Mona Diri, Cristina D Cruz, Eduard Mas-Claret, Nicholas Sadgrove, Thomas A K Prescott, Moses K Langat, Päivi Tammela, Sianne L Schwikkard
{"title":"Antibacterial <i>ent</i>-trachyloban-19-oic acid and other constituents from <i>Croton kinondoensis</i> G.W. Hu, Ngumbau & Q.F. Wang.","authors":"Mona Diri, Cristina D Cruz, Eduard Mas-Claret, Nicholas Sadgrove, Thomas A K Prescott, Moses K Langat, Päivi Tammela, Sianne L Schwikkard","doi":"10.1080/14786419.2024.2434132","DOIUrl":"https://doi.org/10.1080/14786419.2024.2434132","url":null,"abstract":"<p><p>Phytochemical analysis of the twigs and leaves of <i>Croton kinondoensis</i>, endemic to Kenya, yielded known compounds 3-(3',4'-dimethoxyphenyl)-prop-1-ene (<b>1)</b>, 3-(3',4'-dimethoxyphenyl)-propenal (<b>2</b>), lupeol (<b>3</b>) and <i>ent</i>-trachyloban-19-oic acid (<b>4</b>), and a tentatively new <i>ent</i>-clerodane diterpenoid, crotokinondoenolide (<b>5</b>). <i>ent</i>-Trachy-loban-19-oic acid (<b>4</b>) showed good activity against a panel of drug-resistant strains of <i>Staphylococcus aureus</i> and <i>Enterococcus</i> spp with MIC -values of 25 <i>µ</i>g/mL.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical composition and biological activities of essential oil from Grewia bulot leaves. 葛叶精油的化学成分和生物活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-01 DOI: 10.1080/14786419.2023.2275739
Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen
{"title":"Chemical composition and biological activities of essential oil from <i>Grewia bulot</i> leaves.","authors":"Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen","doi":"10.1080/14786419.2023.2275739","DOIUrl":"10.1080/14786419.2023.2275739","url":null,"abstract":"<p><p>This study focused on the chemical composition and biological activities of the essential oil derived from <i>Grewia bulot</i>, a plant species known for its medicinal properties. The analysis of <i>Grewia bulot</i> essential oil revealed the presence of 78 constituents. The major compounds were <i>α</i>-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-<i>epi</i>-cubenol (9.8%), <i>epi</i>-<i>α</i>-cadinol (6.7%), (<i>E</i>,<i>E</i>)-<i>α</i>-farnesene (5.9%), (<i>E</i>)-citral (4.0%), selin-11-en-4-<i>α</i>-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC<sub>50</sub> value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC<sub>50</sub> values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4106-4112"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cocoa as immunomodulatory agent: an update. 可可作为免疫调节剂：最新进展。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-01 DOI: 10.1080/14786419.2023.2272025
Maria Atanassova, Miquel Martorell, Farukh Sharopov, Lyubomir Atanassov, Pradeep Kumar, Javad Sharifi-Rad, Silvia Tejada-Gavela, Marcello Iriti, Raffaele Pezzani, Elena Maria Varoni
{"title":"Cocoa as immunomodulatory agent: an update.","authors":"Maria Atanassova, Miquel Martorell, Farukh Sharopov, Lyubomir Atanassov, Pradeep Kumar, Javad Sharifi-Rad, Silvia Tejada-Gavela, Marcello Iriti, Raffaele Pezzani, Elena Maria Varoni","doi":"10.1080/14786419.2023.2272025","DOIUrl":"10.1080/14786419.2023.2272025","url":null,"abstract":"<p><p>Cocoa is rich in polyphenols, mainly flavonoids, which correlate with several health benefits mediated by their antioxidant, anti-inflammatory and immunomodulatory properties. Cocoa and chocolate consumption have been reported to impact the regulation of the immune system, both in preclinical studies and in human trials. The mechanisms for immunomodulation can involve different effects of cocoa polyphenols on the immune system, acting as anti-inflammatory, antioxidant and anti-allergic agents, as well as the direct influence of cocoa on innate and acquired immunity, with cytokines production and activation of both lymphocyte-dependent and -independent pathways. Cocoa intake has been also correlated to changes in gut microbiota ecology and composition, also affecting the intestinal immune system. This review summarises the updates of the last two decades on cocoa as immunomodulatory agent and explores the health-related benefits of cocoa and chocolate intake.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4196-4207"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and cytotoxic activity of some (+)-salsolidine derivatives. 某些(+)-固体碱衍生物的合成及其细胞毒活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-24 DOI: 10.1080/14786419.2023.2273924
