Materials Today Bio最新文献

{"title":"Nanotechnology-driven strategies for gene therapy of arthritis","authors":"Shuo Wang ,&nbsp;Yuequan Wang ,&nbsp;Qin Chen","doi":"10.1016/j.mtbio.2025.102301","DOIUrl":"10.1016/j.mtbio.2025.102301","url":null,"abstract":"<div><div>Arthritis remains a major global health burden, driven by chronic inflammation and irreversible joint damage, with current treatments often failing to achieve sustained remission. Gene therapy offers a promising strategy to address the root molecular causes by reprogramming dysregulated immune responses and promoting tissue regeneration. However, clinical translation is limited by delivery inefficiency, off-target effects, and immunogenicity. Recent advances in genetic technologies, including RNA-based therapies, DNA-based strategies, and CRISPR-Cas9 gene editing, have broadened the therapeutic toolkit for precise and durable gene modulation. Concurrently, the integration of nanotechnology has enabled the development of smart delivery platforms, such as lipid nanoparticles, polymeric carriers, inorganic nanostructures, extracellular vesicles, membrane-coated systems, and DNA nanoframeworks, to overcome biological barriers and enhance gene transfection. Moreover, emerging therapeutic strategies targeting immune modulation, synovial macrophage reprogramming, inflammatory signaling, cartilage preservation and regeneration, and pain relief further expand the clinical potential. This review provides a comprehensive overview of the key genetic tools, nanoplatforms, and therapeutic approaches driving next-generation gene therapy for arthritis, highlighting a multidisciplinary path toward precise, effective, and long-lasting treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102301"},"PeriodicalIF":10.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy","authors":"Wei Pang ,&nbsp;Yining Shao ,&nbsp;Hefeng Xu ,&nbsp;Tianqi Li ,&nbsp;Linxuan Wu ,&nbsp;Zhipeng Liu ,&nbsp;Lei Zhang ,&nbsp;Wei Chen ,&nbsp;Yiwen Li ,&nbsp;Dake Xu ,&nbsp;Jiaji Cheng ,&nbsp;Xiaoqian Xu","doi":"10.1016/j.mtbio.2025.102303","DOIUrl":"10.1016/j.mtbio.2025.102303","url":null,"abstract":"<div><div>Chiral nanomaterial-mediated phototherapy has attracted attention as an emerging tumor treatment method. In this study, we synthesized chiral nickel oxide (L/D-Cys-NiO) photosensitizers via surface modulation using chiral cysteine molecules, thereby improving the biocompatibility and significantly enhancing the efficacy of photodynamic-chemodynamic therapy. L/D-Cys-NiO can selectively stimulate the production of reactive oxygen species and hydroxyl radicals, providing synergistic therapy in tumor cells with 4-5-fold greater efficacy than conventional phototherapy. L/D-Cys-NiO can also effectively prevent the infiltrative growth and metastasis of tumor cells by reducing their migration and invasiveness by nearly 40 %. <em>In vivo</em> immunohistochemical assays and high-throughput proteomic analysis confirmed that D-Cys-NiO exhibited stronger enhanced permeability and retention effects and induced more significant autophagic behavior than L-Cys-NiO, suggesting a chirality-dependent enhanced autophagy pathway for tumor ablation during photodynamic-chemodynamic synergistic therapy. We expect that these findings will provide exceptional insights into next-generation tumor photosensitizer designs, focusing on the regulation of autophagy in tumor cells through chirality-dependent photoinduction.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102303"},"PeriodicalIF":10.