Materials Today Bio最新文献

{"title":"Multifunctional nanomedicine targeting the 'seed-and-soil' of hair follicles via simultaneous alleviation of oxidative stress and activation of autophagy for androgenetic alopecia therapy","authors":"Yuanzheng Chen ,&nbsp;Qubo Zhu ,&nbsp;Yanbin Zhou ,&nbsp;Wenhu Zhou ,&nbsp;Yan Chen","doi":"10.1016/j.mtbio.2025.102145","DOIUrl":"10.1016/j.mtbio.2025.102145","url":null,"abstract":"<div><div>Androgenetic alopecia (AGA) is a prevalent form of hair loss, which significantly affects both aesthetics and quality of life. Hair regeneration in AGA requires the transition of hair follicles from the telogen phase to the anagen phase, alongside a healthy microenvironment, analogous to seed germination, where breaking dormancy and providing fertile soil are essential. In this context, we propose that targeting the \"seed-and-soil\" model by activating autophagy in hair follicles (seeds) and alleviating oxidative stress in the hair follicle microenvironment (soil) could be an effective strategy for AGA treatment. Through network pharmacology and cell-based experiments, we identified curcumin (Cur) as a potential agent capable of activating autophagy and alleviating oxidative stress—both critical processes for hair follicle regeneration. To facilitate biomedical application, we developed a novel nanoparticle formulation, TFC, achieved by self-assembling Cur and tannic acid with Fe³⁺ via metal coordination. TFC nanoparticles demonstrated excellent colloidal stability, high Cur loading capacity (52 %), and potent antioxidant properties. In vitro studies showed that TFC effectively scavenged reactive oxygen species (ROS) and activated autophagy in human dermal papilla cells, offering significant protection against oxidative stress. In an AGA mouse model, TFC delivered via microneedles accelerated hair growth, promoted hair follicle proliferation, and enhanced angiogenesis, with superior efficacy compared to minoxidil and minimal side effects. This study suggests that Cur-loaded TFC, by targeting oxidative stress and autophagy in hair follicle cells, represents a promising novel approach for AGA treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102145"},"PeriodicalIF":10.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-targeted N-PMIplus@CA nanoplatform for concurrent MDM2 and β-catenin inhibition in p53 wild-type lung adenocarcinoma","authors":"Ni Zhao ,&nbsp;Weiming You ,&nbsp;Xiaoqiang Zheng ,&nbsp;Jin Yan ,&nbsp;Peili Wang ,&nbsp;Yu Yao ,&nbsp;Wangxiao He ,&nbsp;Tianya Liu","doi":"10.1016/j.mtbio.2025.102136","DOIUrl":"10.1016/j.mtbio.2025.102136","url":null,"abstract":"<div><div>Lung adenocarcinoma (LUAD) harboring wild-type p53 remains therapeutically challenging because of the oncogenic MDM2-driven suppression of p53 activity and compensatory activation of Wnt/β-catenin signaling. Here, we report a self-assembled nanoparticle system (N-PMI^plus@CA) enabling simultaneous inhibition of both MDM2 and the Wnt/β-catenin pathway. We observed that concurrent activation of these two pathways is significantly correlated with poor clinical outcomes in patients with LUAD. N-PMI^plus@CA efficiently accumulated in tumor tissues via enhanced permeability and retention (EPR) effects and macropinocytosis, delivering both an optimized MDM2-inhibitory peptide and a β-catenin antagonist (carnosic acid). The dual-inhibition strategy significantly restored p53 function, downregulated β-catenin signaling, suppressed tumor proliferation, and promoted apoptosis in LUAD cell lines and murine models. Remarkably, treatment with N-PMI^plus@CA yielded superior antitumor efficacy in subcutaneous and orthotopic LUAD models compared with monotherapy controls, without detectable systemic toxicity. The unified pharmacokinetic profile achieved by coencapsulation ensured synchronized intracellular delivery and maximal synergistic effects at tumor sites. This nanomedicine approach effectively circumvents traditional dual-drug therapy limitations, such as differential metabolism and systemic adverse effects. Collectively, our findings highlight N-PMI^plus@CA as a promising clinical candidate that addresses a critical unmet need in p53 wild-type LUAD treatment, demonstrating strong translational potential and providing a paradigm for simultaneous targeting of multiple oncogenic pathways.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102136"},"PeriodicalIF":8.