Materials Today Bio最新文献

Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy 纳米材料支持的类风湿关节炎治疗：光子-声学-气体多模态治疗的最新研究

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-06 DOI: 10.1016/j.mtbio.2026.102772

Yuxin Chen, Yasi Deng, Bin Li, Yupei Yang, Hanwen Yuan, Huihong Duan, Wei Wang, Huanghe Yu

{"title":"Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy","authors":"Yuxin Chen, Yasi Deng, Bin Li, Yupei Yang, Hanwen Yuan, Huihong Duan, Wei Wang, Huanghe Yu","doi":"10.1016/j.mtbio.2026.102772","DOIUrl":"10.1016/j.mtbio.2026.102772","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT), photodynamic therapy (PDT), photoacoustic (PA) imaging, sonodynamic therapy (SDT), and gas therapy, have demonstrated the potential to address these limitations. PTT leverages near-infrared (NIR)-responsive nanomaterials to induce localised hyperthermia, triggering apoptosis in pathogenic synovial tissues. PDT relies on photoactivated nanophotosensitizers to precisely eliminate hyperplastic synovium through spatiotemporally controlled reactive oxygen species (ROS) production. PA imaging uses NIR light to excite nanoparticles, generating ultrasound signals that are reconstructed into images, enabling real-time monitoring and assessment of RA joints. SDT employs ultrasound-activated nanosensitizers to produce cytotoxic ROS for the targeted ablation of inflammatory cells. Complementing these approaches, gas therapy, mediated by hydrogen-releasing nanomaterials, exerts immunomodulatory effects by scavenging ROS and regulating the inflammatory microenvironment. This review examines cutting-edge nanotherapeutic strategies that integrate photonic, acoustic, and gaseous modalities for RA management. Through an analysis of innovative nanosystem designs and their therapeutic mechanisms, this review highlights the emerging paradigm of synergistic multimodality approaches, which improve efficacy while reducing systemic adverse effects. This review will provide novel perspectives for advancing next-generation multimodal precision therapies for autoimmune diseases.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102772"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication 纤维集成水凝胶：一个多功能平台，以提高结构和生物性能的3D生物制造

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.mtbio.2026.102799

Annabelle Neuhäusler , Nils Lindner , Andreas Blaeser

{"title":"Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication","authors":"Annabelle Neuhäusler , Nils Lindner , Andreas Blaeser","doi":"10.1016/j.mtbio.2026.102799","DOIUrl":"10.1016/j.mtbio.2026.102799","url":null,"abstract":"<div><div>Hydrogels emerged as versatile biomaterials for tissue engineering due to their extra cellular matrix similarity and mechanical and biochemical properties. Still, hydrogels expose limited stiffness, anisotropy and nutrient diffusion. By reinforcing hydrogels with synthetic and natural fibers, these drawbacks can be effectively addressed, thereby enabling the modeling of advanced biomimetic tissue. This review discusses recent progress in the fabrication of fiber-integrated hydrogels and brings together developments from biomaterials, biofabrication, mechanobiology, and organ-model engineering. Fiber-addition impact on viscoelastic, time-dependent und nonlinear material properties, on multiscale and hierarchical constructs and on mechanical and biological readouts are analyzed. Specifically, the integration of both synthetic and natural fibers into hydrogel matrices is highlighted which significantly broaden their structural and biochemical versatility. These fiber-added hydrogels display improved properties including enhanced stiffness (up to 10-fold increase), anisotropy (>80 % alignment) and nutrient diffusion (4-fold increase). Moreover, the incorporation of fibers directly impacts cellular behavior by promoting adhesion, migration, proliferation and differentiation. Finally, bone, muscle and nerve tissue are exemplary presented in more detail to highlight the broad potential of these composite materials. In conclusion, fiber-embedded hydrogels represent a decisive step toward enhanced 4D-metamaterials.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102799"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment 铜基纳米酶对银屑病治疗有协同作用

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.mtbio.2026.102855

Junyu Zhou , Nianzhou Yu , Xiaoxin Yang , Shanghong Li , Mi Huang , Tianyi Pang , Dong Zhong , Yu Wen , Hong Liu

