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A biomimetic nanoplatform for endogenous self-replenishing of oxygen to promote sonodynamic therapy for targeted ablation of activated macrophages in atherosclerotic plaques 一种用于内源性自我补氧的仿生纳米平台,促进靶向消融动脉粥样硬化斑块中活化巨噬细胞的声动力治疗
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-22 DOI: 10.1016/j.mtbio.2025.102338
Jia Liu , Sijin Chen , Wenli Zhang , Zhongsheng Xu , Yun Liu , Xiyue Rong , Ying Luo , Lian Xu , Junrui Wang , Yi Wang , Qianying Du , Bo Liu , Yu Zhang , Jie Xu , Dajing Guo
{"title":"A biomimetic nanoplatform for endogenous self-replenishing of oxygen to promote sonodynamic therapy for targeted ablation of activated macrophages in atherosclerotic plaques","authors":"Jia Liu ,&nbsp;Sijin Chen ,&nbsp;Wenli Zhang ,&nbsp;Zhongsheng Xu ,&nbsp;Yun Liu ,&nbsp;Xiyue Rong ,&nbsp;Ying Luo ,&nbsp;Lian Xu ,&nbsp;Junrui Wang ,&nbsp;Yi Wang ,&nbsp;Qianying Du ,&nbsp;Bo Liu ,&nbsp;Yu Zhang ,&nbsp;Jie Xu ,&nbsp;Dajing Guo","doi":"10.1016/j.mtbio.2025.102338","DOIUrl":"10.1016/j.mtbio.2025.102338","url":null,"abstract":"<div><div>Atherosclerosis (AS) is a chronic inflammatory condition associated with increased morbidity and mortality. Nanomaterial-based sonodynamic therapy (SDT) shows considerable potential as a noninvasive treatment for AS. The efficacy of SDT is often limited by the unstable generation of reactive oxygen species (ROS) due to inadequate oxygen availability in the cellular microenvironment. In this study, a biomimetic nanoplatform (HMnO<sub>2</sub>-Ce6@MM; HMC@MM) was constructed by coating hollow manganese dioxide (HMnO<sub>2</sub>) nanoparticles loaded with Chlorine e6 (Ce6) with macrophage membranes (MMs) to increase the ROS level for effective ablation of activated macrophages. HMC@MM is actively transported to activated macrophages in atherosclerotic plaques. In the slightly acidic and rich hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) environment of plaques, HMnO<sub>2</sub> reacts with H<sub>2</sub>O<sub>2</sub> to produce Mn<sup>2+</sup> and oxygen. Mn<sup>2+</sup> is applicable in magnetic resonance imaging to detect unstable plaques. Under the condition of endogenous self-replenishing oxygen, HMC@MM-mediated SDT can produce sufficient ROS, subsequently initiating mitochondrial dysfunction and inducing the apoptosis of activated macrophages. Ablation of activated macrophages not only alleviated the inflammatory environment but the apoptotic fragments also triggered efferocytosis of fresh macrophages in the plaque, thereby effectively controlling unstable plaques. The HMC@MM-mediated SDT strategy has comprehensive effects on controlling atherosclerotic plaque progression.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102338"},"PeriodicalIF":10.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections 双ROS/ ph响应负载芒果苷智能微针用于伤口感染的精确治疗
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-22 DOI: 10.1016/j.mtbio.2025.102339
Zhaoping Diao, Jiajun Long, Yang Feng, Guoqing Zhang, Ganghua Yang, Jianqiu Yang, Wenbing Wan
{"title":"Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections","authors":"Zhaoping Diao,&nbsp;Jiajun Long,&nbsp;Yang Feng,&nbsp;Guoqing Zhang,&nbsp;Ganghua Yang,&nbsp;Jianqiu Yang,&nbsp;Wenbing Wan","doi":"10.1016/j.mtbio.2025.102339","DOIUrl":"10.1016/j.mtbio.2025.102339","url":null,"abstract":"<div><div>Infected wound healing remains critically challenged by persistent bacterial biofilms and dysregulated inflammation, whereas conventional silver dressings lack dynamic microenvironment responsiveness and fail to synergize antibacterial efficacy with tissue regeneration. Although conventional silver dressings offer proven antibacterial efficacy, their static nature limits dynamic microenvironment adaptation and synergistic tissue regeneration. To resolve these