Materials Today Bio最新文献

{"title":"Corrigendum to 'A pH-sensitive peptide amphiphilic-based drug delivery system inhibits hepatocellular carcinoma growth by suppressing hepatic stellate cell activation' [Mater Today Bio 32 (2025) 101821].","authors":"Yue Wang, Chen Wei, Xiaoyu Zhao, Fantao Lin, Shijie Liu, Jingkun Bai","doi":"10.1016/j.mtbio.2025.101900","DOIUrl":"https://doi.org/10.1016/j.mtbio.2025.101900","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2025.101821.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101900"},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A microfluidic tumor-on-chip platform deciphers hypoxia-driven FOXO3a/PD-L1 signaling in gastric cancer immunotherapy resistance","authors":"Hanting Xiang ,&nbsp;Fangqian Chen ,&nbsp;Zhebin Dong ,&nbsp;Xianlei Cai ,&nbsp;Yuan Xu ,&nbsp;Zhengwei Chen ,&nbsp;Sangsang Chen ,&nbsp;Tianci Chen ,&nbsp;Jiarong Huang ,&nbsp;Fangfang Chen ,&nbsp;Yahua Zheng ,&nbsp;Jingyun Ma ,&nbsp;Weiming Yu ,&nbsp;Chao Liang","doi":"10.1016/j.mtbio.2025.101925","DOIUrl":"10.1016/j.mtbio.2025.101925","url":null,"abstract":"<div><div>Hypoxia represents a common feature within the microenvironment of various cancerous tumors, which suppresses tumor immunogenicity. Immunotherapy, particularly based on immune checkpoint inhibitors, significantly alters the prognosis of certain tumors and reveals the presence of intrinsic or acquired resistance. Presently available platforms, however, cannot efficiently recapitulate the in vivo tumor microenvironment and elucidate the mechanisms of hypoxia-induced immunotherapy resistance in tumors. In this study, a microfluidic tumor-on-chip model is employed to investigate immunotherapy resistance in gastric cancer (GC) cells within a hypoxic microenvironment. Unlike traditional methods, this chip accurately and efficiently replicates the in vivo tumor hypoxic microenvironment. This microfluidic platform demonstrates the upregulation of the forkhead box O3 (FOXO3a) under hypoxic conditions, subsequently activating downstream programmed cell death ligand-1 (PD-L1) expression, ultimately leading to immunotherapy resistance. In a syngeneic mouse model, FOXO3a deficiency restores sensitivity to immunotherapy by enhancing immune cell enrichment. In clinical samples, FOXO3a levels and the prognosis of patients with gastric cancer receiving immunotherapy are correlated. In summary, by constructing a novel microfluidic chip, the in vivo tumor microenvironment can be efficiently simulated, uncovering the pivotal role of FOXO3a in immunotherapy resistance in gastric cancer.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101925"},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in two-dimensional nanomaterials for regenerative medicine in skeletal muscle repair","authors":"Hongyu Bai ,&nbsp;Lu Liu ,&nbsp;Zhiwen Luo ,&nbsp;Renwen Wan ,&nbsp;Jiwu Chen","doi":"10.1016/j.mtbio.2025.101924","DOIUrl":"10.1016/j.mtbio.2025.101924","url":null,"abstract":"<div><div>Skeletal muscle, the largest organ in the human body, plays vital roles in movement, heat generation, and internal organ protection. While healthy muscle can regenerate effectively, its regenerative capacity declines in conditions like congenital muscular dystrophy, severe trauma, or aging. Two-dimensional (2D) nanomaterials, with unique physicochemical properties such as high surface area, excellent biocompatibility, and tunable mechanical and electrical properties, have shown great promise in different forms of muscle injury, particularly in volumetric muscle loss (VML). Recent studies highlight their diverse applications in muscle regeneration, acting as cell recruitment platforms, drug delivery carriers, structural scaffolds, and anti-inflammatory agents. Additionally, their biological effects and intelligent responsiveness are emerging as key features. Despite these advances, safety concerns regarding toxicity and biodegradability remain a challenge for clinical application. To unlock the full potential of 2D materials, further research is needed, especially through interdisciplinary collaboration to better understand their biological effects. By addressing safety issues and harnessing their multifunctional and intelligent characteristics, 2D nanomaterials can offer a more effective and sustainable approach to skeletal muscle repair, paving the way for next-generation therapies in regenerative medicine.