Materials Today Bio最新文献

{"title":"Decellularized cartilage scaffolds derived from wharton's jelly facilitate cartilage regeneration and inhibit angiogenesis","authors":"Fawei Gao ,&nbsp;Shilong Su ,&nbsp;Jun Qi ,&nbsp;Zhigang Li ,&nbsp;Chenggong Wang ,&nbsp;Da Zhong","doi":"10.1016/j.mtbio.2025.102023","DOIUrl":"10.1016/j.mtbio.2025.102023","url":null,"abstract":"<div><div>The avascular nature of articular cartilage severely limits its ability to self-repair after injury, which poses a challenge for clinical treatment, and tissue engineering aims to address this issue with scaffold-based strategies. However, the defining characteristics of an optimal scaffold remain controversial. In this study, we prepared two types of decellularized wharton's jelly (dWJ) scaffolds by trypsin combined with repeated freeze-thawing (TFT) and nuclease combined with repeated freeze-thawing (NFT), respectively. The scaffolds were tested with general characterization, decellularization effect, extracellular matrix (ECM) composition and structure retention, mechanical properties, biocompatibility, in vivo and in vitro chondrogenic effects, and in vitro anti-angiogenic effects. The results showed that the TFT-dWJ scaffolds possessed higher pore size, porosity, and swelling rate, but their Young's modulus was lower than that of the NFT-dWJ scaffolds. Both scaffolds were generally similar in terms of degradation rates. In comparison, the native ECM structure and the major components of collagen and glycosaminoglycans were better preserved in NFT-dWJ scaffolds. Importantly, dWJ scaffolds showed favorable biocompatibility and markedly promoted the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro, and accelerated cartilage damage repair in vivo. This was particularly evident with NFT-dWJ. Secondly, the dWJ scaffolds exhibited the capability to inhibit localized angiogenesis in human umbilical vein endothelial cells (HUVECs), a property that could be advantageous for preserving avascularity throughout the cartilage regeneration process. This study presents an ECM-derived scaffold fabrication strategy that optimally preserves matrix composition and microstructure, offering a promising solution for cartilage regeneration.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102023"},"PeriodicalIF":8.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic tumor cell membrane-camouflaged nanomicelles for synergistic chemo-immunotherapy of Triple-negative breast cancer","authors":"Xiaoman Xu ,&nbsp;Yunmei Song ,&nbsp;Mingli Li ,&nbsp;Fengxi Liu ,&nbsp;Huiwen Zhang ,&nbsp;Jingxia Xu ,&nbsp;Juwei Gao ,&nbsp;Yanna Lv ,&nbsp;Bo Zhang ,&nbsp;Sanjay Garg","doi":"10.1016/j.mtbio.2025.102012","DOIUrl":"10.1016/j.mtbio.2025.102012","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) remains a clinical challenge due to its aggressive nature. Conventional chemo-immunotherapy suffers from poor tumor targeting and systemic toxicity, necessitating advanced delivery systems for synergistic drug combinations. This study constructed a biomimetic nanodrug delivery system by coating nanomicelles with 4T1 tumor cell membranes. This strategy leverages the homologous targeting ability of tumor cell membranes to improve the accumulation of nanomicelles within TNBC tissues. The cytotoxic agent bortezomib (BTZ) and the immune modulator resiquimod (R848) were encapsulated individually and co-administered to investigate the synergistic chemo-immunotherapeutic efficacy in TNBC treatment. The biomimetic nanomicelles exhibited excellent biocompatibility and homologous targeting capacity, significantly enhancing drug delivery efficiency at the tumor site. <em>In vitro</em> studies demonstrated that biomimetic nanomicelles effectively induced tumor cell apoptosis, repolarized tumor-associated macrophages toward the M1 phenotype and promoted dendritic cell maturation. <em>In vivo</em> experiments further confirmed that the biomimetic nanomicelles markedly inhibited tumor growth and metastasis, enhanced antitumor immune responses, and exhibited strong synergy with BTZ to improve overall therapeutic outcomes in TNBC. This dual-action biomimetic nanomicelles delivery platform achieved efficient chemo-immunotherapeutic synergy and represents a promising strategy for targeted treatment of TNBC, with strong potential for clinical translation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102012"},"PeriodicalIF":8.