Alena Koval'skaya, Arthur Gil'mutdinov, Alexander Lobov, Dmitry Tsypyshev, Vener Vakhitov, Inna Tsypysheva, Vladimir Dokichev, Yulia Vakhitova
{"title":"Synthesis and cytotoxic activity of some (+)-salsolidine derivatives.","authors":"Alena Koval'skaya, Arthur Gil'mutdinov, Alexander Lobov, Dmitry Tsypyshev, Vener Vakhitov, Inna Tsypysheva, Vladimir Dokichev, Yulia Vakhitova","doi":"10.1080/14786419.2023.2273924","DOIUrl":"10.1080/14786419.2023.2273924","url":null,"abstract":"<p><p>On the basis of typical for secondary amino group reactions a number of derivatives of alkaloid (+)-salsolidine was synthesised. Cytotoxic properties of obtained compounds towards the HEK293, A549, MCF-7 and SH-SY5Y cell lines have been evaluated. As a result of the screening, the hit compound - 2-(chloroacetyl)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (<b>11</b>) was identified, that inhibited the metabolic activity of A-549, MCF-7 and SH-SY5Y tumour cell lines with the IC<sub>50</sub> values of 3.83 ± 0.78 µM, 5.84 ± 1.62 µM and 2.89 ± 0,92 µM correspondingly. Based on the effect of <b>11</b> on the cell cycle progression and the molecular docking data, it was preliminary assumed that the cytotoxic activity of the <b>11</b> can be realised through its interaction with the active site of the cyclin-dependent kinase CDK9 (PDB code 3BLR).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4092-4097"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonic-Microwave extraction of glucoside alkaloids from potato peel residue and its antibacterial activity. 超声波-微波法从马铃薯皮渣中提取葡萄糖苷生物碱及其抗菌活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-10 DOI: 10.1080/14786419.2023.2278755
Zhongliang Guan, Qingmin Chen, Ye Xu, Cong Han, Min Wang, Tao Zhao, Handong Zhao, Maorun Fu
{"title":"Ultrasonic-Microwave extraction of glucoside alkaloids from potato peel residue and its antibacterial activity.","authors":"Zhongliang Guan, Qingmin Chen, Ye Xu, Cong Han, Min Wang, Tao Zhao, Handong Zhao, Maorun Fu","doi":"10.1080/14786419.2023.2278755","DOIUrl":"10.1080/14786419.2023.2278755","url":null,"abstract":"<p><p>A new extraction and bacteriostatic ability of glucoside alkaloids in potato peel. To make better use of glucoside alkaloids, this experiment adopted ultrasonic microwave combined extraction of glucoside alkaloids from potato peel; then, the extracts of potato peel were subjected to bacteriostatic assays. The optimum experimental condition of response surface method was that the solid-liquid ratio was 1:18.00 g/mL, the ultrasonic power 505.00 W, the microwave time was 6.10 min and the ultrasonic time was 10.70 min. Under those conditions, the extraction amount of glucoside alkaloids was 292.91 mg/kg, which increased by about 28% compared with the QUEChERS method. The antibacterial activity of the obtained glucoside alkaloids was tested using five kinds of strains, and the results showed that <i>Penicillium</i> and <i>Colletotrichum gloeosporioides</i> were more sensitive. The results indicated that Ultrasonic-Microwave combined extraction was more efficient and convenient than that of QuEChERS method for glucoside alkaloids and related antibacterial compounds from potato peel.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4141-4145"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmanial activity of Brazilian brown propolis and its diterpenes. 巴西棕蜂胶及其二萜的利什曼原虫活性。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-02 DOI: 10.1080/14786419.2023.2277351
Larissa Costa Oliveira, Victor Pena Ribeiro, Mario Ferreira Conceição Santos, Nicoli Dias Oliveira, Matheus Henrique Marques Zago, Iaciara Luana de Xavier Albernaz, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães, Sérgio Ricardo Ambrósio
