Materials Today Bio最新文献

Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair. 使用纳米颗粒/水凝胶混合系统顺序递送IL-10和淫羊藿苷促进骨缺损修复。

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1016/j.mtbio.2024.101374

Xiaojun Li, Zeyue Sun, Xiushuai Shang, Liuting Chen, Xiaofeng Shi, Wei Xu, Shaotian Fu, Qingling He, Qihao Liang, Jie Ma, Xin Sun, Jiaju Lu, Wenjie Jin

{"title":"Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair.","authors":"Xiaojun Li, Zeyue Sun, Xiushuai Shang, Liuting Chen, Xiaofeng Shi, Wei Xu, Shaotian Fu, Qingling He, Qihao Liang, Jie Ma, Xin Sun, Jiaju Lu, Wenjie Jin","doi":"10.1016/j.mtbio.2024.101374","DOIUrl":"10.1016/j.mtbio.2024.101374","url":null,"abstract":"<p><p>The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and sequential delivery of an anti-inflammatory factor (IL-10) and osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) and heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, and poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into the composite hydrogels. The nanoparticle/hydrogel hybrid system demonstrates an array of features including mechanical strength, injectability and photo-crosslinking. The rapid release of IL-10 from the hydrogel effectively exerts immunomodulatory activity, whereas the long-term sustained release of icariin from the PLGA-HA nanoparticles significantly triggers the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Notably, the combined delivery of IL-10 and ICA from the hybrid system exhibit a synergistic effect for bone remodeling in a critical cranial defect rat model. Our findings indicate the importance of the immunomodulatory microenvironment and osteogenic differentiation for high-quality skull remodeling, and thus the dual-factor releasing nanoparticle/hydrogel hybrid system could be a promising candidate for repairing bone defects.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"101374"},"PeriodicalIF":8.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable direct spraying porous nanofibrous membranes stent-loaded polymyxin B for treating diabetic wounds with difficult-to-heal gram-negative bacterial infections 便携式直接喷涂多孔纳米纤维膜支架负载多粘菌素B治疗糖尿病伤口难以愈合的革兰氏阴性细菌感染

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101365

Xiaolan Ou , Wenlai Guo , Heng Tian , Daojiang Yu , Rui Li , Guanghui Gao , Wenrui Qu

{"title":"Portable direct spraying porous nanofibrous membranes stent-loaded polymyxin B for treating diabetic wounds with difficult-to-heal gram-negative bacterial infections","authors":"Xiaolan Ou , Wenlai Guo , Heng Tian , Daojiang Yu , Rui Li , Guanghui Gao , Wenrui Qu","doi":"10.1016/j.mtbio.2024.101365","DOIUrl":"10.1016/j.mtbio.2024.101365","url":null,"abstract":"<div><div>Gram-negative bacteria infections in diabetic wounds are complicated to control, leading to amputation and even death in severe cases. There is an urgent need to develop effective therapeutic strategies. In recent years, electrospinning has attracted much attention due to its resemblance to extracellular matrix (ECM), which can regulate local cellular proliferation, migration, differentiation, etc.; however, its use is limited by its high cost and difficulty in transportation. This study proposes a portable direct-injection porous fibre scaffold containing polymyxin B (PMB) for local slow release for treating diabetic wounds infected with difficult-to-heal Gram-negative bacteria. The handheld portable electrospinner is lightweight and easy to operate and can be directly sprayed in situ to cover wounds with irregular shapes and sizes. When covering the wound in situ, the PVB/PVP nanofiber membrane can protect it from the external environment. Meanwhile, the nanofiber membrane dressing has a porosity of 20 % and a controlled drug-loading capacity. What's more, the evaluation of a whole skin defect model of type II diabetes mellitus infected with Gram-negative bacteria showed that the PMB-loaded nanofiber membrane could effectively inhibit Gram-negative bacteria infection, promote collagen deposition and re-epithelialization, and regulate the polarization of M1-type macrophages to M2-type macrophages, thereby controlling inflammation and promoting vascular regeneration, and significantly accelerating the healing of diabetic wounds. Overall, portable direct-injection porous fibre scaffold-loaded drugs are essential for healing difficult-to-heal wounds as local slow-release drug delivery.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101365"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma 用于TACE治疗的可降解水凝胶可增强肝细胞癌的抗肿瘤免疫