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A viscosity-activable nano-micelle with aggregation-induced emission for boosting NIR-II fluorescence imaging-guided synergetic photodynamic/photothermal therapy of breast cancer","authors":"Wenwen Cai ,&nbsp;Jinyin Ge ,&nbsp;Jie Dong ,&nbsp;Xinyu Guo ,&nbsp;Bo Fan ,&nbsp;Qian Wang ,&nbsp;Peng Yang ,&nbsp;Dongqiang Guo ,&nbsp;Dong Wang ,&nbsp;Ben Zhong Tang ,&nbsp;Ruiping Zhang","doi":"10.1016/j.mtbio.2025.102302","DOIUrl":"10.1016/j.mtbio.2025.102302","url":null,"abstract":"<div><div>In view of the fast-growing achievements of cancer phototheranostics, the exploration of advanced materials shows inexhaustible and vigorous vitality. To overcome those limitations of existing materials, such as aggregation-caused fluorescence quenching, inferior selectivity, and high O₂-dependence, the utilization of specific activatable agents with aggregation-induced emission (AIE) features is highly desirable yet remains challenging. Herein, we have designed an organic small-molecule microenvironment activated AIE agent, namely DPXBI. After encapsulation into amphiphilic DSPE-PEG-RGD through self-assembly, the biocompatibility, water solubility, targeting effect, and circulation time in the blood of obtained nano-micelle ^RM@DPXBI are improved. ^RM@DPXBI showed powerful fluorescence in the second near-infrared (NIR-II) region after being activated by viscosity in the tumor microenvironment, which could accurately identify the boundary of the tumor and determine the optimal accumulation time for following phototherapy. Subsequently, ^RM@DPXBI exerts inhibiting on breast cancer growth through synergistic photodynamic (PDT) and photothermal (PTT) therapy under single laser irradiation. Meanwhile, the phototherapy-induced cellular death increases intracellular viscosity, which further restricts the intramolecular motion of ^RM@DPXBI, resulting in the amplifying of PDT effect. The activated strategy provides a new exploration for the design and development of AIE and viscosity activation agents in tumor theranostics.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102302"},"PeriodicalIF":10.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycelial growth of wood fungus Ganoderma sessile in porous scaffolds","authors":"Natalie Nussbaum ,&nbsp;Nils Repond ,&nbsp;Antoni Gandia ,&nbsp;Peter Fischer ,&nbsp;Patrick A. Rühs","doi":"10.1016/j.mtbio.2025.102282","DOIUrl":"10.1016/j.mtbio.2025.102282","url":null,"abstract":"<div><div>The mycelium of filamentous wood fungi exhibits adaptive growth strategies influenced by their host material. In 2D solid-state fermentation, densely packed substrates limit oxygen access, resulting in hyphal growth mainly at the substrate-air interface. To address this challenge, we investigated open porous scaffolds as growth environments for the filamentous fungus <em>Ganoderma sessile</em>, quantifying mycelial biomass formation via ergosterol content. This quantitative approach directly demonstrates a scaffold-associated biomass increase of 60% after 7 days compared to plate cultures and thus provides experimental evidence linking increased accessible surface area in porous substrates to enhanced biomass formation in solid-state fungal growth. Mycelium colonization of the hydrogel scaffold also enhanced their mechanical properties, including stiffness and elastic recovery. This scaffold-associated biomass increase was not observed for <em>G. lucidum</em> or <em>P. ostreatus</em>, underscoring a species-specific effect with ergosterol levels for <em>G.sessile</em> peaking at 2 wt% malt extract in the substrate, in contrast to both higher and lower malt extract concentrations. These findings improve our understanding of solid-state fermentation, highlight the importance of species-specific responses and guide the design of substrates for fungi-based materials with tailored properties.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102282"},"PeriodicalIF":10.