Materials Today Bio最新文献_第7页

The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis 水凝胶与负载芦丁的黑磷纳米片的组合可治疗类风湿性关节炎

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101264

Jing Hou , Shujiang Yin , Runqing Jiao , Wen Chen , Wenjuan Wang , Han Zhang , Zhiyong Liu , Zhenyang Chen , Xing Tian

{"title":"The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis","authors":"Jing Hou , Shujiang Yin , Runqing Jiao , Wen Chen , Wenjuan Wang , Han Zhang , Zhiyong Liu , Zhenyang Chen , Xing Tian","doi":"10.1016/j.mtbio.2024.101264","DOIUrl":"10.1016/j.mtbio.2024.101264","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by inflammation, joint pain, and cartilage degradation. The fluctuating nature of RA often necessitates long-term oral administration of treatment drugs, which can unfortunately lead to adverse effects such as gastrointestinal discomfort and hepatic and renal dysfunction. Therefore, a percutaneous local delivery method for the release of inflammatory modulators in arthritic joints represents a promising therapeutic approach for RA. In this study, we have developed a unique and innovative therapeutic platform (named BP-Rut@Gel). This hydrogel was formulated by incorporating the drug Rutin (Rut) into Black phosphorus nanosheets (BP) and subsequently integrating them within a Hyaluronic Acid (HA) and Polyvinyl Alcohol (PVA) matrix to create a composite hydrogel. Notably, Secondly, photothermal therapy (PTT) under Near-Infrared Irradiation (NIR) and anti-inflammatory drugs synergistically worked together to efficiently quell inflammation and enhance therapeutic effectiveness. Additionally, toxicity experiments have revealed that our synthesized black phosphorus nanosheet composite hydrogel possesses excellent biocompatibility and significantly reduces the inflammatory response in RA joints. Given these remarkable properties, our BP-Rut@Gel hydrogel held significant promise and demonstrated immense clinical potential for the treatment of RA.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101264"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-pathogenic Trojan horse Nissle1917 triggers mitophagy through PINK1/Parkin pathway to discourage colon cancer 非致病特洛伊木马 Nissle1917 通过 PINK1/Parkin 通路触发有丝分裂，阻止结肠癌的发生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101273

Yang Wang , Yao Liu , Xiaomin Su , Lili Niu , Nannan Li , Ce Xu , Zanya Sun , Huishu Guo , Shun Shen , Minghua Yu

{"title":"Non-pathogenic Trojan horse Nissle1917 triggers mitophagy through PINK1/Parkin pathway to discourage colon cancer","authors":"Yang Wang , Yao Liu , Xiaomin Su , Lili Niu , Nannan Li , Ce Xu , Zanya Sun , Huishu Guo , Shun Shen , Minghua Yu","doi":"10.1016/j.mtbio.2024.101273","DOIUrl":"10.1016/j.mtbio.2024.101273","url":null,"abstract":"<div><div>Bacteria-mediated antitumor therapy has gained widespread attention for its innate tumor-targeting capability and excellent immune activation properties. Nevertheless, the clinical approval of bacterial therapies remains elusive primarily due to the formidable challenge of balancing safety with enhancing <em>in vivo</em> efficacy. In this study, leveraging the probiotic <em>Escherichia coli Nissle1917</em> (<em>EcN</em>) emerges as a promising approach for colon cancer therapy, offering a high level of safety attributed to its lack of virulence factors and its tumor-targeting potential owing to its obligate anaerobic nature. Specifically, we delineate the erythrocyte (RBC) membrane-camouflaged <em>EcN</em>, termed as Trojan horse <em>EcN</em>@RBC, which triggers apoptosis in tumor cells by mitigating mitochondrial membrane potential (MMP) and subsequently activating the PINK1/Parkin pathway associated with mitophagy. Concurrently, the decline in MMP induced by mitophagy disrupts the mitochondrial permeability transition pore (MPTP), leading to the release of Cytochrome C and subsequent apoptosis induction. Moreover, synergistic effects were observed through the combination of the autophagy activator rapamycin, bolstering the antitumor efficacy <em>in vivo</em>. These findings offer novel insights into probiotic-mediated antitumor mechanisms and underscore the therapeutic potential of <em>EcN</em>@RBC for colon cancer patients.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101273"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic nanobead assisted the dual targets driven fluorescent biosensor based on SPEXPAR and MNAzyme for the olfactory marker protein detection 基于 SPEXPAR 和 MNAzyme 的纳米磁珠辅助双目标驱动荧光生物传感器用于嗅觉标志蛋白检测

