Materials Today Bio最新文献

{"title":"Ultra-stretchable, adhesive and photothermal multifunctional hydrogel for renal denervation to treat hypertension","authors":"Heng Lin ,&nbsp;Haosong Xi ,&nbsp;Hengyang Liu ,&nbsp;Ze Zhao ,&nbsp;DangWei Li ,&nbsp;Shixin Wang ,&nbsp;Di Yang ,&nbsp;Jiaxing Huang ,&nbsp;Rui Li ,&nbsp;Jiaming Qiao ,&nbsp;Hong Jiang ,&nbsp;Lilei Yu ,&nbsp;Fan Cheng ,&nbsp;Hongbing Deng","doi":"10.1016/j.mtbio.2025.101966","DOIUrl":"10.1016/j.mtbio.2025.101966","url":null,"abstract":"<div><div>Hypertension is a major risk factors for stroke, cardiovascular diseases, and chronic kidney diseases. Although taking antihypertension drugs improves the prognosis of hypertensive patients to a certain extent, there are still lots of refractory hypertension and non-adherent patients. Therefore, it is imperative to explore more effective and targeted treatment approaches. Herein, we construct a multifunctional photothermal hydrogel to treat hypertension and cardiac remodeling through renal denervation (RDN) under 808 nm near-infrared (NIR) laser irradiation. The prepared multifunctional hydrogel, which is customized based on renal perivascular microenvironment, exhibits excellent stretchability, mechanical properties, flexibility and adhesion, ensuring it with remarkable conformability to the dynamic movements of the renal arteries throughout RDN procedures. Photothermal RDN achieved significant blood pressure reduction, with sustained decreases of 13.3 ± 2.5 mmHg in systolic blood pressure and 10.6 ± 1.2 mmHg in diastolic blood pressure, persisting for 8 weeks post-treatment. Additionally, a reduction in myocardial fibrosis and cardiomyocyte hypertrophy is observed, which indicative of the alleviation of cardiac remodeling. The antihypertensive effect of photothermal RDN is mediated through inhibition of the renin-angiotensin-aldosterone system (RAAS) pathway and activation of the cGMP-PKG signaling cascade. The photothermal hydrogel-mediated RDN treatment provides a promising and innovative strategy for treating hypertension and cardiac remodeling.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101966"},"PeriodicalIF":8.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term SiNPs exposure induced genetic instability and malignant transformation via SQSTM1/p62-mediated autophagy dysfunction in lungs","authors":"Kanglin Yan ,&nbsp;Yuexiao Ma ,&nbsp;Xuemin Shi ,&nbsp;Chen Liang ,&nbsp;Ruiyang Ding ,&nbsp;Zhiwei Sun ,&nbsp;Junchao Duan","doi":"10.1016/j.mtbio.2025.101972","DOIUrl":"10.1016/j.mtbio.2025.101972","url":null,"abstract":"<div><div>As one of the most widely used nanomaterials, silica nanoparticles (SiNPs) have raised significant concerns regarding their toxicity, while their potential carcinogenicity remains poorly understood. During occupational exposure, SiNPs primarily enter the human body through the respiratory tract, thus we aimed to investigate the SiNPs-induced malignant transformation and correlated mechanisms in lungs. Fischer 344 rats underwent weekly intratracheal instillation of SiNPs for six months, followed by an additional six-month observation period to evaluate long-term effects. Results demonstrated the development of precancerous lesions in lungs of rats, which were associated with increased pulmonary glucose metabolism, chronic inflammation, squamous metaplasia, and epithelial-mesenchymal transition (EMT). Similarly, BEAS-2B cells exposed to SiNPs over 40 passages exhibited enhanced abilities in proliferation, migration, invasion, and anchorage-independent colony formation. In addition, genotoxicity was observed in BEAS-2B cells, including increased micronucleus formation, aberrant cell division, and elevated chromosomal aberration frequency. Mechanistically, SiNPs activated SQSTM1/p62-mediated autophagy dysfunction, which in turn induced mitotic catastrophe by interfering with the MDM2/p53/Aurora B signaling pathway. Concurrently, SQSTM1/p62 accumulation suppressed DNA damage repair by enhancing its interaction with RNF168. Molecular docking simulation further predicted that SiNPs directly bind to SQSTM1/p62 through electrostatic interactions, inducing conformational changes in SQSTM1/p62. Notably, SQSTM1/p62-knockout significantly attenuated SiNPs-induced DNA damage and malignant transformation , and modulated the expression of Aurora B and RNF168 signaling pathways. These findings demonstrated the critical role of SQSTM1/p62-mediated autophagy dysfunction in SiNPs-induced genotoxicity and malignant transformation in lungs, offering novel insights into SiNPs-related carcinogenicity.