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-mobility network hydrogel microsphere system to combat chondrocyte senescence for enhanced cartilage repair and regeneration","authors":"Fangqi Xu ,&nbsp;Chen Zhuang ,&nbsp;Lufeng Yao ,&nbsp;Yiwen Xu ,&nbsp;Qihua Cao ,&nbsp;Zherui Fu ,&nbsp;Longfeng Wang ,&nbsp;Yuan Zhu ,&nbsp;Deting Xue ,&nbsp;Ning Zhang ,&nbsp;Xiaohua Yu ,&nbsp;Gangfeng Hu ,&nbsp;Feng Lin","doi":"10.1016/j.mtbio.2025.102138","DOIUrl":"10.1016/j.mtbio.2025.102138","url":null,"abstract":"<div><div>Cellular senescence plays a crucial role in the progression of various diseases, and targeting senescence is a potential therapeutic strategy for osteoarthritis (OA). However, the complex biomechanical environment surrounding chondrocytes significantly affects their senescence process. Currently, few biomaterials are available that have the ability to modulate stresses and counteract chondrocyte senescence. In this study, we used cationic liposomes as the core of the crosslinked structure of the hydrogel network through imine bonding to construct a high-mobility network hydrogel microsphere system (Res@Lipo@HMs). The deformability of liposomes endowed mobility to the crosslinked structure of the hydrogel network. This system not only enhanced joint lubrication through a rolling mechanism but also distributed mechanical stress on chondrocytes by increasing the elastic deformation capacity of the microspheres. Moreover, this approach delayed chondrocyte senescence, improved chondrocyte physiological function, and slowed down OA progression by enhancing mitochondrial function and inhibiting senescence pathways. This study offers new insights into antisenescence strategies for chondrocyte therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102138"},"PeriodicalIF":10.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECM-inspired stem cell secretome sustained releasing composite nanofibrous membranes for accelerated wound healing","authors":"Jiutao Cao ,&nbsp;Shengchang Luo ,&nbsp;Wanling Huang ,&nbsp;Xiaochang Lu ,&nbsp;Ranjith Kumar Kankala ,&nbsp;Shibin Wang ,&nbsp;Peiyao Xu ,&nbsp;Aizheng Chen","doi":"10.1016/j.mtbio.2025.102141","DOIUrl":"10.1016/j.mtbio.2025.102141","url":null,"abstract":"<div><div>Designing dressings that mimic the composition, structure, and function of native skin is of great significance. Despite commercial decellularized extracellular matrix (dECM)-based wound dressings promoted skin regeneration process, reconstructing the fibrous microstructure of native dermis remains a significant challenge. In this work, a dECM-based composite nanofibrous membranes loaded with stem cell secretomes (SCS/dECMM) have been developed for accelerating wound repair, which comprehensively mimicked the dermal tissue in terms of composition, structure, and function. In detail, dermal dECM was prepared by eco-friendly supercritical carbon dioxide (SC-CO₂) technology and then mixed with SCS to obtain SCS/dECMM by using electrospinning technology. The resulting nanofibrous membrane with 555.19 nm diameter that maintained SCS bioactivity while enabling sustained SCS release. SCS/dECMM significantly enhanced cell adhesion, proliferation, migration, and angiogenesis, thereby continuously promoting wound repair. <em>In vivo</em> wound healing results revealed that SCS/dECMM accelerated wound healing by promoting re-epithelialization, collagen deposition, and vascularization. SCS/dECMM offered a novel strategy for accelerating wound healing by replicating the composition, structure, and function of native skin.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102141"},"PeriodicalIF":10.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive LDH nanoplatforms for cancer therapy: Advances in modulating programmed cell death","authors":"Li Wang ,&nbsp;Nana Ran ,&nbsp;TingTing Hu ,&nbsp;Xiaoliang Cui ,&nbsp;Yong Kang ,&nbsp;Min Ge","doi":"10.1016/j.mtbio.2025.102139","DOIUrl":"10.1016/j.mtbio.2025.102139","url":null,"abstract":"<div><div>In recent years, the rapid advancement of nanotechnology and tumor biology has significantly expanded the application of nanomaterials in cancer therapy, particularly through the induction of programmed cell death (PCD) in cancer cells. Layered double hydroxides (LDH), a class of two-dimensional inorganic nanomaterials, have attracted considerable attention due to its tunable structures, excellent biocompatibility, and superior drug delivery capabilities. Emerging research has highlighted the great potential of LDH in modulating various forms of PCD. In this review, we provide a comprehensive overview of recent progress in the use of LDH to regulate different PCD pathways in cancer cells, including apoptosis, autophagy, ferroptosis, cuproptosis and pyroptosis. It emphasizes the underlying mechanisms of action, material design strategies, and the application of LDH in precise cancer therapy. Finally, this review is concluded with perspectives on the key challenges and bottlenecks of bioactive LDH in cancer therapy, providing potential solutions and outlining future perspectives.