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation","authors":"Jianyu Qiu ,&nbsp;Xitong Kang ,&nbsp;Tao Liu ,&nbsp;Jing Liu ,&nbsp;Huansheng Liu ,&nbsp;Xiyang Zhao ,&nbsp;Yong Li ,&nbsp;Qi Liu ,&nbsp;Zhenzhen Nong ,&nbsp;Qingwen Wang ,&nbsp;Zhenzhen Liu","doi":"10.1016/j.mtbio.2025.102017","DOIUrl":"10.1016/j.mtbio.2025.102017","url":null,"abstract":"<div><div>Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by one-step of directed freeze-casting technique via utilizing the FDA-approved poly (vinyl alcohol) (PVA) and carboxymethylcellulose nanofibril (CNF) as the network backbone without any chemical crosslinker. This fully physical crosslinked hydrogel exhibits remarkable mechanical performance because of the highly oriented microstructure and multiple hydrogen bonding, including the matching mechanical property with soft tissue, anti-tearing capability, the great 99 % retention of tensile stress and higher toughness after soaking at PBS for 7 days. And the extremely low swelling ratio of 5.9 % in PBS and combining the higher water-content is superior to other reported anti-swelling hydrogel. Importantly, besides as a robust physical barrier of this hydrogel patch, it also displays the excellent inflammatory regulation via capturing the positively charged proinflammatory cytokines because of the incorporation of the negatively charged CNF, synergistically promoting the remarkable anti-adhesion and tissue pro-healing efficiency. By integrating the anti-adhesion, tissue pro-healing, long-lasting anti-deformation in vivo and excellent bio-compatibility, this hydrogel provides a great candidate of anti-adhesion patch for tension-free repair operations.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102017"},"PeriodicalIF":8.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions","authors":"Rui Fang ,&nbsp;Ning Yu ,&nbsp;Simeng Chen ,&nbsp;Xi Xu ,&nbsp;Jianfa Zhang","doi":"10.1016/j.mtbio.2025.102021","DOIUrl":"10.1016/j.mtbio.2025.102021","url":null,"abstract":"<div><div>Postoperative anti-adhesion materials face significant challenges, including dislocation, the induction of nonspecific tissue adhesions, and secondary fibrinolytic disorders. In this study, we developed a self-leveling, transient, unilaterally bonded Janus patch (J-HD) based on hemoadhican (HD). This patch consists of three distinct functional layers: an anti-adhesion layer, a reinforcement layer, and a wet tissue adhesion layer. Each layer serves a specific purpose: the bottom anti-adhesion layer, composed of HD and Pluronic F127 (PF127), effectively prevents cells, proteins, and tissues from adhering; the middle polyvinyl alcohol (PVA) reinforcement layer enhances the mechanical properties of the film, exhibiting a tensile strength of approximately 2.02 MPa; and the top HD adhesion layer provides strong adhesion to wet tissue with an interfacial toughness of approximately 223.85 J/m². The J-HD patches demonstrate excellent self-leveling ability, unilateral adhesion properties, and effective resistance to fibrin and cell adhesion <em>in vitro</em>. In a rat cecum-abdominal wall adhesion model, the J-HD patch exhibited a significant reduction in abdominal adhesions compared to commercially available Interceed® films. Mechanistically, the J-HD patch effectively regulates the fibrinolytic balance by modulating the levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1), promoting a nonadherent state, reducing excessive inflammatory responses, and facilitating the repair of intestinal wall integrity. <em>In vivo</em> implantation of the J-HD patch does not exhibit significant acute or chronic toxicity, elicits a favorable host response, and demonstrates biocompatibility. This study presents a potential strategy for the clinical design of Janus patches with anti-migratory and anti-adhesive properties.