Materials Today Bio最新文献

{"title":"Nanomedicine-powered redox homeostasis modulation: Disrupting antioxidant systems and inducing oxidative stress for precision tumor therapy.","authors":"Jiale Zhan, Ruie Chen, Muhe Chen, Shuyue Yan, Yitian Zhang, Jiawen He, Ya Meng, Xiangrong Yu, Liewei Wen","doi":"10.1016/j.mtbio.2026.103315","DOIUrl":"10.1016/j.mtbio.2026.103315","url":null,"abstract":"<p><p>Precise regulation of cellular redox balance is fundamental for maintaining normal physiological function and overall homeostasis. Oxidative stress arises when reactive oxygen species (ROS) overwhelm cellular antioxidant defenses, disrupting redox equilibrium. It plays a pivotal role in tumor initiation, progression, and metastasis. Tumor cells maintain remarkably elevated levels of both oxidants and antioxidants compared with normal cells, resulting in a dysregulated redox homeostasis that is particularly vulnerable to oxidative stress induced by exogenous stimuli. A growing body of evidence suggests that deliberate modulation of redox homeostasis through inducing intracellular ROS burst and disrupting antioxidant defense systems to enhance oxidative stress, represents a promising therapeutic strategy for precision tumor therapy. To date, various nanoparticles have been found to disrupt redox balance based on their catalytic activity, biological regulatory functions, and drug-delivery capabilities. In this review, we systematically overview oxidative and antioxidant systems in tumor cells and summarize recent advances in nanomedicine-based strategies for redox homeostasis modulation, with an emphasis on the regulation of metabolites, enzyme activities, and signaling pathways. Moreover, we evaluate current challenges and propose actionable strategies to promote clinical translation. By integrating mechanistic understanding with rational nanodrugs design, this review aims to support the development of redox-targeted therapeutic approaches and promote their future implementation in precision tumor therapy.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103315"},"PeriodicalIF":11.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supercritical CO₂-Decellularized amniotic ECM hydrogel promotes immunomodulatory skin regeneration.","authors":"Seongryeol Ye, Yu-Jin Kim, Jin Yoo, In Cheul Choi, Kangwon Lee, Jong Woong Park, Youngmee Jung","doi":"10.1016/j.mtbio.2026.103293","DOIUrl":"10.1016/j.mtbio.2026.103293","url":null,"abstract":"<p><p>Acute ultraviolet B (UVB) exposure triggers rapid skin inflammation, characterized by immune cell infiltration, extracellular matrix (ECM) degradation, and tissue dysfunction. Although current therapeutic strategies such as hydrating dressings, hyaluronic acid/collagen formulations, and exogenous growth factors provide partial benefits, they are insufficient to promote comprehensive regeneration due to their limited ability to modulate the inflammatory and regenerative microenvironment of damaged skin. In this study, we present a decellularized porcine amniotic membrane (dPAM) hydrogel engineered via supercritical carbon dioxide (scCO₂)-based decellularization. This method effectively removes immunogenic cellular components while preserving ECM-associated bioactive molecules, including VEGF, PDGF, IL-10, and Decorin. Notably, the dPAM hydrogel preserved matrix-bound proteins such as Decorin, which have been associated with tissue regeneration and Wnt-related signaling involved in hair follicle biology. <i>In vitro</i> studies demonstrated that the dPAM hydrogel promotes angiogenesis in endothelial cells and attenuates M1-associated pro-inflammatory responses in macrophages. Moreover, it enhanced pro-regenerative and hair follicle-associated gene responses in human follicle-derived dermal papilla cells (HFDPCs), suggesting that dPAM hydrogel may influence Wnt-related regenerative signaling. In a UVB-induced skin inflammation murine model, the hydrogel exhibited dual functionality by attenuating early immune responses and promoting tissue repair. Collectively, these findings highlight the dPAM hydrogel as a bioactive ECM-based platform capable of creating a pro-regenerative microenvironment for cutaneous repair, with potential applications in photodamage-associated skin injury and broader regenerative biomaterial strategies.