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IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-14 DOI:10.1080/14786419.2025.2566909

Siyuan Liu, Yuansheng Zou, Zeren Dawa, Fangle Liu, Meiqi Wang, Chenchen Zhu, Chaozhan Lin

引用次数: 0

摘要

从trichophorum Franch中分离到一种新的苯酰胺衍生物生物碱(1)和一种新的hetisine型二萜生物碱(2)，共分离到14个已知的生物碱化合物（3 ~ 16，包括12个hetisine型二萜生物碱），其中3个化合物为首次从飞燕草属中发现（10,15,16），3个化合物为首次从trichophorum种中发现（7,9,11）。通过广泛的光谱分析，包括1D NMR， 2D NMR和ESI-MS/HR ESI-MS技术，阐明了它们的结构，并通过测量lps刺激的RAW264.7细胞中NO的产生来评估它们的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Two new alkaloids identified from herb Delphinium trichophorum French, a famous Tibetan drug "Gebu Dilu".

A new benzamide derivative alkaloid (1) and a new hetisine-type diterpenoid alkaloid (2) were isolated from D. trichophorum Franch with fourteen known alkaloids compounds (3∼16, including twelve hetisine-type diterpenoid alkaloids), in which three compounds were discovered firstly from genus Delphinium (10, 15, 16) and three compounds were discovered firstly from species D. -trichophorum (7, 9, 11). Their structures were elucidated by -extensive spectroscopic analyses, including 1D NMR, 2D NMR and ESI-MS/HR ESI-MS techniques, along with their anti-inflammatory activities were evaluated by measuring NO production in LPS-stimulated RAW264.7 cells.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.