Materials Today Bio最新文献_第8页

Functional scaffolds design strategies for retinal repair and regeneration 视网膜修复与再生的功能支架设计策略

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-08 DOI: 10.1016/j.mtbio.2025.102283

Pei Lin Chee , Ming Hao , Gaodan Liu , Pek Yin Michelle Yew , Eunjin Kim , Hang Liu , Thenapakiam Sathasivam , Guojie Xu , Zengping Liu , Dan Kai

{"title":"Functional scaffolds design strategies for retinal repair and regeneration","authors":"Pei Lin Chee , Ming Hao , Gaodan Liu , Pek Yin Michelle Yew , Eunjin Kim , Hang Liu , Thenapakiam Sathasivam , Guojie Xu , Zengping Liu , Dan Kai","doi":"10.1016/j.mtbio.2025.102283","DOIUrl":"10.1016/j.mtbio.2025.102283","url":null,"abstract":"<div><div>The growing strain placed on both society and the healthcare system due to an ageing population should not be underestimated. Age-related macular degeneration (AMD) is a leading cause of blindness worldwide and is projected to affect 288 million people globally by 2040. Current treatment options for AMD primarily focus on disease management rather than offering a definitive cure. Retinal tissue engineering, which aims to develop targeted regenerative strategies to restore or replace damaged retinal tissues, offers pioneering advances that could provide curative solutions for AMD and revolutionize its therapeutic landscape. This review aims to provide a comprehensive overview of biomaterial strategies for retinal repair and regeneration, with a particular focus on scaffold design. To effectively address the underlying causes of retinal degenerative diseases and develop functional scaffolds, the review examines the retinal anatomy, the vision-impairing diseases associated with degeneration and relevant cell types. Building on this foundation, it further discusses various scaffold design strategies, including the selection of biomaterials, the structural and mechanical mimicry of native tissues, and the fabrication of scaffolds for co-culturing. Beyond current strategies, we also explore potential features, such as electrically conductive and photo-responsiveness, that could shape the future of scaffold design in retina tissue engineering. Collectively, these insights provide a robust framework to drive and accelerate the next generation of scaffold development for retinal tissue engineering.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102283"},"PeriodicalIF":10.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy Mn-MIL-100@AKG通过调节线粒体自噬减轻椎间盘退变

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-08 DOI: 10.1016/j.mtbio.2025.102252

Xianglong Chen , Haiyang Gao , Anran Zhang , Pengzhi Shi, Yuhang Chen, Zhangrong Cheng, Wang Wu, Wenbo Wu, Yukun Zhang

{"title":"Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy","authors":"Xianglong Chen , Haiyang Gao , Anran Zhang , Pengzhi Shi, Yuhang Chen, Zhangrong Cheng, Wang Wu, Wenbo Wu, Yukun Zhang","doi":"10.1016/j.mtbio.2025.102252","DOIUrl":"10.1016/j.mtbio.2025.102252","url":null,"abstract":"<div><div>Currently, the therapy of intervertebral disc degeneration (IDD) mostly focuses on basic molecular causes. Research on the alterations of metabolites in the intervertebral disc prior to and following intervertebral disc degeneration (IDD) remains inadequate, with even less therapeutic options available for metabolites. In contrast to traditional investigations of molecular mechanisms, it has been shown that a reciprocal relationship exists between the nutritional metabolism of the intervertebral disc and the molecular mechanisms of degeneration. Impaired energy metabolism in deteriorated nucleus pulposus cells exacerbates numerous degenerative phenotypes within the cells. This work investigated the metabolic alterations in the intervertebral disc after the creation of inflammatory degeneration models and illustrated the therapeutic benefits of α-ketoglutarate (AKG) on degenerated nucleus pulposus cells. This study introduces the first demonstration of a metal-organic framework (MOF)-based delivery system (Mn-MIL-100@AKG) for α-ketoglutarate (AKG) aimed at treating intervertebral disc degeneration (IDD), revealing a unique mode of mitophagy control through the HIF-1α-BNIP3-LC3B axis. Our study elucidated the critical function of autophagy regulation via the HIF-1α-BNIP3-LC3B axis in mitigating NPC degeneration and established a MOF-based AKG drug delivery system, offering a novel approach for the treatment of IDD.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102252"},"PeriodicalIF":10.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle homing peptide modified liposomes loaded with EGCG improved skeletal muscle dysfunction by inhibiting inflammation in aging mice 负载EGCG的肌肉归巢肽修饰脂质体通过抑制衰老小鼠的炎症改善骨骼肌功能障碍