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101972"},"PeriodicalIF":8.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonization of engineered bacteria enhanced lipid nanomedicine accumulation in tumors for sonodynamic immunotherapy","authors":"Ying Xu ,&nbsp;Xiaojun Cai ,&nbsp;Jianrong Wu ,&nbsp;Yuanyi Zheng ,&nbsp;Yaotai Wang","doi":"10.1016/j.mtbio.2025.101943","DOIUrl":"10.1016/j.mtbio.2025.101943","url":null,"abstract":"<div><div>Lipid nanoparticles (LNPs) demonstrate liver-accumalating properties, enhancing drug delivery to hepatic tissues. This localized enrichment reduces systemic toxicity and mitigates drug resistance. However, critical limitations such as off-target effects, rapid clearance, and poor specificity hinder their clinical translation. Inspired by the tumor-targeting ability of bacteria, we constructed a multifunctional engineered bacteria system combining LNPs with probiotics by electrostatic adsorption. Specifically, the surface of <em>Bifidobacterium longum</em> (BL) was modified with sorafenib-loaded LNPs (designated PSI LNPs), enabling precise delivery of lipid nanomedicines to tumor sites. Meanwhile, ultrasound irradiation facilitated drug release and improved efficacy. On the one hand, we used fluorescence imaging to observe and monitor live-engineered bacteria. Compared to the single PSI LNPs group, the tumor accumulation of lipid nanomedicines loaded with engineered bacteria exhibited a 66 % increase. The results demonstrated that the engineered bacteria not only augmented the accumulation of nanomedicines but also prolonged the retention time for a sustained effect on the tumor. On the other hand, we further explored synergistic immune system activation by <em>Bifidobacterium</em> and sonodynamic therapy, which stimulated dendritic cell maturation, T cell infiltration, and CD8⁺ T cell activation. In conclusion, this delivery strategy of engineered bacteria targeting the tumor microenvironment is expected to overcome the limitations of conventional LNPs and provide a promising approach for treating hepatocellular carcinoma.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101943"},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired biomaterial coating for enzyme responsive release of antimicrobial peptides","authors":"Dennis A. Böhner,&nbsp;Karin Mörl,&nbsp;Annette G. Beck-Sickinger","doi":"10.1016/j.mtbio.2025.101958","DOIUrl":"10.1016/j.mtbio.2025.101958","url":null,"abstract":"<div><div>Biofilm formation and implant-associated infections, potentially leading to periprosthetic bone loss and subsequent loss of osseointegration, remain high-risk factors for failure of implants. Consequently, the prevention of bacterial colonization on implant surfaces is of high interest. The development of multi-drug-resistant bacteria led to less effective infection prophylaxis using commonly used antibiotics. Functionalization of implant surfaces with antibacterial agents like antimicrobial peptides to reduce or even prevent bacterial adhesion is a promising perspective. Here, we report on the synthesis of a new peptide-based biomaterial coating. Two antimicrobial peptides, [Nle⁵]-SHAP1 and P5, were successfully coupled to a mussel-derived carrier peptide containing <span>l</span>-3,4-dihydroxyphenylalanine and immobilized onto titanium and poly(ε-caprolactone) (PCL). Incorporation of specific linker sequences enabled protease-mediated release from the surface by matrix metalloproteinase 9 and 2, as well as by neutrophil elastase, enzymes that are frequently found in infected wounds. The antibacterial activity of the coating components was