Materials Today Bio最新文献

{"title":"Functionalized 3D-printed GelMA/Laponite hydrogel scaffold promotes BMSCs recruitment through osteoimmunomodulatory enhance osteogenic via AMPK/mTOR signaling pathway","authors":"Linquan Zhou ,&nbsp;Chengcheng Zhang ,&nbsp;Tengbin Shi ,&nbsp;Dingwei Wu ,&nbsp;Huina Chen ,&nbsp;Jiaxin Han ,&nbsp;Dehui Chen ,&nbsp;Jinxin Lin ,&nbsp;Wenge Liu","doi":"10.1016/j.mtbio.2024.101261","DOIUrl":"10.1016/j.mtbio.2024.101261","url":null,"abstract":"<div><div>The migration and differentiation of bone marrow mesenchymal stem cells (BMSCs) play crucial roles in bone repair processes. However, conventional scaffolds often lack of effectively inducing and recruiting BMSCs. In our study, we present a novel approach by introducing a 3D-bioprinted scaffold composed of hydrogels, with the addition of laponite to the GelMA solution, aimed at enhancing scaffold performance. Both <em>in vivo</em> and <em>in vitro</em> experiments have confirmed the outstanding biocompatibility of the scaffold. Furthermore, for the first time, Apt19s has been chemically modified onto the surface of the hydrogel scaffold, resulting in a remarkable enhancement in the migration and adhesion of BMSCs. Moreover, the scaffold has demonstrated robust osteogenic differentiation capability in both <em>in vivo</em> and <em>in vitro</em> environments. Additionally, the hydrogel scaffold has shown the ability to induce the polarization of macrophages from M1 to M2, thereby facilitating the osteogenic differentiation of BMSCs via the bone immune pathway. Through RNA-seq analysis, it has been revealed that macrophages regulate the osteogenic differentiation of BMSCs through the AMPK/mTOR signaling pathway. In summary, the functionalized GelMA/Laponite scaffold offers a cost-effective approach for tailored in situ bone regeneration.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101261"},"PeriodicalIF":8.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photo-crosslinking injectable Photothermal antibacterial hydrogel based on quaternary ammonium grafted chitosan and hyaluronic acid for infected wound healing","authors":"Xinbo Ma ,&nbsp;Aoao Wang ,&nbsp;Xuelian Zhang ,&nbsp;Juan Zhang ,&nbsp;Jiawei Li ,&nbsp;Xi Fu ,&nbsp;Peng Wang ,&nbsp;Yantao Zhao ,&nbsp;Xiaonan Huang","doi":"10.1016/j.mtbio.2024.101265","DOIUrl":"10.1016/j.mtbio.2024.101265","url":null,"abstract":"<div><div>Antibacterial hydrogels not only provide a better environment for skin wounds to avoid infection but also accelerate wound healing. Herein, chitosan modified by a quaternary ammonium salt (CQ), and hyaluronic acid grafted with methacrylate (HM) were designed and synthesized to prepare an injectable photo-crosslinking hydrogel for wound dressing with inherent antibacterial and photothermal properties. CQ and HM exhibited excellent biocompatibility, improved water retention, and antibacterial activity, illustrating vast potential as an antibacterial material in various applications. MXene, a type of 2D nanomaterial, has been widely researched due to its photothermal properties. The CQ and HM polymer precursor could be mixed with Mxene and then crosslinked with 395 nm UV radiation under mild conditions to form a 3D network structure CQ-HM/MXene hydrogel. This hydrogel displayed an appropriate swelling ratio, elastic modulus, photothermal property and excellent biocompatibility. The injectable property of the hydrogel allowed it to easily cover the wound. In vitro and in vivo studies showed that the injectable hydrogel had low cytotoxicity and excellent antibacterial properties, which could help promote wound healing. In summary, this novel CQ-HA/MXene hydrogel has the potential for application in skin wound healing due to inherent antibacterial activity and photothermal effect.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101265"},"PeriodicalIF":8.