Materials Today Bio最新文献_第10页

Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy 在光热免疫疗法中同时靶向和抑制热休克蛋白 60 以克服耐热性并诱导肿瘤细胞线粒体死亡

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-29 DOI: 10.1016/j.mtbio.2024.101282

Yiling Meng , Tao Wen , Xuanxin Liu , Aiyun Yang , Jie Meng , Jian Liu , Jianhua Wang , Haiyan Xu

{"title":"Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy","authors":"Yiling Meng , Tao Wen , Xuanxin Liu , Aiyun Yang , Jie Meng , Jian Liu , Jianhua Wang , Haiyan Xu","doi":"10.1016/j.mtbio.2024.101282","DOIUrl":"10.1016/j.mtbio.2024.101282","url":null,"abstract":"<div><div>As the most aggressive and metastatic subtype of breast cancer, clinical demands of triple negative breast cancer (TNBC) have far not been met. Heat shock protein 60 (HSP60) is over expressed in tumor cells and impair the efficacy of photothermal therapy. In this work, a conjugate composed of self-designed peptide targeting HSP60 and gold nanorods was constructed, referred to as AuNR-P17. Results showed that AuNR-P17 was able to simultaneously down regulate the level of HSP60 and locate in the mitochondria where HSP60 is enriched in the tumor cells of TNBC, which also impeded the interaction between HSP60 and integrin α<sub>3</sub>, thereby reducing the tumor cells' heat tolerance and metastatic capabilities. At the same time, AuNR-P17 induced remarkable mitochondrial apoptosis when exposed to the laser irradiation of 808 nm. The dual functions of AuNR-P17 led to the decrement of BCL-2 and the activation of p53 and cleaved caspase-3. The danger associated molecular patterns (DAMPs) generated from the mitochondrial apoptosis elicited strong and long-term specific immune responses against TNBC <em>in vivo</em> and ultimately inhibited the tumor metastasis and recurrence with significantly prolonged survival (>100 days) on TNBC mice. In conclusion, this study demonstrated HSP60 a promising potential therapeutic target for triple negative breast cancer and exhibited powerful capacity of AuNR-P17 in photothermal immune therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101282"},"PeriodicalIF":8.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration 探索前沿：生物活性支架在骨肉瘤治疗和骨再生中的潜力与挑战

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-29 DOI: 10.1016/j.mtbio.2024.101276

Huaiyuan Zhang , Yu Wang , Huifen Qiang , Dewen Leng , Luling Yang , Xueneng Hu , Feiyan Chen , Tinglin Zhang , Jie Gao , Zuochong Yu

{"title":"Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration","authors":"Huaiyuan Zhang , Yu Wang , Huifen Qiang , Dewen Leng , Luling Yang , Xueneng Hu , Feiyan Chen , Tinglin Zhang , Jie Gao , Zuochong Yu","doi":"10.1016/j.mtbio.2024.101276","DOIUrl":"10.1016/j.mtbio.2024.101276","url":null,"abstract":"<div><div>The standard treatment for osteosarcoma combines surgery with chemotherapy, yet it is fraught with challenges such as postoperative tumor recurrence and chemotherapy-induced side effects. Additionally, bone defects after surgery often surpass the body's regenerative ability, affecting patient recovery. Bioengineering offers a novel approach through the use of bioactive scaffolds crafted from metals, ceramics, and hydrogels for bone defect repair. However, these scaffolds are typically devoid of antitumor properties, necessitating the integration of therapeutic agents. The development of a multifunctional therapeutic platform incorporating chemotherapeutic drugs, photothermal agents (PTAs), photosensitizers (PIs), sound sensitizers (SSs), magnetic thermotherapeutic agents (MTAs), and naturally occurring antitumor compounds addresses this limitation. This platform is engineered to target osteosarcoma cells while also facilitating bone tissue repair and regeneration. This review synthesizes recent advancements in integrated bioactive scaffolds (IBSs), underscoring their dual role in combating osteosarcoma and enhancing bone regeneration. We also examine the current limitations of IBSs and propose future research trajectories to overcome these hurdles.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101276"},"PeriodicalIF":8.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system 利用两级给药系统提高雷帕霉素在骨关节炎治疗中的保留率和渗透率