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102265

Zongyu Huang , Jianjie Xie , Nana Gao , Huicong Feng , Biaobiao Wang , He Tian , Chao Wu , Chang Liu

{"title":"Muscle homing peptide modified liposomes loaded with EGCG improved skeletal muscle dysfunction by inhibiting inflammation in aging mice","authors":"Zongyu Huang , Jianjie Xie , Nana Gao , Huicong Feng , Biaobiao Wang , He Tian , Chao Wu , Chang Liu","doi":"10.1016/j.mtbio.2025.102265","DOIUrl":"10.1016/j.mtbio.2025.102265","url":null,"abstract":"<div><div>Skeletal muscle aging frequently leads to a reduction in muscle mass and strength, significantly compromising the quality of life in elderly individuals. Skeletal muscle dysfunction during aging is widely recognized to be closely linked to chronic inflammation, oxidative stress and mitochondrial dysfunction. In this study, we confirmed the successful synthesis of M12 (muscle homing peptide)-modified EGCG (Epigallocatechin gallate) liposomes and validated their specific targeting to skeletal muscle through immunofluorescence analysis and in vivo imaging in small animal models. Both in vivo and in vitro experiments demonstrated that M12EGLP effectively suppressed the expression of inflammatory markers such as TNF-α and IL-6, thereby alleviating oxidative stress and restoring mitochondrial function in skeletal muscle. These effects ultimately contributed to the improvement of skeletal muscle dysfunction in aging mice. We have developed M12-modified EGCG liposomes (M12EGLP), a targeted drug delivery system capable of specifically accumulating in skeletal muscle, thereby enhancing the bioavailability and therapeutic potential of EGCG. M12EGLP enhances the exercise capacity of aging mice by reducing skeletal muscle inflammation, which subsequently alleviates oxidative stress and improves mitochondrial function. Therefore, as a novel and targeted drug delivery system, M12EGLP may provide a promising therapeutic strategy for the clinical management of age-related skeletal muscle dysfunction.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102265"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-functional in situ hydrogel for delivering vitamin E–based lipid nanoparticles to enhance cancer immunotherapy 一种双重功能的原位水凝胶，用于输送维生素基脂质纳米颗粒，以增强癌症免疫治疗

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102289

Chaozhu Zheng , Dekang Nie , Zhao Wang , Nanjun Li , Xiaolu Jin , Ya Zhou , Jun Wang , Jun Xu , Zhengqing Cai , Binbin Xu , Zizhuo Wei , Feng Zhou , Yiming Qi

