Analysis of flavonoid glucosides from Ardisia and Damnacanthus spp. using UPLC-DAD-QToF/mS.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-10-06 DOI:10.1080/14786419.2025.2570893

Gelila Asamenew, Heon-Woong Kim, Soo Mug Cho, Jung Bong Kim, Stefan Kehraus, Max Crüsemann, Gabriele M König

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Abstract

In order to investigate the compositional characteristics of leaves and fruits from Ardisia crenata, source of the potent Gq inhibitor FR900359, as well as leaves of other related Ardisia and rarely investigated Damnacanthus species, we report the structural identification and quantification of flavonoid glycosides from these plants. Seven different samples, including leaves of three Ardisia species (A. crenata, A. japonica and A. pusilla), leaves of two Damnacathus species (D. major and D. indicus), and two fruits of Ardisia crenata (red and white), were investigated. A total of forty-six flavonoid glycosides were identified and their quantitative results based on the internal standard, 2,4,5-trimethoxycinnamic acid, are reported for the first time. Also, among these samples, the leaves of the red fruit Ardisia crenata showed the highest content of 20 types of flavonoids including kaempferol 3-O-glucoside (astragalin), at 503.8 ± 11.9 mg/100 g.

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UPLC-DAD-QToF/mS分析紫荆属和丹参属黄酮类苷。

为了研究强效Gq抑制剂FR900359的来源赤荆芥（Ardisia crenata）叶片和果实的成分特征，以及其他相关的赤荆芥（Ardisia crenata）和很少被研究的丹参（Damnacanthus）植物叶片的成分特征，我们报道了这些植物中黄酮类苷的结构鉴定和定量分析。研究了3种黄菖蒲属植物（A. crenata， A. japonica和A. pusilla）的叶片，2种Damnacathus属植物（D. major和D. indicus）的叶片和2种黄菖蒲属植物（红色和白色）的果实。共鉴定出46种黄酮类苷，并首次报道了基于内标2,4,5-三甲氧基肉桂酸的定量结果。红果紫荆叶片中山奈酚3- o -葡萄糖苷（黄芪苷）等20种黄酮类化合物含量最高，为503.8±11.9 mg/100 g。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.