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy","authors":"Baiyang Fu ,&nbsp;Guangyan Li ,&nbsp;Yuan Yao ,&nbsp;Mingfu Zhang ,&nbsp;Yesheng Zhong ,&nbsp;Xi Wang ,&nbsp;Yichi Chen ,&nbsp;Wenlong Liang ,&nbsp;Yao Wang ,&nbsp;Haiyun Lin ,&nbsp;Yutong Zhang ,&nbsp;Qiguang Du ,&nbsp;Zhongkai Xu ,&nbsp;He Cui ,&nbsp;Liping Shi ,&nbsp;Xi Chen ,&nbsp;Jianguo Zhang","doi":"10.1016/j.mtbio.2025.102268","DOIUrl":"10.1016/j.mtbio.2025.102268","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) faces the challenge of limited treatment efficacy due to its highly invasive ability and its immunosuppressive microenvironment. This study found that cuproptosis, as an emerging therapeutic strategy, has unique therapeutic potential in TNBC. Nevertheless, the delivery difficulties of cuproptosis-inducing agents and the limited efficacy of single drugs restrict the clinical application of cuproptosis therapy. Herein, a temperature/pH dual-responsive composite hydrogel was developed to load Elesclomol-Cu (ES-Cu) and glucose oxidase (GOx) (ES-Cu&amp;GOx@FFC). ES and Cu²⁺ can synergistically trigger cuproptosis in TNBC, and GOx can not only inhibit tumor metabolism by mediating glucose deprivation but also initiate the Fenton reaction by continuously generating H₂O₂ and synergizing with copper ions, driving a potent chemodynamic therapy (CDT). Furthermore, ES-Cu&amp;GOx@FFC could significantly improve the immunosuppressive landscape and upregulate programmed death-ligand 1 (PD-L1) expression in TNBC. Combined therapy experiments showed that the combination treatment of ES-Cu&amp;GOx@FFC and αPD-L1 achieved more than 90 % tumor volume regression. In summary, this study provides new insights into the therapeutic role of cuproptosis in TNBC, and integrates cuproptosis, starvation therapy, CDT, and immunotherapy through smart responsive hydrogels, providing an innovative solution for the treatment of TNBC.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102268"},"PeriodicalIF":10.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging polysaccharide-derived nanocarriers to open new horizons in oral vaccine activation","authors":"Siyuan Wang ,&nbsp;Tao Jiang ,&nbsp;Min Jiang ,&nbsp;Yang-Bao Miao","doi":"10.1016/j.mtbio.2025.102300","DOIUrl":"10.1016/j.mtbio.2025.102300","url":null,"abstract":"<div><div>Oral vaccines represent a transformative approach in immunization, offering non-invasive administration, mucosal immune activation, and improved patient compliance. However, their clinical translation is hindered by multiple physiological barriers, such as gastric degradation, enzymatic hydrolysis, and inefficient antigen uptake in gut-associated lymphoid tissues. This review explores the emerging role of polysaccharide-derived nanocarriers, particularly those inspired by traditional Chinese medicine (TCM), in addressing these challenges. We discuss how these biocompatible and biodegradable materials can be engineered to enhance antigen stability, promote targeted delivery to Peyer's patches, and stimulate robust mucosal and systemic immune responses. Key design principles—such as bioadhesion, structural tunability, and immunomodulatory capacity—are highlighted across various carrier systems. Moreover, we examine multifunctional delivery strategies, including co-delivery of adjuvants, pH-responsive release, and mucoadhesive platforms. Special emphasis is placed on the potential integration of polysaccharide nanocarriers into next-generation oral mRNA and nucleic acid vaccine technologies. These insights underscore the promise of polysaccharide-based nanotechnology as a cornerstone for future oral vaccine platforms, paving the way for non-invasive, scalable, and immunologically effective vaccination strategies.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102300"},"PeriodicalIF":10.