{"title":"Novel arneomas A-B and other naphthoquinone active components in <i>Arnebia euchroma</i> I. M. Johnst.","authors":"Li-Li Han, Yibanuer Reheman, Reyilanmu Maisaidi, Cong-Zhao Fan, Lei-Ling Shi, Sheng-Jie Jia","doi":"10.1080/14786419.2025.2568209","DOIUrl":null,"url":null,"abstract":"<p><p><i>Arnebia euchroma</i> I. M. Johnst., a famous traditional medicine in China, is widely used in TCM clinic. As the purpose to dig bioactive constituents, silica gel, preparative High-Performance Liquid Chromatography and other manners were used to analyse its components. As a result, two new compounds arneomas A-B (<b>1-2</b>), and four known ones deoxyalkannin (<b>3</b>), shikonin (<b>4</b>), arnebifuranone (<b>5</b>), heliotropin one A (<b>6</b>) were obtained. Their structures were determined by spectral data and physical and chemical properties. The CCK-8 method was used to assess the cytotoxicity of the compounds towards the human cervical cancer cell line (Hela cells). Compounds <b>2</b> and <b>4</b> show apparent antitumor activity with median inhibition concentration IC<sub>50</sub> of 6.07, 8.37 μM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2568209","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Arnebia euchroma I. M. Johnst., a famous traditional medicine in China, is widely used in TCM clinic. As the purpose to dig bioactive constituents, silica gel, preparative High-Performance Liquid Chromatography and other manners were used to analyse its components. As a result, two new compounds arneomas A-B (1-2), and four known ones deoxyalkannin (3), shikonin (4), arnebifuranone (5), heliotropin one A (6) were obtained. Their structures were determined by spectral data and physical and chemical properties. The CCK-8 method was used to assess the cytotoxicity of the compounds towards the human cervical cancer cell line (Hela cells). Compounds 2 and 4 show apparent antitumor activity with median inhibition concentration IC50 of 6.07, 8.37 μM.
赤藓。是中国著名的传统药物，被广泛应用于中医临床。为了挖掘其生物活性成分，采用了硅胶、制备型高效液相色谱等方法对其成分进行了分析。结果得到了2个新化合物arneomas a - b（1-2）和4个已知化合物脱氧烷素(3)、紫草素(4)、arnebifuranone(5)、heliotropin one a(6)。它们的结构由光谱数据和理化性质确定。采用CCK-8法评价化合物对人宫颈癌细胞系（Hela细胞）的细胞毒性。化合物2和4具有明显的抗肿瘤活性，中位抑制浓度IC50分别为6.07、8.37 μM。
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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