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101343

Xiaokai Zhang , Xiujiao Deng , Jizhou Tan , Haikuan Liu , Hong Zhang , Chengzhi Li , Qingjun Li , Jinxue Zhou , Zeyu Xiao , Jiaping Li

{"title":"Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma","authors":"Xiaokai Zhang , Xiujiao Deng , Jizhou Tan , Haikuan Liu , Hong Zhang , Chengzhi Li , Qingjun Li , Jinxue Zhou , Zeyu Xiao , Jiaping Li","doi":"10.1016/j.mtbio.2024.101343","DOIUrl":"10.1016/j.mtbio.2024.101343","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is a common and deadly cancer, often diagnosed at advanced stages, limiting surgical options. Transcatheter arterial chemoembolization (TACE) is a primary treatment for inoperable and involves the use of drug-eluting microspheres to slowly release chemotherapy drugs. However, patient responses to TACE vary, with some experiencing tumor progression and recurrence. Traditional TACE uses agents like oil-based drug emulsions and polyvinyl alcohol particles, which can permanently block blood vessels and increase tumor hypoxia. Additionally, TACE can suppress the immune system by reducing immune cell numbers and function, contributing to poor treatment outcomes. New approaches, like TACE using degradable starch microspheres and hydrogel-based materials, offer the potential to create different tumor environments that could improve both safety and efficacy. In our research, we developed a composite hydrogel (IF@Gel) made of Poloxamer-407 gel and Fe<sub>3</sub>O<sub>4</sub> nanoparticles, loaded with idarubicin, to use as an embolic material for TACE in a rat model of orthotopic HCC. We observed promising therapeutic effects and investigated the impact on the tumor immune microenvironment, focusing on the role of immunogenic cell death (ICD). The composite hydrogel demonstrated excellent potential as an embolic material for TACE, and IF@Gel-based TACE demonstrated significant efficacy in rat HCC. Furthermore, our findings highlight the potential synergistic effects of ICD with anti-PD-L1 therapy, providing new insights into HCC treatment strategies. This study aims to provide improved treatment options for HCC and to deepen our understanding of the mechanisms of TACE and tumor environment regulation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101343"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Killing two birds with one stone: Siglec-15 targeting integrated bioactive glasses hydrogel for treatment of breast cancer bone metastasis 一举两得：siglece -15靶向整合生物活性玻璃水凝胶治疗乳腺癌骨转移

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101362

Chengkuan Liu , Yangui Zhong , Haibo Huang , Siyuan Lan , Jing Li , Deqiu Huang , Wen Zhang

{"title":"Killing two birds with one stone: Siglec-15 targeting integrated bioactive glasses hydrogel for treatment of breast cancer bone metastasis","authors":"Chengkuan Liu , Yangui Zhong , Haibo Huang , Siyuan Lan , Jing Li , Deqiu Huang , Wen Zhang","doi":"10.1016/j.mtbio.2024.101362","DOIUrl":"10.1016/j.mtbio.2024.101362","url":null,"abstract":"<div><div>Bone metastasis is a fatal consequence of breast cancer that occurs when patients fail to respond to conventional therapies and mainly result from a vicious cycle involving dysregulated bone homeostasis and uncontrolled tumor growth. Recent research has underscored the significance of Siglec-15, a membrane protein implicated in immunosuppression and osteoclast generation. Targeting Siglec-15 may disrupt the “vicious cycle” that causes bone metastases in patients with breast cancer. Herein, we explored the efficacy of targeting Siglec-15 in conjunction with photothermal chemotherapy to impede the progression of bone metastatic during breast cancer and repair tumor-induced osteolysis. First, we formulated an injectable photothermal bioactive glass (BG)-based hydrogel for the local delivery of Siglec-15 shRNA and doxorubicin. The results demonstrated that the hydrogel could kill tumor cells directly through photothermal chemotherapy, provoke intense immune responses and improve the local immunosuppressive microenvironment, which could effectively prevent tumor metastasis and recurrence in a murine model. The combined effect of BGs and Siglec15 shRNA can normalize dysregulated bone homeostasis at the bone metastasis site and significantly reduced bone destruction. Overall, the use of Siglec-15-targeting integrated BG hydrogels may provide a promising therapeutic strategy for treating bone metastasis caused by breast cancer.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101362"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating acute lung injury through scavenging of cell-free DNA by cationic nanoparticles 阳离子纳米颗粒清除游离DNA治疗急性肺损伤