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-28 DOI: 10.1016/j.mtbio.2024.101279

Guangyong Lin , Huirong Huang , Meng Sun , Zhinan He , Shengjie Li , Xindan Liang , Yuqi Yan , Chenyu Qiu , Shize Li , Xinyu Zhao , Wanling Zhu , Longfa Kou , Ruijie Chen

{"title":"Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system","authors":"Guangyong Lin , Huirong Huang , Meng Sun , Zhinan He , Shengjie Li , Xindan Liang , Yuqi Yan , Chenyu Qiu , Shize Li , Xinyu Zhao , Wanling Zhu , Longfa Kou , Ruijie Chen","doi":"10.1016/j.mtbio.2024.101279","DOIUrl":"10.1016/j.mtbio.2024.101279","url":null,"abstract":"<div><div>Osteoarthritis (OA) remains a challenging degenerative joint disease, largely associated with chondrocyte apoptosis during its development. Preserving chondrocytes stands as a promising strategy for OA treatment. Rapamycin (RP) exhibits chondrocyte protection by fostering autophagy. Nevertheless, the swift clearance of intra-articular injections and the dense cartilage extracellular matrix (ECM) hinder RP from effectively reaching chondrocytes. Herein, we developed a \"two-stage\" drug delivery system (RP@PEG-PA@P-Lipo). This system comprises primary nanoparticles (P-Lipo), liposomes modified with a collagen II targeting peptide (WYRGRLC), and secondary nanoparticles (RP@PEG-PA), PEG-modified PAMAM encapsulating rapamycin (RP). RP@PEG-PA@P-Lipo demonstrates adherence to the cartilage surface with WYRGRLC, substantially prolonging retention within the joint cavity. Subsequently, released RP@PEG-PA can effectively penetrate the cartilage and deliver RP to chondrocytes through small size and charge-driven forces. <em>In vitro</em> and <em>in vivo</em> experiments corroborate its notable therapeutic effects on OA. This study holds promise in offering a novel approach for clinical drug delivery and OA treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101279"},"PeriodicalIF":8.7,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy 通过水凝胶包裹 G-Rh2 原位疫苗和全身免疫疗法重塑肿瘤免疫微环境

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101281

Chunhua Li , Dan Lei , Yudong Huang , Yuanhao Jing , Wanru Wang , Lanqi Cen , Zijian Wei , Anni Chen , Xiaoyu Feng , Yushu Wang , Lixia Yu , Ying Chen , Rutian Li

引用次数: 0

The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis 水凝胶与负载芦丁的黑磷纳米片的组合可治疗类风湿性关节炎

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101264

Jing Hou , Shujiang Yin , Runqing Jiao , Wen Chen , Wenjuan Wang , Han Zhang , Zhiyong Liu , Zhenyang Chen , Xing Tian

{"title":"The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis","authors":"Jing Hou , Shujiang Yin , Runqing Jiao , Wen Chen , Wenjuan Wang , Han Zhang , Zhiyong Liu , Zhenyang Chen , Xing Tian","doi":"10.1016/j.mtbio.2024.101264","DOIUrl":"10.1016/j.mtbio.2024.101264","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by inflammation, joint pain, and cartilage degradation. The fluctuating nature of RA often necessitates long-term oral administration of treatment drugs, which can unfortunately lead to adverse effects such as gastrointestinal discomfort and hepatic and renal dysfunction. Therefore, a percutaneous local delivery method for the release of inflammatory modulators in arthritic joints represents a promising therapeutic approach for RA. In this study, we have developed a unique and innovative therapeutic platform (named BP-Rut@Gel). This hydrogel was formulated by incorporating the drug Rutin (Rut) into Black phosphorus nanosheets (BP) and subsequently integrating them within a Hyaluronic Acid (HA) and Polyvinyl Alcohol (PVA) matrix to create a composite hydrogel. Notably, Secondly, photothermal therapy (PTT) under Near-Infrared Irradiation (NIR) and anti-inflammatory drugs synergistically worked together to efficiently quell inflammation and enhance therapeutic effectiveness. Additionally, toxicity experiments have revealed that our synthesized black phosphorus nanosheet composite hydrogel possesses excellent biocompatibility and significantly reduces the inflammatory response in RA joints. Given these remarkable properties, our BP-Rut@Gel hydrogel held significant promise and demonstrated immense clinical potential for the treatment of RA.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101264"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-pathogenic Trojan horse Nissle1917 triggers mitophagy through PINK1/Parkin pathway to discourage colon cancer 非致病特洛伊木马 Nissle1917 通过 PINK1/Parkin 通路触发有丝分裂，阻止结肠癌的发生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101273

