Three new aliphatic compounds from the roots of Saposhnikovia divaricata and their antiproliferative activity on HepG2 cells.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-09-30 DOI:10.1080/14786419.2025.2566468

Yan Liu, Jin-Hong Xue, Yan Sun, Fan-Ying Deng, Si-Yi Wang, Juan Pan, Zhi-Chao Hao, Ke-Zhen Chen, Anam Naseem, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Bing-You Yang

引用次数: 0

Abstract

The phytochemical investigation of Saposhnikovia divaricata (Turcz.) Schischk's roots resulted in the isolation of 16 distinct compounds, including two new aliphatics: sadiesteroside A (1) and 2,3,4-trihydroxyundecanoic acid (2), one new aliphatic hydrocarbon methyl propionate-3-(2-hydroxy-propionate) (3), and thirteen known aliphatics (4-16). The structural elucidation of compounds 1-16 was established by 1D and 2D NMR spectroscopy, supported by high-resolution mass spectrometric analysis and literature references. All isolated compounds' in vitro antiproliferative potential was evaluated using HepG2 cells. The results indicated that compound 3, compound 15, and compound 16 significantly inhibited the activity of HepG2 cells.

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菝葜根茎中三种新的脂肪族化合物及其对HepG2细胞的抗增殖活性。

花楸属植物的植物化学研究Schischk根分离得到16个不同的化合物，包括两个新的脂肪族化合物：甾体苷A(1)和2,3,4-三羟基十一烷酸(2)，一个新的脂肪族烃丙酸甲酯-3-（2-羟基丙酸）(3)和13个已知的脂肪族化合物（4-16）。化合物1-16的结构通过1D和2D核磁共振谱分析得到，高分辨率质谱分析和文献文献支持。所有分离化合物的体外抗增殖潜能用HepG2细胞进行评价。结果表明，化合物3、化合物15、化合物16明显抑制HepG2细胞的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.