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103293"},"PeriodicalIF":11.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic self-assembled nanosoldiers of paotianxiong polysaccharides and α-lipoic acid: Highly specific targeted therapy for mesangial proliferative glomerulonephritis.","authors":"Qiao Ren, Xiaoxi Liang, Jiaxin Jiang, Xue Wen, Yi Lin, Quan Zhang, Jin Wang, Qinwan Huang","doi":"10.1016/j.mtbio.2026.103313","DOIUrl":"10.1016/j.mtbio.2026.103313","url":null,"abstract":"<p><p>As a highly prevalent condition in chronic kidney disease progression, mesangial proliferative glomerulonephritis (MsPGN) has limited therapeutic options, with the glomerular barrier substantially restricting drug efficacy. Reactive oxygen species (ROS), inflammation, and aberrant cellular proliferation play pivotal roles in the pathogenesis of MsPGN. To overcome limitations of conventional drugs and nanocarrier delivery systems in MsPGN treatment, this study proposed an interesting \"drug-carrier integration, synergistic targeting' strategy. Our preliminary experiment found that Paotianxiong polysaccharides (PP) has the effect of inhibiting mesangial cells (MCs) proliferation. Novel self-assembling nanoparticles incorporating hydrophilic PP and hydrophobic α-lipoic acid (LA) were developed. This design integrates the ROS scavenging and anti-inflammatory functions of LA with the superiority of PP in inducing MCs apoptosis, thereby synergistically inhibiting the abnormal proliferation of MCs and improving bioavailability simultaneously. For the first time, nanoparticles were coated with LPS/PDGF-BB-activated MC membranes for biomimetic delivery, enabling targeted MsPGN therapy. The prepared nanoparticles (average size: 74 nm) demonstrated significant uptake in MCs. In vitro, they exhibited remarkable capabilities in inhibiting MCs proliferation, scavenging ROS, and reducing inflammation. In vivo, they can achieve the synergistic effect of active and passive targeting and effectively accumulate in glomerular MCs. Through the synergistic effects of regulating oxidative stress, inhibiting M1 macrophage polarization, and suppressing growth factor expression, they can effectively alleviate MsPGN. Furthermore, no significant adverse effects were observed during treatment. Overall, this study constructed a novel self-assembled nanoformulation for MsPGN treatment, provided a new and promising biomimetic nano-delivery strategy targeting glomerular MCs.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103313"},"PeriodicalIF":11.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferrostatin-1-loaded black phosphorus quantum dots (BPQD@Fer-1) nanodelivery system attenuates T cell-mediated rejection after kidney transplantation.","authors":"Ming-Xiao Zhang, Zi-Yin Chen, Hao-Tian Tan, Chang-Yu Ma, Zhuo-Lun Sun, Han-Chao Liu, Ming-Guang Zhang, Sheng-Song Ou, Jian-Feng Wang","doi":"10.1016/j.mtbio.2026.103292","DOIUrl":"10.1016/j.mtbio.2026.103292","url":null,"abstract":"<p><p>The long-term viability of kidney transplantation is commonly hindered by initial ischemia-reperfusion injury (IRI) and the ensuing T cell-mediated rejection (TCMR). Upon reperfusion, the inevitable IRI provokes an acute surge of reactive oxygen species (ROS), thereby driving profound tubular ferroptosis. Dying cells release damage-associated molecular patterns (DAMPs) that attract alloreactive T cells, intensifying oxidative stress and ferroptosis in a destructive feedback loop. To alleviate the severity of TCMR, we developed ultra-small black phosphorus quantum dots (BPQD) loaded with ferrostatin-1, a ferroptosis inhibitor (BPQD@Fer-1 nanoparticles) delivered directly via <i>ex vivo</i> graft perfusion. Owing to its ultra-small size, BPQD@Fer-1 efficiently accumulates within the renal tubules. This pre-arming strategy enables BPQD@Fer-1 to provide an immediate, synergistic defense: simultaneously quenching the initial ROS storm and blocking downstream lipid peroxidation. In a rat transplant model, preventing early tubular ferroptosis effectively silences DAMP release and cuts off recruitment signals for host T cells. Consequently, BPQD@Fer-1 sharply reduces CD8⁺ T cell infiltration, demonstrating that preemptive <i>ex vivo</i> protection effectively circumvents subsequent immune rejection.