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101272

Jing Qi , Xuemin Cao , Hongyi Bao , Tuodi Zhang , Yichen Wang , Ya Wen , Junling Yang , Guixuan Ge , Ping Wang , Lin Chen , Feng Wang

引用次数: 0

Decellularized extracellular matrix-based disease models for drug screening 用于药物筛选的基于细胞外基质的脱细胞疾病模型

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101280

Zhoujiang Chen , Ji Wang , Ranjith Kumar Kankala , Mingli Jiang , Lianlin Long , Wei Li , Liang Zou , Aizheng Chen , Ya Liu

{"title":"Decellularized extracellular matrix-based disease models for drug screening","authors":"Zhoujiang Chen , Ji Wang , Ranjith Kumar Kankala , Mingli Jiang , Lianlin Long , Wei Li , Liang Zou , Aizheng Chen , Ya Liu","doi":"10.1016/j.mtbio.2024.101280","DOIUrl":"10.1016/j.mtbio.2024.101280","url":null,"abstract":"<div><div><em>In vitro</em> drug screening endeavors to replicate cellular states closely resembling those encountered <em>in vivo</em>, thereby maximizing the fidelity of drug effects and responses within the body. Decellularized extracellular matrix (dECM)-based materials offer a more authentic milieu for crafting disease models, faithfully emulating the extracellular components and structural complexities encountered by cells <em>in vivo</em>. This review discusses recent advancements in leveraging dECM-based materials as biomaterials for crafting cell models tailored for drug screening. Initially, we delineate the biological functionalities of diverse ECM components, shedding light on their potential influences on disease model construction. Further, we elucidate the decellularization techniques and methodologies for fabricating cell models utilizing dECM substrates. Then, the article delves into the research strides made in employing dECM-based models for drug screening across a spectrum of ailments, including tumors, as well as heart, liver, lung, and bone diseases. Finally, the review summarizes the bottlenecks, hurdles, and promising research trajectories associated with the dECM materials for drug screening, alongside their prospective applications in personalized medicine. Together, by encapsulating the contemporary research landscape surrounding dECM materials in cell model construction and drug screening, this review underscores the vast potential of dECM materials in drug assessment and personalized therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101280"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity 可注射、释放氧气、热敏性水凝胶可促进血管化骨形成，延长氧气输送时间，提高骨诱导性

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101267

Yixin Xu , Shaowei Zheng , Zinan Tang , Qiang Zhong , Rong Chen , Pinkai Wang , Jinlang Fu , Jiajun Xie , Yanhong Ning , Mingyuan Lei , Ding Wang , Huaming Mai , Hao Li , Chunhan Sun , Zhanjun Shi , Hao Cheng , Zhe Shi