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized PDAC chip with functional endothelial barrier for tumour biomarker detection: A platform for precision medicine applications","authors":"Karina Goluba ,&nbsp;Vadims Parfejevs ,&nbsp;Evita Rostoka ,&nbsp;Kaspars Jekabsons ,&nbsp;Ilze Blake ,&nbsp;Anastasija Neimane ,&nbsp;Annija Anete Ule ,&nbsp;Roberts Rimsa ,&nbsp;Reinis Vangravs ,&nbsp;Andrejs Pcolkins ,&nbsp;Una Riekstina","doi":"10.1016/j.mtbio.2024.101262","DOIUrl":"10.1016/j.mtbio.2024.101262","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterised by poor survival rates and an increasing global incidence. Advances in the staging and categorization of pancreatic tumours, along with the discovery of functional mutations, have made precision treatments possible, which may lead to better clinical results. To further improve customized treatment approaches, in vitro models that can be used for functional drug sensitivity testing and precisely mimic the disease at the organ level are required. In this study, we present a workflow for creating a personalized PDAC chip utilising primary tumour-derived human pancreatic organoids (hPOs) and Human Umbilical Vein Endothelial Cells (HUVECs) to simulate the vascular barrier and tumour interactions within a PDMS-free organ-on-a-chip system. The patient PDAC tissue, expanded as tumour hPOs, could be cultured as adherent cells on the chip for more than 50 days, allowing continuous monitoring of cell viability through outflows from tumour and endothelial channels. Our findings demonstrate a gradual increase in cell density and cell turnover in the pancreatic tumor channel. Tumour-specific biomarkers, including CA-19.9, TIMP-1, Osteopontin, MIC-1, ICAM-1 and sAXL were consistently detected in the PDAC chip outflows. Comparative analyses between tissue culture plates and microfluidic conditions revealed significant differences in biomarker secretion patterns, highlighting the advantages of the microfluidics approach. This PDAC chip provides a stable, reproducible tumour model system with a functional endothelial cell barrier, suitable for drug sensitivity and secretory biomarker studies, thus serving as a platform for functional precision medicine application and multi-organ chip development.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101262"},"PeriodicalIF":8.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590006424003235/pdfft?md5=3c34b0243a5867e4e0927a84a7d409fc&pid=1-s2.0-S2590006424003235-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in studies on tracheal stent design addressing the related complications","authors":"Shiliang Chen ,&nbsp;Tianming Du ,&nbsp;Hanbing Zhang ,&nbsp;Yanping Zhang ,&nbsp;Aike Qiao","doi":"10.1016/j.mtbio.2024.101263","DOIUrl":"10.1016/j.mtbio.2024.101263","url":null,"abstract":"<div><div>Tracheal stents can be used to quickly reconstruct the airway and relieve symptoms of dyspnea in patients with tracheal stenosis. However, existing tracheal stents lead to complications such as granulation tissue formation, difficulty in removal, persistent growth of malignant tumors, stent migration, and mucus plugging. In this article, we reviewed the main methods used to reduce complications associated with tracheal stent design. Drug-eluting stents can inhibit granulation tissue formation and prevent infection and local chemotherapy. The biodegradable stent can support the trachea for some time, maintain tracheal patency, and degrade gradually, which avoids removing or replacing the stent. Radioactive stents loaded with I¹²⁵ have good potential for inhibiting the persistent growth of malignant tumors. Three-dimensional printing technology enables the manufacturing of patient-specific stents, which increases the degree of matching between the complex tracheal anatomy and the stent, thus providing a new solution for stent migration caused by structural mismatch. Minimizing the barrier of the stent to mucociliary clearance, providing an anti-fouling coating, and culturing respiratory epithelial cells on the surface of the stent are the main methods used to reduce mucus plugging. We also proposed future research directions for tracheal stents to guide the design and manufacture of ideal tracheal stents.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101263"},"PeriodicalIF":8.