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103292"},"PeriodicalIF":11.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A blood-brain barrier model based on flexible tubes to tailor the biophysical and chemical environment for drug delivery testing.","authors":"Maria Alexaki, Attilio Marino, Marie Celine Lefevre, Claudio Canale, Davide Odino, João F Mano, Mariana B Oliveira, Gianni Ciofani","doi":"10.1016/j.mtbio.2026.103307","DOIUrl":"10.1016/j.mtbio.2026.103307","url":null,"abstract":"<p><p>The development of physiologically relevant <i>in vitro</i> models of the blood-brain barrier (BBB) is critical for reliable assessment of drug permeability and neurotherapeutic transport. Current platforms often fail to reproduce the three-dimensional geometry and mechanical compliance of cerebral microvessels, limiting their translational relevance. Here, we report the fabrication of soft, flexible and self-supporting tubular membranes <i>via</i> polyelectrolyte complexation of alginate and ε-poly-L-lysine, yielding cylindrical constructs that closely mimic the architecture and flexibility of small brain vessels. The resulting biomaterials support robust endothelial cell adhesion and the formation of a functional barrier, exhibiting controlled permeability consistent with selective molecular transport. Importantly, the compliant tubular constructs enable the application of external mechanical compression, allowing controlled modulation of vessel deformation and barrier integrity in a manner relevant to pathological conditions such as tumor-induced vascular compression. By integrating physiologically relevant cylindrical geometry with a mechanically compliant and deformable microenvironment, this platform provides a tunable and reproducible basis for endothelial barrier formation and mechanical perturbation, enabling the development of a more biomimetic <i>in vitro</i> BBB model.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103307"},"PeriodicalIF":11.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An orally deliverable Co₃O₄@MMT nanozyme platform for inflammatory bowel disease via ROS scavenging, barrier repair, and mucosal homeostasis regulation.","authors":"Yinxi Li, Qinxuan Zhou, Yuxuan She, Bin Lu, Mengting Wu, Tianhao Chen, Pengcheng Ye, Li Yu, Wenzhao Liu, Hui Deng, Xiaowen Hu","doi":"10.1016/j.mtbio.2026.103310","DOIUrl":"10.1016/j.mtbio.2026.103310","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by a self-perpetuating pathological loop, where excessive reactive oxygen species (ROS) induce mucosal inflammation, which in turn drives further ROS production. This oxidative-inflammatory cycle leads to intestinal epithelial barrier disruption and gut microbiota dysbiosis. Current immunosuppressive therapies primarily target downstream inflammation, while fail to address the foundational oxidative stress and achieve complete mucosal healing. To bridge this gap, we developed an orally deliverable nanozyme platform by anchoring cobalt oxide (Co₃O₄) nanoparticles onto montmorillonite nanosheets (Co₃O₄@MMT). This design leverages the Co²⁺/Co³⁺ redox cycling within Co₃O₄ for efficient multi-enzymatic ROS scavenging. Furthermore, transcriptomic analysis and literature evidence suggest that the released Co²⁺ ions can activate the HIF-1α pathway-a key regulator of epithelial repair. The MMT component protects the nanozyme from gastrointestinal degradation and facilitates its electrostatic accumulation at inflamed colonic sites. In murine colitis models, oral Co₃O₄@MMT treatment effectively alleviated disease severity, suppressed inflammation, restored barrier integrity, and rebalanced gut microbiota. This work presents an integrated oral strategy that concurrently targets oxidative stress, inflammation, and barrier restoration, offering a comprehensive therapeutic approach for IBD.