{"title":"Injectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity","authors":"Yixin Xu , Shaowei Zheng , Zinan Tang , Qiang Zhong , Rong Chen , Pinkai Wang , Jinlang Fu , Jiajun Xie , Yanhong Ning , Mingyuan Lei , Ding Wang , Huaming Mai , Hao Li , Chunhan Sun , Zhanjun Shi , Hao Cheng , Zhe Shi","doi":"10.1016/j.mtbio.2024.101267","DOIUrl":"10.1016/j.mtbio.2024.101267","url":null,"abstract":"<div><div>The failure or delay in healing of critical bone defects is primarily due to early local anoxic conditions and reduced osteogenic activity. In this research, we integrated calcium peroxide (CPO) embedded polycaprolactone (PCL) microspheres and osteoinductive nanoparticles (Hydroxyapatite/Laponite) into a thermosensitive hydrogel (Pluronic F127), thereby formulating an injectable oxygen-releasing osteogenic thermosensitive hydrogel. Notably, the oxygen-releasing microspheres (ORMs) within the composite hydrogel provide stable oxygen release for up to 21 days, ensuring the survival, migration, and bioactivity of both mesenchymal stem cells and endothelial cells under anoxic conditions. Additionally, the composite hydrogel significantly augments the osteogenic potential of bone marrow mesenchymal stem cells by providing a biomimetic microenvironment with the incorporation of nano-hydroxyapatite/laponite. Ultimately, the injectable composite hydrogel successfully stimulated bone regeneration within a cranial defect in a rat model after 8 weeks, with enhanced vascularization and bone quality. The engineered hydrogel provides a minimally invasive approach to stimulate bone regeneration with a sustained oxygen supply and osteogenic microenvironment provision, underlining its potential for treating critical bone defects.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101267"},"PeriodicalIF":8.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer cell membrane-coated siRNA-Decorated Au/MnO2 nanosensitizers for synergistically enhanced radio-immunotherapy of breast cancer 用于协同增强乳腺癌放射免疫疗法的癌细胞膜包被 siRNA Decorated Au/MnO2 纳米敏化剂

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-26 DOI: 10.1016/j.mtbio.2024.101275

Diyu Wang , Subin Lin , Tuanwei Li , Xiaohu Yang , Xiang Zhong , Qian Chen , Guoqin Jiang , Chunyan Li

{"title":"Cancer cell membrane-coated siRNA-Decorated Au/MnO2 nanosensitizers for synergistically enhanced radio-immunotherapy of breast cancer","authors":"Diyu Wang , Subin Lin , Tuanwei Li , Xiaohu Yang , Xiang Zhong , Qian Chen , Guoqin Jiang , Chunyan Li","doi":"10.1016/j.mtbio.2024.101275","DOIUrl":"10.1016/j.mtbio.2024.101275","url":null,"abstract":"<div><div>Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO<sub>2</sub> nanosensitizer (R&F@Au/MnO<sub>2</sub>-CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO<sub>2</sub> is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO<sub>2</sub>-CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO<sub>2</sub> upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101275"},"PeriodicalIF":8.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-organic transistors printed on a biodegradable and bioderived substrate for sustainable bioelectronics 印制在可生物降解和生物衍生基底上的全有机晶体管，实现可持续生物电子学

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-26 DOI: 10.1016/j.mtbio.2024.101274

Fabrizio A. Viola , Ksenija Maksimovic , Pietro Cataldi , Camilla Rinaldi , Elena Stucchi , Filippo Melloni , Athanassia Athanassiou , Mario Caironi

{"title":"All-organic transistors printed on a biodegradable and bioderived substrate for sustainable bioelectronics","authors":"Fabrizio A. Viola , Ksenija Maksimovic , Pietro Cataldi , Camilla Rinaldi , Elena Stucchi , Filippo Melloni , Athanassia Athanassiou , Mario Caironi","doi":"10.1016/j.mtbio.2024.101274","DOIUrl":"10.1016/j.mtbio.2024.101274","url":null,"abstract":"<div><div>Biodegradable electronics is an incipient need in order to mitigate the alarming increase of electronic waste worldwide caused by capillary penetration of electronic devices and sensors. Flexibility, solution processability, low capital expenditure, and energy-efficient processes, which are distinctive features of organic printed electronics, have to be complemented by a sustainable sourcing and end-of-life of materials employed. This requirement calls for solutions where materials, especially substrates that typically represent the largest volume, can be biodegraded in the environment with no harm, yet assuring that no precious resources are dispersed. In this work, the bioderived and biodegradable biopolymer polyhydroxybutyrate (PHB) was used as a substrate, cast from an acetic acid solution, for all-organic field effect transistors (OFETs) based on an inkjet printed polymer semiconductor. The OFETs showed small device-to-device variation, a proper current modulation with <em>I</em><sub><em>ON</em></sub>/<em>I</em><sub><em>OFF</em></sub> of about 1.2·10<sup>3</sup>, mobility values as high as 0.07 cm<sup>2</sup>/Vs in saturation regime and channel length/width normalized leakage currents in the order of nA, which remained almost unaltered also after intensive mechanical stresses upon bending and rolling. Such mechanical stability and flexibility, together with the biodegradability and bioderivation, make PHB an appealing candidate for the development of sustainable printed bioelectronics, with widespread future applications in the biomedical and food packaging sector.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101274"},"PeriodicalIF":8.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration 具有持续释放多柔比星功能的多巴胺功能化缺钙羟基磷灰石三维打印支架，用于骨肉瘤的协同化疗-光热疗法和加速骨再生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-25 DOI: 10.1016/j.mtbio.2024.101253

