Chemical composition and cytotoxic activities of Rhodomyrtus tomentosa (Aiton) Hassk. essential oil extracted by microwave-assisted hydrodistillation.

IF 1.6 3区 化学 Q3 CHEMISTRY, APPLIED
Quoc-Trung Nguyen, Vu Le Nguyen, Duc-Hien Nguyen, Phu Hoang Dang
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Abstract

Rhodomyrtus tomentosa (Aiton) Hassk. has been widely used in traditional medicine; however, limited attention has been paid to its essential oil's chemical profile and biological activities. In this study, essential oil was extracted from fresh leaves of R. tomentosa using microwave-assisted hydrodistillation. The oil yield was 0.72% (v/w), and gas chromatography-mass spectrometry (GC-MS) analysis revealed a composition highly enriched in monoterpene hydrocarbons, with α-pinene comprising approximately 79.73% of the total content. Minor constituents included β-caryophyllene, α-terpineol, and d-limonene. The cytotoxic potential of R. tomentosa essential oil (RtEO) was evaluated against three human cancer cell lines: breast adenocarcinoma (MCF-7), epidermoid carcinoma (KB), and lung carcinoma (A549) using the WST-1 assay. RtEO exhibited significant dose-dependent cytotoxicity, with IC50 values of 14.30 µg/mL, 19.91 µg/mL, and 20.63 µg/mL, respectively. These results suggest that RtEO possesses promising broad-spectrum anticancer activity, warranting further investigation as a potential natural source of bioactive compounds for cancer therapy.

毛蕊红的化学成分及细胞毒活性研究。微波辅助加氢蒸馏提取精油。
毛毛菱形(亚洲)已广泛用于传统医学;然而,对其精油的化学成分和生物活性的研究却很少。本研究采用微波辅助加氢蒸馏法,从毛蕊花鲜叶中提取精油。产油率为0.72% (v/w),气相色谱-质谱(GC-MS)分析结果表明,其组成中富含单萜烃,其中α-蒎烯含量约占总含量的79.73%。次要成分包括β-石竹烯、α-松油醇和d-柠檬烯。采用WST-1法研究了毛毛藤精油(RtEO)对乳腺癌(MCF-7)、表皮样癌(KB)和肺癌(A549)三种人类癌细胞系的细胞毒性。RtEO表现出明显的剂量依赖性细胞毒性,IC50值分别为14.30µg/mL、19.91µg/mL和20.63µg/mL。这些结果表明,RtEO具有良好的广谱抗癌活性,值得进一步研究作为癌症治疗生物活性化合物的潜在天然来源。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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