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-activated piezoelectric scaffolds target dual Ca2+/NF-κB signaling pathways to orchestrate immunomodulation and osteogenesis for accelerated bone regeneration","authors":"Hui Zheng ,&nbsp;Pengfei Yan ,&nbsp;Peng Liu ,&nbsp;Chang Yan ,&nbsp;Mengqi Zhao ,&nbsp;Zuyong Wang ,&nbsp;Xiaofei Zheng ,&nbsp;Huajun Wang ,&nbsp;Rongkai Zhang ,&nbsp;Luke P. Lee ,&nbsp;Swee Hin Teoh","doi":"10.1016/j.mtbio.2025.102299","DOIUrl":"10.1016/j.mtbio.2025.102299","url":null,"abstract":"<div><div>Critical-sized bone defects fail to heal due to dysregulated inflammation and impaired osteogenesis. To overcome the limitations of static biomaterials, we engineered 3D-printed polycaprolactone scaffolds incorporating polydopamine coated BaTiO₃/β-TCP nanoparticles (10 %PBT) for dynamic ultrasound (US) activation. Integrated in vitro/in vivo analyses revealed that US-activated piezoelectricity triggered two synergistic pathways: (1) Voltage gated calcium channel (VGCC) dependent Ca²⁺ influx specifically in osteoblasts (inhibited by ω-Hexatoxin-HV1A), activating Ca²⁺/NFAT signaling and direct mineralization; and (2) Suppression of NF-κB p65 phosphorylation and nuclear translocation in macrophages, driving anti-inflammatory M2 polarization. Crucially, M2 macrophages secreted pro-regenerative factors (BMP-2, VEGF), enhancing osteoblast differentiation and angiogenesis via paracrine signaling. In rat critical defects, 10 %PBT + US achieved 3 fold higher bone volume (BV/TV), mature collagen, increased CD31⁺ vessels, and elevated Runx2/BMP-2 expression. This work unveils a paradigm of targeted electro immunoengineering: wireless US dynamically orchestrates VGCC mediated Ca²⁺ osteoinduction and NF-κB inhibited M2 polarization with BMP-2/VEGF secretion, providing potent, growth factor free spatiotemporal control of Ca²⁺ and inflammatory signaling for precision bone regeneration.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102299"},"PeriodicalIF":10.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in chronic wound therapy: engineering strategies and advanced delivery systems for enhanced regeneration","authors":"Le Ding ,&nbsp;Tingrui Zhang ,&nbsp;Yixiao Pan ,&nbsp;Jun Liu ,&nbsp;Tianyou Ma ,&nbsp;Hanxue Zhou ,&nbsp;Quangang Zhu ,&nbsp;Zongguang Tai ,&nbsp;Zhongjian Chen","doi":"10.1016/j.mtbio.2025.102298","DOIUrl":"10.1016/j.mtbio.2025.102298","url":null,"abstract":"<div><div>Chronic wounds, including diabetic foot ulcers, are notoriously difficult to heal due to their complex pathological microenvironments, which are marked by persistent inflammation and impaired angiogenesis. These challenges place a significant burden on both patients and healthcare systems. Extracellular vesicles (EVs), as natural carriers, can modulate the wound microenvironment and facilitate tissue regeneration by delivering bioactive molecules such as proteins and nucleic acids. EVs offer advantages including low immunogenicity and excellent biocompatibility. However, unmodified EVs face limitations such as low therapeutic payloads, limited targeting capability, and vulnerability to degradation. Building on this foundation, this review provides a detailed overview of the specific roles and mechanisms of EVs in wound healing. It focuses particularly on condition-specific strategies, engineering approaches, and the use of biomaterials to further enhance the therapeutic efficacy of EVs in treating chronic wounds. Finally, we highlight the current challenges faced in the clinical translation of EV-based therapies and propose emerging strategies to address these obstacles, offering new directions for chronic wound management.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102298"},"PeriodicalIF":10.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-induced field effect transistor-based biosensor consisted of aptamer and ReS2 single crystal layer for exosome detection","authors":"Moonbong Jang ,&nbsp;Woongki Na ,&nbsp;Minyoung Lee ,&nbsp;Seokho Jung ,&nbsp;Yeeun Woo ,&nbsp;Hah Young Yoo ,&nbsp;Taek Lee ,&nbsp;Junhong Min","doi":"10.1016/j.mtbio.2025.102281","DOIUrl":"10.1016/j.mtbio.2025.102281","url":null,"abstract":"<div><div>Field-effect transistor (FET)-based biosensors are promising platforms for point-of-care diagnostics because of their low power requirements, miniaturization capabilities, and high sensitivity toward charged biomolecules. In