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102021"},"PeriodicalIF":8.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond natural silk: Bioengineered silk fibroin for bone regeneration","authors":"Keyu Zhou ,&nbsp;Tao Yuan ,&nbsp;Supeng Wang ,&nbsp;Fengyang Hu ,&nbsp;Li Luo ,&nbsp;Liang Chen ,&nbsp;Lei Yang","doi":"10.1016/j.mtbio.2025.102014","DOIUrl":"10.1016/j.mtbio.2025.102014","url":null,"abstract":"<div><div>Bone regeneration and repair are among the most challenging clinical challenges to overcome. Despite extensive research on bone-tissue repair and regeneration, it remains difficult to achieve perfect regeneration and repair of bone tissue using the current treatments. One new treatment is bone-tissue engineering (TE), which has attracted attention because of its low invasiveness. Silk fibroin (SF), a high-molecular-weight natural fibrous protein secreted by silkworms and spiders, is an ideal choice for melt electrowriting (MEW) of bone TE scaffolds owing to its superior mechanical properties, controlled biodegradation rate, and high biocompatibility. It contains 18 essential amino acids and is widely used in bone grafting. Their physical and chemical properties may be essential for stem cell growth and differentiation, making them ideal scaffold materials for bone TE. In this review, the three primary components of bone TE and the bone-healing process are presented. With an emphasis on recent advancements and the use of bone TE, both in <em>vitro</em> and in <em>vivo</em>, we examined the use of SF in bone TE from the standpoint of its origin and structure. To offer new concepts and avenues for related research, we have also looked at the possible topics for SF research and the present difficulties.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102014"},"PeriodicalIF":8.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red-emissive carbon dot-cobalt oxyhydroxide nanosystem: A turn-on sensor for α-Glucosidase activity and inhibitor identification","authors":"Huihui Sun ,&nbsp;Chuanyuan Gao ,&nbsp;Yumin Yang ,&nbsp;Changqing Liu ,&nbsp;Han Qin ,&nbsp;Mengyuan Tan ,&nbsp;Jin Li ,&nbsp;Xiaoxia Li ,&nbsp;Kunze Du ,&nbsp;Yanxu Chang","doi":"10.1016/j.mtbio.2025.102018","DOIUrl":"10.1016/j.mtbio.2025.102018","url":null,"abstract":"<div><div>The development of efficient methods for sensing αlpha-glucosidase (α-Glu) and screening its inhibitors has attracted significant attention due to their pivotal role in discovering therapeutic medicines for Type 2 diabetes. Herein, a low-cost and sensitive fluorometric strategy based on red carbon dots (R-CDs) and cobalt oxyhydroxide nanosheets (CoOOH NSs) had been established to detect α-Glu and screen its inhibitory compounds in natural products. As a switched fluorescence source, the fluorescence of R-CDs at 625 nm could be quenched by CoOOH NSs via Förster resonance energy transfer (FRET), assembled into nonfluorescent R-CDs@CoOOH nanocompositecomposites (R-CDs@CoOOH NCs). α-Glu hydrolyzed L-ascorbic acid-2-<em>O</em>-<em>α</em>-D-glucopyranose to produce ascorbic acid, which could reduce CoOOH NSs to Co²⁺, destroying R-CDs@CoOOH NCs and restoring the emission of red fluorescence. The proposed method exhibited a linear α-Glu range from 0.01 to 15 U mL⁻¹ and a low limit of detection (LOD) of 0.0037 U mL⁻¹. Meanwhile, high-performance liquid chromatography-DAD-fraction collector (HPLC-DAD-FC) had been employed and combined with ultra-high-performance liquid chromatography-triple quadrupole time-of-flight mass spectrometry to isolate, enrich, and characterize compounds from <em>Polygonum cuspidatum</em> (<em>PC</em>). This strategy was further extended by integrating the fluorometric platform with the HPLC-DAD-FC system to explore the inhibitory effects of <em>PC</em> extracts and anti-diabetic ingredients. Finally, 85 constituents were identified, with seven compounds exhibiting high α-Glu inhibitory activity. Consequently, the established strategy could accurately determine α-Glu in vitro and screen its inhibitors from natural products.