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101360

Ziyan Huang , Cong Wei , Hanbin Xie , Xue Xiao , Tienan Wang , Yihan Zhang , Yongming Chen , Ziqing Hei , Tianyu Zhao , Weifeng Yao

引用次数: 0

Scalable fabrication of freely shapable 3D hierarchical Cu-doped hydroxyapatite scaffolds via rapid gelation for enhanced bone repair 快速凝胶法制备可自由成形的三维分层掺铜羟基磷灰石支架，增强骨修复

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101370

Hui Yang , Sirui Huang , Xinwei Zhu , Yasi Chen , Chunming Xu , Ruohan Li , Pan Bu , Yufan Jiang , Changwei Li , Jie Yang , Zhenyi Chen , Weijie Peng , Lin Liu

{"title":"Scalable fabrication of freely shapable 3D hierarchical Cu-doped hydroxyapatite scaffolds via rapid gelation for enhanced bone repair","authors":"Hui Yang , Sirui Huang , Xinwei Zhu , Yasi Chen , Chunming Xu , Ruohan Li , Pan Bu , Yufan Jiang , Changwei Li , Jie Yang , Zhenyi Chen , Weijie Peng , Lin Liu","doi":"10.1016/j.mtbio.2024.101370","DOIUrl":"10.1016/j.mtbio.2024.101370","url":null,"abstract":"<div><div>Critical-sized bone defects present a formidable challenge in tissue engineering, necessitating innovative approaches that integrate osteogenesis and angiogenesis for effective repair. Inspired by the hierarchical porous structure of natural bone, this study introduces a novel method for the scalable production of ultra-long, copper-doped hydroxyapatite (Cu-HAp) fibers, utilizing the rapid gelation properties of guar gum (GG) under controlled conditions. These fibers serve as foundational units to fabricate three-dimensional porous scaffolds with a biomimetic hierarchical architecture. The scaffolds exhibit a broad pore size distribution (1–500 μm) and abundant nanoporous features, mimicking the native bone extracellular matrix. Physicochemical characterization and <em>in vitro</em> assays demonstrated that the copper doping significantly enhanced osteogenic and angiogenic activities, with optimized concentrations (0.8 % and 1.2 % Cu) facilitating the upregulation of osteogenesis-related genes and proteins, as well as promoting endothelial cell proliferation. <em>In vivo</em> studies further confirmed the scaffolds' efficacy, with the 1.2Cu-HAp group showing a remarkable increase in bone regeneration (bone volume/total volume ratio: 35.7 ± 1.87 %) within the defect site. This research offers a promising strategy for the rapid fabrication of multifunctional scaffolds that not only support bone tissue repair but also actively accelerate the healing process through enhanced vascularization.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101370"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration 微环境反应性可注射水凝胶用于神经血管骨再生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101369

Wanshun Wang , Hu Chen , Jiacong Xiao , Dan Luo , Yonghui Hou , Jiheng Zhan , Yu Hou , Xing Li , Huili Yang , Shudong Chen , Dingkun Lin

