Jia Liu , Sijin Chen , Wenli Zhang , Zhongsheng Xu , Yun Liu , Xiyue Rong , Ying Luo , Lian Xu , Junrui Wang , Yi Wang , Qianying Du , Bo Liu , Yu Zhang , Jie Xu , Dajing Guo
{"title":"一种用于内源性自我补氧的仿生纳米平台,促进靶向消融动脉粥样硬化斑块中活化巨噬细胞的声动力治疗","authors":"Jia Liu , Sijin Chen , Wenli Zhang , Zhongsheng Xu , Yun Liu , Xiyue Rong , Ying Luo , Lian Xu , Junrui Wang , Yi Wang , Qianying Du , Bo Liu , Yu Zhang , Jie Xu , Dajing Guo","doi":"10.1016/j.mtbio.2025.102338","DOIUrl":null,"url":null,"abstract":"<div><div>Atherosclerosis (AS) is a chronic inflammatory condition associated with increased morbidity and mortality. Nanomaterial-based sonodynamic therapy (SDT) shows considerable potential as a noninvasive treatment for AS. The efficacy of SDT is often limited by the unstable generation of reactive oxygen species (ROS) due to inadequate oxygen availability in the cellular microenvironment. In this study, a biomimetic nanoplatform (HMnO<sub>2</sub>-Ce6@MM; HMC@MM) was constructed by coating hollow manganese dioxide (HMnO<sub>2</sub>) nanoparticles loaded with Chlorine e6 (Ce6) with macrophage membranes (MMs) to increase the ROS level for effective ablation of activated macrophages. HMC@MM is actively transported to activated macrophages in atherosclerotic plaques. In the slightly acidic and rich hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) environment of plaques, HMnO<sub>2</sub> reacts with H<sub>2</sub>O<sub>2</sub> to produce Mn<sup>2+</sup> and oxygen. Mn<sup>2+</sup> is applicable in magnetic resonance imaging to detect unstable plaques. Under the condition of endogenous self-replenishing oxygen, HMC@MM-mediated SDT can produce sufficient ROS, subsequently initiating mitochondrial dysfunction and inducing the apoptosis of activated macrophages. Ablation of activated macrophages not only alleviated the inflammatory environment but the apoptotic fragments also triggered efferocytosis of fresh macrophages in the plaque, thereby effectively controlling unstable plaques. The HMC@MM-mediated SDT strategy has comprehensive effects on controlling atherosclerotic plaque progression.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102338"},"PeriodicalIF":10.2000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A biomimetic nanoplatform for endogenous self-replenishing of oxygen to promote sonodynamic therapy for targeted ablation of activated macrophages in atherosclerotic plaques\",\"authors\":\"Jia Liu , Sijin Chen , Wenli Zhang , Zhongsheng Xu , Yun Liu , Xiyue Rong , Ying Luo , Lian Xu , Junrui Wang , Yi Wang , Qianying Du , Bo Liu , Yu Zhang , Jie Xu , Dajing Guo\",\"doi\":\"10.1016/j.mtbio.2025.102338\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Atherosclerosis (AS) is a chronic inflammatory condition associated with increased morbidity and mortality. Nanomaterial-based sonodynamic therapy (SDT) shows considerable potential as a noninvasive treatment for AS. The efficacy of SDT is often limited by the unstable generation of reactive oxygen species (ROS) due to inadequate oxygen availability in the cellular microenvironment. In this study, a biomimetic nanoplatform (HMnO<sub>2</sub>-Ce6@MM; HMC@MM) was constructed by coating hollow manganese dioxide (HMnO<sub>2</sub>) nanoparticles loaded with Chlorine e6 (Ce6) with macrophage membranes (MMs) to increase the ROS level for effective ablation of activated macrophages. HMC@MM is actively transported to activated macrophages in atherosclerotic plaques. In the slightly acidic and rich hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) environment of plaques, HMnO<sub>2</sub> reacts with H<sub>2</sub>O<sub>2</sub> to produce Mn<sup>2+</sup> and oxygen. Mn<sup>2+</sup> is applicable in magnetic resonance imaging to detect unstable plaques. Under the condition of endogenous self-replenishing oxygen, HMC@MM-mediated SDT can produce sufficient ROS, subsequently initiating mitochondrial dysfunction and inducing the apoptosis of activated macrophages. Ablation of activated macrophages not only alleviated the inflammatory environment but the apoptotic fragments also triggered efferocytosis of fresh macrophages in the plaque, thereby effectively controlling unstable plaques. The HMC@MM-mediated SDT strategy has comprehensive effects on controlling atherosclerotic plaque progression.</div></div>\",\"PeriodicalId\":18310,\"journal\":{\"name\":\"Materials Today Bio\",\"volume\":\"35 \",\"pages\":\"Article 102338\"},\"PeriodicalIF\":10.2000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Today Bio\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590006425009093\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590006425009093","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
A biomimetic nanoplatform for endogenous self-replenishing of oxygen to promote sonodynamic therapy for targeted ablation of activated macrophages in atherosclerotic plaques
Atherosclerosis (AS) is a chronic inflammatory condition associated with increased morbidity and mortality. Nanomaterial-based sonodynamic therapy (SDT) shows considerable potential as a noninvasive treatment for AS. The efficacy of SDT is often limited by the unstable generation of reactive oxygen species (ROS) due to inadequate oxygen availability in the cellular microenvironment. In this study, a biomimetic nanoplatform (HMnO2-Ce6@MM; HMC@MM) was constructed by coating hollow manganese dioxide (HMnO2) nanoparticles loaded with Chlorine e6 (Ce6) with macrophage membranes (MMs) to increase the ROS level for effective ablation of activated macrophages. HMC@MM is actively transported to activated macrophages in atherosclerotic plaques. In the slightly acidic and rich hydrogen peroxide (H2O2) environment of plaques, HMnO2 reacts with H2O2 to produce Mn2+ and oxygen. Mn2+ is applicable in magnetic resonance imaging to detect unstable plaques. Under the condition of endogenous self-replenishing oxygen, HMC@MM-mediated SDT can produce sufficient ROS, subsequently initiating mitochondrial dysfunction and inducing the apoptosis of activated macrophages. Ablation of activated macrophages not only alleviated the inflammatory environment but the apoptotic fragments also triggered efferocytosis of fresh macrophages in the plaque, thereby effectively controlling unstable plaques. The HMC@MM-mediated SDT strategy has comprehensive effects on controlling atherosclerotic plaque progression.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).