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101924"},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden piece in inflammatory bowel diseases: The significance of intestinal mucus in mediating the bacteria-cells crosstalk","authors":"Giuseppe Guagliano ,&nbsp;Lucia Boeri ,&nbsp;Marta Merli ,&nbsp;Hongji Yan ,&nbsp;Francesco Briatico Vangosa ,&nbsp;Livia Visai ,&nbsp;Sonja Visentin ,&nbsp;Paola Petrini ,&nbsp;Lorenzo Sardelli","doi":"10.1016/j.mtbio.2025.101937","DOIUrl":"10.1016/j.mtbio.2025.101937","url":null,"abstract":"<div><div>Inflammatory bowels diseases (IBD) are chronic conditions with a complex not yet fully understood pathogenesis, characterized by a compromised intestinal barrier. Traditionally, the gut microbiota and the intestinal epithelium have been considered the primary contributors to this dysfunction. However, emerging evidence underscore the crucial role of a third key player: the intestinal mucus. Mucus acts as an equal partner alongside the epithelium and microbiota, functioning as a cell-free interface that filters molecules and toxins while preventing bacterial penetration through its unique structural and compositional properties. Despite its significance, the role of mucus in IBD remains underappreciated, with relative few studies focusing specifically on mucus compared to ones centred on epithelial cells and bacteria. This review explores the features of the intestinal barrier by exanimating each component of the gut mucosa (<em>i.e.</em>, epithelium, microbiota, and mucus) from a mucus-centred perspective. In this way, we aim to highlight the crucial role of mucus in IBD and its importance for new potential therapeutic treatments.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101937"},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma.","authors":"Qixin Zhao, Shenglu Liu, Tao Bi, Ting Wang, Lei Chen, Juan Huang, Xuemei Yang, Xiyu Dai, Zengjin Liu, Qin Sun","doi":"10.1016/j.mtbio.2025.101940","DOIUrl":"10.1016/j.mtbio.2025.101940","url":null,"abstract":"<p><p>Pancreatic malignancies rank among the most aggressive and fatal carcinomas in modern oncology, presenting significant therapeutic challenges due to their inherent chemoresistance. In the context of our experimental investigations, we have developed a mitochondria-targeted hydrogel formulation, termed SWMU690@PUE, which demonstrates the ability to modulate mitochondrial homeostasis effectively. The hydrogel construct was precisely designed via the spontaneous supramolecular assembly of puerarin (PUE) and SWMU690 components, facilitated under carefully controlled thermodynamic conditions. Comprehensive <i>in vitro</i> analyses of the SWMU690@PUE complex were conducted to rigorously evaluate its efficacy in regulating mitochondrial homeostasis. The experimental findings revealed that SWMU690@PUE exhibited pronounced selectivity for mitochondrial targeting, subsequently diminishing mitochondrial membrane potential-a pivotal parameter in cellular bioenergetics. Our study further demonstrated that SWMU690@PUE effectively mitigates the chemoresistance phenotype associated with mitochondrial dysfunction. This therapeutic potential was exemplified by its capacity to induce mitochondria-mediated apoptotic and ferroptotic cell death, critical oncocidal pathways, in pancreatic carcinoma cells across both <i>in vitro</i> and <i>in vivo</i> models. Additionally, SWMU690@PUE displayed significant antineoplastic activity, as evidenced by its robust inhibition of pancreatic cancer cell proliferation in both experimental frameworks. In conclusion, this study presents an innovative therapeutic approach specifically designed to overcome the persistent challenge of chemoresistance in the treatment of pancreatic neoplasms.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101940"},"PeriodicalIF":8.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing nanoprodrugs to enhance cancer immunotherapy: overcoming barriers to precision treatment.","authors":"Yunfan Lin, Pei Lin, Xu Chen, Xinyuan Zhao, Li Cui","doi":"10.1016/j.mtbio.2025.101933","DOIUrl":"10.1016/j.mtbio.2025.101933","url":null,"abstract":"<p><p>Nanoprodrugs, leveraging advanced nanoparticle-based delivery systems, represent a promising strategy to enhance the efficacy of immunotherapy in cancer treatment. These systems offer precise tumor targeting, controlled drug release, and the potential to modulate the immune microenvironment, addressing several limitations of conventional therapeutic approaches. This review systematically evaluates the role of nanoprodrugs in improving immunotherapy outcomes, focusing on their ability to overcome challenges such as poor bioavailability, systemic toxicity, and limited tumor specificity. We also discuss the key advantages of these systems, including their ability to co-deliver immune checkpoint inhibitors and other immunomodulatory agents, potentially enabling more synergistic and effective treatment strategies. Despite their promise, several challenges remain, including achieving precise control over drug release, integrating multiple stimulus-responsive mechanisms, addressing tumor heterogeneity, and overcoming barriers to clinical translation. The review concludes with a perspective on future directions, emphasizing the need for further optimization of nanomaterial design, improved delivery strategies, and solutions to the complexities of the tumor microenvironment to maximize the clinical impact of nanoprodrugs in cancer immunotherapy.