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102018"},"PeriodicalIF":8.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering functionally-optimized aptamers against SARS-Cov-2 for blocking spike-ACE2 interaction and aptasensor detection","authors":"Xiangdong Lai ,&nbsp;Weiwei Zhao ,&nbsp;Lihua Jiang ,&nbsp;Jing Li ,&nbsp;Muhammad Faizan Munawer ,&nbsp;Jiejuan Lai ,&nbsp;Jesus Alejandro Martinez Juarez ,&nbsp;Miraj Ud din ,&nbsp;Xiaoyang Zhang ,&nbsp;Zhongquan Song ,&nbsp;Tao Wu ,&nbsp;Yiyue Ge ,&nbsp;Hui Jiang ,&nbsp;Xiaohui Liu ,&nbsp;Xuemei Wang","doi":"10.1016/j.mtbio.2025.102020","DOIUrl":"10.1016/j.mtbio.2025.102020","url":null,"abstract":"<div><div>Both the limited research about structure-function relationship and the ill-defined process of conformational dynamic change greatly impede the development of aptamer engineering transformation and seriously restrict the practical applications of aptamers. In this work, an optimization strategy combining exonuclease III (Exo III) digestion and in silico simulation was presented for the first time for constructing high-affinity and functional aptamers and clarifying the three-dimensional (3D) structure of aptamer-target complexes and the conformational dynamic conversion in the process of aptamer recognizing its target. As a demonstration, the parent aptamer (Apt2) against SARS-CoV-2 spike subunit 1 (S1) was mutated or truncated at the predicted binding sites to produce eight derivatives (Seq1–Seq8). The progeny Seq3 exhibited a higher affinity for S1 and a better blocking effect on S1-angiotensin-converting enzyme 2 (ACE2) interaction compared to Apt2. Subsequently, Seq3 sealed the pores of nickel-doped zeolitic imidazolate framework-8 (NZIF-8) loaded with Rhodanine (Rho) to fabricate the aptasensor (NZIF-8-Rho-Apt) for inactivated virus detection, showing excellent performances in spiked actual samples. Therefore, this post systematic evolution of ligands by exponential enrichment (post-SELEX) is a very effective and general strategy for acquiring functionally-optimized aptamers.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102020"},"PeriodicalIF":8.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoids for tissue repair and regeneration","authors":"Biao Yu ,&nbsp;Dongyang Zhou ,&nbsp;Fuxiao Wang ,&nbsp;Xiao Chen ,&nbsp;Mengmeng Li ,&nbsp;Jiacan Su","doi":"10.1016/j.mtbio.2025.102013","DOIUrl":"10.1016/j.mtbio.2025.102013","url":null,"abstract":"<div><div>Tissue damage and dysfunction are common consequences of various diseases and trauma, severely impacting patients' quality of life. Organoids, three-dimensional cell clusters formed through the self-organization of stem cells, not only recapitulate the developmental processes of native tissues but also exhibit remarkable plasticity and long-term expansion capabilities, demonstrating potential to overcome limitations of conventional therapeutic approaches. Particularly in addressing challenges such as immune rejection and regenerative efficiency, organoid technology has shown distinct advantages. This review summarizes the applications of organoids in tissue repair, including the biological principles and cultivation strategies of organoid culture, as well as their specific applications and preclinical research progress across diverse tissues (e.g., brain, liver, intestine, bone). Additionally, it discusses current challenges in organoid technology, such as large-scale production, heterogeneity control, and clinical translation, while outlining future development directions.