{"title":"Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment","authors":"Junyu Zhou , Nianzhou Yu , Xiaoxin Yang , Shanghong Li , Mi Huang , Tianyi Pang , Dong Zhong , Yu Wen , Hong Liu","doi":"10.1016/j.mtbio.2026.102855","DOIUrl":"10.1016/j.mtbio.2026.102855","url":null,"abstract":"<div><div>Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and sustained skin inflammation. Cuproptosis, a novel regulated cell death pathway, inhibits proliferation by promoting cellular demise, offering a promising therapeutic strategy for psoriasis. Herein, we first identified that cuproptosis induction is a potential therapeutic avenue for psoriasis treatment. Then, a copper-based nanozyme (Cu-NZ) was developed to enhance cuproptosis through cascade catalytic therapy, leveraging multi-enzymatic effects for psoriasis treatment. The Cu-NZs exhibited distinct multi-enzymatic activities, including catalase (CAT)-, superoxide dismutase (SOD)-, oxidase (OXD)-, and peroxidase (POD)-like activities, which sustained the generation of cytotoxic Reactive Oxygen Species (ROS), relieved hypoxia via O<sub>2</sub> release, and ultimately triggered augmented cuproptosis. In vitro results demonstrated that Cu-NZs suppressed HaCaT cells proliferation and inflammatory factor expression while inducing mitochondrial dysfunction through ROS elevation. Mechanistically, Cu-NZs modulated the expression of cuproptosis-related genes and proteins (DLAT, FDX1, LIAS). In vivo studies confirmed that topical Cu-NZs gel significantly alleviated imiquimod (IMQ)-induced psoriatic phenotypes in mice without inducing systemic organ toxicity. Collectively, Cu-NZs mitigated psoriasis manifestations by triggering cuproptosis in keratinocytes, thereby inhibiting their pathological activation and proliferation. These findings provided a theoretical foundation for the clinical translation of Cu-NZs-based therapies.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102855"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomically preserved MXene quantum dots as a redox-responsive nanoplatform for light-controlled bidirectional ROS engineering 原子保存MXene量子点作为光控双向ROS工程的氧化还原响应纳米平台。

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1016/j.mtbio.2026.102864

Dejia Hu , Tianhao Xia , Danyang Xiao , Bufeng Liang , Yuyi Li , Jinkun Li , Zhongliao Zeng , Jianxiong Ma , Yan Li

{"title":"Atomically preserved MXene quantum dots as a redox-responsive nanoplatform for light-controlled bidirectional ROS engineering","authors":"Dejia Hu , Tianhao Xia , Danyang Xiao , Bufeng Liang , Yuyi Li , Jinkun Li , Zhongliao Zeng , Jianxiong Ma , Yan Li","doi":"10.1016/j.mtbio.2026.102864","DOIUrl":"10.1016/j.mtbio.2026.102864","url":null,"abstract":"<div><div>MXene quantum dots (MQDs) combine the intrinsic reductive properties of MXenes with the photoactivity induced by quantum confinement, positioning them as promising agents for dynamic redox regulation in therapeutic applications. However, their translation into practice has been limited by persistent synthetic issues, including transition-metal leaching and oxidative degradation. To address these challenges, a sodium ascorbate-mediated coordination and reduction strategy was developed for hydrothermal synthesis of structurally intact Ti<sub>2</sub>C MQDs with improved crystallinity and high titanium retention. The resulting MQDs exhibit a unique extension of optical absorption into the visible range, which facilitates efficient ROS generation under visible-light irradiation and confers potent antibacterial properties against pathogenic bacteria. Concurrently, the MQDs demonstrate broad-spectrum ROS scavenging ability. At the cellular level, they effectively reduced oxidative stress and inflammation while promoting M2 macrophage polarization. Capitalizing on these dual redox activities and excellent biocompatibility, a collagen–alginate microneedle patch (MQDs@Col-SA MN) was designed to evaluate their therapeutic potential. In a diabetic wound model, this system achieved ∼80 % smaller wound area than untreated controls at Day 10, while also outperforming a positive control dressing. This study represents the first report of structurally preserved MQDs capable of adaptive redox regulation, underscoring their utility as a versatile platform for microenvironment modulation and regenerative medicine.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102864"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing 通过生物-无机混合微球系统协调肌腱-骨愈合的免疫-软骨微环境。