Lu Wang , Zihan Dai , Jianqiang Bi , Yunzhen Chen , Ziyu Wang , Zhenqian Sun , Zhongjie Ji , Hongliang Wang , Yan Zhang , Limei Wang , Junjie Mao , Junxing Yang

{"title":"Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration","authors":"Lu Wang , Zihan Dai , Jianqiang Bi , Yunzhen Chen , Ziyu Wang , Zhenqian Sun , Zhongjie Ji , Hongliang Wang , Yan Zhang , Limei Wang , Junjie Mao , Junxing Yang","doi":"10.1016/j.mtbio.2024.101253","DOIUrl":"10.1016/j.mtbio.2024.101253","url":null,"abstract":"<div><div>Interior bone-tissue regeneration and rapid tumor recurrence post-resection are critical challenges in osteosarcoma and other bone cancers. Conventional bone tissue engineering scaffolds lack inhibitory effects on bone tumor recurrence. Herein, multifunctional scaffolds (named DOX/PDA@CDHA) were designed through the spontaneous polymerization of Dopamine (PDA) on the surface of Calcium Deficient Hydroxyapatite (CDHA) scaffolds, followed by in situ loading of the chemotherapeutic drug Doxorubicin (DOX). The PDA coating endowed the scaffolds with significant photothermal properties, while the gradual release of DOX provided an effective chemotherapeutic effect. The on-demand release of DOX at tumor sites, triggered by dual stimulation (near-infrared (NIR) light and the acidic pH typical of tumor microenvironments), specifically targets cancer cells, thereby mitigating systemic side effects. These unique characteristics facilitated effective osteosarcoma eradication both in vitro and in vivo. Moreover, the scaffold's composition, which mimics the mineral phase of natural bone and is enhanced by PDA's biocompatibility, promotes critical osteogenic and angiogenic processes. This facilitates not only tumor eradication but also the regeneration of healthy bone tissue. Collectively, this study presents a potent candidate for the regeneration of bone defects induced by osteosarcoma.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101253"},"PeriodicalIF":8.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted regulation of autophagy using sorafenib-loaded biomineralization nanoenzyme for enhanced photodynamic therapy of hepatoma 利用装载索拉非尼的生物矿化纳米酶靶向调节自噬，增强肝癌的光动力疗法

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-24 DOI: 10.1016/j.mtbio.2024.101270

Tianming Lu , Zixian Liu , Ruoning Qian , Yitian Zhou , Jun Li , Qiang Zhang , Hao Yang , Wenli Lu , Yanlin Xin , Zejuan Xie , Lesan Yan , Shanshan Wang , Ruogu Qi , Zhengguang Zhang