{"title":"Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration","authors":"Wanshun Wang , Hu Chen , Jiacong Xiao , Dan Luo , Yonghui Hou , Jiheng Zhan , Yu Hou , Xing Li , Huili Yang , Shudong Chen , Dingkun Lin","doi":"10.1016/j.mtbio.2024.101369","DOIUrl":"10.1016/j.mtbio.2024.101369","url":null,"abstract":"<div><div>Bone is a richly innervated and vascularized tissue, whereas nerve-vascular network reconstruction was often ignored in biomaterial design, resulting in delayed or incomplete bone healing. Inspired by the bone injury microenvironments, here we report a controllable drug delivery strategy using a pH and reactive oxygen species (ROS) dual-response injectable hydrogel. Based on the dynamic borate ester bond covalent crosslinking, nano-hydroxyapatite (HA) and curculigoside (CCG) are integrated into PVA/TSPBA (PT) to construct a responsive injectable hydrogel (PTHC), which scavenges excessive ROS from the injury microenvironment and responsively releases HA and CCG, providing favorable homeostasis and <em>in situ</em> sustained release drug delivery system for bone repair. Additionally, PTHC hydrogel can alleviate ROS-mediated intracellular oxidative and exhibit multiple biological activities of angiogenesis, neurogenesis, and osteogenesis. Furthermore, it reconstructs the microvascular network, accelerates sensory nerve repair, secretes neurotransmitters and bioactive factors, and improves neuro-vascularized bone regeneration. This multi-bioactive injectable hydrogel system offers a promising advance in therapeutic materials for bone repair.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101369"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A three-phase strategy of bionic drug reservoir scaffold by 3D printing and layer-by-layer modification for chronic relapse management in traumatic osteomyelitis 外伤性骨髓炎慢性复发治疗的3D打印及逐层修饰仿生药物储存库支架三相策略

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101356

Yutong Zhang , Tongtong Xu , Tieshu Li , Hening Chen , Guangzhe Xu , Wenxin Hu , Yongting Li , Yue Dong , Zhihui Liu , Bing Han

{"title":"A three-phase strategy of bionic drug reservoir scaffold by 3D printing and layer-by-layer modification for chronic relapse management in traumatic osteomyelitis","authors":"Yutong Zhang , Tongtong Xu , Tieshu Li , Hening Chen , Guangzhe Xu , Wenxin Hu , Yongting Li , Yue Dong , Zhihui Liu , Bing Han","doi":"10.1016/j.mtbio.2024.101356","DOIUrl":"10.1016/j.mtbio.2024.101356","url":null,"abstract":"<div><div>We have developed a novel three-phase strategy for osteomyelitis treatment, structured into three distinct phases: the “strong antimicrobial” phase, the “monitoring and osteogenesis” phase and the “bone repair” phase. To implement this staged therapeutic strategy, we engineered a bionic drug reservoir scaffold carrying a dual-drug combination of antimicrobial peptides (AMPs) and simvastatin (SV). The scaffold integrated a bilayer gel drug-carrying structure, based on an induced membrane and combined with a 3D-printed rigid bone graft using a layer-by-layer modification strategy. The mechanical strength of the composite scaffold (73.40 ± 22.44 MPa) is comparable to that of cancellous bone. This scaffold enables controlled, sequential drug release through a spatial structure design and nanoparticle drug-carrying strategy. AMPs are released rapidly, with the release efficiency of 74.90 ± 8.19 % at 14 days (pH = 7.2), thus enabling rapid antimicrobial therapy. Meanwhile, SV is released over a prolonged period, with a release efficiency of 98.98 ± 0.05 % over 40 days in vitro simulations, promoting sustained osteogenesis and facilitating the treatment of intracellular infections by activating macrophage extracellular traps (METs). The antimicrobial, osteogenic and immunomodulatory effects of the scaffolds were verified through in vitro and in vivo experiments. It was demonstrated that composite scaffolds were able to combat the chronic recurrence of osteomyelitis after debridement, by providing rapid sterilization, stimulating METs formation, and supporting osteogenic repair.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101356"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

99mTc/90Y radiolabeled biodegradable gel microspheres for lung shutting fraction assessment and radioembolization in hepatocellular carcinoma theranostics 99mTc/90Y放射标记可生物降解凝胶微球用于肝细胞癌治疗中的肺关闭分数评估和放射栓塞

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101367

Yi Dong , Lingling Yin , Jintao Huang , Di Hu , Jing Sun , Zhe Zhang , Zhihao Li , Bin-Yan Zhong , Ran Zhu , Guanglin Wang

