p53 mediates the cellular responses to cis-trimethoxystilbene in breast cancer cell lines.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-07 DOI:10.1080/14786419.2025.2566908

Julia Mirian Paulino, Natália Dos Santos Gonçalves, Heber Eduardo Andrada, Arthur Barcelos Ribeiro, Carlos Henrique Inácio Ramos, Cassia Suemi Mizuno, Raquel Alves Dos Santos

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引用次数: 0

Abstract

The present study investigated the cellular inhibitory effects of cis-trimethoxystilbene (cis-TMS) on the chemoresistant MDA-MB-231 breast cancer cell line and the role of p53 in mediating the cellular responses to this compound. Treatment with cis-TMS significantly inhibited the growth of MDA-MB-231 cells, reducing the cell viability by approximately 75% at 2.5 µM and increasing apoptosis rates to nearly 20%. Silencing p53 in MCF-10A and MCF-7 cell lines revealed that cis-TMS-induced apoptosis and cell cycle arrest were p53-dependent. The interaction studies suggest that cis-TMS does not alter the conformation of p53 at low concentrations but may influence its activity at higher doses. The results suggest that cis-TMS selectively targets cancer cells with functional p53, offering a potential targeted therapy approach. However, the reliance on p53 and the risk of genomic instability pose limitations, requiring further research to optimise the therapeutic strategies involving cis-TMS.

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P53介导乳腺癌细胞系对顺式三甲氧基苯乙烯的细胞反应。

本研究探讨了顺式三甲氧基苯乙烯（cis-TMS）对化疗耐药的MDA-MB-231乳腺癌细胞株的细胞抑制作用，以及p53介导对该化合物的细胞反应的作用。顺式tms处理显著抑制MDA-MB-231细胞的生长，2.5µM时细胞活力降低约75%，凋亡率增加近20%。在MCF-10A和MCF-7细胞系中沉默p53表明顺式tms诱导的细胞凋亡和细胞周期阻滞依赖于p53。相互作用研究表明，顺式tms在低浓度下不会改变p53的构象，但在高剂量下可能会影响其活性。结果表明，顺式tms选择性靶向具有功能p53的癌细胞，提供了一种潜在的靶向治疗方法。然而，对p53的依赖和基因组不稳定的风险存在局限性，需要进一步研究以优化涉及顺式tms的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.