Antifungal cytochalasans from the co-culture of two endophytic fungi Aspergillus spelaeus and Xylaria sp.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-09-30 DOI:10.1080/14786419.2025.2566463

Xian-Hua He, Ye-Fang Hu, Hua-Chun Feng, Li-Qi Liang, Lan-Fang Zou, Qian Wu, Min Liang, Jun Li, Wei-Feng Xu, Rui-Yun Yang

引用次数: 0

Abstract

A new cytochalasan, sophochalasin (1), together with ten known analogous compounds were obtained from the co-culture of two endophytic fungi Aspergillus spelaeus and Xylaria sp. The structure and the absolute configuration of 1 were established via NMR and ECD spectral analysis. In antifungal assay, aspochalasin B (2) exhibited notable antifungal activity against Fusarium oxysporum, Colletotrichum siamense, Alternaria alternata and Fusarium oxysporium f. sp. cucumberinum with MICs of 16 μg/mL.

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两种内生真菌spelaeus Aspergillus和Xylaria sp.共培养的抗真菌细胞松弛酶。

从两种内生真菌Aspergillus spelaeus和Xylaria sp.共培养中获得了一个新的细胞chalasin sophochalasin(1)和10个已知的类似化合物，并通过NMR和ECD光谱分析确定了1的结构和绝对构型。在抗真菌实验中，aspochalasin B(2)对黄瓜尖孢镰刀菌（Fusarium oxysporum）、炭疽菌（Colletotrichum siamense）、褐变菌（Alternaria alternata）和黄瓜尖孢镰刀菌（Fusarium oxysporium f. spum）表现出显著的抗真菌活性，mic值为16 μg/mL。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.