{"title":"A dual-functional in situ hydrogel for delivering vitamin E–based lipid nanoparticles to enhance cancer immunotherapy","authors":"Chaozhu Zheng , Dekang Nie , Zhao Wang , Nanjun Li , Xiaolu Jin , Ya Zhou , Jun Wang , Jun Xu , Zhengqing Cai , Binbin Xu , Zizhuo Wei , Feng Zhou , Yiming Qi","doi":"10.1016/j.mtbio.2025.102289","DOIUrl":"10.1016/j.mtbio.2025.102289","url":null,"abstract":"<div><div>Conventional mRNA lipid nanoparticles often fail to elicit robust antitumor immunity due to their limited capacity to overcome the immunosuppressive tumor microenvironment (TME). Rational design of ionizable lipids with intrinsic bioactivity presents a promising strategy to enhance mRNA-based cancer immunotherapy. Here, we synthesized a bioactive vitamin E–based ionizable lipid to formulate lipid nanoparticles co-loaded with IL-12 mRNA and the IDO1 inhibitor NLG919 (N@VEBLNP), which were subsequently embedded into polyether F127-diacrylate hydrogel (NVF Gel). This hydrogel enables thermosensitive gelation for intratumoral injection and photocrosslinkable curing for postoperative site retention in the treatment of triple-negative breast cancer (TNBC). Specifically, NVF Gel exerted a dual immunomodulatory function: sustained release of N@VEBLNPs activated migratory cDC1s and augmented antigen presentation in tumor-draining lymph nodes, while concomitant release of NLG919 inhibited IDO1 expression, reduced regulatory T cells, and reprogrammed M2 macrophages toward the M1 phenotype. In 4T1 murine models, NVF Gel transformed the tumor environment into a more “immune-hot” state, effectively suppressed tumor growth and delayed postoperative recurrence. Collectively, NVF Gel provides a versatile platform for in situ cancer immunization and tumor microenvironment modulation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102289"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous induction of immunogenic cell death and PD-L1 downregulation by bufalin-based nanovaccines for potentiate HCC immunotherapy 以蟾毒灵为基础的纳米疫苗同时诱导免疫原性细胞死亡和PD-L1下调以增强HCC免疫治疗

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102294

Zhe Li , Lixia Chen , Ruifeng Zeng , Yi Shen , Jinshuai Lan , Tong Zhang , Yue Ding

{"title":"Simultaneous induction of immunogenic cell death and PD-L1 downregulation by bufalin-based nanovaccines for potentiate HCC immunotherapy","authors":"Zhe Li , Lixia Chen , Ruifeng Zeng , Yi Shen , Jinshuai Lan , Tong Zhang , Yue Ding","doi":"10.1016/j.mtbio.2025.102294","DOIUrl":"10.1016/j.mtbio.2025.102294","url":null,"abstract":"<div><div>Immunotherapy is a promising treatment in hepatocellular carcinoma (HCC), but with low response rate clinically. Immunogenic cell death (ICD) is considered as a strategy to enhance immunotherapy response. However, chemotherapeutic drugs with ICD make tumor cells upregulating PD-L1 expression to deactivate T-cells via PD-1/PD-L1 pathway. Here, Bufalin (Buf) was validated for the first time as an ICD inducer. Buf triggered reactive oxygen species (ROS) related endoplasmic reticulum (ER) stress to elicit apoptosis and ICD via PERK/eIF2α/ATF-4/CHOP in HCC cells. Additionally, Buf downregulated the expression of PD-L1 to avoid immune escape. Buf can simultaneously activate dendritic cell (DC) maturation and interrupt the PD-1/PD-L1 pathway. To amplify immunotherapy and decrease adverse cardiac reactions of Buf, SP94-modified liposome-coated zeolite imidazolate framework-8 loaded with Buf (Buf-ZIF-lipo-SP94) was designed to effectively increase drug accumulation in tumor by HCC-specific targeting SP94 receptor-mediated endocytosis. Importantly, ZIF-8 with the ability of triggering ROS generation itself synergized Buf to induce stronger ICD effects. Buf-ZIF-lipo-SP94 achieved synergistic effects with anti-PD-L1 for HCC immunotherapy, showing better tumor inhibition rate (>90 %), survival of animals and safety. This study uncovered the potential of Buf in inducing ICD and downregulating PD-L1 expression, developing a Buf-loaded nanovaccine for combination strategy of immunotherapy in HCC.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102294"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A H2-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration h2 -生物反应器用于感染性骨缺损再生的线粒体康复

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102295

Chunru Kong , Chao Si , Haofeng Liu , Yawen Wang , Jiakai Qiao , Xiaoduo Tang , Hongchen Sun , Junhu Zhang , Bei Chang