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103310"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage-adhesive/penetrating pH-responsive polyphenol-glucosamine nanoparticles alleviate osteoarthritis by matrix remodeling and immune regulation.","authors":"Yeling Chen, Ting Zhang, Ruoyang He, Zheng Wang, Baojin Ma, Fei Gao, Shaohua Ge","doi":"10.1016/j.mtbio.2026.103301","DOIUrl":"10.1016/j.mtbio.2026.103301","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a chronic, whole-joint degenerative disease that ultimately leads to joint deformity and permanent loss of function. Chondrocyte dysfunction secondary to inflammatory responses and oxidative stress impedes the regenerative remodeling of cartilage. Here, a kind of cartilage-adhesive/penetrating self-assembled nanoparticles (GE NPs) are constructed through multiple dynamic covalent and non-covalent interactions between epigallocatechin gallate (EGCG) and glucosamine (GlcN). The hydrogen bonding interactions between GE NPs and the cartilage surface mediate their prolonged retention within the joint cavity. The optimized particle size allows GE NPs to readily penetrate the fibrous matrix of cartilage, facilitating deep tissue delivery. GE NPs reverse OA progression by scavenging reactive oxygen species (ROS) and regulating macrophage polarization, thereby establishing an anti-inflammatory microenvironment and rescuing chondrocytes from apoptosis. Simultaneously, pH-responsive GlcN release promotes the synthesis and secretion of proteoglycans, thereby enhancing cartilage matrix regeneration in the inflammatory microenvironment. In vivo experiments demonstrate that GE NPs facilitate cartilage regeneration and alleviate OA progression within one month. Overall, this cartilage-adhesive, deeply penetrating, and pH-responsive nanoplatform for the co-delivery of GlcN and EGCG represents a synergistic approach to OA treatment.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103301"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deformable <i>Bacillus subtilis</i> with gut homing for tumor treatment via bacterial metabolism-facilitated synergistic approach for starvation, chemotherapy, and immunotherapy.","authors":"Tao Sun, Xiang Wang, Yawen Jiang, Mingxiu Liu, Lianting Huang, Limei Yang, Bei Guo, Kewei Wang, Guodong Sun, Yi Zhang, Wei Xue","doi":"10.1016/j.mtbio.2026.103295","DOIUrl":"10.1016/j.mtbio.2026.103295","url":null,"abstract":"<p><p>Cancer treatment remains a critical global health challenge, which often requires multimodal and targeted therapeutic strategies, yet integrating these modalities typically demands complex formulations. Oncolytic bacterial therapy offers unique opportunities for targeted drug delivery and immune modulation, yet clinical translation has been hindered by safety concerns and tedious engineering modification. Here, we report a deformable <i>Bacillus subtilis</i> (DBS), constructed through one-step cisplatin-induced morphological transformation that elongates the bacterium while simultaneously incorporating chemotherapeutic payloads. The resulting DBS integrated three synergistic antitumor mechanisms: Chemotherapy, Starvation, and Immunotherapy. Metabolically, DBS actively consumes glucose and lactate within the tumor microenvironment (TME), thereby depriving tumor cells of key nutrients and reshaping the microenvironment to become more permissive to therapy. Concurrently, anaerobe-targeting DBS releases the encapsulated cisplatin locally in the TME, enabling direct cytotoxic killing while limiting systemic exposure. Furthermore, DBS leverages its intrinsic immunogenicity to potentiate immune cell activation, while its elongated morphology prolongs tumor retention and facilitates enhanced interactions with infiltrating immune cells. Proteases secreted by DBS hydrolyze the extracellular matrix, facilitating immune cell infiltration and boosting anti-tumor immune responses. Surprisingly, DBS exhibits intestinal homing and is safely cleared through fecal excretion after treatment, minimizing systemic side effects. This study presents an efficient and safe live-bacterial platform for cancer therapy, underscoring the broad potential of bacterial morphology engineering as a facile strategy to integrate multiple synergistic antitumor mechanisms within a single microbial therapeutic.