（±）-Harmansenoids A和B，两对具有心脏保护作用的新间苯三酚。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-01 DOI:10.1080/14786419.2025.2567636

Silian Zhou, Junhui Du

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引用次数: 0

摘要

从金丝桃科（Hypericum monogynum L）中分离到6个新的间苯三酚，分别为天然对映体（±）- harmansenoid A(1)和B(2)，以及2个已知的间苯三酚。采用核磁共振（NMR）、质谱（HR-ESI-MS）、ECD分析和计算化学方法对其平面结构和立体化学结构进行了表征。此外，采用MTT法评价了所有化合物的心脏保护活性。其中化合物3的抑菌效果最强。

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(±)-Harmansenoids A and B, two pairs of new phloroglucinols with cardioprotective effects from Hypericum monogynum L. (Hypericaceae).

Six new phloroglucinols which were assigned as two pairs of natural enantiomer (±)-Harmansenoids A (1) and B (2) together with two known ones were separated from Hypericum monogynum L (Hypericaceae). The planer and stereochemical structure were elucidated by using NMR, HR-ESI-MS, ECD analysis and computational chemistry method. Further, the cardioprotective activity of all compounds were evaluated by MTT method. Among them, compound 3 exhibited the strongest effect than other isolates.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.