Materials Today Bio最新文献

{"title":"Low-toxicity vitrification of small-diameter arterial grafts by achieving a Cryo-Stasis state.","authors":"Zhiyang Zhao, Bing Zhang, Gang Zhao","doi":"10.1016/j.mtbio.2026.103439","DOIUrl":"10.1016/j.mtbio.2026.103439","url":null,"abstract":"<p><p>Small-diameter arterial grafts are crucial for vascular reconstruction yet lack preservation methods that maintain viability and function, as current approaches face a trade-off between ice damage from slow freezing and cytotoxicity from high-concentration cryoprotectants. We discovered that low-dose combinatorial ice inhibitors enhance cellular tolerance to cryoprotectant toxicity via lamin B1-mediated nuclear stabilization, which inhibits synergistic chemical and osmotic shock injury during unloading. Based on these findings, we developed CTX-RYST (Cryo & Toxico-Regulated Yoke-Steadying Technology), integrating a low-dose ice inhibitor (CTX) with a one-step unloading method that reduces processing time by 75% (to 15 min) and achieves superior viability and attachment versus conventional multi-step unloading. This strategy improved graft quality: Human Umbilical Vein Endothelial Cells adhesion increased from 8% to 89%, ice formation was nearly eliminated (melting enthalpy 0.28 J/g), and viscoelasticity and migration reached native levels. In rat carotid artery transplants, stenosis decreased from 24% to 4%. Thus, CTX-RYST achieves \"Cryo-Stasis\" (simultaneous suppression of ice and solution damage), establishing a low-toxicity cryopreservation paradigm that restores functional integrity for small-diameter vascular transplantation.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103439"},"PeriodicalIF":11.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface bioengineering of lanthanide nanoparticles for theranostic applications: From hydrophilic modification to multimodal imaging and therapy.","authors":"Xuan Tan, Yunqiu Zhang, Shuping Wu, Dengyu Ma, Jinyu Yan, Jinwei Lu, Shikai Lin, Shiyan Li, Zhexin Hong, Shihui Jiang, Guowei Li","doi":"10.1016/j.mtbio.2026.103462","DOIUrl":"10.1016/j.mtbio.2026.103462","url":null,"abstract":"<p><p>Lanthanide nanoparticles (LnNPs) are recognized as next-generation luminescent bioprobes due to their tunable emission spectra, long luminescence lifetimes, and high photostability. Although extensively studied, these nanomaterials have recently garnered renewed interest across biodetection, bioimaging, and therapeutics. To serve as suitable optical labels, LnNPs need to overcome inherent limitations such as hydrophobic surfaces, insufficient luminescence intensity, and limited environmental responsiveness. Accordingly, the integration of optical modulation, hydrophilic surface modification, and biofunctionality has become essential for advancing their biomedical applications. Recent surface engineering strategies have systematically addressed challenges related to hydrophilicity, colloidal stability, and biocompatibility, with substantial progress achieved. This review outlines mainstream approaches for hydrophilic surface modification and bio-functionalization of LnNPs, including ligand engineering, surface coating, and biomimetic modification. The design rationale and implementation of these methods are discussed, alongside representative applications in multimodal imaging and targeted therapy. Current challenges and future prospects in this rapidly evolving field are also summarized.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103462"},"PeriodicalIF":11.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Dual-layer microneedles for immunomodulation and infection-responsive therapy in diabetic foot ulcers' [Mater. Today Bio 35 (2025) 102490].","authors":"Li Chen, Mengyi Zhan, Li Zhang, Zhuohang Xiong, Chi Zhang, Xuanxuan Zhang, Zhengyang Yang, Lixin Ma, Yibin Cheng, Huanhuan Chen","doi":"10.1016/j.mtbio.2026.103464","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103464","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2025.102490.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103464"},"PeriodicalIF":11.