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103295"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally injectable visible light-cured carboxymethyl chitosan hydrogels with indocyanine green-methyl-β-cyclodextrin for breast cancer phototherapy.","authors":"Sun-Jung Yoon, Sae Hyun Kim, Wheemoon Cho, Gun-Jae Jung, Dong Nyoung Heo, Su-Hak Heo, Youngbum Yoo, Suk-Ho Moon, Heung Jae Chun, Dae Hyeok Yang","doi":"10.1016/j.mtbio.2026.103311","DOIUrl":"10.1016/j.mtbio.2026.103311","url":null,"abstract":"<p><p>Chemotherapy is the main therapy for triple-negative breast cancer (TNBC) but causes severe systemic toxicity. A hydrogel system that can be injected into the tumor along with photothermal/photodynamic combination therapy can potentially overcome systemic toxicity. Herein, we developed visible light-cured carboxymethyl chitosan methacrylate (CMCSMA) hydrogels containing an indocyanine green-methyl-β-cyclodextrin inclusion complex (ICG-ic-CD) as an injectable therapy for photo-triggered TNBC therapy. <i>In vitro</i> cell viability results from the inclusion complex of ICG and Me-βCD, which improves photostability and protects against light-induced degradation, revealed that 200 μg/mL ICG-ic-CD (ICG₂₀₀-ic-CD) hydrogel possessed good biocompatibility and had a photo-triggered TNBC therapeutic effect. In addition, various CMCSMA/ICG₂₀₀-ic-CD hydrogels demonstrated superior photothermal/photodynamic combination therapy <i>in vitro</i> and <i>in vivo</i>. These findings suggest that hydrogels composed of CMCSMA and 200 μg/mL of ICG-ic-CD (CMCSMA/ICG₂₀₀-ic-CD) possess an optimal crosslinking density that enables facile injection and effective diffusion of the ICG-ic-CD into tumor tissue. Moreover, the visible light-cured CMCSMA hydrogel system described here holds promise as a versatile local drug delivery platform for various cancer treatments, including chemotherapy, hormone therapy, and gene therapy, as the loading and release of drugs and biomolecules can be effectively controlled using this system.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103311"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tetrahedral framework DNA-based bioswitchable miR-26a-5p delivery system for idiopathic pulmonary fibrosis.","authors":"Ziwei Lei, Cheng Chen, Jiajie Shi, Zong Shen, Ping Ling, Chenru Wei, Banghui Zhu, Weishi Kong, Zhibin Zhang, Tianyu Chen, Bing Xiang, Hongyi He, Hao Tang, Xiaoyan Zhu, Yu Sun","doi":"10.1016/j.mtbio.2026.103309","DOIUrl":"10.1016/j.mtbio.2026.103309","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal interstitial lung disease with severely limited therapeutic options. MicroRNAs, especially miR-26a-5p, have exhibited potent anti-fibrotic effects in preclinical studies. However, their clinical translation has been impeded by intrinsic susceptibility to enzymatic degradation in physiological environments and poor cellular internalization efficiency. In this study, we developed a tetrahedral framework nucleic acid-based bioswitchable miRNA delivery system, termed BiRDS26, for the targeted delivery of miR-26a-5p. BiRDS26 demonstrated robust anti-fibrotic activity in both in vitro and in vivo models, mechanistically mediated by the coordinated suppression of the Hippo and Wnt signaling pathways. Collectively, these results position BiRDS26 as a rationally engineered nanotherapeutic platform with significant translational potential for IPF treatment.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"38 ","pages":"103309"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}