{"title":"A H2-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration","authors":"Chunru Kong , Chao Si , Haofeng Liu , Yawen Wang , Jiakai Qiao , Xiaoduo Tang , Hongchen Sun , Junhu Zhang , Bei Chang","doi":"10.1016/j.mtbio.2025.102295","DOIUrl":"10.1016/j.mtbio.2025.102295","url":null,"abstract":"<div><div>The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed a double-network hydrogel scaffold composed of phenylboronic acid-modified quaternary chitosan and glycidyl methacrylated poly(vinyl alcohol) (QP-P), crosslinked via dynamic boronic ester bonds and covalent bonds, loaded with magnesium microspheres (Mg spheres) (QP-P/Mg). This double-crosslinking network confers excellent injectability and tissue adhesion while integrating potent antibacterial, ROS-scavenging, pro-angiogenic, and osteogenic functions. Notably, Mg spheres enable controlled hydrolysis through a boronic ester-magnesium ion (Mg<sup>2+</sup>) complexation mechanism, providing sustained release of hydrogen (H<sub>2</sub>) and Mg<sup>2+</sup>, with H<sub>2</sub> potently alleviating oxidative stress and restoring mitochondrial homeostasis via the Nrf2/HO-1 pathway and Mg<sup>2+</sup> promoting vascularized bone regeneration. In a rat IBDs model, QP-P/Mg achieved substantial bone regeneration, with a BV/TV ratio of 45.32 % ± 8.22 % after 4 weeks, representing a 6.27-fold improvement over controls. These findings underscore the potential of this H<sub>2</sub>-releasing hydrogel scaffold with multifunctional properties to promote vascularized bone regeneration in IBDs through ROS elimination and mitochondrial rehabilitation, offering promising clinical translational opportunities for the treatment of IBDs.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102295"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment-responsive hydrogels for spatiotemporal delivery of epigallocatechin gallate and BMP-2 to promote osteoporotic bone defect repair 表没食子儿茶素没食子酸酯和BMP-2的时空递送微环境响应水凝胶促进骨质疏松性骨缺损修复

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102290

Peilun Xiao , Guang Shi , Zeyao Lu , Shijia Liu , Chongjun Huang , Yuhai Zhao , Lei Wang , Zhihang Wang , Huiyi Zhang , Yuanfan Liu , Jingfeng Li , Ying Xu , Ye Tian

{"title":"Microenvironment-responsive hydrogels for spatiotemporal delivery of epigallocatechin gallate and BMP-2 to promote osteoporotic bone defect repair","authors":"Peilun Xiao , Guang Shi , Zeyao Lu , Shijia Liu , Chongjun Huang , Yuhai Zhao , Lei Wang , Zhihang Wang , Huiyi Zhang , Yuanfan Liu , Jingfeng Li , Ying Xu , Ye Tian","doi":"10.1016/j.mtbio.2025.102290","DOIUrl":"10.1016/j.mtbio.2025.102290","url":null,"abstract":"<div><div>Regenerating osteoporotic bone defects is still a major challenge. Conventional bone tissue engineering materials often fail to achieve on-demand drug delivery. At the same time, the therapeutic logic of osteoporotic bone defects requires spatiotemporal drug delivery to eliminate excess inflammation and high reactive oxygen species (ROS) at an early stage. When inflammation subsides, appropriate drugs are needed to match osteoblast differentiation and bone regeneration. Therefore, we designed a ROS-responsive Polyvinyl alcohol–4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylphenylboronic acid (PVA-TSPBA) hydrogel loaded with epigallocatechin gallate (EGCG) and bone morphogenetic protein-2 (BMP-2). On the one hand, the ROS-responsive properties of composite hydrogels enable controlled delivery of EGCG in the high ROS microenvironment at an early stage of osteoporotic bone defects. On the other hand, BMP-2 is anchored within tannic acid-loaded zeolitic imidazolate framework-8 (TA-ZIF-8), which allows a sustained release and matches late osteoblast differentiation and bone repair. The metal-organic frameworks (MOFs)-enhanced composite hydrogel has good mechanical properties and can provide good support for bone defects. Furthermore, the EGCG + BMP-2@TA-ZIF-8+PVA-TSPBA hydrogel (abbreviated as E + B@TZ + Gel) exhibited excellent biocompatibility. Bioinformatics analysis showed that the composite hydrogel enhanced bone repair by promoting osteogenesis via the PI3K/AKT/mTOR pathway. Thus, the hydrogel system with therapeutic logic and microenvironment regulation offers a promising strategy for the regeneration of osteoporotic bone defects.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102290"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epileptogenic zone-targeting nanoparticle drug delivery system for antiseizure medication 用于抗癫痫药物的致痫区靶向纳米颗粒给药系统

