Xiaoli Ma, Jingjing Tian, Ruru Sun, Wenhao Fan, Lei Wang, Hao Ma, Changcai Bai, Bin Ma, Jian Ma, Zhijun Song
{"title":"蒙古长春花全草化学成分研究。","authors":"Xiaoli Ma, Jingjing Tian, Ruru Sun, Wenhao Fan, Lei Wang, Hao Ma, Changcai Bai, Bin Ma, Jian Ma, Zhijun Song","doi":"10.1080/14786419.2025.2566905","DOIUrl":null,"url":null,"abstract":"<p><p>A new polyphenolic compound, vinmonone (<b>1</b>), together with 15 previously reported compounds (<b>2 </b>-<b> 16</b>) were isolated and characterised from the whole herbs of <i>Vincetoxicum mongolicum</i> Maxim. The structure of new compound (<b>1</b>) was determined through MR and HR-ESI-MS spectroscopic data analysis. Biological assay results showed that compounds <b>7 </b>-<b> 9</b>, <b>11</b> and <b>12</b> showed antioxidant activity with IC<sub>50</sub> 5.6, 11.8, 5.4, 6.2, 11.2 ug/mL, respectively, compounds <b>7</b>, <b>9</b> and <b>11</b> showed tyrosinase inhibitory activity with IC<sub>50</sub> 33.1, 30.1, 34.7 ug/mL, respectively. In addition, compounds <b>3</b> and <b>16</b> showed anti-bacterial activity against <i>Staphylococcus aureus</i> with MIC 25.1, 20.5 ug/mL, respectively, compounds <b>3</b> and <b>7</b> also showed anti-fungi activity against <i>Candida albicans</i> with MIC 3.4, 4.8 μg/mL, respectively. These finding provides a scientific basis for elucidating the chemical diversity and activity of <i>V. mongolicum.</i></p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chemical constituents from the whole herbs of <i>Vincetoxicum mongolicum</i> Maxim.\",\"authors\":\"Xiaoli Ma, Jingjing Tian, Ruru Sun, Wenhao Fan, Lei Wang, Hao Ma, Changcai Bai, Bin Ma, Jian Ma, Zhijun Song\",\"doi\":\"10.1080/14786419.2025.2566905\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A new polyphenolic compound, vinmonone (<b>1</b>), together with 15 previously reported compounds (<b>2 </b>-<b> 16</b>) were isolated and characterised from the whole herbs of <i>Vincetoxicum mongolicum</i> Maxim. The structure of new compound (<b>1</b>) was determined through MR and HR-ESI-MS spectroscopic data analysis. Biological assay results showed that compounds <b>7 </b>-<b> 9</b>, <b>11</b> and <b>12</b> showed antioxidant activity with IC<sub>50</sub> 5.6, 11.8, 5.4, 6.2, 11.2 ug/mL, respectively, compounds <b>7</b>, <b>9</b> and <b>11</b> showed tyrosinase inhibitory activity with IC<sub>50</sub> 33.1, 30.1, 34.7 ug/mL, respectively. In addition, compounds <b>3</b> and <b>16</b> showed anti-bacterial activity against <i>Staphylococcus aureus</i> with MIC 25.1, 20.5 ug/mL, respectively, compounds <b>3</b> and <b>7</b> also showed anti-fungi activity against <i>Candida albicans</i> with MIC 3.4, 4.8 μg/mL, respectively. These finding provides a scientific basis for elucidating the chemical diversity and activity of <i>V. mongolicum.</i></p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2566905\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2566905","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Chemical constituents from the whole herbs of Vincetoxicum mongolicum Maxim.
A new polyphenolic compound, vinmonone (1), together with 15 previously reported compounds (2 - 16) were isolated and characterised from the whole herbs of Vincetoxicum mongolicum Maxim. The structure of new compound (1) was determined through MR and HR-ESI-MS spectroscopic data analysis. Biological assay results showed that compounds 7 - 9, 11 and 12 showed antioxidant activity with IC50 5.6, 11.8, 5.4, 6.2, 11.2 ug/mL, respectively, compounds 7, 9 and 11 showed tyrosinase inhibitory activity with IC50 33.1, 30.1, 34.7 ug/mL, respectively. In addition, compounds 3 and 16 showed anti-bacterial activity against Staphylococcus aureus with MIC 25.1, 20.5 ug/mL, respectively, compounds 3 and 7 also showed anti-fungi activity against Candida albicans with MIC 3.4, 4.8 μg/mL, respectively. These finding provides a scientific basis for elucidating the chemical diversity and activity of V. mongolicum.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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