A new limonoid, digsecokigelianolide, among the secondary metabolites from kigelia africana (lam.) benth. and evaluation of their antibacterial and antioxidant activity.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-08 DOI:10.1080/14786419.2025.2568952

Moise Diguir, Bernard Dabole, Isaac Silvère Gade, Peron Bosco Leutcha, Honore Wangso, Matthieu Matcheme, Albert Atangana Fouda, Jean Noël Nyemb, Moussa Djaouda, Alessandro Venditti, Alex De Theodore Atchadé, Benoit Koubala Bargui

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Abstract

The present work investigates the phytochemical study and the antibacterial and antioxidant activities of Kigelia africana (Lam.) Benth. Column chromatography separation on silica gel of fractions led to the isolation of a new limonoid derivative named digsecokigelianolide (1), as well as nine known compounds (2-10). The structures of the isolated compounds were determined by comprehensive spectroscopic analysis, including 1 & 2D NMR, IR, UV, mass spectrometry and comparison with previous reported data. Compound 1 showed moderate antiradical activity (IC₅₀ = 181.12 µg/mL) against ABST^•+ radical compared to BHT (159.48 µg/mL) used as standard, and a good antibacterial activity against Salmonella typhi (MIC: 22.0 mm), Escherichia coli (MIC: 15.0 mm) and Pseudomonas aeruginosa (MIC: 20 mm) at the concentration of 25 mg/mL. Compound 9 and 10 showed good antiradical (which ranges from 56.39 to 61.16% of inhibition) and antibacterial (which ranges from 12 to 20 mm of inhibition zone) activities.

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研究了非洲木兰花次生代谢产物中一个新的类柠檬素——digsecokigelanolide。并对其抗菌和抗氧化活性进行了评价。

本文主要研究了非洲木兰花（Kigelia africana, Lam.）的植物化学成分及其抗菌和抗氧化活性。Benth。硅胶柱层析分离得到了一种新的类柠檬衍生物，命名为digsecokigelianolide(1)，以及9个已知化合物（2-10）。通过1、2D NMR、IR、UV、质谱等综合光谱分析，并与已有报道的数据进行对比，确定了分离化合物的结构。与BHT（159.48µg/mL）相比，化合物1对ABST•+自由基的抑制活性为中等（IC50 = 181.12µg/mL），在25 mg/mL浓度下对伤寒沙门菌（MIC: 22.0 mm）、大肠埃希菌（MIC: 15.0 mm）和铜绿假单胞菌（MIC: 20 mm）具有良好的抑菌活性。化合物9和10表现出良好的抗自由基活性（抑制率为56.39% ~ 61.16%）和抗菌活性（抑制范围为12 ~ 20 mm）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.