手性金纳米颗粒通过巨噬细胞自噬调控骨免疫微环境实现骨再生

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-07-25 DOI:10.1016/j.mtbio.2025.102131

Jiaolong Wang , Ning Gao , Junchao Wei , Lan Liao

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引用次数: 0

摘要

免疫微环境协调骨再生，这可以通过巨噬细胞自噬来控制。本研究利用手性谷胱甘肽配体合成L/D（左手或右手）-手性（L/D- aunps）的金纳米颗粒，立体选择性调节巨噬细胞自噬，并进一步调控骨再生的免疫微环境。值得注意的是，与D-AuNPs相比，L-AuNPs表现出更好的巨噬细胞摄取效率和更高的自噬水平。同时，L-AuNPs改善成骨微环境，进一步促进骨再生。此外，体内实验结果显示，L-AuNPs能显著促进颅骨缺损的愈合。这些发现表明手性AuNPs可以立体选择性地调节巨噬细胞自噬，为手性纳米颗粒在骨免疫中的应用开辟了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration

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Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration

The immune microenvironment orchestrates bone regeneration, which can be manipulated by macrophage autophagy. Herein, gold nanoparticles with L/D (left-handed or right-handed)-chirality (L/D-AuNPs) were synthesized with chiral glutathione ligands to stereoselectively regulate macrophage autophagy, and further manipulate immune microenvironment for bone regeneration. Notably, L-AuNPs exhibited superior macrophage uptake efficiency and higher autophagy level compared to D-AuNPs. Meanwhile, L-AuNPs improved the osteogenic microenvironment, further promoting bone regeneration. In addition, the in vivo results showed that the healing of skull defect was significantly enhanced by L-AuNPs. These findings demonstrated that chiral AuNPs can stereoselectively regulate macrophage autophagy and open an avenue for applications of chiral nanoparticles in osteoimmunity.

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).