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable decellularized Wharton's jelly hydrogel containing CD56+ umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection","authors":"Simiao Kang ,&nbsp;Xin Shi ,&nbsp;Yong Chen ,&nbsp;Lin Zhang ,&nbsp;Quanbo Liu ,&nbsp;Ziyang Lin ,&nbsp;Hongbin Lu ,&nbsp;Haile Pan","doi":"10.1016/j.mtbio.2024.101258","DOIUrl":"10.1016/j.mtbio.2024.101258","url":null,"abstract":"<div><p>Traditional meniscectomy or suture for meniscal tear usually leads to failed self-healing, cartilage degeneration and worse osteoarthritis. The strategies that facilitate the healing process of torn meniscus and safeguard knee cartilage against degeneration will be promising for clinical therapy. The CD56⁺ umbilical cord mesenchymal stem cells (UCSCs) (CD56⁺UCSCs) were sorted from Wharton's jelly using flow cytometer. Then, the modified decellularized Wharton's Jelly hydrogel (DWJH) was combined with isolated CD56⁺Exos from CD56⁺UCSCs to fabricate DWJH/CD56⁺Exos. The in vitro studies were performed to characterize the DWJ (decellularized Wharton's Jelly). The injectability and rheological properties were assessed by shear rate and frequency sweep analysis. The biocompatibility and chondrogenic differentiation inducibility of DWJH/CD56⁺Exos were performed on human bone marrow mesenchymal stem cells (hBMSCs) and RAW 264.7 cells. The release dynamics was evaluated in vitro and in vivo experiments. As for the in vivo experiments, the operated rats that subjected to a 2 mm full-thickness longitudinal tear in right medial anterior meniscus were injected a single dose of DWJH/CD56⁺Exos. At 4 and 8 weeks postoperatively, torn meniscus healing and articular cartilage degeneration were evaluated by hematoxylin and eosin (H&amp;E), safranin O/fast green (SO&amp;FG), and Sirius red staining. In in vitro experiments, the injectable DWJH/CD56⁺Exos demonstrated excellent biocompatibility, exosome releasing efficiency, injectable property and chondrogenic inducibility. The results of in vivo experiments revealed that DWJH/CD56⁺Exos degraded over time, promoted meniscal chondrogenesis, organized meniscal extracellular matrix remodeling, safeguard articular cartilage and inhibited secondary cartilage degeneration, which accelerated further facilitated torn meniscus healing. The novel injectable DWJH/CD56⁺Exos promoted meniscal tear healing by promoting meniscal chondrogenesis, safeguarding articular cartilage, and inhibiting secondary cartilage degeneration.</p></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101258"},"PeriodicalIF":8.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590006424003193/pdfft?md5=6cbe89f9553ac2098ff0f9278161da8e&pid=1-s2.0-S2590006424003193-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro vascularization of 3D cell aggregates in microwells with integrated vascular beds","authors":"Maria G. Fois ,&nbsp;Zeinab N. Tahmasebi Birgani ,&nbsp;Carmen López-Iglesias ,&nbsp;Kèvin Knoops ,&nbsp;Clemens van Blitterswijk ,&nbsp;Stefan Giselbrecht ,&nbsp;Pamela Habibović ,&nbsp;Roman K. Truckenmüller","doi":"10.1016/j.mtbio.2024.101260","DOIUrl":"10.1016/j.mtbio.2024.101260","url":null,"abstract":"<div><div>Most human tissues possess vascular networks supplying oxygen and nutrients. Engineering of functional tissue and organ models or equivalents often require the integration of artificial vascular networks. Several approaches, such as organs on chips and three-dimensional (3D) bioprinting, have been pursued to obtain vasculature and vascularized tissues <em>in vitro</em>. This technical feasibility study proposes a new approach for the <em>in vitro</em> vascularization of 3D microtissues. For this, we thermoform arrays of round-bottom microwells into thin non-porous and porous polymer films/membranes and culture vascular beds on them from which endothelial sprouting occurs in a Matrigel-based 3D extra cellular matrix. We present two possible culture configurations for the microwell-integrated vascular beds. In the first configuration, human umbilical vein endothelial cells (HUVECs) grow on and sprout from the inner wall of the non-porous microwells. In the second one, HUVECs grow on the outer surface of the porous microwells and sprout through the pores toward the inside. These approaches are extended to lymphatic endothelial cells. As a proof of concept, we demonstrate the <em>in vitro</em> vascularization of spheroids from human mesenchymal stem cells and MG-63 human osteosarcoma cells. Our results show the potential of this approach to provide the spheroids with an abundant outer vascular network and the indication of an inner vasculature.