基于LC-MS/ ms的真菌Rosellinia sanctacrucana新细胞松弛素的发现

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-09-29 DOI:10.1080/14786419.2025.2565279

Nisha Sharma, Poonam Choudhary, Priya Kumari, Mohd Murtaza, Vidushi Abrol, Chetan Kumar, Rohit Singh, Sundeep Jaglan, Manoj Kushwaha

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引用次数: 0

摘要

采用LC-MS/MS对玫瑰菌的乙酸乙酯提取物进行了分析，发现在m/z 558.272 [m + H]+处有一个峰，分子式为C30H39NO9，为细胞松弛素类。该化合物的分子量比19,20-环氧细胞松弛素- n高18 Da，其5和6位具有开放的二醇结构。将其命名为Cytochalasin-Augusta，采用高效液相色谱法纯化，并用1H NMR、13C NMR、HSQC、HMBC和noesi光谱对其进行了表征。

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LC-MS/MS-based discovery of new cytochalasin from fungus Rosellinia sanctae-cruciana.

The ethyl acetate extract of the fungus Rosellinia sanctae-cruciana was analysed using LC-MS/MS, revealing a peak at m/z 558.272 [M + H]⁺ with the molecular formula C₃₀H₃₉NO₉, indicative of the cytochalasin class. The isolated compound, 18 Da higher in molecular weight than 19,20-Epoxycytochalasin-N, featured an opened diol structure at positions 5 and 6. Named Cytochalasin-Augusta, it was purified using HPLC and characterised by ¹H NMR,¹³C NMR, HSQC, HMBC, and NOESY spectroscopy.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.