Undescribed isoprenoids obtained from Dictamnus dasycarpus Turcz and their cytotoxic activities.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-01 DOI:10.1080/14786419.2025.2565265

Sun Ye, Si-Yi Wang, Yang Xu, Jia-Tong Wu, Juan Pan, Zhi-Chao Hao, Wei Guan, Zhen-Peng Xu, Yuan-Yuan Zhou, Shao-Wa Lv, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang

引用次数: 0

Abstract

Four new isoprenoids, dictamtriterpenols B-E (1-4), and fifteen known compounds (5-19) were isolated from Dictamnus dasycarpus Turcz. And the structures of all compounds were determined through techniques such as nuclear magnetic resonance spectroscopy. Compounds 1, 4, 7, 13, and 15 exhibited notable cytotoxic effects against HepG2 cells (IC₅₀ 1.55-18.55 μM). Similarly, compounds 1, 3, 8, 9, and 12 demonstrated significant cytotoxicity against A549 cells (IC₅₀ 1.63-8.56 μM).

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未描述的异戊二烯类化合物及其细胞毒活性。

从芦竹中分离到了4个新的类异戊二烯类化合物、双氨三萜B-E（1-4）和15个已知化合物（5-19）。并通过核磁共振波谱等技术确定了所有化合物的结构。化合物1、4、7、13和15对HepG2细胞具有显著的细胞毒作用（IC50为1.55 ~ 18.55 μM）。同样，化合物1、3、8、9和12对A549细胞具有显著的细胞毒性（IC50为1.63 ~ 8.56 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.