{"title":"Targeted regulation of autophagy using sorafenib-loaded biomineralization nanoenzyme for enhanced photodynamic therapy of hepatoma","authors":"Tianming Lu , Zixian Liu , Ruoning Qian , Yitian Zhou , Jun Li , Qiang Zhang , Hao Yang , Wenli Lu , Yanlin Xin , Zejuan Xie , Lesan Yan , Shanshan Wang , Ruogu Qi , Zhengguang Zhang","doi":"10.1016/j.mtbio.2024.101270","DOIUrl":"10.1016/j.mtbio.2024.101270","url":null,"abstract":"<div><div>Sorafenib (SF), a multi-targeted tyrosine kinase inhibitor, serves as a primary therapeutic modality for advanced liver cancer. Nonetheless, its clinical efficacy is hindered by various obstacles, such as limited bioavailability and inadequate accumulation. This study introduces a novel biomimetic mineralization enzyme, known as BSA@Pt/Ce6/SF@M (PCFM). The PCFM incorporates platinum (Pt) as a catalytic agent, SF as a molecular-targeted therapeutic agent, and Ce6 as a photosensitizer within liver cancer cell membranes. This strategy enables the combination of various anti-tumor treatments, such as photodynamic therapy (PDT) and autophagy induction, leading to increased bioavailability of SF and achieving a multidimensional synergistic anticancer effect. The PDT effect produced by Ce6 in PCFM greatly enhances SF-induced autophagy, effectively promoting autophagic cell death. Furthermore, Pt dissociates from the biomineralization process, acquiring peroxidase properties through chemokinetic reactions. This facilitates the catalysis of significant oxygen generation, addressing the challenge of hypoxia in the tumor microenvironment and improving the efficacy of PDT. Moreover, the SF further enhances therapeutic efficacy by inducing autophagy in response to energy deprivation, as indicated by the reduced levels of HIF-1α, p62, along with increased levels of ROS and LC3-Ⅱ/Ι. This biomineralization-based nanoenzyme exhibits strong anti-tumor characteristics, offering a novel strategy for overcoming challenges in liver cancer treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101270"},"PeriodicalIF":8.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing 无定形磷酸锌纳米团簇负载聚碳酸酯热敏水凝胶：促进伤口愈合的创新策略

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-24 DOI: 10.1016/j.mtbio.2024.101266

Siwen Chen , Yutong Li , Sihang Ren , Yuanyuan Yang , Zhipeng Hou , Siyu Han , Wanhong Zhang , Jing Guo , Jianshe Hu , Xing Zhang , Liqun Yang

{"title":"Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing","authors":"Siwen Chen , Yutong Li , Sihang Ren , Yuanyuan Yang , Zhipeng Hou , Siyu Han , Wanhong Zhang , Jing Guo , Jianshe Hu , Xing Zhang , Liqun Yang","doi":"10.1016/j.mtbio.2024.101266","DOIUrl":"10.1016/j.mtbio.2024.101266","url":null,"abstract":"<div><div>Skin trauma is a matter of great concern for public health, emphasizing the importance of reconstructing the microenvironment at the trauma site to facilitate tissue regeneration. Therefore, the investigation of innovative wound dressings has significant research and clinical implications. In this study, we prepared a thermosensitive hydrogel based on a hydrophilic-hydrophobic-hydrophilic triblock polycarbonate polymer (PTP), and created a composite hydrogel, PTPH-AZP, by incorporating amorphous zinc phosphate (AZP) nanoclusters. We evaluated the effects of PTPH-AZP on human umbilical vein endothelial cells (HUVECs) and the ability to promote skin wound healing. According to the results, PTPH-AZP was found to promote the proliferation, migration, and tube formation of HUVECs through the sustained release of Zn<sup>2+</sup> at appropriate concentrations. <em>In vivo</em> experiments demonstrated that in the early-mid stages of wound healing, PTPH-AZP promotes increases in Platelet Endothelial Cell Adhesion Molecule-1 (CD31) and α-Smooth Muscle Actin (α-SMA) content within the wound area, facilitating accelerated re-epithelialization and enhanced collagen deposition. In later healing stages, epidermal thickness in the PTPH-AZP treated group was significantly improved, aligning with surrounding intact skin with no instances of attenuated or hypertrophic scarring observed. The findings from the <em>in vivo</em> study suggested that PTPH-AZP may have a positive impact on vascularization and wound healing. In conclusion, this study presents a promising strategy for skin wound healing, highlighting the potential of PTPH-AZP as an effective therapeutic approach.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101266"},"PeriodicalIF":8.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0