limitations, we developed an intelligent microneedle patch (PCMA MN) integrating a pH/reactive oxygen species (ROS)-dual-responsive hydrogel matrix composed of gallic acid-grafted chitosan (CG) and TSPBA-crosslinked polyvinyl alcohol (PT) for on-demand drug release, mangiferin (MF)-loaded PLGA microspheres for promoting angiogenesis, and a synergistic silver-gallic acid antibacterial coating. PCMA MNs demonstrated bactericidal capacity comparable to silver dressings, while significantly accelerating wound closure by 14.25 %. This regenerative improvement was driven by enhanced angiogenesis and dynamic macrophage polarization toward regenerative M2 phenotypes, which collectively resolved inflammation and facilitated collagen deposition. Our bioresponsive platform establishes a novel strategy coordinating real-time pharmacokinetics with pro-regenerative immunomodulation, offering transformative potential for complex wound management.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102339"},"PeriodicalIF":10.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering macrophage responses through 3D scaffold microarchitecture 通过3D支架微结构工程巨噬细胞反应
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-21 DOI: 10.1016/j.mtbio.2025.102328
Chiara Martinelli , Srijan Chakraborty , Giovanni Buccioli , Matteo Vicini , Claudio Conci , Giulio Cerullo , Roberto Osellame , Giuseppe Chirico , Emanuela Jacchetti , Manuela Teresa Raimondi
{"title":"Engineering macrophage responses through 3D scaffold microarchitecture","authors":"Chiara Martinelli ,&nbsp;Srijan Chakraborty ,&nbsp;Giovanni Buccioli ,&nbsp;Matteo Vicini ,&nbsp;Claudio Conci ,&nbsp;Giulio Cerullo ,&nbsp;Roberto Osellame ,&nbsp;Giuseppe Chirico ,&nbsp;Emanuela Jacchetti ,&nbsp;Manuela Teresa Raimondi","doi":"10.1016/j.mtbio.2025.102328","DOIUrl":"10.1016/j.mtbio.2025.102328","url":null,"abstract":"<div><div>Biomaterial implantation in living tissues triggers a physiological response known as foreign body reaction, leading to the recruitment of macrophages, that can polarize either into a pro-inflammatory (M1) or an anti-inflammatory (M2) phenotype. Currently, there is growing interest in tailoring the physical properties of biomaterials to promote efficient tissue regeneration. Tridimensionality can profoundly influence macrophage behaviour; however, there is no clear consensus on the underlying mechanisms. 3D microstructures may play a crucial role in modulating immune cells, promoting anti-inflammatory responses, and supporting effective tissue repair and regeneration. In this study, we designed and fabricated 3D scaffolds with large pores (50 × 50 × 20 μm<sup>3</sup>) and small pores (15 × 15 × 15 μm<sup>3</sup>) by two-photon polymerization. Both microstructures effectively influenced macrophage cytoskeletal organization and cellular metabolic activity. Notably, they were not sufficient to induce spontaneous macrophage polarization, indicating that they are intrinsically immunologically inert. When combined with chemical stimulation, as typically occurs physiologically, they elicited distinct responses. The investigation of two pore sizes allowed us to find a balance between the anti-inflammatory and pro-inflammatory phenotypes, with a slight upregulation of Arg1 by large pores, and a marked increase of iNOS expression by small pores. Our results demonstrate that 3D microstructures are versatile tools for multiple applications. Their precisely tunable architecture enables fine control over macrophage behaviour, opening new avenues both for <em>in vivo</em> tissue engineering, by preventing fibrosis and promoting anti-inflammatory and pro-regenerative responses, and for the development of <em>in vitro</em> platforms to model inflamed tissues for screening anti-inflammatory drugs.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102328"},"PeriodicalIF":10.2,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electroacupuncture at Huatuo-Jiaji acupoints combined with conductive hydrogel synergistically improves bladder and motor functions after spinal cord injury 电针华佗夹脊穴配合导电水凝胶可协同改善脊髓损伤后膀胱及运动功能
