Juanjuan Liu, Ya Gao, Hu Chen, Guoyong Luo, Shaoping Yang
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引用次数: 0
Abstract
To develop highly effective natural anti-tumor agents, 12 isopimaroyl 1,2,4-triazole-thioether compounds were designed and synthesised. Anti-tumor activity tests showed that the majority of these target compounds exhibited moderate to excellent inhibitory effects against HepG2, K562, and PC-3 cells, with a particular selectivity for PC-3 cells. Compound 5 g demonstrated promising anticancer activity against HepG2 cells, surpassing the reference drug 5-FU. Compound 5k exhibited comparable activity to 5-FU against K562 cells. Additionally, the p-NO2 substituted compounds 5h and 5l displayed the most significant anti-tumor activity, with IC50 values of 7.42 ± 1.45 μmol/L and 8.38 ± 1.67 μmol/L, respectively. Molecular docking studies further revealed a docking model of compound 5h with 5ds3 protein, suggesting its potential as a promising anti-PC-3 drug.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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