{"title":"Potential anti-gout properties and determined by UPLC-Q/TOF-MS of total saponins from <i>Smilax nipponica</i> Miq.","authors":"Chengjun Yuan, Heying Chen, Zhuobin Zhao, Zexi Wang, Lanlan Zhong, Yulan Xing, Chen Jin","doi":"10.1080/14786419.2025.2565701","DOIUrl":null,"url":null,"abstract":"<p><p>The roots and rhizomes of <i>Smilax nipponica</i> Miq. have long been used in traditional Chinese medicine to treat gout. Steroid saponins, characteristic compounds of the <i>Smilax</i> genus, were investigated for their potential in alleviating inflammatory responses in gouty arthritis rats. Thirty-two steroidal saponin compounds were obtained by UPLC-Q/TOF-MS from total saponins of <i>S. nipponica.</i> Gracillin, Paris D, Smilnipponicoside A, Smilnipponicoside C, and Dioscin were the predicted active ingredients in the treatment of gout through network pharmacological tools. Two new pregnanol saponins, Smilnipponicoside A and Smilnipponicoside C, have been shown to have inhibitory effects on the inflammatory response of RAW264.7 mouse macrophages stimulated by sodium urate, which is associated with the PI3K/Akt signalling pathway.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2565701","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
The roots and rhizomes of Smilax nipponica Miq. have long been used in traditional Chinese medicine to treat gout. Steroid saponins, characteristic compounds of the Smilax genus, were investigated for their potential in alleviating inflammatory responses in gouty arthritis rats. Thirty-two steroidal saponin compounds were obtained by UPLC-Q/TOF-MS from total saponins of S. nipponica. Gracillin, Paris D, Smilnipponicoside A, Smilnipponicoside C, and Dioscin were the predicted active ingredients in the treatment of gout through network pharmacological tools. Two new pregnanol saponins, Smilnipponicoside A and Smilnipponicoside C, have been shown to have inhibitory effects on the inflammatory response of RAW264.7 mouse macrophages stimulated by sodium urate, which is associated with the PI3K/Akt signalling pathway.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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