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-21 DOI: 10.1016/j.mtbio.2025.102335
Qiang Zhang , Feng Wei , Lulu Zhang , Can Liang , Yan Zhuang , Ning Jiang , Wenjie Weng , Xusheng Qiu , Huiru Wang , Yixin Chen , Jianwu Dai , He Shen
{"title":"Electroacupuncture at Huatuo-Jiaji acupoints combined with conductive hydrogel synergistically improves bladder and motor functions after spinal cord injury","authors":"Qiang Zhang ,&nbsp;Feng Wei ,&nbsp;Lulu Zhang ,&nbsp;Can Liang ,&nbsp;Yan Zhuang ,&nbsp;Ning Jiang ,&nbsp;Wenjie Weng ,&nbsp;Xusheng Qiu ,&nbsp;Huiru Wang ,&nbsp;Yixin Chen ,&nbsp;Jianwu Dai ,&nbsp;He Shen","doi":"10.1016/j.mtbio.2025.102335","DOIUrl":"10.1016/j.mtbio.2025.102335","url":null,"abstract":"<div><div>Spinal cord injury (SCI) compromises the electrophysiological properties of tissues and disrupts the electrical transmission pathways, ultimately resulting in motor dysfunction and neurogenic bladder impairment. Therefore, restoration of normal electrophysiological functions in injured spinal cord tissues is crucial for SCI rehabilitation. Electrical stimulation (ES) exhibits therapeutic potential for neurological disorders via neuronal modulation, showing enhanced efficacy in combination with traditional Chinese medicine practices, such as targeted acupuncture. Specifically, acupuncture at Huatuo-Jiaji acupoints, located bilaterally along the vertebral column, exerts neurological regulatory effects. In this study, we developed a dual-modality therapeutic approach combining implantable biomimetic conductive hydrogels for internal ES with electroacupuncture at Huatuo-Jiaji acupoints for external ES to reconstruct the neural electrical microenvironment and synergistically enhance the electrophysiological recovery post-SCI. The engineered conductive hydrogels, fabricated by incorporating carbon nanotubes into photocrosslinkable gelatin matrices, showed dual functionality by facilitating endogenous electrical signal propagation and enhancing the exogenous ES efficacy. This combination therapy significantly attenuated the inflammatory responses and glial scar formation, concurrently promoting axonal regeneration and mitigating demyelination. Functional assessments revealed substantial improvements in both locomotor recovery and neurogenic bladder control in complete spinal cord transection model rats. Mechanistic investigations revealed the downregulation of the Janus kinase–signal transducer and activator of transcription signaling pathway as a key regulator of anti-inflammatory effects of the combination treatment. Overall, our innovative internal–external ES integration strategy offers a promising translational approach for SCI repair by simultaneously enhancing neural regeneration and facilitating functional restoration.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102335"},"PeriodicalIF":10.2,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative 3D-printed porous piezoelectric poly(vinylidene fluoride) cages with accelerated spinal fusion 创新的3d打印多孔压电聚偏氟乙烯(偏氟乙烯)笼子,加速脊柱融合
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102333
Hao Zhang , Guoqing Gao , Lihan Wang , Chunlu Li , Chang Xu , Xufeng Dong , Lin Sang