Yang Wang , Yao Liu , Xiaomin Su , Lili Niu , Nannan Li , Ce Xu , Zanya Sun , Huishu Guo , Shun Shen , Minghua Yu

{"title":"Non-pathogenic Trojan horse Nissle1917 triggers mitophagy through PINK1/Parkin pathway to discourage colon cancer","authors":"Yang Wang , Yao Liu , Xiaomin Su , Lili Niu , Nannan Li , Ce Xu , Zanya Sun , Huishu Guo , Shun Shen , Minghua Yu","doi":"10.1016/j.mtbio.2024.101273","DOIUrl":"10.1016/j.mtbio.2024.101273","url":null,"abstract":"<div><div>Bacteria-mediated antitumor therapy has gained widespread attention for its innate tumor-targeting capability and excellent immune activation properties. Nevertheless, the clinical approval of bacterial therapies remains elusive primarily due to the formidable challenge of balancing safety with enhancing <em>in vivo</em> efficacy. In this study, leveraging the probiotic <em>Escherichia coli Nissle1917</em> (<em>EcN</em>) emerges as a promising approach for colon cancer therapy, offering a high level of safety attributed to its lack of virulence factors and its tumor-targeting potential owing to its obligate anaerobic nature. Specifically, we delineate the erythrocyte (RBC) membrane-camouflaged <em>EcN</em>, termed as Trojan horse <em>EcN</em>@RBC, which triggers apoptosis in tumor cells by mitigating mitochondrial membrane potential (MMP) and subsequently activating the PINK1/Parkin pathway associated with mitophagy. Concurrently, the decline in MMP induced by mitophagy disrupts the mitochondrial permeability transition pore (MPTP), leading to the release of Cytochrome C and subsequent apoptosis induction. Moreover, synergistic effects were observed through the combination of the autophagy activator rapamycin, bolstering the antitumor efficacy <em>in vivo</em>. These findings offer novel insights into probiotic-mediated antitumor mechanisms and underscore the therapeutic potential of <em>EcN</em>@RBC for colon cancer patients.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101273"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic nanobead assisted the dual targets driven fluorescent biosensor based on SPEXPAR and MNAzyme for the olfactory marker protein detection 基于 SPEXPAR 和 MNAzyme 的纳米磁珠辅助双目标驱动荧光生物传感器用于嗅觉标志蛋白检测

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101272

Jing Qi , Xuemin Cao , Hongyi Bao , Tuodi Zhang , Yichen Wang , Ya Wen , Junling Yang , Guixuan Ge , Ping Wang , Lin Chen , Feng Wang

引用次数: 0

Decellularized extracellular matrix-based disease models for drug screening 用于药物筛选的基于细胞外基质的脱细胞疾病模型

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101280

Zhoujiang Chen , Ji Wang , Ranjith Kumar Kankala , Mingli Jiang , Lianlin Long , Wei Li , Liang Zou , Aizheng Chen , Ya Liu

{"title":"Decellularized extracellular matrix-based disease models for drug screening","authors":"Zhoujiang Chen , Ji Wang , Ranjith Kumar Kankala , Mingli Jiang , Lianlin Long , Wei Li , Liang Zou , Aizheng Chen , Ya Liu","doi":"10.1016/j.mtbio.2024.101280","DOIUrl":"10.1016/j.mtbio.2024.101280","url":null,"abstract":"<div><div><em>In vitro</em> drug screening endeavors to replicate cellular states closely resembling those encountered <em>in vivo</em>, thereby maximizing the fidelity of drug effects and responses within the body. Decellularized extracellular matrix (dECM)-based materials offer a more authentic milieu for crafting disease models, faithfully emulating the extracellular components and structural complexities encountered by cells <em>in vivo</em>. This review discusses recent advancements in leveraging dECM-based materials as biomaterials for crafting cell models tailored for drug screening. Initially, we delineate the biological functionalities of diverse ECM components, shedding light on their potential influences on disease model construction. Further, we elucidate the decellularization techniques and methodologies for fabricating cell models utilizing dECM substrates. Then, the article delves into the research strides made in employing dECM-based models for drug screening across a spectrum of ailments, including tumors, as well as heart, liver, lung, and bone diseases. Finally, the review summarizes the bottlenecks, hurdles, and promising research trajectories associated with the dECM materials for drug screening, alongside their prospective applications in personalized medicine. Together, by encapsulating the contemporary research landscape surrounding dECM materials in cell model construction and drug screening, this review underscores the vast potential of dECM materials in drug assessment and personalized therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101280"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity 可注射、释放氧气、热敏性水凝胶可促进血管化骨形成，延长氧气输送时间，提高骨诱导性

