Julia Mirian Paulino, Natália Dos Santos Gonçalves, Heber Eduardo Andrada, Arthur Barcelos Ribeiro, Carlos Henrique Inácio Ramos, Cassia Suemi Mizuno, Raquel Alves Dos Santos
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p53 mediates the cellular responses to cis-trimethoxystilbene in breast cancer cell lines.
The present study investigated the cellular inhibitory effects of cis-trimethoxystilbene (cis-TMS) on the chemoresistant MDA-MB-231 breast cancer cell line and the role of p53 in mediating the cellular responses to this compound. Treatment with cis-TMS significantly inhibited the growth of MDA-MB-231 cells, reducing the cell viability by approximately 75% at 2.5 µM and increasing apoptosis rates to nearly 20%. Silencing p53 in MCF-10A and MCF-7 cell lines revealed that cis-TMS-induced apoptosis and cell cycle arrest were p53-dependent. The interaction studies suggest that cis-TMS does not alter the conformation of p53 at low concentrations but may influence its activity at higher doses. The results suggest that cis-TMS selectively targets cancer cells with functional p53, offering a potential targeted therapy approach. However, the reliance on p53 and the risk of genomic instability pose limitations, requiring further research to optimise the therapeutic strategies involving cis-TMS.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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