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102139"},"PeriodicalIF":8.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering DNA nanopores: from structural evolution to sensing and transport","authors":"Fengyu Liu ,&nbsp;Tatsuo Arai ,&nbsp;Dezhou Guo ,&nbsp;Zhuangde Jiang ,&nbsp;Libo Zhao ,&nbsp;Xiaoming Liu","doi":"10.1016/j.mtbio.2025.102137","DOIUrl":"10.1016/j.mtbio.2025.102137","url":null,"abstract":"<div><div>Synthetic nanopores, inspired by natural ion channels and nuclear pore complexes, hold immense potential for elucidating cellular transport mechanisms and enhancing molecular sensing technologies. DNA nanotechnology, particularly DNA origami, stands out as a transformative platform for designing biomimetic nanopores, leveraging its biocompatibility, structural programmability, and mechanical tunability. This review traces the structural evolution of DNA nanopores across three phases: early hybrid designs with solid-state platforms, vertically-inserted nanopores in lipid bilayers, and horizontally-arranged nanopores with advanced functionalities. Unlike prior reviews, we integrate this progression with critical insights into limitations—such as stability, scalability, and noise—while highlighting breakthroughs in single-molecule sensing and controlled transmembrane transport. We conclude by outlining strategies for next-generation DNA nanopores, offering a roadmap for their optimization in synthetic biology and nanomedicine.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102137"},"PeriodicalIF":10.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginseng-derived nanoparticles accelerate diabetic wound healing by modulating macrophage polarization and restoring endothelial cell function","authors":"Liangliang Fan ,&nbsp;Xuxia Jia ,&nbsp;Fusong Dong ,&nbsp;Song Yang ,&nbsp;Wenjing Li ,&nbsp;Ronghua Zhao ,&nbsp;Lijia Yin ,&nbsp;Daqing Zhao ,&nbsp;Jiawen Wang","doi":"10.1016/j.mtbio.2025.102143","DOIUrl":"10.1016/j.mtbio.2025.102143","url":null,"abstract":"<div><div>Vascular dysfunction and disruption of the balance between different subtypes of macrophages are key factors contributing to the poor healing of diabetic wounds. This study revealed that ginseng-derived nanoparticles (GDNPs) can promote angiogenesis and regulate macrophage polarization in the diabetic wound microenvironment, thereby promoting diabetic wound healing. GDNPs were found to significantly promote the cell viability of human umbilical vein endothelial cells (HUVECs) exposed to H₂O₂ under high glucose (HG) conditions while increasing the angiogenic capacity of HUVECs, and attenuating the elevated levels of H₂O₂-induced oxidative stress. Moreover, GDNPs effectively regulated macrophage (RAW264.7) polarization towards the M2 phenotype, exerting anti-inflammatory effects. The results indicated that GDNPs act on the PI3K/AKT/HIF-1α and TLR4/MyD88/MAPK pathways to promote angiogenesis, reduce inflammatory and oxidative stress, modulate macrophage polarization, and accelerate wound healing in diabetes. This study provides insights into the therapeutic benefits of GDNPs in diabetic wound healing.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102143"},"PeriodicalIF":10.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-triggered copper-doped carbon nitride nanocomposite inducing domino effect for synergistic tumor therapy and immune microenvironment reprogramming","authors":"Xiaoqian Zhang ,&nbsp;Guanhua Qiu ,&nbsp;Yuanyuan Chen ,&nbsp;Sida Wang ,&nbsp;Chuangye Han ,&nbsp;Shutian Mo ,&nbsp;Junjie Liu ,&nbsp;Duo Wang ,&nbsp;Zisan Zeng","doi":"10.1016/j.mtbio.2025.102132","DOIUrl":"10.1016/j.mtbio.2025.102132","url":null,"abstract":"<div><div>Multimodal targeted combination therapies harnessing synergistic interactions have emerged as a transformative paradigm in oncology, gradually superseding conventional monotherapies. We herein report a near-infrared (NIR) light-triggered multifunctional nanocomposite based on copper-doped graphitic-phase carbon nitride (named CNCu@HA), which efficiently eliminates tumors by inducing apoptosis, cuproptosis, and immunogenic cell death (ICD) while initiating robust immune responses. Specifically, the incorporation of copper ions enhances NIR photoabsorption and effectively separates the electron-hole pairs. Moreover, copper ions exhibit Fenton-like reaction capabilities. Consequently, the