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101260"},"PeriodicalIF":8.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofunctional coatings and drug-coated stents for restenosis therapy","authors":"Yanghui Wen ,&nbsp;Yihuan Li ,&nbsp;Rui Yang ,&nbsp;Yunjie Chen ,&nbsp;Yan Shen ,&nbsp;Yi Liu ,&nbsp;Xiaomei Liu ,&nbsp;Botao Zhang ,&nbsp;Hua Li","doi":"10.1016/j.mtbio.2024.101259","DOIUrl":"10.1016/j.mtbio.2024.101259","url":null,"abstract":"<div><div>Palliative therapy utilizing interventional stents, such as vascular stents, biliary stents, esophageal stents, and other stents, has been a prevalent clinical strategy for treating duct narrowing and partial blockage. However, stent restenosis after implantation usually significantly compromises therapeutic efficacy and patient safety. Clinically, vascular stent restenosis is primarily attributed to endothelial hyperplasia and coagulation, while the risk of biliary stent occlusion is heightened by bacterial adhesion and bile sludge accumulation. Similarly, granulation tissue hyperplasia leads to tracheal stent restenosis. To address these issues, surface modifications of stents are extensively adopted as effective strategies to reduce the probability of restenosis and extend their functional lifespan. Applying coatings is one of the technical routes involving a complex selection of materials, drug loading capacities, release rates, and other factors. This paper provides an extensive overview of state of the art drug-coated stents, addressing both challenges and future prospects in this domain. We aim to contribute positively to the ongoing development and potential clinical applications of drug-coated stents in interventional therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101259"},"PeriodicalIF":8.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259000642400320X/pdfft?md5=9d2fcbb3ea958168f7dd57ea72f03103&pid=1-s2.0-S259000642400320X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoinductivity enhancement by tailoring the surface chemical bond status: A strategy to mobilize host bone growth factors for in situ bone regeneration","authors":"Ruiyan Li ,&nbsp;Kan Zhang ,&nbsp;Chuanyao Dong ,&nbsp;Kaiwen Wang ,&nbsp;Xinlei Gu ,&nbsp;Yanguo Qin","doi":"10.1016/j.mtbio.2024.101256","DOIUrl":"10.1016/j.mtbio.2024.101256","url":null,"abstract":"<div><div>The incorporation of growth factors and biomaterials is a promising strategy for improving osseointegration. However, current strategies to develop biomaterials with exogenous growth factors present disadvantages like inefficiency, difficult deployment, and potential off-target activation, making their translation into clinical practice challenging. This study reveals a bioactive N-doped tantalum carbide (TaC) solid solution film that can be used to construct a TaCN film via bionic interface engineering to recruit host bone growth factors to the wounded site and improve bone regeneration. X-ray photoelectron spectroscopy (XPS) and protein absorption analysis reveal that the performance of TaCN is related to the surface chemical bonds of films. The introduction of N to TaC causes a cascade effect wherein negative charges enrich on the TaCN surface, and the recruitment of positively charged bone growth factors around the TaCN film is facilitated. Under these circumstances, the endogenous bone growth factors enhance bone healing. The TaCN film shows an outstanding performance for <em>in vivo</em> osteogenic differentiation along with a superior <em>in vitro</em> cytocompatibility. Incorporation of N atoms into TaC provides a new clinically translatable strategy to mobilize host bone growth factors for <em>in situ</em> bone regeneration without the need for incorporation of exogenous growth factors.