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-reprogramming calcium alginate microspheres enhance exosome-mediated antigen cross-presentation to boost embolization-immunotherapy in hepatocellular carcinoma.","authors":"Xiaoju Guo, Shiji Fang, Liyun Zheng, Mengzhu Han, Yiming Ding, Jiale Chen, Pan Qin, Yeyu Zhang, Gaofeng Shu, Zhongwei Zhao, Xiaoqiang Li, Chenying Lu, Minjiang Chen, Jiansong Ji","doi":"10.1016/j.mtbio.2026.103459","DOIUrl":"10.1016/j.mtbio.2026.103459","url":null,"abstract":"<p><p>Transarterial chemoembolization (TACE) is a first-line therapeutic modality for hepatocellular carcinoma (HCC). Nevertheless, its therapeutic efficacy remains constrained by the hostile tumor microenvironment (TME), typified by acidity and an immunosuppressive milieu. Here, multifunctional microspheres (RC6CaAlgMS) were developed to neutralize the acidic TME and relieve immunosuppression. The uniform-sized calcium alginate microspheres were fabricated using microfluidic technology, incorporating pH-responsive CaCO₃ nanocarriers to efficiently encapsulate R848 and C6-ceramide (C6). Their physicochemical properties were characterized, and the embolization efficiency was validated using decellularized liver and rabbit kidney models. Furthermore, their antitumor activities and mechanism were evaluated in both <i>in vitro</i> and <i>in vivo</i>. R848 and C6 were efficiently encapsulated into RC6CaAlgMS, where they acted synergistically to reprogram tumor-associated macrophages (TAMs) toward an M1-like phenotype and to enhance both exosome secretion and exosome-mediated antigen cross-presentation. RC6CaAlgMS produced uniform vascular embolization and efficiently occluded the renal arterial branches. <i>In vitro</i> studies demonstrated that RC6CaAlgMS synergized with DOX-based chemotherapy to suppress the growth of murine HCC by neutralizing acidic TME and remodeling the immune landscape. When combined with PD-L1 blockade therapy, DOX-loaded RC6CaAlgMS effectively inhibited both primary and distant tumors, eliciting an abscopal-like effect driven by enhanced antigen dissemination and T-cell priming. In an orthotopic rat TACE model, the combination of DOX-loaded RC6CaAlgMS with PD-L1 blockade achieved complete tumor eradication. Collectively, this study establishes a multifunctional microsphere platform that effectively remodels and overcomes the post-TACE immunosuppressive TME, offering a potent strategy for integrating embolization with immunotherapy in HCC.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103459"},"PeriodicalIF":11.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-enabled ferroptosis self-amplifying nanoplatform synergizes with photothermal therapy to enhance chemotherapeutic efficacy against pancreatic cancer.","authors":"Pan Yang, Shuai He, Mingdong Xu, Yanying Sun, Jingyi Gao, Jian Chen, Tongtong Niu, Liguo Hao","doi":"10.1016/j.mtbio.2026.103469","DOIUrl":"10.1016/j.mtbio.2026.103469","url":null,"abstract":"<p><p>Pancreatic cancer responds poorly to conventional chemotherapy, largely because of the pronounced resistance of tumor cells to chemotherapy-induced apoptosis. Ferroptosis, a non-apoptotic form of programmed cell death, has emerged as a promising strategy to overcome this resistance. However, its therapeutic efficacy is often limited by insufficient hydrogen peroxide (H₂O₂) and excessive glutathione (GSH) in the tumor microenvironment (TME). Herein, we developed a nanoplatform, HM-MnO₂@DOX/CaO₂@PDA/HA (HMDCPH), using hollow mesoporous manganese dioxide (HM-MnO₂) as a carrier to co-deliver doxorubicin (DOX) and calcium peroxide (CaO₂). The crosslinked PDA/HA shell enhanced both the tumor-targeting capability and biocompatibility of the nanoplatform. In the TME, HM-MnO₂ depleted GSH and promoted reactive oxygen species (ROS) generation, whereas CaO₂ decomposition generated H₂O₂ and released Ca²⁺, inducing mitochondrial calcium overload and further aggravating oxidative stress. These synergistic effects enhanced lipid peroxidation (LPO) and exacerbated ferroptosis-related oxidative damage. Moreover, the near-infrared (NIR)-triggered photothermal effect further strengthened the antitumor efficacy of HMDCPH. In addition, nanoplatform degradation released Mn²⁺, enabling T₁-weighted magnetic resonance imaging (MRI). Collectively, this study presents a synergistic nanotherapeutic strategy that integrates chemotherapy, photothermal therapy, and ferroptosis-related mechanisms to overcome chemoresistance in pancreatic cancer.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103469"},"PeriodicalIF":11.