The new ten-numbered macrolide, diaporthsin L, from endophytic fungus Diaporthe sp. G-4 isolated from Strobilanthes cusia (Nees) Kuntze.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-10 DOI:10.1080/14786419.2025.2568950

Jun-Yi Li, Zhen-Xian Cun, Hui-Hui Sun, Jie-Zheng Shi, Wen-Xiang Yan, Jun-Meng Xia, Dong Gan, Mao-Ru Li, Ju-Cheng Zhang, Zhong-Tao Ding

引用次数: 0

Abstract

One new ten-membered macrolide, named diaporthsin L (1), along with fourteen known compounds (2-15) were isolated from the endophytic fungus Diaporthe sp. G-4 which isolated from the medicinal plant Strobilanthes cusia (Nees) Kuntze. The structures were elucidated on the basis of their 1D and 2D NMR data, mass spectrometric data and X-ray crystallographic analysis. Compound 10 was initially isolated from metabolites of endophytic fungus, while compounds 6, 9, and 12 were obtained from the Diaporthe sp. genus for the first time. Diaporthsin L (1) showed weak cytotoxicity against human leukaemia cells (HL-60) with IC₅₀ value of 126.53 ± 1.13 µM.

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从孔子花内生真菌Diaporthe sp. G-4中分离得到新的十编号大环内酯类化合物diaporsin L。

从药用植物球芽草（Strobilanthes cusia (Nees) Kuntze）内生真菌Diaporthe sp. G-4中分离到一个新的十元大环内酯类化合物，命名为diaporsin L(1)和14个已知化合物（2-15）。根据它们的一维和二维核磁共振数据、质谱数据和x射线晶体学分析对其结构进行了鉴定。化合物10为首次从内生真菌代谢产物中分离得到，化合物6、9和12为首次从该属植物中分离得到。Diaporthsin L(1)对人白血病细胞（HL-60）表现出较弱的细胞毒性，IC50值为126.53±1.13µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.