{"title":"One new ten-membered macrolide and one new pyridinone derivative from the mangrove endophytic fungus <i>Alternaria porri #</i>25.","authors":"Fengting Tang, Namei Zheng, Yuhui Wang, Jinjun Li, Ronglan Tan, Zhiyun Du, Huarong Huang, Guangying Chen","doi":"10.1080/14786419.2025.2570894","DOIUrl":null,"url":null,"abstract":"<p><p>One new ten-membered macrolide derivative, porriolide (<b>1</b>), and one new 2(1H)-pyridinone derivative (±)-porripyridone (<b>2</b>), together with seven known compounds alternariol 4-methyl ether (<b>3</b>), alternariol (<b>4</b>), 5'-methoxy-6-methylbiphenyl-3,4,3'-triol (<b>5</b>), altenusinoide A (<b>6</b>), harziano pyridone (<b>7</b>), penicilloxalone A (<b>8</b>), and cytosporin D (<b>9</b>) were obtained from mangrove endophytic fungus <i>Alternaria porri</i> #25. Their structures were elucidated using comprehensive spectroscopic methods, and the absolute configuration of the new compounds were further confirmed by ECD spectra and single-crystal X-ray diffraction analysis, respectively. Compounds <b>2</b> and <b>7</b> exhibited cytotoxic activities against prostate cancer VCap and PC-3 cells with IC<sub>50</sub> values ranging from 22.94 ± 0.53 μmol/L to 38.13 ± 0.93 μmol/L, while compound <b>1</b> showed no cytotoxic activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2570894","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
One new ten-membered macrolide derivative, porriolide (1), and one new 2(1H)-pyridinone derivative (±)-porripyridone (2), together with seven known compounds alternariol 4-methyl ether (3), alternariol (4), 5'-methoxy-6-methylbiphenyl-3,4,3'-triol (5), altenusinoide A (6), harziano pyridone (7), penicilloxalone A (8), and cytosporin D (9) were obtained from mangrove endophytic fungus Alternaria porri #25. Their structures were elucidated using comprehensive spectroscopic methods, and the absolute configuration of the new compounds were further confirmed by ECD spectra and single-crystal X-ray diffraction analysis, respectively. Compounds 2 and 7 exhibited cytotoxic activities against prostate cancer VCap and PC-3 cells with IC50 values ranging from 22.94 ± 0.53 μmol/L to 38.13 ± 0.93 μmol/L, while compound 1 showed no cytotoxic activity.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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