assessed individually as well as combined in a broth dilution assay setup. Reduction of bacterial growth has been shown after 4 h of incubation upon enzymatic release using PCL nanoparticles coated with the most promising candidate. All tested coatings were non-cytotoxic for eukaryotic osteogenic SaOS-2 and monocytic THP-1 cells. This study offers a promising approach for functionalizing biomaterial surfaces with antimicrobial peptides, potentially reducing the incidence of implant-associated infections. To overcome limitations of non-fouling and contact-killing surfaces, enzyme-sensitive sequences were incorporated that allow for triggered release of the antimicrobial peptides and thus for combating bacteria at the peri-implant site.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101958"},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timp2-modified gelatinhydroxyphenylpropionic acid hydrogels reverse enhanced scleral recovery and suppress myopia development in mice","authors":"Kaiqi Liu ,&nbsp;Ting Li ,&nbsp;Lingwen Gu ,&nbsp;Zhenyu Jiang ,&nbsp;Jing Jiang ,&nbsp;Xi Yang ,&nbsp;Yang Zhou ,&nbsp;Xiao Feng ,&nbsp;Qianqian Gong ,&nbsp;Lihua Zhao ,&nbsp;Yiming Chen ,&nbsp;Chao Yang ,&nbsp;Tao Jiang","doi":"10.1016/j.mtbio.2025.101942","DOIUrl":"10.1016/j.mtbio.2025.101942","url":null,"abstract":"<div><div>A novel therapeutic strategy for form deprivation myopia (FDM) involving Timp2-modified scleral stem cells (SSC^Timp2) embedded in gelatin-hydroxyphenylpropionic acid (Gtn-HPA) hydrogel was investigated. Transcriptome and single-cell RNA sequencing analyses identified Timp2 as a crucial factor in FDM progression due to its reduced expression in FDM sclera. The developed SSC^Timp2-Gtn-HPA hydrogel composite demonstrated excellent biocompatibility, rapid gelation, and degradation properties. <em>In vitro</em> studies showed that SSC^Timp2-GH promoted human scleral fibroblast (HSF) proliferation, inhibited apoptosis, and prevented differentiation. <em>In vivo</em> experiments in mice showed that SSC^Timp2-GH effectively regulated ocular parameters, facilitated scleral recovery, and improved FDM conditions. These results highlight the potential of SSC^Timp2-GH as a promising therapeutic approach for myopia treatment by enhancing scleral recovery.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101942"},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of PVA hydrogel loaded with luteolin nanoparticles in anti EMT treatment after GBM","authors":"Long Zhou ,&nbsp;Qingyu Zhao ,&nbsp;Lijuan Gu ,&nbsp;Renfu Tian ,&nbsp;Yong Li ,&nbsp;Xiaoxing Xiong","doi":"10.1016/j.mtbio.2025.101956","DOIUrl":"10.1016/j.mtbio.2025.101956","url":null,"abstract":"<div><h3>Background</h3><div>Glioblastoma multiforme (GBM) is the most common and worst-prognosed primary malignant tumor in the central nervous system. Epithelial mesenchymal transition (EMT) is an important cause of postoperative invasion and recurrence in GBM. Due to the presence of the blood-brain barrier, local therapy may be the preferred route for treatment of GBM after surgery.</div></div><div><h3>Methods</h3><div>Our objective is to develop an anti- EMT functional hydrogel for post-GBM surgery tamponade. We fabricated self-assembled luteolin nanoparticles (LU NPs) via the solvent evaporation method, and characterized their morphology and particle size using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Furthermore, biological evaluations were conducted through CCK-8 assays, EdU staining, flow cytometry for cell cycle analysis, scratch assays, transwell assays and western blot. Ultimately, we constructed a polyvinyl alcohol (PVA) hydrogel loaded with luteolin nanoparticles and validated its therapeutic efficacy in vivo experiments.</div></div><div><h3>Results</h3><div>We successfully synthesized LU NPs, which significantly inhibited GBM cell proliferation, as well as GBM cell invasion and migration in vitro. Furthermore, LU NPs downregulated the EMT signaling pathway. We discovered that the observed anti-tumor effects of LU NPs were dependent on the function of β-catenin. Additionally, we successfully constructed a PVA hydrogel loaded with LU NPs (LU@gel). Finally, in the postoperative model of intracranial GBM xenograft in mice, LU@gel effectively suppressed GBM proliferation and EMT, significantly prolonging the survival time of the mice.