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-07 DOI: 10.1016/j.mtbio.2025.102297

Honglu Ping , Qi Zhang , Xiaojie Chen , Yi Wang , Di Wu , Jianhong Wang , Jun Zhang

{"title":"Epileptogenic zone-targeting nanoparticle drug delivery system for antiseizure medication","authors":"Honglu Ping , Qi Zhang , Xiaojie Chen , Yi Wang , Di Wu , Jianhong Wang , Jun Zhang","doi":"10.1016/j.mtbio.2025.102297","DOIUrl":"10.1016/j.mtbio.2025.102297","url":null,"abstract":"<div><div>Epilepsy is a chronic neurological disorder affecting over 65 million people worldwide, characterized by abnormal excessive excitation of neuronal networks. Traditional antiseizure medications (ASMs), such as phenytoin (PHT), have limited therapeutic efficacy due to poor blood-brain barrier (BBB) penetration and off-target toxicity. To address these issues, this study proposes an electrically responsive closed-loop system drug delivery system (DDS) using PHT as a model drug. The system utilizes electro-responsive nanoparticles made from polypyrrole (PPY), which can contract in response to electrical stimulation, allowing for on-demand drug release during epileptic discharges. Additionally, the excessive activation of tryptophan metabolism in people with epilepsy leads to tryptophan (Trp) depletion, promoting its uptake in the epileptogenic zone and creating a \"metabolic trapping\" effect. Meanwhile, hyaluronic acid (HA) binds to CD44 receptors, enhancing nanoparticle retention at the lesion, thereby creating a \"targeted delivery-extended retention\" effect. This non-invasive epileptogenic zone-targeting PPY-HA-PHT-Trp DDS may enhance ASM effect and have potential applications in clinical settings.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102297"},"PeriodicalIF":10.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Band-interface cooperative engineering of bismuth-based heterojunctions for sonodynamic-chemodynamic synergistic breast cancer therapy 铋基异质结的带界面协同工程用于声动力-化学动力协同治疗乳腺癌

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-06 DOI: 10.1016/j.mtbio.2025.102296

Xueyu Li , Jun Du , Qingxuan Meng , Lejin Zhu , Yuqing Miao , Yuhao Li , Qing Miao