{"title":"Innovative 3D-printed porous piezoelectric poly(vinylidene fluoride) cages with accelerated spinal fusion","authors":"Hao Zhang ,&nbsp;Guoqing Gao ,&nbsp;Lihan Wang ,&nbsp;Chunlu Li ,&nbsp;Chang Xu ,&nbsp;Xufeng Dong ,&nbsp;Lin Sang","doi":"10.1016/j.mtbio.2025.102333","DOIUrl":"10.1016/j.mtbio.2025.102333","url":null,"abstract":"<div><div>Spinal fusion is an efficient treatment for degenerative disc disease, however, poor osseointegration capacity of spinal cages often cause clinical implant failure. Herein, we proposed an innovative piezoelectric interbody fusion cage with porous structure, load-carrying capacity and enhanced osseointegration effect via 3D printing technology. Firstly, poly(vinylidene fluoride) (PVDF), poly(lactic acid) PLA and ceramic barium titanate (BTO) were compounded to prepare the composite filament with improved 3D printability and good piezoelectric effect. It is found that both BTO and PLA are favored for <em>β</em>-phase transformation and PLA effectively solves the warping issue during the 3D-printing. Then, cages with triangular lattice with varying infill densities are designed and fabricated. It is found that triangular PVDF/PLA/BTO structure with lower infill density exhibits stronger piezoelectric effect, and all the samples exhibited compressive properties analogous to trabecular bone. Furthermore, the <em>in vitro</em> cellular assays and <em>in vivo</em> large animal model sheep experiments validated an obvious piezoelectric effect on osseointegration for PVDF/PLA/BTO cages. After three-month implantation, it presented promoted new bone formation with a bone volume of 76.8 % in contrast with that of 49.3 % in PEEK counterpart. Therefore, the current study highlights a promising material for intervertebral fusion cages with good biomimetic mechanical performance and spinal osseointegration effect.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102333"},"PeriodicalIF":10.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilirubin-polymer nanocarriers enable targeted farrerol delivery for glaucoma neuroprotection via Nrf2-mediated ferroptosis/apoptosis inhibition 胆红素聚合物纳米载体能够通过nrf2介导的铁凋亡/细胞凋亡抑制靶向法瑞罗递送青光眼神经保护
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102304
Jing Wang , Yixian Liu , Rong Rong , Xiaobo Xia
{"title":"Bilirubin-polymer nanocarriers enable targeted farrerol delivery for glaucoma neuroprotection via Nrf2-mediated ferroptosis/apoptosis inhibition","authors":"Jing Wang ,&nbsp;Yixian Liu ,&nbsp;Rong Rong ,&nbsp;Xiaobo Xia","doi":"10.1016/j.mtbio.2025.102304","DOIUrl":"10.1016/j.mtbio.2025.102304","url":null,"abstract":"<div><div>Glaucoma, a leading cause of irreversible blindness, is characterized by progressive retinal ganglion cell (RGC) degeneration with limited treatment options. The natural flavonoid farrerol exhibits neuroprotective potential through antioxidative and anti-inflammatory effects, but its therapeutic application is limited by poor bioavailability and photodegradation. This study investigates farrerol's neuroprotective mechanisms and develops an optimized nanoformulation for enhanced efficacy. In vitro oxygen-glucose deprivation/reperfusion (OGD/R) and in vivo ischemia-reperfusion (IR) models demonstrate that farrerol significantly improves RGC survival and visual function. Mechanistic studies reveal that farrerol activates the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway, reduces reactive oxygen species (ROS) accumulation, and modulates key ferroptosis markers (glutathione peroxidase 4 (GPX4) and acyl-CoA synthetase long-chain family member 4 (ACSL4)), thereby inhibiting RGC apoptosis. To overcome delivery limitations, farrerol-loaded bilirubin nanoparticles (FB-NPs) are developed, showing enhanced stability and neuroprotective effects in glaucomatous injury models. These findings identify the Nrf2/ferroptosis/apoptosis axis as a novel therapeutic target and present an effective nanodelivery strategy for glaucoma treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102304"},"PeriodicalIF":10.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-targeted albumin nanoparticles for the Co-delivery of low-dose paclitaxel and PCSK9 inhibitor in melanoma treatment 双靶向白蛋白纳米颗粒联合递送低剂量紫杉醇和PCSK9抑制剂治疗黑色素瘤
