Juan Wang, Zhixiao Yang, Shuangya Xu, Yuhuai Long, Yuan Yuan, Yufan Chen, Die Zhang, Bang Chen, Hongping He, Baojing Li
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引用次数: 0
Abstract
Aralia elata (Araliaceae), widely distributed in Asia, is traditionally used for treating arthritis, cardiovascular diseases, tumours and asthma. Phytochemical analysis of its buds led to the isolation of three previously undescribed triterpenoid saponins-Aralianudasides C-E (1-3). Aralianudaside C (1) represents the first taraxastane-type saponin identified in Araliaceae, featuring a β-D-glucose moiety at C-3. Aralianudaside D (2) contains a rare D-xylose unit linked to C-6' of C-3-O-glucose, while Aralianudaside E (3) possesses a unique trisaccharide chain with D-glucose attached to C-4'' of C-3'-O-glucose. Furthermore, compounds 2 and 3 significantly reduced IL-6 expression in LPS-induced 16HBE airway epithelial cells with the suppression rate of 31.63% and 37.27% (the suppression rate of positive control Dex was 79.04%).
楤木广泛分布于亚洲，传统上用于治疗关节炎、心血管疾病、肿瘤和哮喘。对其芽进行植物化学分析，分离出三种以前未描述过的三萜皂苷- aralianudasides C-E（1-3）。Aralianudaside C(1)是在Araliaceae中发现的第一个taraxastane型皂苷，其C-3位点具有β- d -葡萄糖片段。aralianudside D(2)含有一个罕见的D-木糖单元，与C-3- o -葡萄糖的C-6‘相连，而aralianudside E(3)具有一个独特的三糖链，D-葡萄糖与C-3’- o -葡萄糖的C-4'相连。化合物2和3显著降低lps诱导的16HBE气道上皮细胞IL-6的表达，抑制率分别为31.63%和37.27%（阳性对照Dex抑制率为79.04%）。
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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