{"title":"Band-interface cooperative engineering of bismuth-based heterojunctions for sonodynamic-chemodynamic synergistic breast cancer therapy","authors":"Xueyu Li , Jun Du , Qingxuan Meng , Lejin Zhu , Yuqing Miao , Yuhao Li , Qing Miao","doi":"10.1016/j.mtbio.2025.102296","DOIUrl":"10.1016/j.mtbio.2025.102296","url":null,"abstract":"<div><div>The clinical efficacy of sono-immunotherapy is limited by the low reactive oxygen species (ROS) yield of sonosensitizers and the antioxidant defense mechanisms within the tumor microenvironment (TME). Herein, leveraging bandgap and interfacial engineering strategies, we fabricate a bismuth-based nanoheterojunction BiF<sub>3</sub>:Ce-BiOI-PEG (BCOP) via an ion-exchange method. BCOP integrates efficient sono-catalytic ROS generation with TME-responsive Fenton-like catalytic activity, enabling synergistic enhancement of sonodynamic therapy (SDT) and chemodynamic therapy (CDT). Under ultrasound (US) irradiation, the BCOP heterojunction significantly boosts ROS production efficiency by utilizing its built-in electric field to drive directional carrier separation. Concurrently, the acidic TME triggers a Ce<sup>3+</sup>-mediated Fenton-like reaction, converting endogenous H<sub>2</sub>O<sub>2</sub> into highly toxic hydroxyl radicals (•OH). Furthermore, dual glutathione (GSH) depletion via Bi<sup>3+</sup> coordination coupled with hole (h<sup>+</sup>)-mediated oxidation effectively impairs the antioxidant capacity of the TME, synergistically amplifying oxidative stress-induced damage in tumor cells. In vitro cell experiments demonstrate that BCOP induces mitochondrial damage, apoptosis, and immunogenic cell death (ICD) in breast cancer cells. In vivo studies further confirm its ability to activate a systemic anti-tumor immune response and markedly inhibit tumor growth. This study provides a band-interfacial cooperative regulation strategy for multimodal tumor immunotherapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102296"},"PeriodicalIF":10.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional phyto-nanozymes for dual regulation of microbial metabolism and overinflammation microenvironment in diabetic wound 功能性植物纳米酶对糖尿病创面微生物代谢和过度炎症微环境的双重调节

IF 10.2 1区医学

Materials Today Bio Pub Date : 2025-09-06 DOI: 10.1016/j.mtbio.2025.102293

Shan He , Zhenhao Li , Wenguo Huang , Yujie Peng , Libin Niu , Huangding Wen , Youshan Xv , Shuo Li , Zhiqing Li

{"title":"Functional phyto-nanozymes for dual regulation of microbial metabolism and overinflammation microenvironment in diabetic wound","authors":"Shan He , Zhenhao Li , Wenguo Huang , Yujie Peng , Libin Niu , Huangding Wen , Youshan Xv , Shuo Li , Zhiqing Li","doi":"10.1016/j.mtbio.2025.102293","DOIUrl":"10.1016/j.mtbio.2025.102293","url":null,"abstract":"<div><div>Chronic wound management demands multifunctional therapeutic strategies that simultaneously address excessive inflammation and oxidative stress. To meet this challenge, we engineered a three-dimensional biomimetic scaffold (CSSTF) by integrating collagen-based thermosensitive hydrogel, a SiO<sub>2</sub>-supported copper single-atom catalyst (Cu-SAC-SE), and tea tree oil-encapsulated liposomes (TTO@Lpo). This composite design enables sustained release of bioactive components, achieving synergistic ROS scavenging, mitochondrial protection, and suppression of NLRP3 inflammasome-mediated pyroptosis. Notably, CSSTF exhibits dual immunomodulatory effects by attenuating neutrophil extracellular trap (NET) formation and shifting macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype, thereby mitigating inflammation-associated tissue damage. Parallelly, TTO@Lpo orchestrates microbial remodeling by selectively inhibiting pathogenic bacteria while enriching beneficial commensals, coupled with elevated production of anti-inflammatory metabolites (e.g., short-chain fatty acids), establishing a self-reinforcing \"microbiota-metabolism-inflammation\" regulatory loop. In diabetic murine models, CSSTF significantly accelerated wound closure through coordinated mechanisms: (1) enhanced angiogenesis via VEGF upregulation, (2) NETosis suppression that dampens cytokine storms, and (3) ECM reconstruction facilitated by fibroblast activation. Beyond material innovation, this work pioneers a phyto-bionic therapeutic platform leveraging enzymatic catalysis and microbiome reprogramming, offering a paradigm shift in chronic wound treatment through simultaneous physical barrier restoration and dynamic biological modulation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102293"},"PeriodicalIF":10.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0