</div></div><div><h3>Conclusions</h3><div>In summary, we have demonstrated that LU@gel exhibits potent anti-GBM effects, primarily attributed to the inhibition of β-catenin-mediated cell proliferation and EMT.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101956"},"PeriodicalIF":8.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-enabled molecular imaging diagnosis of osteoarthritis","authors":"Tianrui Zhang ,&nbsp;Qianyi Zhang ,&nbsp;Jingqian Wei ,&nbsp;Quanbin Dai ,&nbsp;Dzenita Muratovic ,&nbsp;Wenjie Zhang ,&nbsp;Ashish Diwan ,&nbsp;Zi Gu","doi":"10.1016/j.mtbio.2025.101952","DOIUrl":"10.1016/j.mtbio.2025.101952","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the most common type of arthritis and affects patients with chronic pain, while imposing a heavy burden on public health systems worldwide. Current imaging technologies such as X-ray, MRI, and CT assist the diagnosis and monitoring of OA by providing anatomical pathological information. However, given the complex nature and progression of OA, conventional imaging technologies are limited in the molecular pathological information they are able to present and identify from the various health conditions of OA patients. Thus, nanoparticle-assisted imaging is promising to revolutionize the diagnosis and monitoring of OA, improving the sensitivity and specificity of imaging by enhancing the detection of key biomarkers such as proteoglycans, glycosaminoglycans, type II and X collagen, and inflammatory factors. In this review, the anatomical and pathological characteristics of OA, existing imaging modalities for OA diagnosis, and recent advances in the development of functionalized nanoparticles for molecular imaging of OA are summarized, highlighting the specific roles of nanoparticles in targeting biomarker molecules in different stages of OA progression. Additionally, the combined fields of artificial intelligence (AI) and imaging technology are discussed, followed by an overview of current challenges and future development of nanoparticles for molecular imaging of OA.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101952"},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3R (remove-remodel-repair)-integrated self-assembled Chlorella-gelatin-PEG hydrogel for diabetic wound healing","authors":"Yulin Li ,&nbsp;Ruiying He ,&nbsp;Yu Huang ,&nbsp;Tinglin Zhang ,&nbsp;Lan Xiao ,&nbsp;Yin Xiao ,&nbsp;Haifeng Liu ,&nbsp;He Bai ,&nbsp;Shiyong Wu ,&nbsp;Minghao Xue ,&nbsp;Huifen Qiang ,&nbsp;Yan Wu ,&nbsp;Meng Li ,&nbsp;Chuan Yin ,&nbsp;Jie Gao","doi":"10.1016/j.mtbio.2025.101935","DOIUrl":"10.1016/j.mtbio.2025.101935","url":null,"abstract":"<div><div>Diabetic wound healing remains a critical clinical challenge due to persistent bacterial infections, oxidative stress, and chronic inflammation. Inspired by the principles of traditional Chinese medicine, we developed a multifunctional hydrogel (CPGel) via solvent-driven self-assembly of bioactive Chlorella extracts, gelatin, and polyethylene glycol (PEG). The CPGel synergizes the 3R strategy: (1) Remove—complete eradication of <em>E. coli</em> and <em>S. aureus</em> via intrinsic antibacterial activity; (2) Remodel—65 % ROS scavenging and immunomodulation by polarizing macrophages from proinflammatory M1 to anti-inflammatory M2 phenotypes to resolve chronic inflammation; and (3) Repair—accelerated tissue regeneration via 9-fold angiogenesis (α-SMA) and 2-fold collagen I deposition. Mechanically robust (compressive strength: 4.16 MPa; tensile strength: 627 kPa) and antifreezing (−100 °C), CPGel demonstrated exceptional transparency and adhesion, ensuring seamless integration with wound sites. In diabetic mice, CPGel achieved 100 % wound closure within 21 days, surpassing controls (73 %), while promoting neovascularization and hair follicle regeneration. This study bridges traditional herbal medicine with advanced biomaterial engineering, offering a scalable, toxin-free platform that addresses the triad of diabetic wound pathogenesis. By harmonizing the 3R strategy-Remove, Remodel, and Repair-CPGel represents a paradigm shift in chronic wound management, with high potential for clinical translation and sustainable therapeutic design.