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102013"},"PeriodicalIF":8.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis","authors":"Qifan Yang ,&nbsp;Jing Liu ,&nbsp;Yanwei Liu ,&nbsp;Shun Liu ,&nbsp;Xiaokang Wei ,&nbsp;Yilin Yang ,&nbsp;Weijie Zhang ,&nbsp;Shuqi Zhang ,&nbsp;Maosheng Zhang ,&nbsp;Bin Liu ,&nbsp;Xinyu Wang ,&nbsp;Dong Zhu","doi":"10.1016/j.mtbio.2025.102009","DOIUrl":"10.1016/j.mtbio.2025.102009","url":null,"abstract":"<div><h3>Background</h3><div>Obesity-induced osteoporosis is a prevalent complication among obese individuals. Conventional anti-osteoporosis medications often lack therapeutic specificity and may exacerbate lipid metabolism disorders. Consequently, identifying suitable pharmacological interventions for obesity-induced osteoporosis, elucidating its underlying biological mechanisms, and developing nanodrug delivery systems with enhanced biocompatibility and targeted delivery remain significant challenges.</div></div><div><h3>Methods</h3><div>This study reveals that the pathogenesis of obesity-induced osteoporosis is primarily driven by excessive mitophagy. Notably, Exendin-4 (Ex-4) has been shown to ameliorate mitophagy and mitigate obesity-induced osteoporosis. The nanocomposite DSPE-PEG-ALN (DPA)@Neutrophil membrane (NM)@Cu-TCPP(Zn)/Ex-4 (CTZE), characterized by high biocompatibility and reactive oxygen species (ROS) responsiveness, effectively targets bone tissue, reduces ROS levels, and regulates the release of Cu²⁺, Zn²⁺, Ex-4, and Alendronate (ALN). This composite interferes with B-cell lymphoma-2 (BCL2)- Beclin-1 (BECN1) binding via the tet methylcytosine dioxygenase 2 (TET2)/PTEN-induced putative kinase protein 1 (PINK1)/Parkin (E3 ubiquitin-protein ligase parkin) pathway, thereby promoting osteoblast differentiation and mineralization. The safety and efficacy of this nano-delivery platform were validated in a mouse model of obesity-induced osteoporosis.</div></div><div><h3>Conclusions</h3><div>In summary, our study illustrates that excessive mitophagy plays a crucial role in obesity-induced osteoporosis. Furthermore, DPA@NM@CTZE exhibits significant potential for the precise treatment of obesity-induced osteoporosis, mitigating the side effects of Ex-4, and enhancing the bone microenvironment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102009"},"PeriodicalIF":8.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis guided application of nanozymes in the treatment of inflammatory bowel disease","authors":"Fang Lei ,&nbsp;Qizhen Huang ,&nbsp;Chengfeng Zhang ,&nbsp;Youhui Lin ,&nbsp;Yan Zhang ,&nbsp;Faming Wang","doi":"10.1016/j.mtbio.2025.102008","DOIUrl":"10.1016/j.mtbio.2025.102008","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut that has caused an escalating burden on the global healthcare system in recent years. Researchers have been actively seeking innovative therapeutic strategies to combat this intractable disease. Recent advances in nanozyme technology have opened up new avenues for the development of novel therapeutic strategies for IBD. This review provides a comprehensive overview of the related works in the developments and applications of different nanozymes for IBD therapy. By overviewing the known pathogenesis of IBD and pathogenesis-guided applications of nanozymes in IBD therapy, this review highlights the opportunities for nanozyme-based strategies to address IBD via the underlying mechanisms. This review also examines the current state of nanozyme research in IBD, including the design and application of nanozymes, and discusses the challenges and future directions for this emerging field. In addition, by integrating the understanding of IBD pathogenesis with the development of nanozyme technology, this review aims to stimulate further research to uncover new opportunities for this debilitating disease.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 102008"},"PeriodicalIF":8.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}