白术中三个新苯丙类化合物。kitam交货。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-08 DOI:10.1080/14786419.2025.2569806

Zhao Sun, Jing Wang, Yan Liu, Jie Sun, Zhen-Xing Fang, Hai-Long Yu, Bing-You Yang, Yuan-Yuan Zhou

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引用次数: 0

摘要

从白术根茎70%水提液中分离得到3个新的苯丙素（1-3）和18个已知的苯丙素（4-21）。Kitam交货。通过一维、二维核磁共振谱和质谱等光谱技术对其结构进行了鉴定。采用CCK-8法测定各化合物的细胞毒活性。化合物1、11和13对人肿瘤（BGC-823、HepG-2、HeLa）细胞系的IC50值在34.19 ~ 48.38 μM范围内，具有中等抑癌活性。

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Three new phenylpropanoids from Atractylodes japonica Koidz. ex kitam.

Three new phenylpropanoids (1-3), together with eighteen known phenylpropanoids (4-21), were isolated from a 70% aqueous EtOH extract of the rhizomes of Atractylodes japonica Koidz. ex Kitam. Their structures were elucidated by spectroscopic techniques, including 1D, 2D NMR spectra and HR-ESI-MS. All the isolated compounds were evaluated for cytotoxicity activity by CCK-8 assay. Compounds 1, 11 and 13 exhibited moderate activities with IC₅₀ values in the range of 34.19-48.38 μM against human cancer (BGC-823, HepG-2, HeLa) cell lines.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.