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102329
Ling Chen , Meng Hu , Hui-min Yan , Xue-Qing Ding , Qiu-xiang Yang , Ling Wang , Hong Pan
{"title":"Dual-targeted albumin nanoparticles for the Co-delivery of low-dose paclitaxel and PCSK9 inhibitor in melanoma treatment","authors":"Ling Chen ,&nbsp;Meng Hu ,&nbsp;Hui-min Yan ,&nbsp;Xue-Qing Ding ,&nbsp;Qiu-xiang Yang ,&nbsp;Ling Wang ,&nbsp;Hong Pan","doi":"10.1016/j.mtbio.2025.102329","DOIUrl":"10.1016/j.mtbio.2025.102329","url":null,"abstract":"<div><div>The immunosuppressive microenvironment and impaired antigen presentation represent significant challenges in melanoma treatment. This study explores strategies to overcome these barriers by simultaneously inducing tumor cell immunogenic cell death (ICD) and enhancing antigen presentation. We developed hyaluronic acid/R8-RGD dual-modified albumin nanoparticles (HR/LDPP-NPs) designed to co-deliver low-dose paclitaxel (PTX) and the PCSK9 inhibitor PF-06446846. PTX induces ICD, releasing calreticulin (CRT), ATP, and HMGB1 danger signals, thereby transforming tumor cells into an in situ antigen source and initiating dendritic cell-mediated T-cell responses, akin to an intrinsic vaccine effect. Simultaneously, the inhibition of PCSK9 significantly upregulates tumor MHC-I expression, counteracting immune evasion. This synergistic approach, combining in situ vaccination with enhanced antigen presentation, significantly amplifies antitumor immunity. Both in vitro and in vivo experiments demonstrate that these spatiotemporally coordinated dual-targeting nanoparticles achieve substantial therapeutic efficacy with significantly reduced toxicity, presenting a novel chemo-immunotherapeutic strategy for melanoma treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102329"},"PeriodicalIF":10.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Living bacteria-loaded antibacterial hydrogel-coated gauze: A revolutionary solution for multi-drug-resistant bacterial infections 活细菌负载抗菌水凝胶涂层纱布:多重耐药细菌感染的革命性解决方案
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102337
Minghui Xie , Yang Xue , Wantong Lin , Zibing Jiang , Yichun Chen , Yue Pei , Xu Wu , Xiubin Xu
{"title":"Living bacteria-loaded antibacterial hydrogel-coated gauze: A revolutionary solution for multi-drug-resistant bacterial infections","authors":"Minghui Xie ,&nbsp;Yang Xue ,&nbsp;Wantong Lin ,&nbsp;Zibing Jiang ,&nbsp;Yichun Chen ,&nbsp;Yue Pei ,&nbsp;Xu Wu ,&nbsp;Xiubin Xu","doi":"10.1016/j.mtbio.2025.102337","DOIUrl":"10.1016/j.mtbio.2025.102337","url":null,"abstract":"<div><div>Chronic wounds infected by methicillin-resistant <em>Staphylococcus aureus</em> (<em>MRSA</em>) pose critical therapeutic challenges due to the prevalence of multi-drug-resistant (MDR) pathogens. To address this issue, a biocompatible live bacteria-loaded hydrogel-coated gauze (APAG) was developed by integrating an engineering <em>Pseudomonas</em> sp. SC11pLAFR-GFP with an alginate/ε-polylysine-polyacrylamide (Alg/ε-PL-PAAm) double-network hydrogel. The hierarchical hydrogel architecture, achieved through physical entrapment in the Alg/ε-PL core, ensures bacterial viability, while the chemically crosslinked PAAm outer layer regulates metabolite diffusion kinetics, synergistically enhancing therapeutic efficacy. The engineered bacteria hydrogel gauze (SC11@APAG) demonstrated sustained antimicrobial production for more than 48 h through the metabolic activity of the loaded <em>Pseudomonas</em> sp. SC11. This biohybrid not only effectively combats <em>MRSA</em> infection in mice wounds but also enhances wound healing. This “bacterial antagonism” strategy combines the native antimicrobial properties of <em>Pseudomonas</em> sp. with advanced material engineering, establishing a new paradigm for intelligent biomedical textiles in combating antimicrobial resistance.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102337"},"PeriodicalIF":10.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structurally reprogrammed modified citrus pectin (MCP) enables potentiated galectin-3 sequestration and injectable carboxymethyl chitosan/berberine hydrogel construction for osteoarthritis immunotherapy 结构重编程修饰的柑橘果胶(MCP)能够增强半乳糖凝集素-3的隔离和可注射的羧甲基壳聚糖/小檗碱水凝胶构建,用于骨关节炎的免疫治疗