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation\" [Mater. Today Bio 37 (2026) 103004].","authors":"Yongjun Chen, Haiyan Yao, Chen Li, Yun Zhou, Junlin Ren, Runhui Liu, Junchao Wei, Liang Hao","doi":"10.1016/j.mtbio.2026.103432","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103432","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2026.103004.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103432"},"PeriodicalIF":11.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered dual-responsive mucoadhesive hydrogel co-delivering fullerenol against radiation-induced vaginal injury and microbiota dysbiosis.","authors":"Maoru Zhao, Chengyan Wang, Yi Huang, Liangdi Wang, Jiangwei Xiao, Zhanjun Gu","doi":"10.1016/j.mtbio.2026.103470","DOIUrl":"10.1016/j.mtbio.2026.103470","url":null,"abstract":"<p><p>Radiation-induced vaginal injury (RIVI) is a prevalent complication following pelvic radiotherapy for gynecological cancers, which is mainly caused by severe mucosal oxidative stress triggered by highly destructive reactive oxygen species (ROS), such as hydroxyl radicals (·OH). Conventional prophylactic agents struggle due to instability, inadequate radical targeting, and short residence time in the vaginal lumen. To overcome the existing challenges, we develop a biomaterial-based prophylactic strategy that enables effective neutralization of toxic radicals and smart mucosal adhesion. Taking advantage of carbon-based nano-antioxidant fullerenol (FOH) as a reliable \"radical sponge\" for ·OH clearance, we engineer pH- and temperature-responsive amino-terminated Pluronic F127 (AF127) <i>in situ</i> hydrogel as the carrier of FOH. The AF127@FOH system is suitable for facile vaginal administration and can achieve <i>in situ</i> gelation. More importantly, AF127 can be protonated in the acidic vaginal environment, thereby enhancing mucoadhesion with vaginal mucins through electrostatic interactions and prolonging local residence. This design enables a locally sustained release of FOH, which inhibits the initial burst of ROS, mitigating oxidative damage, early tissue damage, and subsequent vaginal microbial dysbiosis. Our work provides an advanced topical treatment approach for RIVI and expands the application of smart biomaterials in mucosal radiation protection.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103470"},"PeriodicalIF":11.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering cuproptosis with nanomedicine: Design, combination therapy, and translation in cancer.","authors":"Dongsheng Fan, Jianxin Liu, Fang Ren, Long Wang, Jing Wei, Dalian Qin, Xiaogang Zhou, Jianming Wu, Xiao Zou, Anguo Wu","doi":"10.1016/j.mtbio.2026.103466","DOIUrl":"10.1016/j.mtbio.2026.103466","url":null,"abstract":"<p><p>Cuproptosis is a distinct form of regulated cell death triggered by copper and characterized by the aggregation of lipoylated mitochondrial proteins, destabilization of iron-sulfur cluster proteins, and proteotoxic stress. Unlike nonspecific copper toxicity, cuproptosis depends on a defined biochemical context shaped by FDX1-associated protein lipoylation, oxidative carbon metabolism, and mitochondrial substrate competence. These features may create a therapeutic vulnerability in tumors with high oxidative phosphorylation, but they also impose substantial translational challenges. Free copper ions and conventional copper ionophores often lack the tumor selectivity, pharmacological control, and safety required for systemic use, and copper exposure alone is insufficient unless it can be converted into sustained mitochondrial stress in susceptible tumor cells. Nanomedicine can provide spatiotemporal and chemical control over tumor copper stress. By enabling tumor-selective accumulation, stimulus-responsive activation, mitochondrial targeting, and modulation of copper homeostasis, nanoplatforms may help convert cuproptosis from a biochemical phenomenon into a therapeutically tractable strategy. These capabilities create opportunities to integrate cuproptosis with broader tumor vulnerabilities, including redox imbalance, metabolic plasticity, and altered immune states. This Review examines the molecular basis of cuproptosis and tumor susceptibility, the design and combination strategies of cuproptosis-oriented nanomedicines, and the translational challenges that must be addressed to move the field beyond proof of concept. Future advances are likely to depend on precise control of copper bioavailability and mitochondrial targeting, together with biomarker-guided patient selection and clinically tractable platform design.