Tarcísio Cícero de Lima Araújo, Nathália Andrezza Carvalho de Souza, Eduardo Anselmo Pereira, Pedro Guilherme Souza de Sá, Victória Laysna Dos Anjos Santos, Juliane Maria Dos Santos Silva, Larissa Araújo Rolim
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Chemical analysis of Cannabis sativa L. roots from Northeastern Brazil and their potential in the development of new drugs.
This study analyzes the chemical characteristics of a lyophilised aqueous extract of Cannabis sativa roots (AECsR) from northeastern Brazil using analytical techniques. Thermogravimetry was used for thermal analysis. Fourier transform infra-red spectroscopy (FTIR), high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS) and HPLC coupled to diode array detector (DAD) were used for the chemical analysis. Thermogravimetry analysis revealed two thermal events. FTIR analysis showed five bands of interest. HPLC-MS analysis suggested the presence of four compounds. HPLC-DAD confirmed the presence of N-trans-feruloyltyramine and identified and quantified p-coumaric acid for the first time in Cannabis roots from Vale do São Francisco - Brazil. This finding represents a step forward in the chemical standardisation of Cannabis root extracts, facilitating the use of this data for the development of new drugs derived from the Cannabis roots.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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