particular, light-induced FET (L-FET) facilitate photo-generated carrier signal amplification using an external light source, enabling high detection sensitivity from minimal sample volumes. This study proposed the first L-FET biosensor that integrated single-crystal ReS₂ with biomolecules to achieve effective photo-generated carrier signal amplification. ReS₂ maintains its single-layer electronic characteristics even in bulk, thus minimizing signal variability across devices. The ReS₂ current channel is established via mechanical exfoliation onto Au electrodes on a SiO₂ substrate, and photo-generated carrier amplification was induced using a photoconductive effect via laser illumination. Signal variation was assessed using 2-channel I-V measurements following the biomolecular complex formation. The results demonstrated an approximately two times increase in the photo-generated carrier amplification ratio. The detection range for exosomes targeting CD9 protein within human serum was determined to be 10²–10⁷ exosomes/mL, with a limit of detection (LOD) of 9.79 × 10³ exosomes/mL, thereby demonstrating stable detection even at low concentrations. The proposed L-FET biosensor design which incorporated direct bioconjugation with semiconductor devices offered a fundamental advance for early diagnostic platforms. The device's simplified architecture and signal amplification mechanism exhibited advantages for large-scale production, enhancing its commercial viability, and highlighting its potential to impact the evolution of next-generation medical diagnostic technologies enormously. This study introduced a new paradigm for FET-based biosensors, positioning this platform as a candidate for diverse biomarker detection and early disease diagnostic applications.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102281"},"PeriodicalIF":10.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered mesenchymal stem cells-laden chondroitin sulfate hydrogel promotes diabetic wound healing through ROS scavenging and macrophage polarization","authors":"Xi Cao ,&nbsp;Ziqi Shen ,&nbsp;Xiaohua Wang ,&nbsp;Yuanyuan Chu ,&nbsp;Runkong Wang ,&nbsp;Liyang Zhu ,&nbsp;Ruixue Zhong ,&nbsp;Zhong Zhang ,&nbsp;Mingquan Wu ,&nbsp;Xu Zhou ,&nbsp;Lei Zhang","doi":"10.1016/j.mtbio.2025.102271","DOIUrl":"10.1016/j.mtbio.2025.102271","url":null,"abstract":"<div><div>The treatment of diabetic wound complications has long been a formidable challenge in the clinic, and a multifunctional biomaterial dressing holds great promise as an ideal approach for promoting diabetic wound healing. In this study, we designed a crosslinked chondroitin sulfate (CS) and polyethylene glycol (PEG) hydrogel (CS gel) as a reservoir via a Michael addition reaction. To further enhance the biological functions, surface-engineered mesenchymal stem cells (MSCs) modified with bilirubin-modified chondroitin sulfate-mediated mixed micellar backpacks possessing ROS scavenging/responsive and CD44-targeting abilities (DCMMs) were incorporated into the hydrogel system. The hydrogel served as a physical carrier, providing a sustained-release platform that ensured the long-term presence and controlled delivery of MSCs-tethered micellar backpacks at the wound site. <em>In vitro</em> experiments revealed the remarkable capacity of the hydrogel for ROS scavenging and regulating macrophage polarization. <em>In vivo</em> investigations in diabetic mouse models further confirmed the therapeutic potential, revealing a significant acceleration of wound closure, attenuation of inflammation, and augmentation of angiogenesis. Overall, this innovative hydrogel system that encapsulates surface-engineered mesenchymal stem cells (MSCs-DCMMs) represents a promising remedy and a framework for stem-cell-based therapeutic systems to treat diabetic wounds.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102271"},"PeriodicalIF":10.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}