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103466"},"PeriodicalIF":11.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno-modulatory nanozyme film with self-switchable activity for adaptive infection-inflammation-repair cascade in wound infection therapy and healing.","authors":"Wenlong Zhang, Yilin Yuan, Jiaqi Liu, Jiang Du, Xinxin Zhao, Zhen Jin, Xianglong Zhu, Xiaojuan Huang, Dapeng Wu, Junqing Hu","doi":"10.1016/j.mtbio.2026.103465","DOIUrl":"10.1016/j.mtbio.2026.103465","url":null,"abstract":"<p><p>The key for nanozymes to achieving sequential infection-inflammation-repair in wound infection therapy and healing lies in how to resolve the contradiction of reactive oxygen species (ROS) regulation between antibacterial therapy and anti-inflammation. Herein, a freestanding pristine CuGeO₃ (CGO) nanozyme film (NF) composed of nanowires is first designed and simply synthesized. Such a NF with flexibility, wet tissue adhesion properties, alongside water/blood absorbing capability could serve as a wound dressing and present superb antibacterial/antibiofilm efficacy for photothermal/chemodynamic synergistic therapy of wound infection owing to its extraordinarily outstanding photothermal performance, and glutathione depletion-enhanced peroxidase-like activity to generate ROS in acidic infection microenvironments (IMEs). Attractively, it is disclosed that after completing infection therapy, the enzyme activity of this CGO NF automatically and continuously switches into catalase-like activity to eliminate ROS as IMEs switches into neutral microenvironments. This promotes the M2 phenotype polarization of macrophages to relieve inflammation and accelerate wound repair. Furthermore, the longer and entangled nanowire structure of the CGO NF prone to retention in the wound site minimizes its toxicity to healthy tissues. Overall, it is the first paradigm to leverage a photothermal NF consisting of inorganic nanomaterials only as a wound dressing. Based on such a safe, effective, activity-switchable NF dressing, adaptive infection-inflammation-repair cascade in wound infection therapy and healing has been realized, achieving 98.7% wound closure within 10 days. We believe this work will foster the therapeutic application of activity-switchable nanozymes, and provide meaningful insights into nanozymes-based wound infection therapy and healing.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103465"},"PeriodicalIF":11.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GenX exposure induces neurodevelopmental impairment and synaptic toxicity in hESC-derived cerebral organoids.","authors":"Sung-Ae Hyun, Young-Ju Lee, Moon Yi Ko, Euijun Min, Heejin Park, Younhee Kim, Dae Youn Hwang, Byoung-Seok Lee, Minhan Ka","doi":"10.1016/j.mtbio.2026.103458","DOIUrl":"10.1016/j.mtbio.2026.103458","url":null,"abstract":"<p><p>GenX, also known as hexafluoropropylene oxide dimer acid (HFPO-DA), was introduced in 2009 as a purportedly safer alternative to perfluorooctanoic acid (PFOA). However, nearly two decades of use have raised increasing safety concerns owing to its reported association with multiple forms of organ damage. However, only a few studies have systematically evaluated the molecular mechanisms underlying the neurotoxicity of GenX exposure. In this study, we aimed to investigate the neurodevelopmental impairments and synaptic toxicity induced by GenX during cortical development using human embryonic stem cell-derived cerebral organoids. We found that early exposure to GenX resulted in reduced organoid size and concentration-dependent deficits in basal neural progenitor cell proliferation. Moreover, GenX exposure prior to differentiation impaired synapse formation and decreased the number of excitatory synapses. We also found that early GenX exposure disrupted neural activity and altered neural network organization. RNA sequencing and Gene Ontology analyses revealed that these effects were associated with dysregulation of neuropeptide signaling pathways, synapse assembly, and postsynaptic organization. Collectively, these impairments in neurogenesis and neural activity indicate that GenX exerts neurotoxic effects and may pose a potential risk factor for neurodevelopmental disorders.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103458"},"PeriodicalIF":11.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}