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101267

Yixin Xu , Shaowei Zheng , Zinan Tang , Qiang Zhong , Rong Chen , Pinkai Wang , Jinlang Fu , Jiajun Xie , Yanhong Ning , Mingyuan Lei , Ding Wang , Huaming Mai , Hao Li , Chunhan Sun , Zhanjun Shi , Hao Cheng , Zhe Shi

{"title":"Injectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity","authors":"Yixin Xu , Shaowei Zheng , Zinan Tang , Qiang Zhong , Rong Chen , Pinkai Wang , Jinlang Fu , Jiajun Xie , Yanhong Ning , Mingyuan Lei , Ding Wang , Huaming Mai , Hao Li , Chunhan Sun , Zhanjun Shi , Hao Cheng , Zhe Shi","doi":"10.1016/j.mtbio.2024.101267","DOIUrl":"10.1016/j.mtbio.2024.101267","url":null,"abstract":"<div><div>The failure or delay in healing of critical bone defects is primarily due to early local anoxic conditions and reduced osteogenic activity. In this research, we integrated calcium peroxide (CPO) embedded polycaprolactone (PCL) microspheres and osteoinductive nanoparticles (Hydroxyapatite/Laponite) into a thermosensitive hydrogel (Pluronic F127), thereby formulating an injectable oxygen-releasing osteogenic thermosensitive hydrogel. Notably, the oxygen-releasing microspheres (ORMs) within the composite hydrogel provide stable oxygen release for up to 21 days, ensuring the survival, migration, and bioactivity of both mesenchymal stem cells and endothelial cells under anoxic conditions. Additionally, the composite hydrogel significantly augments the osteogenic potential of bone marrow mesenchymal stem cells by providing a biomimetic microenvironment with the incorporation of nano-hydroxyapatite/laponite. Ultimately, the injectable composite hydrogel successfully stimulated bone regeneration within a cranial defect in a rat model after 8 weeks, with enhanced vascularization and bone quality. The engineered hydrogel provides a minimally invasive approach to stimulate bone regeneration with a sustained oxygen supply and osteogenic microenvironment provision, underlining its potential for treating critical bone defects.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101267"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer cell membrane-coated siRNA-Decorated Au/MnO2 nanosensitizers for synergistically enhanced radio-immunotherapy of breast cancer 用于协同增强乳腺癌放射免疫疗法的癌细胞膜包被 siRNA Decorated Au/MnO2 纳米敏化剂

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-26 DOI: 10.1016/j.mtbio.2024.101275

Diyu Wang , Subin Lin , Tuanwei Li , Xiaohu Yang , Xiang Zhong , Qian Chen , Guoqin Jiang , Chunyan Li

{"title":"Cancer cell membrane-coated siRNA-Decorated Au/MnO2 nanosensitizers for synergistically enhanced radio-immunotherapy of breast cancer","authors":"Diyu Wang , Subin Lin , Tuanwei Li , Xiaohu Yang , Xiang Zhong , Qian Chen , Guoqin Jiang , Chunyan Li","doi":"10.1016/j.mtbio.2024.101275","DOIUrl":"10.1016/j.mtbio.2024.101275","url":null,"abstract":"<div><div>Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO<sub>2</sub> nanosensitizer (R&F@Au/MnO<sub>2</sub>-CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO<sub>2</sub> is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO<sub>2</sub>-CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO<sub>2</sub> upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101275"},"PeriodicalIF":8.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0