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.mtbio.2026.102851

Wencai Liu , Yuhao Yu , Hui Xu , Weiming Lin, Xin Wang, Yiming Li, Xiping Jiang, Chenrui Yuan, Yifei Wang, Xinyue Yang, Di Wu, Lingzhi Kong, Weilin Yu, Wei Song, Yaohua He

{"title":"Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing","authors":"Wencai Liu , Yuhao Yu , Hui Xu , Weiming Lin, Xin Wang, Yiming Li, Xiping Jiang, Chenrui Yuan, Yifei Wang, Xinyue Yang, Di Wu, Lingzhi Kong, Weilin Yu, Wei Song, Yaohua He","doi":"10.1016/j.mtbio.2026.102851","DOIUrl":"10.1016/j.mtbio.2026.102851","url":null,"abstract":"<div><div>The structural failure of rotator cuff repair is largely attributed to fibrovascular scar formation driven by a persistent inflammatory microenvironment and insufficient fibrocartilage regeneration at the tendon-to-bone interface. To address this, a microfluidic-generated GelMA microsphere system co-encapsulating Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles and bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (sEVs) is developed. This composite system (ZIF-8/sEVs@MS) enables the sustained release of Zn<sup>2+</sup> and sEVs, which synergistically reprogram macrophages (Mφ) from a pro-inflammatory M1 phenotype to a reparative M2 state and restore the CXCL12/CXCR4 axis for endogenous stem cell recruitment. Transcriptomic analysis elucidates that the system reactivates the PI3K/AKT signaling pathway, thereby reversing inflammation-mediated inhibition and driving chondrogenic differentiation. In a rat rotator cuff repair model, the functionalized microspheres significantly enhance fibrocartilaginous enthesis regeneration, biomechanical structural integrity, and limb function. This study establishes a dual-functional “immuno-chondrogenic” strategy that coordinates immune microenvironment modulation with tissue-specific differentiation to facilitate functional tendon-to-bone healing.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102851"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems 基于天然生物聚合物的纳米药物输送系统穿透血脑屏障及治疗脑病的研究进展

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-25 DOI: 10.1016/j.mtbio.2026.102849

Lijing Qin , Xiu Wang , Tongjuan Liang , Yongyi Bi , Zhijun Guo , Wenzhong Li , Wanjun Liang

{"title":"Research progress of blood-brain barrier penetrating and brain diseases therapy by natural biopolymer - based nanomedicine delivery systems","authors":"Lijing Qin , Xiu Wang , Tongjuan Liang , Yongyi Bi , Zhijun Guo , Wenzhong Li , Wanjun Liang","doi":"10.1016/j.mtbio.2026.102849","DOIUrl":"10.1016/j.mtbio.2026.102849","url":null,"abstract":"<div><div>Brain diseases are one of the most critical threats to human health. The blood-brain barrier (BBB) prevents drugs from entering the brain, rendering standard treatments for neurological illnesses ineffective. In recent years, there has been an increase in interest in nanotechnology-based research to develop innovative drug delivery systems (NDDS) for drug loading, BBB penetration, and precision delivery to diseased areas. Nanocarriers made from natural biomaterials, in particular, solve the drawbacks of standard nanocarriers, such as low stability and inadequate targeting, while simultaneously providing benefits such as simplicity of modification and good biodegradability. This review focuses on the most recent advances in NDDS based on natural biomaterials for overcoming the BBB in treating brain diseases, with a particular emphasis on the methods and mechanisms by which natural biopolymers—such as polysaccharides, peptides, and polynucleotides—break through the BBB and enhance brain-targeted delivery. We explore current challenges and future application prospects of natural biopolymers in permeable nanomedicine delivery systems for the BBB, aiming to provide key insights for advancing cross-BBB delivery platforms toward smarter, multifunctional development, subsequent research, and translational applications.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102849"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect 阿仑膦酸修饰PLGA载17β-雌二醇和维生素D3给药系统具有抗骨质疏松作用

