A new isoflavone glycoside from the stems of Eclipta prostrata (L.) L. with glycosidase inhibitory activity.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-15 DOI:10.1080/14786419.2025.2572536

Yuan Gao, Ying-Xiao Xiao, Hao Xu, Xue-Feng Wu, Yi-Lin Li, Hyun-Sun Lee, Long Cui

引用次数: 0

Abstract

A new isoflavone glycoside, prostratanoside A (1), along with four known compounds (2-5), was isolated from the stems of Eclipta prostrata (L.) L. Their structures were elucidated through comprehensive spectroscopic (NMR and MS) and physicochemical analyses. All isolated compounds were evaluated for their in vitro α-glucosidase inhibitory activity. Notably, compound 1 displayed the most potent inhibition, with an IC₅₀ value of 10.3 ± 1.2 μM. Besides, the potential binding sites of 1 were predicted by molecular docking.

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黄芩茎中一个新的异黄酮苷L.具有糖苷酶抑制活性。

从黄芩（Eclipta prostrata (L.)）茎中分离到一个新的异黄酮苷，prostratanoside A(1)和4个已知化合物（2-5）。L.通过综合波谱（核磁共振、质谱）和理化分析对其结构进行了鉴定。对所有分离得到的化合物进行体外α-葡萄糖苷酶抑制活性评价。其中化合物1的抑制作用最强，IC50值为10.3±1.2 μM。此外，通过分子对接预测了1的潜在结合位点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.