Quoc-Trung Nguyen, Vu Le Nguyen, Duc-Hien Nguyen, Phu Hoang Dang
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Chemical composition and cytotoxic activities of Rhodomyrtus tomentosa (Aiton) Hassk. essential oil extracted by microwave-assisted hydrodistillation.
Rhodomyrtus tomentosa (Aiton) Hassk. has been widely used in traditional medicine; however, limited attention has been paid to its essential oil's chemical profile and biological activities. In this study, essential oil was extracted from fresh leaves of R. tomentosa using microwave-assisted hydrodistillation. The oil yield was 0.72% (v/w), and gas chromatography-mass spectrometry (GC-MS) analysis revealed a composition highly enriched in monoterpene hydrocarbons, with α-pinene comprising approximately 79.73% of the total content. Minor constituents included β-caryophyllene, α-terpineol, and d-limonene. The cytotoxic potential of R. tomentosa essential oil (RtEO) was evaluated against three human cancer cell lines: breast adenocarcinoma (MCF-7), epidermoid carcinoma (KB), and lung carcinoma (A549) using the WST-1 assay. RtEO exhibited significant dose-dependent cytotoxicity, with IC50 values of 14.30 µg/mL, 19.91 µg/mL, and 20.63 µg/mL, respectively. These results suggest that RtEO possesses promising broad-spectrum anticancer activity, warranting further investigation as a potential natural source of bioactive compounds for cancer therapy.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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