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102330
Chi Lin , Fwu-Long Mi , Chia-Yun Cha , Fang-Yu Hsu , Siti Ayu Ulfadillah , Min-Lang Tsai , Hsien-Tsung Lu
{"title":"Structurally reprogrammed modified citrus pectin (MCP) enables potentiated galectin-3 sequestration and injectable carboxymethyl chitosan/berberine hydrogel construction for osteoarthritis immunotherapy","authors":"Chi Lin ,&nbsp;Fwu-Long Mi ,&nbsp;Chia-Yun Cha ,&nbsp;Fang-Yu Hsu ,&nbsp;Siti Ayu Ulfadillah ,&nbsp;Min-Lang Tsai ,&nbsp;Hsien-Tsung Lu","doi":"10.1016/j.mtbio.2025.102330","DOIUrl":"10.1016/j.mtbio.2025.102330","url":null,"abstract":"<div><div>Osteoarthritis (OA) remains a major clinical challenge due to the lack of effective treatments capable of halting disease progression. Chronic synovial inflammation and cartilage degradation are hallmark features, wherein galectin-3 (Gal-3), a β-galactoside-binding lectin, plays a pivotal upstream role by driving M1 macrophage activation and chondrocyte apoptosis. Modified citrus pectin (MCP), a natural Gal-3 binder, possesses therapeutic potential but is hindered by rapid clearance and limited joint retention. Herein, we present oxidized MCP (oxMCP), structurally reprogrammed MCP, that functions as a Gal-3-sequestering and crosslinkable matrix. This transformation was achieved via periodate oxidation, which introduced dialdehyde groups for Schiff base crosslinking with N, O-carboxymethyl chitosan (NOCC), while simultaneously enhancing Gal-3 affinity by reducing the molecular weight, increasing the chain flexibility, and exposing β-(1 → 4)-galactan motifs. These changes markedly amplified Gal-3-associated bioactivities, including M1 macrophage suppression and chondroprotection. The resulting oxMCP/NOCC hydrogel was further integrated with berberine (BBR), a cationic alkaloid with M2-polarizing activity, which reinforced the hydrogel network via non-covalent interactions and empowered the M2-polarizing capacity. The oxMCP/NOCC/BBR hydrogel exhibited excellent self-healing, low swelling, slow degradation, and sustained drug release, key features for intra-articular delivery. <em>In vitro</em>, it suppressed oxidative stress, matrix degradation, and chondrocyte apoptosis while promoting macrophage polarization toward the M2 phenotype. In vivo, intra-articular administration alleviated synovial inflammation and preserved cartilage in a rat OA model. This work transformed MCP from a short-acting Gal-3 blocker into a durable, bioactivity-enhanced therapeutic platform with immunomodulatory and cartilage-protective capabilities, offering a transformative strategy for a localized pathology-adaptive OA intervention.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102330"},"PeriodicalIF":10.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the dual immunomodulatory function of myeloid-derived suppressor cells to reshape the inflammatory microenvironment for osteoarthritis therapy 利用骨髓源性抑制细胞的双重免疫调节功能重塑骨关节炎治疗的炎症微环境
IF 10.2 1区 医学
Materials Today Bio Pub Date : 2025-09-20 DOI: 10.1016/j.mtbio.2025.102332
Zili Guo , Tao Chen , Xuehuan Wen , Qiangchang Fu , Jiabin Lai , Jiajin Li , Jiayu Chen , Jie Weng , Wang Wen , Qihua Cao , Junxiong Zhu , Zhaoming Ye , Xiaohua Yu , Lifeng Jiang
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