triggered domino effect of CNCu@HA not only achieves photothermal ablation of tumor cells but also functions as a dual Fenton-like catalyst and photosensitizer, generating excessive reactive oxygen species (ROS) and depleting glutathione (GSH). This process enhances the synergistic efficacy of chemodynamic therapy (CDT) and photodynamic therapy (PDT), promoting tumor cell apoptosis. The resultant intracellular oxidative stress overload impairs mitochondrial function, downregulates ATP levels, and suppresses ATP-dependent heat shock proteins expression, thereby synchronously augmenting the therapeutic effect of mild photothermal therapy (mPTT). Additionally, reduced ATP levels impede copper ion efflux, leading to intracellular copper ions accumulation. Cu²⁺ react with endogenous hydrogen peroxide (H₂O₂) to produce O₂ and Cu⁺, alleviating intratumoral hypoxia and increasing cancer cell susceptibility to cuproptosis. These CNCu@HA-induced cytotoxic effects trigger ICD-driven dendritic cell maturation, M1 macrophage polarization, and CD8⁺ T cell infiltration. This process activates a multilayered cascade of synergistic interactions, potentiating the immune response, reshaping the tumor immune microenvironment, and achieving a domino therapeutic effect, demonstrating remarkable antitumor efficacy in both <em>in vitro</em> and <em>in vivo</em> models.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102132"},"PeriodicalIF":10.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration","authors":"Jiaolong Wang ,&nbsp;Ning Gao ,&nbsp;Junchao Wei ,&nbsp;Lan Liao","doi":"10.1016/j.mtbio.2025.102131","DOIUrl":"10.1016/j.mtbio.2025.102131","url":null,"abstract":"<div><div>The immune microenvironment orchestrates bone regeneration, which can be manipulated by macrophage autophagy. Herein, gold nanoparticles with L/D (left-handed or right-handed)-chirality (L/D-AuNPs) were synthesized with chiral glutathione ligands to stereoselectively regulate macrophage autophagy, and further manipulate immune microenvironment for bone regeneration. Notably, L-AuNPs exhibited superior macrophage uptake efficiency and higher autophagy level compared to D-AuNPs. Meanwhile, L-AuNPs improved the osteogenic microenvironment, further promoting bone regeneration. In addition, the <em>in vivo</em> results showed that the healing of skull defect was significantly enhanced by L-AuNPs. These findings demonstrated that chiral AuNPs can stereoselectively regulate macrophage autophagy and open an avenue for applications of chiral nanoparticles in osteoimmunity.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102131"},"PeriodicalIF":10.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable composite microspheres/hydrogel membranes for Achilles tendon regeneration","authors":"Meng Yang ,&nbsp;Chong Zhang ,&nbsp;Bo-Yun Lu ,&nbsp;Yu-Cheng Zhu ,&nbsp;Xin-Rui Fu ,&nbsp;Yang Wu ,&nbsp;Zi-Tian Zheng ,&nbsp;Chang-Shuo Liu ,&nbsp;Jin Cheng ,&nbsp;Hong-Jie Huang ,&nbsp;Jian-Quan Wang","doi":"10.1016/j.mtbio.2025.102129","DOIUrl":"10.1016/j.mtbio.2025.102129","url":null,"abstract":"<div><div>Tendon injury is a common condition with potential for disability. Severe injuries such as tendon rupture often require surgical suturing to restore their structure and function. The healing process of tendons is a critical factor affecting clinical outcomes; however, their poor blood supply and low cellular density limit self-regeneration capabilities. This leads to insufficient quality and biomechanical properties of the repaired tendon, playing a significant role in the high rate of re-rupture in clinical practice. Tendon healing involves endogenous (tenocyte proliferation) and exogenous (fibroblast invasion) mechanisms. An imbalance between these two mechanisms often leads to postoperative adhesions, which significantly impacts clinical efficacy. Thus, this project aims to design an injectable, sustained-release methacryloyl gelatin (GelMA) hydrogel microsphere modified with Platelet-Derived Growth Factor-BB (PDGF-BB) and fibronectin (Fn), in conjunction with an anti-adhesion hyaluronic acid methacrylate (HAMA) hydrogel membrane. This combination is designed to promote tendon healing and prevent adhesions. This study will utilize an Achilles tendon rupture animal model to assess the effectiveness of composite microspheres/hydrogel membranes in enhancing tendon repair and preventing adhesions, offering insights for new clinical strategies in tendon rupture treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"34 ","pages":"Article 102129"},"PeriodicalIF":8.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}