Bioactive LDH nanoplatforms for cancer therapy: Advances in modulating programmed cell death

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-07-26 DOI:10.1016/j.mtbio.2025.102139

Li Wang , Nana Ran , TingTing Hu , Xiaoliang Cui , Yong Kang , Min Ge

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Abstract

In recent years, the rapid advancement of nanotechnology and tumor biology has significantly expanded the application of nanomaterials in cancer therapy, particularly through the induction of programmed cell death (PCD) in cancer cells. Layered double hydroxides (LDH), a class of two-dimensional inorganic nanomaterials, have attracted considerable attention due to its tunable structures, excellent biocompatibility, and superior drug delivery capabilities. Emerging research has highlighted the great potential of LDH in modulating various forms of PCD. In this review, we provide a comprehensive overview of recent progress in the use of LDH to regulate different PCD pathways in cancer cells, including apoptosis, autophagy, ferroptosis, cuproptosis and pyroptosis. It emphasizes the underlying mechanisms of action, material design strategies, and the application of LDH in precise cancer therapy. Finally, this review is concluded with perspectives on the key challenges and bottlenecks of bioactive LDH in cancer therapy, providing potential solutions and outlining future perspectives.

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用于癌症治疗的生物活性LDH纳米平台：调节程序性细胞死亡的进展

近年来，纳米技术和肿瘤生物学的快速发展极大地扩展了纳米材料在癌症治疗中的应用，特别是通过诱导癌细胞的程序性细胞死亡（PCD）。层状双氢氧化物（LDH）是一类二维无机纳米材料，因其结构可调、生物相容性好、给药能力强而备受关注。新兴研究强调了LDH在调节各种形式的PCD方面的巨大潜力。在这篇综述中，我们全面概述了LDH在癌细胞中调节不同PCD途径的最新进展，包括凋亡、自噬、铁凋亡、铜凋亡和焦亡。它强调了潜在的作用机制，材料设计策略，以及LDH在精确癌症治疗中的应用。最后，本文总结了生物活性LDH在癌症治疗中的关键挑战和瓶颈，提出了潜在的解决方案，并概述了未来的发展前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).