{"title":"99mTc/90Y radiolabeled biodegradable gel microspheres for lung shutting fraction assessment and radioembolization in hepatocellular carcinoma theranostics","authors":"Yi Dong , Lingling Yin , Jintao Huang , Di Hu , Jing Sun , Zhe Zhang , Zhihao Li , Bin-Yan Zhong , Ran Zhu , Guanglin Wang","doi":"10.1016/j.mtbio.2024.101367","DOIUrl":"10.1016/j.mtbio.2024.101367","url":null,"abstract":"<div><div>Transarterial radioembolization (TARE) is a well-established clinical therapy for the treatment of patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who are ineligible for radical treatment. However, commercialized radioactive microspheres still have some issues, such as high density, complicated preparation, non-biodegradability. Furthermore, the use of different radioactive microspheres during TARE and lung shunt fraction assessment has led to inconsistencies in biodistribution in certain cases. This study employed biodegradable hyaluronic acid (HA) as the backbone and modified with bisphosphonate and methacrylic acid to prepare biodegradable gel microspheres (HAMS) using the water-in-oil emulsification and photo-crosslinking for labeling the diagnostic radionuclide of <sup>99m</sup>Tc and therapeutic radionuclide of <sup>90</sup>Y. Both <sup>99m</sup>Tc radiolabeled HAMS (<sup>99m</sup>Tc-HAMS) and radiolabeled <sup>90</sup>Y-HAMS (<sup>90</sup>Y-HAMS) were highly efficient in radiolabeling and exhibited excellent radiostability <em>in vitro</em> and <em>in vivo</em>. <sup>99m</sup>Tc-HAMS are highly effective in assessing the LSF, while <sup>90</sup>Y-HAMS, administered though TARE, are effective in inhibiting the growth of in situ HCC without any side effects. Both <sup>99m</sup>Tc-HAMS and <sup>90</sup>Y-HAMS have promising clinical applications in HCC theranostics.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101367"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis 增强了自愈透明质酸水凝胶对骨关节炎早期干预的治疗潜力

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-12-01 DOI: 10.1016/j.mtbio.2024.101353

Dongze Wu , Shuhui Yang , Zhe Gong , Xinxin Zhu , Juncong Hong , Haitao Wang , Wenbin Xu , Juncheng Lai , Xiumei Wang , Jiye Lu , Xiangqian Fang , Guoqiang Jiang , Jinjin Zhu

{"title":"Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis","authors":"Dongze Wu , Shuhui Yang , Zhe Gong , Xinxin Zhu , Juncong Hong , Haitao Wang , Wenbin Xu , Juncheng Lai , Xiumei Wang , Jiye Lu , Xiangqian Fang , Guoqiang Jiang , Jinjin Zhu","doi":"10.1016/j.mtbio.2024.101353","DOIUrl":"10.1016/j.mtbio.2024.101353","url":null,"abstract":"<div><div>Osteoarthritis (OA) is characterized by symptoms such as abnormal lubrication function of synovial fluid and heightened friction on the cartilage surface in its early stages, prior to evident cartilage damage. Current early intervention strategies employing lubricated hydrogels to shield cartilage from friction often overlook the significance of hydrogel-cartilage adhesion and enhancement of the cartilage extracellular matrix (ECM). Herein, we constructed a hydrogel based on dihydrazide-modified hyaluronic acid (HA) (AHA) and catechol-conjugated aldehyde-modified HA (CHA), which not only adheres to the cartilage surface as an effective lubricant but also improves the extracellular environment of chondrocytes in OA. Material characterization experiments on AHA/CHA hydrogels with varying concentrations validated their exceptional self-healing capabilities, superior injectability and viscoelasticity, sustained adhesion strength to cartilage, and a low friction coefficient. Chondrocytes exhibited robust adhesion and proliferation on the AHA/CHA hydrogel surface, with the upregulation of cartilage matrix protein expression. Intra-articular injection of AHA/CHA hydrogels was performed following destabilization of the medial meniscus (DMM) surgery in mice to assess its protective effect on cartilage. The AHA/CHA hydrogel effectively attenuated the degree of cartilage wear, facilitated chondrocytes' anabolic metabolism, and restored the ECM of cartilage. Therefore, the AHA/CHA hydrogel emerges as a promising therapeutic approach in clinical practices of OA treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101353"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0