Materials Today Bio最新文献

{"title":"Corrigendum to 'A triple-mode strategy on JQ1-loaded nanoplatform for superior antitumor therapy in pancreatic cancer' [Mater Today Bio. 2025 Mar 21;32:101696].","authors":"Zhiguo Li, Jinxin Duan, Zhiwen Liu, Weifan Li, Yiyin Mai, Hao Fu, Guotao Yuan, Jiawei Wang","doi":"10.1016/j.mtbio.2026.103640","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103640","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2025.101696.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"40 ","pages":"103640"},"PeriodicalIF":11.0,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Aptamer engineering exosomes loaded on biomimetic periosteum to promote angiogenesis and bone regeneration by targeting injured nerves via JNK3 MAPK pathway' [Mater. Today Bio 16 (2022) 100434].","authors":"Yanlin Su, Qing Gao, Rongli Deng, Lian Zeng, Jingyi Guo, Bing Ye, Jialin Yu, Xiaodong Guo","doi":"10.1016/j.mtbio.2026.103586","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103586","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2022.100434.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"40 ","pages":"103586"},"PeriodicalIF":11.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Rare-earth cerium-coordinated ICG nanoprobe for tumor hypoxia relief and intensified photodynamic therapy\" [Mater. Today Bio 37 (2026) 102937].","authors":"Xiaohang Liu, Zhiyang Fan, Liya Xie, Wei Zang, Li Li, Yueyang He, Dongfang Ding, Jianwu Chen, Yun Zhang, Xiaolong Liu, Yang Li, Yao Huang","doi":"10.1016/j.mtbio.2026.103560","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103560","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2026.102937.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"40 ","pages":"103560"},"PeriodicalIF":11.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Incorporation of paclitaxel in mesenchymal stem cells using nanoengineering upregulates antioxidant response, CXCR4 expression and enhances tumor homing\" [Mater. Today Bio. 19 (2023) 100567].","authors":"Swayam Prabha, Carmen Merali, Drishti Sehgal, Emmanuelle Nicolas, Nitu Bhaskar, Magda Flores, Shubhmita Bhatnagar, Susheel Kumar Nethi, Carlos A Barrero, Salim Merali, Jayanth Panyam","doi":"10.1016/j.mtbio.2026.103516","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103516","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2023.100567.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"40 ","pages":"103516"},"PeriodicalIF":11.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Triamcinolone acetonide nanoparticles ameliorate interstitial cystitis and anxiety/depression by targeting the bladder-metabolic-brain axis\" [Mater. Today Bio 38 (2026) 103112].","authors":"Zhicheng Liu, Qian Ju, Yuanyuan Yang, Qudong Lu, Rong Huang, Jing Yang, Ying Bao, Tao Jiang, Yiji Peng, Yuting Liu, Dinglin Zhang, Wenhao Shen","doi":"10.1016/j.mtbio.2026.103536","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103536","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2026.103112.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"40 ","pages":"103536"},"PeriodicalIF":11.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linker-directed lipid-antigen conjugates co-enhance lymph node targeting and antigen presentation for potent T cell immunity.","authors":"Junfei Zhu, Licheng Bai, Chun Wang, Jiating Liu, Yuhua Chen, Wenxia Zhang, Jun Weng, Lin Wei, Zigong Wei","doi":"10.1016/j.mtbio.2026.103505","DOIUrl":"10.1016/j.mtbio.2026.103505","url":null,"abstract":"<p><p>The clinical efficacy of peptide-based cancer vaccines is limited by inefficient lymphatic delivery and suboptimal antigen presentation. Here, we report a rationally engineered class of lipid-antigen conjugates that co-enhance lymph node (LN) targeting and antigen-presenting cell (APC) uptake through molecular-level structural optimization. By systematically varying lipid tail composition and linker chemistry, we identify a lead construct (dOA-K-O) incorporating a dioleic acid (dOA) lipid tail and an L-lysine (K) linker, which outperforms the clinically used DSPE-PEG₂₀₀₀ conjugate (DSPE-O). Mechanistically, the positively charged L-lysine linker promotes albumin binding while reducing excessive self-assembly, enhancing lymphatic trafficking and facilitating APC internalization. <i>In vivo</i>, dOA-K-O elicits robust antigen cross-presentation and induces an 8-fold increase in antigen-specific CD8⁺ T cell responses compared to unmodified antigenic peptide and 3-fold higher than DSPE-O. This enhanced cellular immunity translates into marked tumor suppression in both prophylactic and therapeutic B16-OVA melanoma models. Our results establish a design paradigm in which linker chemistry and lipid tail composition are synergistically optimized to boost the immunogenicity of peptide vaccines for cancer immunotherapy, which may provide a chemical and structural basis for the optimization of peptide-based vaccine delivery systems.