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101935"},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norcantharidin/Cu2+ dual-depleting GSH nanocatalyst with pH-responsive for CT/CDT synergistic cancer therapy","authors":"Xiaohuan Guo ,&nbsp;Bingbing Cai ,&nbsp;Qi Fang,&nbsp;Yanyan Chen,&nbsp;Yuzhu Zhou,&nbsp;Zhixing Liang,&nbsp;Changchun Wen,&nbsp;Yan-Cheng Liu,&nbsp;Hong Liang","doi":"10.1016/j.mtbio.2025.101959","DOIUrl":"10.1016/j.mtbio.2025.101959","url":null,"abstract":"<div><div>The high level of glutathione (GSH) in tumor cells can consume reactive oxygen species (ROS), seriously affecting the efficacy of chemodynamic therapy (CDT). Although it took a great deal of effort, developing a tumor-specific CDT that efficiently depletes GSH remains a formidable challenge. Herein, we propose a pH-responsive nanocatalyst containing the active molecule norcantharidin (NCTD) and Cu²⁺ for dual GSH depletion, achieving efficient GSH depletion. Due to the weakly acidic tumor microenvironment (TME), the catalyst releases NCTD and Cu²⁺ in a pH-responsive manner for the synergistic therapy of chemotherapy (CT) and CDT. Both components consume GSH and subsequently produce ROS, reducing the antioxidant capacity of cancer cells while increasing oxidative stress. This disrupts cellular redox homeostasis, leading to mitochondrial dysfunction and inducing tumor cell apoptosis. This work not only develops nanomaterials with dual GSH depletion capabilities for high-efficiency CDT but also achieves synergistic CT and CDT tumor therapy with the addition of NCTD, an active ingredient of traditional Chinese medicine.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101959"},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-driven secondary structural remodeling in biomimetic nanosystem to enhance tumor chemo-phototherapy","authors":"Weijie Wang ,&nbsp;Chenguang Sun ,&nbsp;Linhao Jing ,&nbsp;Yaning Xia ,&nbsp;Shuijun Zhang ,&nbsp;Yupeng Shi","doi":"10.1016/j.mtbio.2025.101955","DOIUrl":"10.1016/j.mtbio.2025.101955","url":null,"abstract":"<div><div>The integration of chemotherapy and phototherapy for treating advanced liver cancer has gained considerable attention. However, challenges such as short drug retention times significantly impact patient prognosis. We introduce a light-triggered nanosystem that employs molecular aggregation control for PTT and sustained chemotherapy. This nanosystem, known as Reg/IR783@CM nanoparticles (RIMNPs), consists of a core-shell carrier-free nanodrug self-assembled from the chemotherapy drug regorafenib (Reg) and the photothermal agent IR783, coated with a homologous liver cancer cell membrane. The developed core-shell nanocarrier exhibits excellent water dispersibility, high drug load, extended blood circulation, and tumor site enrichment. Upon light exposure, the nanosystem provides outstanding near-infrared imaging and robust photothermal effects. Concurrently, light exposure accelerates the degradation of the outer IR783 layer, resulting in regorafenib exposure and triggering secondary assembly, which significantly enhances drug retention at the tumor site. Our findings indicate that the nanosystem effectively suppresses tumor growth by combining photothermal therapy with the inhibition of tumor cell proliferation and angiogenesis, and by modulating tumor-associated macrophages. Notably, this nanosystem also demonstrates low cytotoxicity and high biocompatibility. This study presents a novel light-driven in-situ assembly strategy, offering a simplified and effective approach for constructing tumor imaging and treatment systems.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101955"},"PeriodicalIF":8.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}