{"title":"Leishmanial activity of Brazilian brown propolis and its diterpenes.","authors":"Larissa Costa Oliveira, Victor Pena Ribeiro, Mario Ferreira Conceição Santos, Nicoli Dias Oliveira, Matheus Henrique Marques Zago, Iaciara Luana de Xavier Albernaz, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães, Sérgio Ricardo Ambrósio","doi":"10.1080/14786419.2023.2277351","DOIUrl":"10.1080/14786419.2023.2277351","url":null,"abstract":"<p><p>Propolis is a natural product widely used in folk medicine. Among its various applications, its antiparasitic properties stand out. Due to its great biodiversity, Brazil is a major producer of several types of propolis. This study proposes to evaluate the leishmanicidal properties of the hydroalcoholic extract of propolis collected in the southern region of Brazil (Brown propolis - HEBP) and its main isolated compounds: abietic acid (1), 13-epi-cupressic acid (2), 13-epi-torulosol (3), dehydroabietic acid (4), <i>cis</i>-communic acid (5) and <i>ent</i>-agatic acid (6). In general, the diterpenes did not show activity against the promastigotes of <i>Leishmania</i> (<i>Leishmania</i>) <i>amazonensis</i> at the evaluated concentrations. However, the HEBP was very active with an inhibition concentration of 50% at 8.32 µg/mL. Moreover, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) assays showed morphological and structural alterations in promastigote forms of <i>L</i>. (<i>L.</i>) <i>amazonensis</i> when incubated with HEBP.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4302-4306"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of insect endogenous cellulases for lignocellulosic break down deciphered using molecular docking studies. 利用分子对接研究揭示了昆虫内源性纤维素酶对木质纤维素分解的潜力。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-15 DOI: 10.1080/14786419.2023.2280169
Nivetha Ramanathan, Bhuvaragavan Sreeramulu, Meenakumari Mani, Janarthanan Sundaram
{"title":"Potential of insect endogenous cellulases for lignocellulosic break down deciphered using molecular docking studies.","authors":"Nivetha Ramanathan, Bhuvaragavan Sreeramulu, Meenakumari Mani, Janarthanan Sundaram","doi":"10.1080/14786419.2023.2280169","DOIUrl":"10.1080/14786419.2023.2280169","url":null,"abstract":"<p><p>Insects possess cellulolytic system capable of producing variegate enzymes with multifarious specificities to break down complex lignocellulosic products. Astonishingly, endoglucanases, exoglucanases and β-glycosidases act sequentially in a synergistic system to facilitate the breakdown of cellulose to utilisable energy source glucose. <i>In silico</i> docking studies of endo-β-1,4-glucanase from 19 different insects belonging to six different orders identified that it possesses high affinity for all the six substrates, including CMC, cellulose, cellotriose, cellotetraose, cellopentose and cellohexaose. Additionally, β-glucosidase from nearly all the reported insect sources also showed considerable affinity towards cellobiose. Van der Waals, conventional hydrogen bonds and carbon-hydrogen bonds stabilise the interaction between the enzyme and different substrates. Molecular dynamics simulations also held up the stability of various complexes. Efficient breakdown of lignocelluloses-based substrates becoming a major focus of industrial and academic communities worldwide, this study can perhaps complement the propensity of insect cellulases for prospected applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4146-4154"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134647914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation and skin protection activities of polysaccharides from Schnabelia terniflora. 燕尾莲多糖的鉴定及皮肤保护活性研究。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-16 DOI: 10.1080/14786419.2023.2280791
Ying Zhao, Yixian Liu, Huoxiang Zhou, Wei Guo, Weidong Wang, Huiping Chen
{"title":"Characterisation and skin protection activities of polysaccharides from <i>Schnabelia terniflora</i>.","authors":"Ying Zhao, Yixian Liu, Huoxiang Zhou, Wei Guo, Weidong Wang, Huiping Chen","doi":"10.1080/14786419.2023.2280791","DOIUrl":"10.1080/14786419.2023.2280791","url":null,"abstract":"<p><p>The bioactivities of crude polysaccharides from leaves (L-Ps) and flowers (F-Ps) of <i>Schnabelia terniflora</i> (Maxim.) P. D. Cantino were studied, and the characteristics of purified fractions were analysed by HPLC, HP-GPC and NMR. L-Ps exhibited strong DPPH radical scavenging activity (IC<sub>50</sub> value of 251.53 ± 4.62 μg/mL) and tyrosinase inhibition (IC<sub>50</sub> value of 163.52 ± 2.59 μg/mL). However, the maximum moisture absorption (74.67 ± 1.53%) and retention (68.00 ± 3.61%) abilities were observed in F-Ps. Two main fractions separated by DEAE-Sepharose fast flow column from L-Ps were eluted with 0.1 and 0.3 M NaCl, while one main fraction from F-Ps was eluted with 0.1 M NaCl. Purified fractions were obviously different in monosaccharide composition, molecular weight and <sup>1</sup>H NMR and <sup>13</sup>C NMR spectra. Therefore, the current manuscript can provide an important evidence for the potential development of L-Ps and F-Ps as promising ingredients in cosmetics industry.