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103505"},"PeriodicalIF":11.0,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric g-C₃N₄/rGO heterojunction remodels the periodontitis immune microenvironment to promote neurovascular-bone coupled osseointegration.","authors":"Dan Li, Zhen Ai, Jinyang Lv, Yijun Zheng, Chao Zhang","doi":"10.1016/j.mtbio.2026.103498","DOIUrl":"10.1016/j.mtbio.2026.103498","url":null,"abstract":"<p><p>Dental implant restoration is required for tooth loss caused by periodontitis; however, the success rate of implantation in periodontitis patients is significantly lower than that in healthy individuals. On the one hand, biofilm colonization compromises early osseointegration of the implant; on the other hand, the chronic inflammatory microenvironment associated with periodontitis undermines long-term implant stability. Therefore, there is an urgent need for a strategy that integrates both antibacterial and osteogenic microenvironment-modulating functions to promote early osseointegration and long-term stability of dental implants. Herein, a two-dimensional nano-heterostructure was fabricated using g-C₃N₄ and rGO to construct a piezoelectric conductive hydrogel (CN/rGO) for implant restoration in periodontitis patients. Upon ultrasound stimulation, the CN/rGO hydrogel generates a piezoelectric field around the implant: in the early stage, it exerts antibacterial effects to promote initial osseointegration; over the long term, it modulates the immune microenvironment, thereby facilitating neurovascular regeneration and enhancing sustained osseointegration. Notably, inhibition of the JAK-STAT signaling pathway plays a pivotal role in CN/rGO-mediated macrophage phenotype regulation and reversal of the inflammatory microenvironment. This combined strategy of early piezoelectric antibacterial activity and long-term osteogenic microenvironment modulation holds significant implications for promoting early osseointegration and long-term stability of implants in periodontitis patients. The piezoelectric heterostructure-based design proposed in this study promotes neurovascular-guided bone regeneration around implants under inflammatory conditions, offering a feasible approach for improving implant success rates in periodontitis patients, preventing peri-implantitis, and enhancing the full-cycle service performance of dental implants.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103498"},"PeriodicalIF":11.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A manganese-luteolin co-loaded antioxidant hydrogel for synergistic alleviation of oxidative stress and immunomodulation in intervertebral disc degeneratio\" [38(2026), 103257].","authors":"Yaohong Wu, Qin Chen, Mingliang Zhong, Yunsheng Chen, Rongchun Chen, Jiaolan Wu, Guiyong Jiang, Hangzhan Ma, Xiaochuan Li","doi":"10.1016/j.mtbio.2026.103476","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103476","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2026.103257.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103476"},"PeriodicalIF":11.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Photocatalytic oxygen evolution and antibacterial biomimetic repair membrane for diabetes wound repair via HIF1-α pathway' [Mater. Today Bio 20 (2023) 100616].","authors":"Yanlin Su, Bing Ye, Ziming Zhang, Qing Gao, Lian Zeng, Yizhou Wan, Wenzhe Sun, Siyue Chen, Daping Quan, Jialin Yu, Xiaodong Guo","doi":"10.1016/j.mtbio.2026.103490","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103490","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2023.100616.][This corrects the article DOI: 10.1016/j.mtbio.2023.100797.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103490"},"PeriodicalIF":11.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An infection-responsive multifunctional hydrogel enables potent activity against methicillin-resistant <i>Staphylococcus aureus</i> and promotes wound healing.","authors":"Chuanliang Fu, Wenjing Zhang, Renyuan Wang, Runyi Cao, Zhengjie Chen, Peilin Wang, Ying Peng, Yilin Huo, Yi Hu, Zun Ren, Hao Zhang, Yersen Mulat, Zhengjie Luo, Yahui Dai, Min Zhou, Haodong Lin","doi":"10.1016/j.mtbio.2026.103494","DOIUrl":"10.1016/j.mtbio.2026.103494","url":null,"abstract":"<p><p>Infected wounds remain a significant clinical challenge due to bacterial resistance and impaired healing. Therefore, developing effective antibacterial agents and precise delivery systems is crucial for rapid wound repair. To address this, we constructed zeolitic imidazolate framework-8 (ZIF-8) nanoparticles loaded with the host defense peptide-mimicking glycine-poly(2-oxazoline) (Gly-POX) and incorporated them into methacrylated gelatin (GelMA) to prepare the Gel-P@Z nanocomposite hydrogel. The hydrogel integrates the following core design elements: the pH-responsive degradation of ZIF-8 enables targeted drug release within the infected microenvironment; Gly-POX, mimicking the structure of host defense peptides, exerts membrane-disruptive antibacterial activity against MRSA, which possesses a negatively charged cell membrane, through its positively charged side chains; and the GelMA hydrogel provides a three-dimensional extracellular matrix-like scaffold that supports cell adhesion and proliferation. Gel-P@Z exhibited a slow and sustained release of Gly-POX and achieved >99% antibacterial efficacy against drug-resistant bacteria without toxicity. Moreover, Gel-P@Z promoted macrophage polarization from M1 to M2 phenotype and enhanced efferocytosis, while also facilitating fibroblast migration and inducing contraction in <i>ex vivo</i> fascia explants. In a murine full-thickness MRSA-infected wound model, Gel-P@Z effectively cleared bacteria, modulated the inflammatory microenvironment, and promoted both angiogenesis and collagen deposition. RNA-seq analysis revealed that Gel-P@Z accelerated healing via upregulation of the TGF-β signaling pathway, driving fibroblast-to-myofibroblast transition and promoting tissue fibrosis. This work not only proposes a novel strategy for antibacterial polymer delivery but also offers a promising solution for the management of infected wounds.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103494"},"PeriodicalIF":11.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}