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101933"},"PeriodicalIF":8.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A based <i>Cistanche deserticola</i> polysaccharide functional-nanoparticle delivery system for effective oral vaccine to facilitate both systemic and mucosal immunity through enhancing oral delivery.","authors":"Jin He, Tianyu Zhu, Lin Yu, Ningning Mao, Xuanqi Lu, Xiaofeng Shi, Xiangwen Deng, Yang Yang, Deyun Wang","doi":"10.1016/j.mtbio.2025.101939","DOIUrl":"10.1016/j.mtbio.2025.101939","url":null,"abstract":"<p><p>Oral vaccines received great interest in preventing of global pandemics due to the ability to facilitate both systemic and mucosal immune responses. However, the enzymatic degradation, low permeability of mucus barrier, and lack of effective and safe mucosal adjuvants continue to remain significant challenge for oral vaccine. Herein, we developed a novel delivery system based on nanoparticles functionalized by plant polysaccharides to address the above challenges. Firstly, the <i>Cistanche deserticola</i> polysaccharide (CDP) functional-dendritic fibrous nano-silica (DFNS) nanoparticles (CDP-DFNS) were prepared. Encouragingly, the CDP-DFNS with prominent physicochemical and structural characteristics showed high cellular uptake and lead to a high transmembrane transport and intestinal epithelium permeability of antigen. Furthermore, CDP-DFNS significantly induced the antigen internalization and activation of dendritic cells after transport across epithelial cells. In addition, the in vivo experiment results reveled that CDP-DFNS was efficiently facilitated both antigen-specific systemic and mucosal immunity. In conclusion, CDP-DFNS represents a promising candidate for oral vaccine delivery, offering a unique combination of carrier and adjuvant properties. However, further research is needed to evaluate its efficacy in larger animal models and human clinical trials to confirm its translational potential, and fully establish its potential as a next-generation oral vaccine platform.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101939"},"PeriodicalIF":8.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid detection of brain tumor cells using memristors for biomedical applications.","authors":"Longhui Fu, Huangtao Chen, Bai Sun, Zelin Cao, Kaikai Gao, Mengna Wang, Wentao Yan, Kun Wang, Teng Wu, Siyuan Zhang, Shouping Gong, Pengyu Ren","doi":"10.1016/j.mtbio.2025.101934","DOIUrl":"10.1016/j.mtbio.2025.101934","url":null,"abstract":"<p><p>Brain tumors often lead to compression or hemorrhage that can seriously threaten patients' life. However, the rapid detection of brain tumor types has always been a bottleneck technology in the field of neuroscience research. Herein, it is firstly developed a rapid detection method of brain tumor cells by using a memristor with Ag/WO₃/Ti structure, aiming to provide an innovative diagnostic tool. Four brain tumor cell lines representing varying degrees of malignancy, including LN-18, SHG44, U251, and U87, were selected. Each tumor cell suspension was loaded onto the memristor surface, which can induce a noticeable change I‒V curves of the device being recorded. Thus, the memristor's resistance states impacted by different cell lines could be used to identify the types of brain tumors. Our results demonstrated that the memristor can rapidly and effectively identify different types of brain tumor cells based on the changes in its resistance states, especially distinguishing between highly invasive brain tumor cells (U251 and U87) and low invasive brain tumor cells (LN-18 and SHG44). These results support a rapid detection for brain tumor cell with promising clinical applications, thus paving the way for optimization of treatment protocols as well as guidance of the surgical process during operation.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101934"},"PeriodicalIF":8.