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4191-4195"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on ayurvedic herb Leptadenia reticulata (Jeevanti): a phytochemistry and pharmacological perspective. 从植物化学和药理的角度综述印度育吠陀草药网麻的研究进展。
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-21 DOI: 10.1080/14786419.2023.2282119
Sonali Kumari, Ravi Saini, Aditi Bhatnagar, Abha Mishra
{"title":"A comprehensive review on ayurvedic herb <i>Leptadenia reticulata</i> (Jeevanti): a phytochemistry and pharmacological perspective.","authors":"Sonali Kumari, Ravi Saini, Aditi Bhatnagar, Abha Mishra","doi":"10.1080/14786419.2023.2282119","DOIUrl":"10.1080/14786419.2023.2282119","url":null,"abstract":"<p><p><i>Leptadenia reticulata</i> is a vital Ayurvedic medicinal herb, commonly known as Jivanti or Jiv, and contains revitalising, rejuvenating, and lactogenic activities. It has been used in traditional medicine for treating respiratory disorders, wounds, inflammation, cough, dehydration, tuberculosis, colitis, chickenpox, dysentery, eye diseases, night blindness, fever, and snake bites. It is a perennial herb of Indian origin belonging to the Asclepiadaceae family and has been utilised for its therapeutic properties since ancient times. It is a key ingredient in several marketed herbal drugs, including chyawanprash, speman, and leptaden. Several potent compounds, including β-sitosterol, γ-sitosterol, phytol, α-amyrin, β-amyrin, apigenin, reticulin, deniculatin, leptaculatin, diosmetin, and rutin are present in this herb and attributed various pharmacological activities, including antidiabetic, antimicrobial, antioxidant, anti-abortifacient, anticancer, antipyretic, analgesic, anti-inflammatory, and antiulcer properties. This review provides an in-depth analysis of the distribution, ethnobotanical use, botanical description, phytocompounds, and pharmacological activities of <i>Leptadenia reticulata.</i></p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4234-4260"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferlapioside: a new bromine substituted iridoid glycoside from the roots of Ferula lapidosa Korovin.
IF 1.9 3区 化学
Natural Product Research Pub Date : 2024-12-01 DOI: 10.1080/14786419.2024.2432613
Xin-Xin Li, Kholida Ibodullaevna Khasanova, Jia-Huan Shang, Anarbay Uraimovich Babekov, Wen-Jun Li, Jing-Juan Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Ying-Jun Zhang
{"title":"Ferlapioside: a new bromine substituted iridoid glycoside from the roots of <i>Ferula lapidosa</i> Korovin.","authors":"Xin-Xin Li, Kholida Ibodullaevna Khasanova, Jia-Huan Shang, Anarbay Uraimovich Babekov, Wen-Jun Li, Jing-Juan Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Ying-Jun Zhang","doi":"10.1080/14786419.2024.2432613","DOIUrl":"https://doi.org/10.1080/14786419.2024.2432613","url":null,"abstract":"<p><p>One new bromine substituted iridoid glycoside, ferlapioside (<b>1</b>), was isolated from the roots of <i>Ferula lapidosa</i> Korovin, together with 10 known ones including seven iridoid glycosides (<b>2</b>-<b>8</b>) and three sesquiterpene lactones (<b>9</b>-<b>11</b>). Their structures were elucidated by extensive spectroscopic analyses, e.g. 1D and 2D-NMR, HR-ESI-MS, IR, UV, CD techniques, and comparison with literature values. Compounds <b>1</b> and <b>3</b>-<b>11</b> were evaluated for inhibitory activity against LPS-induced NO production in the RAW 264.7 cells and the <i>in vitro</i> cytotoxic activity against five human cancer cell lines (HL-60, A549, SMMC-7721, MDA-MB-231 and SW480). However, none of them exhibit significant anti-inflammatory and cytotoxic activity. This study will provide a scientific basis and reference for the further development and utilisation of <i>Ferula</i> plants.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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