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1016/j.mtbio.2026.102789

Yonghui Wang , Sidi Zhang , Xinrun Ma , Donghao Hu , Junran Liu , Lu Wei , Xue Lei , Yan Hu , Fuyou Li , Yanhong Gao

{"title":"Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect","authors":"Yonghui Wang , Sidi Zhang , Xinrun Ma , Donghao Hu , Junran Liu , Lu Wei , Xue Lei , Yan Hu , Fuyou Li , Yanhong Gao","doi":"10.1016/j.mtbio.2026.102789","DOIUrl":"10.1016/j.mtbio.2026.102789","url":null,"abstract":"<div><div>Postmenopausal osteoporosis caused by estrogen deficiency often requires hormone replacement therapy (HRT), but its systemic side effects limit clinical application. Here, we developed a bone-targeted Poly (lactic-co-glycolic acid) (PLGA) nanocarrier modified with Alendronic acid (ADA) to co-deliver 17β-Estradiol (E2) and Vitamin D3 (VitD3), aiming to enhance efficacy and safety. The ADA-functionalized nanoparticles (E2+VD@PLGA<sub>IR780</sub>ADA) showed high drug loading (7.2 wt% for E2 and 2.3 wt% for VitD3), sustained release (>90 % over 48 h). In ovariectomized (OVX) mice, targeted delivery significantly improved bone mineral density, restored trabecular structure, and reduced serum bone resorption markers, while markedly alleviating E2-induced endometrial thickening. In vivo imaging confirmed selective bone accumulation. Mechanistically, co-administration of VitD3 and E2 elicits enhanced pro-osteogenic effects by virtue of VitD3-mediated Vitamin D Receptor (VDR) upregulation and amplified E2-induced estrogen receptor (ER) expression, which collectively drive robust activation of the PI3K/AKT/mTOR signaling cascade.This bone-specific nanoplatform offers a promising and safer strategy for osteoporosis therapy beyond conventional HRT.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102789"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair 双响应PDA-HP水凝胶使线粒体靶向轻度光热治疗脊髓修复

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.mtbio.2026.102783

Yi Li , Jiaxuan Hu , Bing Ran , Huisheng Zhong , Nayin Zhong , Yi Zhong , Xinyu Fu , Xinying Liu , Guanghua Wu , Qinwen Zhong , Juan Li

{"title":"Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair","authors":"Yi Li , Jiaxuan Hu , Bing Ran , Huisheng Zhong , Nayin Zhong , Yi Zhong , Xinyu Fu , Xinying Liu , Guanghua Wu , Qinwen Zhong , Juan Li","doi":"10.1016/j.mtbio.2026.102783","DOIUrl":"10.1016/j.mtbio.2026.102783","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is a devastating neurological disorder with substantial economic and psychological burdens, underscoring the urgent need for effective therapeutic strategies. Here, we developed a dual-responsive hydrogel composed of polydopamine (PDA) and heparin-poloxamer (HP) that enables controllable mild photothermal stimulation under near-infrared (NIR) irradiation. The PDA-HP hydrogel exhibited excellent biocompatibility, biodegradability, and stable photothermal conversion. In a mouse SCI model, in situ administration of PDA-HP combined with NIR irradiation markedly improved locomotor recovery and mitigated tissue damage. Mechanistically, PDA-HP/NIR therapy reduced oxidative stress, preserved mitochondrial structure, restored ATP production, and—most notably—normalized the maladaptive overexpression of heat-shock protein 70 (HSP70) induced by SCI, thereby decreasing apoptosis and promoting neuronal survival. Quantitative proteomics further identified stress-chaperone and mitochondrial pathways as major targets of this intervention. To our knowledge, this is the first study demonstrating that PDA-HP-mediated mild photothermal modulation restores mitochondrial function through HSP70 normalization in SCI. These findings highlight a mitochondria-targeted mild photothermal strategy as a promising and clinically translatable approach for spinal cord repair.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102783"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge 逃避细胞摄取：由疏水性和负电荷调节的无药物癌症治疗

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2025-12-30 DOI: 10.1016/j.mtbio.2025.102752

Kazuki Moroishi , Masahiko Nakamoto , Satoshi Fujita , Marie Kawahara , Ryohei Katayama , Michiya Matsusaki