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101256"},"PeriodicalIF":8.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259000642400317X/pdfft?md5=25b495d61b81a0da61a68010356ef54b&pid=1-s2.0-S259000642400317X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data encryption/decryption and medical image reconstruction based on a sustainable biomemristor designed logic gate circuit","authors":"Fulai Lin ,&nbsp;Yuchen Cheng ,&nbsp;Zhuoqun Li ,&nbsp;Chengjiang Wang ,&nbsp;Wei Peng ,&nbsp;Zelin Cao ,&nbsp;Kaikai Gao ,&nbsp;Yu Cui ,&nbsp;Shiyang Wang ,&nbsp;Qiang Lu ,&nbsp;Kun Zhu ,&nbsp;Dinghui Dong ,&nbsp;Yi Lyu ,&nbsp;Bai Sun ,&nbsp;Fenggang Ren","doi":"10.1016/j.mtbio.2024.101257","DOIUrl":"10.1016/j.mtbio.2024.101257","url":null,"abstract":"<div><p>Memristors are considered one of the most promising new-generation memory technologies due to their high integration density, fast read/write speeds, and ultra-low power consumption. Natural biomaterials have attracted interest in integrated circuits and electronics because of their environmental friendliness, sustainability, low cost, and excellent biocompatibility. In this study, a sustainable biomemristor with Ag/mugwort:PVDF/ITO structure was prepared using spin-coating and magnetron sputtering methods, which exhibited excellent durability, significant resistance switching (RS) behavior and unidirectional conduction properties when three metals were used as top electrode. By studying the conductivity mechanism of the device, a charge conduction model was established by the combination of F-N tunneling, redox, and complexation reaction. Finally, the novel logic gate circuits were constructed using the as-prepared memristor, and further memristor based encryption circuit using 3-8 decoder was innovatively designed, which can realize uniform rule encryption and decryption of medical information for data and medical images. Therefore, this work realizes the integration of memristor with traditional electronic technology and expands the applications of sustainable biomemristors in digital circuits, data encryption, and medical image security.</p></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101257"},"PeriodicalIF":8.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590006424003181/pdfft?md5=9258854e503cd043b76fd500defd6700&pid=1-s2.0-S2590006424003181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections","authors":"Min Ge ,&nbsp;Feng Jiang ,&nbsp;Han Lin","doi":"10.1016/j.mtbio.2024.101255","DOIUrl":"10.1016/j.mtbio.2024.101255","url":null,"abstract":"<div><p>The rapid rise of antibiotic-resistant strains and the persistence of biofilm-associated infections have significantly challenged global public health. Unfortunately, current clinical high-dose antibiotic regimens and combination therapies often fail to completely eradicate these infections, which can lead to adverse side effects and further drug resistance. Amidst this challenge, however, the burgeoning development in nanotechnology and nanomaterials brings hopes. This review provides a comprehensive summary of recent advancements in nanomaterials for treating bacterial infections. Firstly, the research progress of catalytic therapies in the field of antimicrobials is comprehensively discussed. Thereafter, we systematically discuss the strategies of nanomaterials for anti-bacterial infection therapies, including endogenous response catalytic therapy, exogenous stimulation catalytic therapy, and catalytic immunotherapy, in order to elucidate the mechanism of nanocatalytic anti-infections. Based on the current state of the art, we conclude with insights on the remaining challenges and future prospects in this rapidly emerging field.</p></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101255"},"PeriodicalIF":8.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590006424003168/pdfft?md5=f751ebbf6c235e07c4e7c6ff65b1a6e4&pid=1-s2.0-S2590006424003168-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}