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Take a (statistical) look at microbial motility: analytical assessment of the early-stage interaction between B. subtilis and ZnO-based antimicrobial surfaces","authors":"Gavino Bassu ,&nbsp;Margherita Izzi ,&nbsp;Adele Castellani ,&nbsp;Rosaria Anna Picca ,&nbsp;Emiliano Fratini ,&nbsp;Marco Laurati ,&nbsp;Nicola Cioffi","doi":"10.1016/j.mtbio.2025.101921","DOIUrl":"10.1016/j.mtbio.2025.101921","url":null,"abstract":"<div><div>Understanding the bioactivity mechanisms and surface properties of antimicrobial coatings is crucial for the development of safer and more environmentally friendly materials, limiting the development of antimicrobial resistance through a correct control of dose-effect relations. In this work, the early stages of interaction between inorganic antimicrobial agents and microorganisms were investigated. Specifically, the short-time motility of bacteria after 30 min of contact with ZnO-based bioactive surfaces was inspected by laser scanning confocal microscopy (LSCM), proposing an innovative statistical method to study the bacteriostatic/bactericidal activity of antimicrobials. ZnO nanostructures (NSs) were synthesized using a scalable electrochemical synthesis in aqueous phase. Two stabilizers, Sodium Dodecyl Sulphate (SDS) and Poly-Diallyl-Dimethyl-Ammonium chloride (PDDA), were employed to produce elongated and flower-like ZnO NSs morphologies. Inorganic antimicrobials were embedded into three polymeric matrices (polyethylene oxide (PEO), polylactic acid (PLA), and poly-vinyl-methyl-ketone (PVMK)) to produce nanocomposite coatings providing different release of Zn²⁺ ions, ranging from 20 to 120 ppm over time (i.e. tunable bioactivity). The antimicrobial surfaces were characterized using UV–Vis, FTIR and X-ray photoelectron spectroscopies, and scanning and transmission electron microscopies. To establish an analytical dose-effect correlation, the influence of Zn²⁺ release on the motility of <em>Bacillus subtilis</em> was evaluated using particle tracking analysis of LSCM images to access the dynamical behavior of the bacteria at short times after direct contact with the bioactive surfaces. The average mean squared displacements (MSDs) revealed that the run-and-tumble dynamics of native <em>B.</em> s<em>ubtilis</em> turns into sub-diffusive motion under the effect of Zn²⁺ ions release indicating a strong biostatic effect already in the first minutes of contact. For the highest concentration of Zn²⁺ released from the PEO and PVMK matrices the time-dependent diffusion coefficient D(τ) approaches zero, indicating an almost complete motility suppression. Direct LSCM imaging of live-dead bacteria was additionally used to assess viability as a function of bioactive ion release revealing that even for the larger Zn²⁺ ions release less than 20 % of the cells were damaged after 30 min of exposure, i.e. the bioactive surfaces have a biostatic rather than bactericidal effect. This direct approach offers a new paradigm in the development of bacteriostatic vs bactericidal strategies, allowing for a precise engineering of antimicrobial coatings to achieve a desired spatio-temporal effect.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101921"},"PeriodicalIF":8.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro/nanorobots in antimicrobial therapy: Addressing challenges of antibiotic resistance.","authors":"Xutong Chen, Yong Li, Chunhua Wang, Zhiqiang Chen, Zhijie Xu, Fada Xia, Yuanliang Yan, Ming Gao","doi":"10.1016/j.mtbio.2025.101936","DOIUrl":"10.1016/j.mtbio.2025.101936","url":null,"abstract":"<p><p>Antibiotic resistance has emerged as a critical global health challenge, particularly when bacteria form biofilms that render conventional antimicrobial treatments markedly less effective. Bacteria residing within biofilm exhibit increased resistance to antimicrobial agents and host immune defenses, complicating treatment and contributing to recurrent infections. Antimicrobial micro- and nanorobots (MNRs) have garnered significant attention as a promising strategy to combat drug-resistant bacteria and biofilms, owing to their exceptional motility, precise targeting, and improved penetration capabilities. Despite their potential, challenges related to biocompatibility, imaging integration, and clinical translation remain unresolved. This review summarizes the latest developments in the therapy of micro/nanorobots for antimicrobial therapy, emphasizing innovative strategies for bacterial eradication and biofilm disruption while addressing the technical hurdles and exploring future research directions.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"101936"},"PeriodicalIF":8.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}