{"title":"Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge","authors":"Kazuki Moroishi , Masahiko Nakamoto , Satoshi Fujita , Marie Kawahara , Ryohei Katayama , Michiya Matsusaki","doi":"10.1016/j.mtbio.2025.102752","DOIUrl":"10.1016/j.mtbio.2025.102752","url":null,"abstract":"<div><div>Self-aggregation and inducing cell membrane disruption in response to tumor microenvironment-stimuli is expected to be a promising approach for cancer treatment, but is limited by its insufficient stimuli-responsive cytotoxicity due to a lack of in-depth understanding of molecular characteristics, resulting in low selectivity of cell death induction. In this study, we focused on engineering polymer aggregation in detail to further improve tumor microenvironment-responsive cytotoxicity. PVA-U with grafting degrees (G.D.) of 3 % (PVA-U3), 15 % (PVA-U15), and 25 % (PVA-U25) were synthesized and their aggregation properties cytotoxicity was evaluated. The difference in half maximal inhibitory concentration (IC<sub>50</sub>) values between pH 7.4 and pH 6.5 for PVA-U15 was 4.3-fold, which was greater than that of PVA-U25 at 2.8-fold, suggesting that tumor microenvironment-responsive cytotoxicity could be regulated by controlling G.D. of UDCA. Interestingly, PVA-U15 formed aggregates in the pericellular environment and adsorbed on the cell, effectively inducing cell death whereas PVA-U3 and PVA-U25 showed internalization in the cell. These results indicated that the balance of the surface charge and hydrophobicity could contribute to the adsorption on the cell membrane. These findings are expected to contribute to the development of membrane disruption strategies to control the aggregation properties and cell membrane interaction.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102752"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel dual-reactive primer enhances bond durability and builds chemical interlocking structures at the caries-affected dentin–biomaterial interface 一种新型的双反应引物增强了牙本质-生物材料界面的结合耐久性和化学连锁结构

IF 10.2 1区医学

Materials Today Bio Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.mtbio.2026.102793

Kai Tang , Rongchen Xu , Longyan Duan , Zhenyu Yang , Xinkai Cui , Wen Niu , Wei Zhou , Franklin R. Tay , Lina Niu , Fu Wang , Jihua Chen

{"title":"A novel dual-reactive primer enhances bond durability and builds chemical interlocking structures at the caries-affected dentin–biomaterial interface","authors":"Kai Tang , Rongchen Xu , Longyan Duan , Zhenyu Yang , Xinkai Cui , Wen Niu , Wei Zhou , Franklin R. Tay , Lina Niu , Fu Wang , Jihua Chen","doi":"10.1016/j.mtbio.2026.102793","DOIUrl":"10.1016/j.mtbio.2026.102793","url":null,"abstract":"<div><div>Dental caries remains a major challenge in clinical dentistry, with successful resin restoration relying on the formation of a durable dentin–resin interface. In minimally invasive dentistry (MID), caries-affected dentin (CAD) is routinely preserved and often becomes the primary bonding substrate. However, bonding to CAD is suboptimal, and current strategies to improve this interface are limited. Here, we present a novel bonding strategy based on a dual-reactive functional monomer, ITCM, in combination with pretreatment application techniques. A simple 5-s ITCM pretreatment significantly enhanced both immediate and aged bond strength to CAD. Acting as a “molecular bridge”, ITCM bridges hydrophilic CAD layer with hydrophobic adhesive layer, facilitating the formation of a chemical interlocking structure, increasing CAD surface energy, and promoting deep adhesive infiltration. In addition, ITCM improves collagen enzymatic resistance and functions as a non-zinc-binding inhibitor of MMPs. Biocompatibility assessments demonstrated acceptable in vitro and in vivo safety, supporting its clinical potential. This study addresses a critical challenge in dentistry by introducing a chemical bonding strategy tailored to CAD. The ITCM pretreatment strategy provides a foundation for next-generation adhesives aimed at reinforcing the CAD–resin interface, extending restoration longevity, and preventing secondary caries.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"37 ","pages":"Article 102793"},"PeriodicalIF":10.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0